Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 6, 2013, Pages 2258-2263

  Lu, Ying ^a   Chen, Bing ^a   Song, Jun Hong ^a   Zhen, Tao ^a   Wang, Bai Yan ^a   Li, Xin ^b   Liu, Ping ^a   Yang, Xin ^c   Zhang, Qun Ling ^d   Xi, Xiao Dong ^a   Chen, Sheng Di ^c   Zuo, Jian Ping ^b   Chen, Zhu ^a   Chen, Sai Juan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

Cytokines; Traditional Chinese medicine

Indexed keywords

ANTIINFLAMMATORY AGENT; DITERPENOID; ERIOCALYXIN B; INTERLEUKIN 12; INTERLEUKIN 6; JANUS KINASE 1; JANUS KINASE 2; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; REACTIVE OXYGEN METABOLITE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMYELINATION; DRUG EFFICACY; FEMALE; GENE EXPRESSION; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; MULTIPLE SCLEROSIS; MYELITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SCLEROSIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH17 CELL;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNITY; DITERPENES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOSUPPRESSIVE AGENTS; MEDICINE, CHINESE TRADITIONAL; MICE; MICE, INBRED C57BL; NF-KAPPA B; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TH1 CELLS; TH17 CELLS;

EID: 84873430253     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222426110     Document Type: Article

References (35)

1. Thompson AJ, Toosy AT, Ciccarelli O (2010) Pharmacological management of symptoms in multiple sclerosis: Current approaches and future directions. Lancet Neurol 9(12):1182-1199.
2. Conway D, Cohen JA (2010) Combination therapy in multiple sclerosis. Lancet Neurol 9(3):299-308.
3. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140(6):918-934.
4. Hafler DA (2004) Multiple sclerosis. J Clin Invest 113(6):788-794.
5. Zhou L, Chong MM, Littman DR (2009) Plasticity of CD4+ T cell lineage differentiation. Immunity 30(5):646-655.
6. Hofstetter H, Gold R, Hartung HP (2009) Th17 Cells in MS and experimental autoimmune encephalomyelitis. Int MS J 16(1):12-18.
7. Qin X, et al. (2010) Regulation of Th1 and Th17 cell differentiation and amelioration of experimental autoimmune encephalomyelitis by natural product compound berberine. J Immunol 185(3):1855-1863.
8. Lassmann H, van Horssen J (2011) The molecular basis of neurodegeneration in multiple sclerosis. FEBS Lett 585(23):3715-3723.
9. Zhu J, Paul WE (2010) Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev 238(1):247-262.
10. Bettelli E, Korn T, Oukka M, Kuchroo VK (2008) Induction and effector functions of T(H)17 cells. Nature 453(7198):1051-1057.
11. Leung CH, et al. (2006) Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive manner. Mol Pharmacol 70(6):1946-1955.
12. Wang L, et al. (2007) Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner. Cell Death Differ 14(2):306-317.
13. Zhang YW, et al. (2010) Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways. Exp Hematol 38(3):191-201.
14. Stromnes IM, Goverman JM (2006) Passive induction of experimental allergic encephalomyelitis. Nat Protoc 1(4):1952-1960.
15. Zhen T, et al. (2012) Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein. Sci Transl Med 4:127ra138.
16. Liu CX, et al. (2012) Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol 8(5):486-493.
17. Hilliard B, Samoilova EB, Liu TS, Rostami A, Chen Y (1999) Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice: Roles of NF-kappa B in the activation and differentiation of autoreactive T cells. J Immunol 163(5):2937-2943.
18. Wang Z, et al. (2007) Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. J Immunol 179(9):5958-5965.
19. κB in immunobiology. Cell Res 21(2):223-244.
20. κB pathway in ovarian cancer stem cells. Am J Reprod Immunol 65(4):438-447.
21. Dasgupta S, et al. (2004) Antineuroinflammatory effect of NF-kappaB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J Immunol 173(2):1344-1354.
22. Hultqvist M, Olofsson P, Gelderman KA, Holmberg J, Holmdahl R (2006) A new arthritis therapy with oxidative burst inducers. PLoS Med 3(9):e348.
23. Olofsson P, et al. (2003) Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet 33(1):25-32.
24. Hultqvist M, et al. (2004) Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci USA 101(34):12646-12651.
25. Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM (2008) IL-12-and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med 205(7):1535-1541.
26. Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G (2010) Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS ONE 5(11):e15531.
27. Imitola J, Chitnis T, Khoury SJ (2005) Cytokines in multiple sclerosis: From bench to bedside. Pharmacol Ther 106(2):163-177.
28. Miossec P, Korn T, Kuchroo VK (2009) Interleukin-17 and type 17 helper T cells. N Engl J Med 361(9):888-898.
29. Liu X, et al. (2010) Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med 16(2):191-197.
30. Kebir H, et al. (2007) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13(10):1173-1175.
31. Tse HM, et al. (2010) NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity. J Immunol 185(9):5247-5258.
32. Ghoreschi K, et al. (2011) Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 208(11):2291-2303.
33. Zozulya AL, Clarkson BD, Ortler S, Fabry Z, Wiendl H (2010) The role of dendritic cells in CNS autoimmunity. J Mol Med (Berl) 88(6):535-544.
34. Skarica M, et al. (2009) Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis. J Immunol 182(7):4192-4199.
35. Barnes PJ, Karin M (1997) Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336(15):1066-1071.