Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle

Cardiovascular Research

Volumn 74, Issue 1, 2007, Pages 151-158

  Lidington, Darcy ^a,b   Li, Fuyan ^a,b   Tyml, Karel ^a,b  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Impaired vasodilation; Nitric oxide synthases; Sepsis

Indexed keywords

7 NITROINDAZOLE; ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOENZYME; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; ERYTHROCYTE; GENE DELETION; LIGATION; MALE; NONHUMAN; PERFORATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEPSIS; SKELETAL MUSCLE; VASODILATATION; WESTERN BLOTTING;

ACETYLCHOLINE; ANIMALS; ARTERIOLES; BIOLOGICAL FACTORS; BLOOD FLOW VELOCITY; ENDOTHELIUM, VASCULAR; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; SEPSIS; VASODILATION; VASODILATOR AGENTS;

EID: 33847611016     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2006.12.022     Document Type: Article

References (32)

1. Bone R.C. Gram-negative sepsis. Background, clinical features, and intervention. Chest 100 (1991) 802-808
2. Lam C., Tyml K., Martin C., and Sibbald W. Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94 (1994) 2077-2083
3. Gocan N.C., Scott J.A., and Tyml K. Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle. Am J Physiol Heart Circ Physiol 278 (2000) H1480-H1489
4. Hollenberg S.M., Cunnion R.E., and Zimmerberg J. Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats. Am J Physiol 264 (1993) H660-H663
5. Baker C.H., and Sutton E.T. Arteriolar endothelium-dependent vasodilation occurs during endotoxin shock. Am J Physiol 264 (1993) H1118-H1123
6. Broccard A., Hurni J.M., Eckert P., Liaudet L., Schaller M.D., Lazor R., et al. Tissue oxygenation and hemodynamic response to NO synthase inhibition in septic shock. Shock 14 (2000) 35-40
7. Feihl F., Waeber B., and Liaudet L. Is nitric oxide overproduction the target of choice for the management of septic shock?. Pharmacol Ther 91 (2001) 179-213
8. Lirk P., Hoffmann G., and Rieder J. Inducible nitric oxide synthase-time for reappraisal. Curr Drug Targets Inflamm Allergy 1 (2002) 89-108
9. Wu F., Wilson J.X., and Tyml K. Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression. Free Radic Biol Med 37 (2004) 1282-1289
10. el-Dwairi Q., Comtois A., Guo Y., and Hussain S.N. Endotoxin-induced skeletal muscle contractile dysfunction: contribution of nitric oxide synthases. Am J Physiol 274 (1998) C770-C779
11. McKinnon R.L., Lidington D., Bolon M., Ouellette Y., Kidder G.M., and Tyml K. Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO. Cardiovasc Res 69 (2006) 236-244
12. Scott J.A., Machoun M., and McCormack D.G. Inducible nitric oxide synthase and vascular reactivity in rat thoracic aorta: effect of aminoguanidine. J Appl Physiol 80 (1996) 271-277
13. Yildiz G., Demiryurek A.T., Sahin-Erdemli I., and Kanzik I. Comparison of antioxidant activities of aminoguanidine, methylguanidine and guanidine by luminol-enhanced chemiluminescence. Br J Pharmacol 124 (1998) 905-910
14. Lidington D., Ouellette Y., Li F., and Tyml K. Conducted vasoconstriction is reduced in a mouse model of sepsis. J Vasc Res 40 (2003) 149-158
15. Dietrich H.H. Effect of locally applied epinephrine and norepinephrine on blood flow and diameter in capillaries of rat mesentery. Microvasc Res 38 (1989) 125-135
16. Mitchell D., Yu J., and Tyml K. Comparable effects of arteriolar and capillary stimuli on blood flow in rat skeletal muscle. Microvasc Res 53 (1997) 22-32
17. Tyml K., and Ellis C.G. Evaluation of the flying spot technique as a television method for measuring red cell velocity in microvessels. Int J Microcirc Clin Exp 1 (1982) 145-155
18. Tyml K., Yu J., and McCormack D.G. Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis. J Appl Physiol 84 (1998) 837-844
19. Huang A., Sun D., Smith C.J., Connetta J.A., Shesely E.G., Koller A., et al. In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF. Am J Physiol Heart Circ Physiol 278 (2000) H762-H768
20. Sakr Y., Dubois M.J., De B.D., Creteur J., and Vincent J.L. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32 (2004) 1825-1831
21. Spronk P.E., Ince C., Gardien M.J., Mathura K.R., Oudemans-van Straaten H.M., and Zandstra D.F. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 360 (2002) 1395-1396
22. De B.D., Creteur J., Preiser J.C., Dubois M.J., and Vincent J.L. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166 (2002) 98-104
23. Hoffmann J.N., Vollmar B., Laschke M.W., Inthorn D., Fertmann J., Schildberg F.W., et al. Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia. Crit Care Med 32 (2004) 1011-1017
24. Boczkowski J., Vicaut E., and Aubier M. In vivo effects of Escherichia coli endotoxemia on diaphragmatic microcirculation in rats. J Appl Physiol 72 (1992) 2219-2224
25. Lopez A., Lorente J.A., Steingrub J., Bakker J., McLuckie A., Willatts S., et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32 (2004) 21-30
26. Hayashi Y., Nishio M., Naito Y., Yokokura H., Nimura Y., Hidaka H., et al. Regulation of neuronal nitric-oxide synthase by calmodulin kinases. J Biol Chem 274 (1999) 20597-20602
27. Hashiguchi N., Ogura H., Tanaka H., Koh T., Nakamori Y., Noborio M., et al. Enhanced expression of heat shock proteins in activated polymorphonuclear leukocytes in patients with sepsis. J Trauma 51 (2001) 1104-1109
28. Song Y., Zweier J.L., and Xia Y. Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding. Biochem J 355 (2001) 357-360
29. Stamler J.S., and Meissner G. Physiology of nitric oxide in skeletal muscle. Physiol Rev 81 (2001) 209-237
30. Nishida C.R., and Ortiz de Montellano P.R. Autoinhibition of endothelial nitric-oxide synthase. Identification of an electron transfer control element. J Biol Chem 274 (1999) 14692-14698
31. Miyamoto A., Laufs U., Pardo C., and Liao J.K. Modulation of bradykinin receptor ligand binding affinity and its coupled G-proteins by nitric oxide. J Biol Chem 272 (1997) 19601-19608
32. In: Vanhoutte P.M. (Ed). Endothelium dependent hyperpolarizations. Pharmacol Res vol. 48 (2004) 503-580