The biosynthesis of capuramycin-type antibiotics: Identification of the A-102395 biosynthetic gene cluster, mechanism of self-resistance, and formation of uridine-5′-carboxamide

Journal of Biological Chemistry

Volumn 290, Issue 22, 2015, Pages 13710-13724

  Cai, Wenlong ^a   Goswami, Anwesha ^a   Yang, Zhaoyong ^b   Liu, Xiaodong ^a   Green, Keith D ^a   Barnard Britson, Sandra ^a   Baba, Satoshi ^c   Funabashi, Masanori ^c   Nonaka, Koichi ^c   Sunkara, Manjula ^d   Morris, Andrew J ^d   Spork, Anatol P ^e   Ducho, Christian ^e   Garneau Tsodikova, Sylvie ^a   Thorson, Jon S ^a   Van Lanen, Steven G ^a  

^a University of Kentucky   (United States)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^c DAIICHI SANKYO CO   (Japan)

^d UNIVERSITY OF KENTUCKY   (United States)

^e SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOCHEMISTRY; CARBON; CLONING; ENCODING (SYMBOLS); GENE ENCODING; GENES;

BIOSYNTHETIC GENE CLUSTER; C-C BOND FORMATION; CELL WALL BIOSYNTHESIS; COMPARATIVE GENOMICS; HETEROLOGOUS PRODUCTION; ISOTOPIC ENRICHMENT; PHOSPHOTRANSFERASES; STRUCTURAL COMPONENT;

BIOSYNTHESIS;

2 OXOGLUTARIC ACID; A 102395; A 500359; A 503083; AMIDE; ANTIBIOTIC AGENT; CAPURAMYCIN; DIOXYGENASE; THREONINE; TRANSALDOLASE; UNCLASSIFIED DRUG; URIDINE 5' ALDEHYDE TRANSALDOLASE; URIDINE 5' CARBOXAMIDE; URIDINE 5' MONOPHOSPHATE DIOXYGENASE; A-102395; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; HEME; PROTEIN BINDING; RECOMBINANT PROTEIN; URIDINE; URIDINE PHOSPHATE;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL BOND; CHEMICAL COMPOSITION; CONTROLLED STUDY; CPR19 GENE; CPR25 GENE; DRUG DETERMINATION; DRUG RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; GENE; GENE CLUSTER; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CHEMISTRY; DRUG DESIGN; ESCHERICHIA COLI; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; STREPTOMYCES;

BACTERIA (MICROORGANISMS);

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; HEME; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OPEN READING FRAMES; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; RECOMBINANT PROTEINS; STREPTOMYCES; THREONINE; TRANSALDOLASE; URIDINE; URIDINE MONOPHOSPHATE;

EID: 84930225562     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.646414     Document Type: Article

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