Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock

Shock

Volumn 42, Issue 5, 2014, Pages 432-439

  Starr, Anna ^a   Sand, Claire ^a   Heikal, Lamia ^a   Kelly, Peter ^b   Spina, Domenico ^a   Crabtree, Mark ^c   Channon, Keith ^c   Leiper, James ^b   Nandi, Manasi ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

circulatory shock; microvascular flow; sepsis; Tetrahydrobiopterin; vascular nitric oxide

Indexed keywords

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; NITRIC OXIDE; REGULATOR PROTEIN; TETRAHYDROBIOPTERIN; BIOPTERIN; CARRIER PROTEIN; GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, MOUSE; SAPROPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BLOOD BIOCHEMISTRY; CONTROLLED STUDY; FEEDBACK SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOTENSION; INFLAMMATION; MESENTERY BLOOD FLOW; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SEPSIS; SEPTIC SHOCK; SHOCK; TELEMETRY; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HEMODYNAMICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPLANCHNIC BLOOD FLOW; TRANSGENIC MOUSE;

ANIMALS; BIOPTERIN; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEMODYNAMICS; MICE, INBRED C57BL; MICE, TRANSGENIC; NITRIC OXIDE; SHOCK, SEPTIC; SPLANCHNIC CIRCULATION;

EID: 84930086255     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000235     Document Type: Article

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