Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F

Laboratory Investigation

Volumn 95, Issue 6, 2015, Pages 648-659

  Oliveira, Amanda R ^a   Beyer, Georg ^a   Chugh, Rohit ^a   Skube, Steven J ^a   Majumder, Kaustav ^a   Banerjee, Sulagna ^a   Sangwan, Veena ^a   Li, Lihua ^a   Dawra, Rajinder K ^a   Subramanian, Subbaya ^a   Saluja, Ashok K ^a   Dudeja, Vikas ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANNEXIN; CASPASE; LACTATE DEHYDROGENASE; MESSENGER RNA; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TRIPTOLIDE; 14-O-PHOSPHONOOXYMETHYLTRIPTOLIDE; ALKYLATING AGENT; DITERPENE; EPOXIDE; ORGANOPHOSPHATE; PHENANTHRENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER MODEL; CANCER PATIENT; CANCER SURVIVAL; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HCT116 CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; S PHASE CELL CYCLE CHECKPOINT; TRANSCRIPTION INITIATION; TRIPTERYGIUM WILFORDII; TUMOR XENOGRAFT; ANIMAL; APOPTOSIS; CELL CYCLE CHECKPOINT; CELL SURVIVAL; COLON TUMOR; DRUG EFFECTS; DRUG SCREENING; GENETICS; METABOLISM; NUDE MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL SURVIVAL; COLONIC NEOPLASMS; DITERPENES; E2F TRANSCRIPTION FACTORS; EPOXY COMPOUNDS; FEMALE; HCT116 CELLS; HT29 CELLS; HUMANS; MICE, NUDE; ORGANOPHOSPHATES; PHENANTHRENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84930034847     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2015.46     Document Type: Article

References (29)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63: 11-30
2. Andre T, Boni C, Navarro M, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 2009; 27: 3109-3116
3. Braun AH, Achterrath W, Wilke H. New systemic frontline treatment for metastatic colorectal carcinoma. Cancer 2004; 100: 1558-1577
4. Phillips PA, Dudeja V, McCarroll JA, et al. Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70. Cancer Res 2007; 67: 9407-9416
5. Banerjee S, Thayanithy V, Sangwan V, et al. Minnelide reduces tumor burden in preclinical models of osteosarcoma. Cancer Lett 2013; 335: 412-420
6. Rousalova I, Banerjee S, Sangwan V, et al. Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo. PLoS One 2013; 8: e77411
7. Clawson KA, Borja-Cacho D, Antonoff MB, et al. Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma. J Surg Res 2010; 163: 244-249
8. Antonoff MB, Chugh R, Borja-Cacho D, et al. Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo. Surgery 2009; 146: 282-290
9. Yang S, Chen J, Guo Z, et al. Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther 2003; 2: 65-72
10. Fidler JM, Li K, Chung C, et al. PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. Mol Cancer Ther 2003; 2: 855-862
11. Liu J, Shen M, Yue Z, et al. Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21. Phytomedicine 2012; 19: 756-762
12. Chugh R, Sangwan V, Patil SP, et al. A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med 2012; 4156ra39
13. Chen Z, Sangwan V, Banerjee S, et al. miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death. Mol Cancer 2013; 12: 105
14. Banerjee S, Sangwan V, McGinn O, et al. Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription Factor Sp1. J Biol Chem 2013; 288: 33927-33938
15. Mujumdar N, Mackenzie TN, Dudeja V, et al. Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology 2010; 139: 598-608
16. Roig AI, Eskiocak U, Hight SK, et al. Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology 2010; 138: 1012-1021
17. Dudeja V, Chugh RK, Sangwan V, et al. Pro-survival role of heat shock factor 1 (HSF1) in the pathogenesis of pancreatobiliary tumors. Am J Physiol Gastrointest Liver Physiol 2011; 300: G948-G955
18. Zhang H, Zhu W, Su X, et al. Triptolide inhibits proliferation and invasion of malignant glioma cells. J Neurooncol 2012; 109: 53-62
19. Zhao F, Chen Y, Li R, et al. Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro. Toxicology 2010; 267: 70-79
20. Li W, Liu Y, Li XX, et al. MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status. Planta Med 2011; 77: 27-31
21. Wanebo HJ, LeGolvan M, Paty PB, et al. Meeting the biologic challenge of colorectal metastases. Clin Exp Metastasis 2012; 29: 821-839
22. Stevens C, La Thangue NB. E2F and cell cycle control: a doubleedged sword. Arch Biochem Biophys 2003; 412: 157-169
23. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13: 1501-1512
24. Martinez-Balbas MA, Bauer UM, Nielsen SJ, et al. Regulation of E2F1 activity by acetylation. Embo J 2000; 19: 662-671
25. Zhu W, Ou Y, Li Y, et al. A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway. Mol Pharmacol 2009; 75: 812-819
26. Westerheide SD, Kawahara TL, Orton K, et al. Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. J Biol Chem. 2006; 281: 9616-9622
27. Pucci B, Kasten M, Giordano A. Cell cycle and apoptosis. Neoplasia 2000; 2: 291-299
28. Irwin M, Marin MC, Phillips AC, et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 2000; 407: 645-648
29. Moroni MC, Hickman ES, Lazzerini Denchi E, et al. Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol 2001; 3: 552-558