Resilient brain aging: Characterization of discordance between Alzheimer's disease pathology and cognition

Current Alzheimer Research

Volumn 10, Issue 8, 2013, Pages 844-851

  Negash, Selam ^a   Wilson, Robert S ^b   Leurgans, Sue E ^b   Wolk, David A ^a   Schneider, Julie A ^b   Buchman, Aron S ^b   Bennett, David A ^b   Arnold, Steven E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cognitive activity; Neuropathology; Reading level; Reserve; Resilience

Indexed keywords

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CLINICAL EVALUATION; COGNITION; CONTROLLED STUDY; COPING BEHAVIOR; DEATH; DEMOGRAPHY; DEPENDENT VARIABLE; FEMALE; HUMAN; INDEPENDENT VARIABLE; LIFESTYLE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; READING; RISK FACTOR; SOCIAL STATUS;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; BRAIN; COGNITION; COGNITION DISORDERS; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS;

EID: 84888071728     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/15672050113109990157     Document Type: Article

References (42)

1. Tomlinson BE, Blessed G, Roth M. Observations on the brains of non-demented old people. J Neurol Sci 7(2): 331-356 (1968).
2. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, et al. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 66(12): 1837-1844 (2006).
3. Iacono D, Markesbery WR, Gross M, Pletnikova O, Rudow G, Zandi P, et al. The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life. Neurology 73(9): 665-673 (2009).
4. O'Brien RJ, Resnick SM, Zonderman AB, Ferrucci L, Crain BJ, Pletnikova O, et al. Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA). J Alzheimers Dis 18(3): 665-75 (2009).
5. White L. Brain Lesions at Autopsy in Older Japanese-American Men as Related to Cognitive Impairment and Dementia in the Final Years of Life: A Summary Report from the Honolulu-Asia Aging Study. J Alzheimers Dis 18(3): 713-25 (2009).
6. Head E, Corrada MM, Kahle-Wrobleski K, Kim RC, Sarsoza F, Goodus M, et al. Synaptic proteins, neuropathology and cognitive status in the oldest-old. Neurobiol Aging 30(7): 1125-1134 (2009).
7. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C. Age, neuropathology, and dementia. N Engl J Med 360(22): 2302-2309 (2009).
8. Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, et al. Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23: 138-144 (1988).
9. Haroutunian V, Schnaider-Beeri M, Schmeidler J, Wysocki M, Purohit DP, Perl DP, et al. Role of the neuropathology of Alzheimer disease in dementia in the oldest-old. Arch Neurol 65(9): 1211-1217 (2008).
10. Ewbank DC, Arnold SE. Cool with plaques and tangles. N Engl J Med 360(22): 2357-2359 (2009).
11. Loebrich S, Nedivi E. The function of activity-regulated genes in the nervous system. Physiol Rev 89(4): 1079-1103 (2009).
12. Di Filippo M, Tozzi A, Costa C, Belcastro V, Tantucci M, Picconi B, et al. Plasticity and repair in the post-ischemic brain. Neuropharmacology 55(3): 353-362 (2008).
13. Berlucchi G, Buchtel HA. Neuronal plasticity: historical roots and evolution of meaning. Exp Brain Res 192(3): 307-319 (2009).
14. Stern C, Munn Z. Cognitive leisure activities and their role in preventing dementia: a systematic review. Int J Evid Based Healthc 8(1): 2-17 (2010).
15. Wilson RS, Bienias JL, Evans DA, Bennett DA. Religious Orders Study: overview and change in cognitive and motor speed. Aging Neuropschol Cogn 11: 280-303 (2004).
16. Bennett DA, Schneider JA, Buchman AS, Mendes de Leon C, Bienias JL, Wilson RS. The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology 25(4): 163-175 (2005).
17. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical Diagnosis of Alzheimer's Disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944 (1984).
18. Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA. Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 62(7): 1148-1155 (2004).
19. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 18(4): S1-2 (1997).
20. Braak H, Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16(3): 271-278 (1995).
21. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41(4): 479-486 (1991).
22. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, et al. Concensus guidlines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB). Neurology 47: 1113-1124 (1996).
23. Wilson RS, Scherr PA, Bienias JL, Mendes de Leon CF, Everson-Rose SA, Bennett DA, et al. Socioeconomic characteristics of the community in childhood and cognition in old age. Exp Aging Res 31(4): 393-407 (2005).
24. Medi-Span Inc. Master Drug Data Base Documentation Manual. Indianapolis I, Medi-Span Inc. IN: Medi-Span, 1995.
25. Nelson HE. The National Adult Reading Test. Windsor, England: The NFER-Publishing Co. Ltd.; 1982.
26. Wilson RS, Scherr PA, Schneider JA, Tang Y, Bennett DA. Relation of cognitive activity to risk of developing Alzheimer disease. Neurology 69(20): 1911-1920 (2007).
27. Bennett DA, Wilson RS, Schneider JA, Evans DA, Aggarwal NT, Arnold SE, et al. Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease. Neurology 60(2): 246-252 (2003).
28. SAS Institute Inc. SAS/STAT User's Guide Version 8. Cary NSI, 2000.
29. Negash S, Bennett DA, Wilson RS, Schneider JA, Arnold SE. Cognition and neuropathology in aging: multidimensional perspectives from the rush religious orders study and rush memory and aging project. Curr Alzheimer Res 8(4): 336-340 2011).
30. MacCallum RC, Zhang S, Preacher KJ, Rucker DD. On the practice of dichotomization of quantitative variables. Psychological Methods 7: 19-40 (2002).
31. Cohen J. The cost of dichotomization. Appl Psychol Meas 7: 249-253 (1983).
32. Karoly P, Ruehlman LS. Psychological "resilience" and its correlates in chronic pain: findings from a national community sample. Pain123(1-2): 90-97 (2006).
33. Lamond AJ, Depp CA, Allison M, Langer R, Reichstadt J, Moore DJ, et al. Measurement and predictors of resilience among community-dwelling older women. J Psychiatr Res 43(2): 148-154 (2008).
34. Riudavets MA, Iacono D, Resnick SM, O'Brien R, Zonderman AB, Martin LJ, et al. Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. Neurobiol Aging 28(10): 1484-1492 (2007).
35. Bennett DA. Postmortem indices linking risk factors to cognition: results from the Religious Order Study and the Memory and Aging Project. Alzheimer Dis Assoc Disord 20(3 Suppl 2): S63-68 (2006).
36. Negash S, Xie S, Davatzikos C, Clark CM, Trojanowski JQ, Shaw LM, et al. Cognitive and Functional Resilience Despite Molecular Evidence of Alzheimer's Disease Pathology. Alzheimer's and Dementia 9(3): e89-95 (2013).
37. Jefferson AL, Gibbons LE, Rentz DM, Carvalho JO, Manly J, Bennett DA, et al. A life course model of cognitive activities, socioeconomic status, education, reading ability, and cognition. J Am Geriatr Soc 59(8): 1403-1411 (2011).
38. Verghese J, Lipton RB, Katz MJ, Hall CB, Derby CA, Kuslansky G, et al. Leisure activities and the risk of dementia in the elderly. N Engl J Med 348(25): 2508-2516 (2003).
39. West MJ, Kawas CH, Stewart WF, Rudow GL, Troncoso JC. Hippocampal neurons in pre-clinical Alzheimer's disease. Neurobiol Aging 25(9): 1205-1212 (2004).
40. Iacono D, O'Brien R, Resnick SM, Zonderman AB, Pletnikova O, Rudow G, et al. Neuronal hypertrophy in asymptomatic Alzheimer disease. J Neuropathol Exp Neurol 67(6): 578-589 (2008).
41. Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol. 56(8): 933-944 (1997).
42. Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol 119(1): 7-35 (2010).