Metallothionein Abrogates GTP Cyclohydrolase I Inhibition-Induced Cardiac Contractile and Morphological Defects Role of Mitochondrial Biogenesis

Hypertension

Volumn 53, Issue 6, 2009, Pages 1023-1031

  Ceylan Isik, Asli F ^a,c   Guo, Kelly K ^a   Carlson, Edward C ^b   Privratsky, Jamie R ^b   Liao, Song Jie ^c   Cai, Lu ^d   Chen, Alex F ^a,c   Ren, Jun ^a,b  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d University of Louisville School of Medicine   (United States)

Author keywords

BH4; Cardiomyocyte mechanics; Enos uncoupling; Metallothionein; Superoxide

Indexed keywords

2,4 DIAMINO 6 HYDROXY PYRIMIDINE; CALCIUM; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; METALLOTHIONEIN; PYRIMIDINE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; 5 DEHYDRO 3 DEOXY D ARABINO HEPTULOSONIC ACID 7 PHOSPHATE; 5,6,7,8-TETRAHYDROBIOPTERIN; 5-DEHYDRO-3-DEOXY-D-ARABINO-HEPTULOSONIC ACID-7-PHOSPHATE; BIOPTERIN; DRUG DERIVATIVE; NITRIC OXIDE; RNA; SUGAR ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONGENITAL HEART MALFORMATION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALYSIS OF VARIANCE; ANIMAL; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; ECHOCARDIOGRAPHY; HEART CONTRACTION; HEART MITOCHONDRION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; OXYGEN CONSUMPTION; PHYSIOLOGY; PROBABILITY; RANDOMIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BIOPTERIN; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; GTP CYCLOHYDROLASE; MALE; METALLOTHIONEIN; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NITRIC OXIDE; OXYGEN CONSUMPTION; PROBABILITY; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SENSITIVITY AND SPECIFICITY; SUGAR ACIDS;

EID: 67049159464     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.108.123422     Document Type: Article

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