Eriocalyxin B inhibits STAT3 signaling by covalently targeting STAT3 and blocking phosphorylation and activation of STAT3

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Yu, Xiaokui ^a   He, Li ^a   Cao, Peng ^b   Yu, Qiang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b Jiangsu Provincial Hospital of Chinese Medicine   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; CYSTEINE; DITERPENOID; DITHIOTHREITOL; ERIOCALYXIN B; GLUTATHIONE; PHOSPHATASE; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; UNCLASSIFIED DRUG; DITERPENE; HERBACEOUS AGENT; MOLECULAR LIBRARY; STAT3 PROTEIN, HUMAN;

A549 CELL LINE; APOPTOSIS; ARTICLE; COVALENT BOND; DRUG MECHANISM; HEPG2 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MTT ASSAY; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; GENETICS; HEP-G2 CELL LINE; METABOLISM; MOLECULAR LIBRARY; MOLECULAR MODEL; PHOSPHORYLATION; TUMOR CELL LINE;

ISODON ERIOCALYX;

APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CYSTEINE; DITERPENES; DRUGS, CHINESE HERBAL; HEP G2 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STAT3 TRANSCRIPTION FACTOR;

EID: 84930227324     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128406     Document Type: Article

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