Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

Cardiovascular Research

Volumn 93, Issue 4, 2012, Pages 694-701

  Adlam, David ^a   Herring, Neil ^a   Douglas, Gillian ^a   De Bono, Joseph P ^a   Li, Dan ^a   Danson, Edward J ^a   Tatham, Amy ^a   Lu, Cheih Ju ^a   Jennings, Katie A ^a   Cragg, Stephanie J ^a   Casadei, Barbara ^a   Paterson, David J ^a   Channon, Keith M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Autonomic function; Exercise; Heart rate; Tetrahydrobiopterin

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BIOLOGICAL MARKER; CARBACHOL; CYCLIC AMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FORSKOLIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; PROPRANOLOL; RECEPTOR PROTEIN; TETRAHYDROBIOPTERIN; TYROSINE 3 MONOOXYGENASE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; BRADYCARDIA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; ENZYME ACTIVITY; EXERCISE; GCH1 GENE; GENE; GENE EXPRESSION; GENETIC VARIABILITY; HEART RATE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STELLATE GANGLION; TACHYCARDIA; VAGUS NERVE STIMULATION; WILD TYPE;

ADRENERGIC BETA-AGONISTS; ANIMALS; AUTONOMIC NERVOUS SYSTEM; BIOPTERIN; BRADYCARDIA; DISEASE MODELS, ANIMAL; GTP CYCLOHYDROLASE; HEART RATE; ISOPROTERENOL; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NITRIC OXIDE SYNTHASE; PHYSICAL CONDITIONING, ANIMAL; RECEPTORS, ADRENERGIC, BETA; VAGUS NERVE STIMULATION;

EID: 84863296038     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs005     Document Type: Review

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