Functional and kinetic analysis of the phosphotransferase capp conferring selective self-resistance to capuramycin antibiotics

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 12899-12905

  Yang, Zhaoyong ^a   Funabashi, Masanori ^b   Nonaka, Koichi ^b   Hosobuchi, Masahiko ^b   Shibata, Tomoyuki ^b   Pahari, Pallab ^a   Van Lanen, Steven G ^a  

^a University of Kentucky   (United States)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID MOIETY; AMINOGLYCOSIDES; ANTIBIOTIC ACTIVITY; BIOSYNTHETIC GENE CLUSTER; CATALYZED REACTIONS; CELL WALL BIOSYNTHESIS; KINETIC ANALYSIS; KINETIC MECHANISM; MYCOBACTERIUM SMEGMATIS; PEPTIDOGLYCANS; PHOSPHOTRANSFERASES; POTENTIAL MECHANISM; RELATED COMPOUNDS; SECOND GENERATION; SUBSTRATE KINETICS; TRANSLOCASES;

ACIDS; ANTIBIOTICS; BACTERIOLOGY; BIOCHEMISTRY; BIOSYNTHESIS; ESCHERICHIA COLI; PHOSPHORYLATION; PURIFICATION;

GENE ENCODING;

A 500359A; A 500359B; A 503083A; A 503083B; ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; CAPURAMYCIN; CARRIER PROTEIN; HEXURONIC ACID; HYDROXYL GROUP; PEPTIDOGLYCAN; PHOSPHOTRANSFERASE; PROTEIN CAPP; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME KINETICS; ESCHERICHIA COLI; GENE CLUSTER; GENETIC CODE; GENETIC IDENTIFICATION; IC 50; MOLECULAR MECHANICS; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CLONING, MOLECULAR; DRUG RESISTANCE, BACTERIAL; KANAMYCIN KINASE; KINETICS; MYCOBACTERIUM SMEGMATIS; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS;

EID: 77951240306     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.104141     Document Type: Article

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