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Volumn 19, Issue 2, 2013, Pages 339-357

Alzheimer disease pharmacologic treatment and treatment research

Author keywords

[No Author keywords available]

Indexed keywords

AVAGACESTAT; CEREBROLYSIN; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; GINKGO BILOBA EXTRACT; MEMANTINE; PLACEBO; RIVASTIGMINE; SEMAGACESTAT; TACRINE;

EID: 84876375022     PISSN: 10802371     EISSN: 15386899     Source Type: Journal    
DOI: 10.1212/01.CON.0000429180.60095.d0     Document Type: Review
Times cited : (39)

References (80)
  • 1
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus R, Dean R, Beer B, et al. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982;217(4558):408-414.
    • (1982) Science , vol.217 , Issue.4558 , pp. 408-414
    • Bartus, R.1    Dean, R.2    Beer, B.3
  • 2
    • 0015965912 scopus 로고
    • Human memory and the cholinergic system. A relationship to aging?
    • Drachman DA, Leavitt J. Human memory and the cholinergic system. A relationship to aging? Arch Neurol 1974;30(2):113-121.
    • (1974) Arch Neurol , vol.30 , Issue.2 , pp. 113-121
    • Drachman, D.A.1    Leavitt, J.2
  • 3
    • 84870344171 scopus 로고    scopus 로고
    • Antidementia drugs
    • Sadock BJ, Sadock MD, Ruiz P, editors, Philadelphia, PA: Lippincott Williams & Wilkins
    • Schneider LS. Antidementia drugs. In: Sadock BJ, Sadock MD, Ruiz P, editors. Comprehensive textbook of psychiatry. 9th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2009:4119-4130.
    • (2009) Comprehensive Textbook of Psychiatry. 9th Ed , pp. 4119-4130
    • Schneider, L.S.1
  • 4
    • 77954115000 scopus 로고    scopus 로고
    • Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials
    • McArthur RA, Gray J, Schreiber R. Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials. Curr Opin Investig Drugs 2010;11(7):740-760.
    • (2010) Curr Opin Investig Drugs , vol.11 , Issue.7 , pp. 740-760
    • McArthur, R.A.1    Gray, J.2    Schreiber, R.3
  • 5
    • 37649026816 scopus 로고    scopus 로고
    • Donepezil for dementia due to Alzheimer's disease
    • Birks J, Harvey RJ. Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev 2006;(1):CD001190.
    • (2006) Cochrane Database Syst Rev , Issue.1
    • Birks, J.1    Harvey, R.J.2
  • 6
    • 3042567016 scopus 로고    scopus 로고
    • Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): Randomised double-blind trial
    • Courtney C, Farrell D, Gray R, et al. Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet 2004; 363(9427):2105-2115.
    • (2004) Lancet , vol.363 , Issue.9427 , pp. 2105-2115
    • Courtney, C.1    Farrell, D.2    Gray, R.3
  • 7
    • 0031902795 scopus 로고    scopus 로고
    • A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease
    • Corey-Bloom J, Anand R, Veach J. A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol 1998;1:55-65.
    • (1998) Int J Geriatr Psychopharmacol , vol.1 , pp. 55-65
    • Corey-Bloom, J.1    Anand, R.2    Veach, J.3
  • 8
    • 0033528436 scopus 로고    scopus 로고
    • Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial
    • Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. BMJ 1999; 318(7184):633-638.
    • (1999) BMJ , vol.318 , Issue.7184 , pp. 633-638
    • Rosler, M.1    Anand, R.2    Cicin-Sain, A.3
  • 9
    • 34547634202 scopus 로고    scopus 로고
    • IDEAL: A 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease
    • Winblad B, Grossberg G, Frölich L, et al. IDEAL: a 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease. Neurology 2007;69(4 suppl 1):S14-S22.
    • (2007) Neurology , vol.69 , Issue.4 SUPPL. 1
    • Winblad, B.1    Grossberg, G.2    Frölich, L.3
  • 10
    • 33645510613 scopus 로고    scopus 로고
    • Galantamine for Alzheimer's disease and mild cognitive impairment
    • Loy C, Schneider L. Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev 2006;(1):CD001747.
    • (2006) Cochrane Database Syst Rev , Issue.1
    • Loy, C.1    Schneider, L.2
  • 11
    • 66149160502 scopus 로고    scopus 로고
    • Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: A population-based cohort study
    • Gill SS, Anderson GM, Fischer HD, et al. Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study. Arch Intern Med 2009;169(9):867-873.
    • (2009) Arch Intern Med , vol.169 , Issue.9 , pp. 867-873
    • Gill, S.S.1    Anderson, G.M.2    Fischer, H.D.3
  • 12
    • 77955253242 scopus 로고    scopus 로고
    • Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week randomized double-blind study
    • Farlow MR, Salloway S, Tariot PN, et al. Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: a 24-week, randomized, double-blind study. Clin Ther 2010;32(7):1234-1251.
    • (2010) Clin Ther , vol.32 , Issue.7 , pp. 1234-1251
    • Farlow, M.R.1    Salloway, S.2    Tariot, P.N.3
  • 13
    • 42749100518 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for Alzheimer's disease
    • Birks J. Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev 2006;(1):CD005593.
    • (2006) Cochrane Database Syst Rev , Issue.1
    • Birks, J.1
  • 14
    • 0030801505 scopus 로고    scopus 로고
    • The severe impairment battery: Concurrent validity and the assessment of longitudinal change in Alzheimer's disease
    • Schmitt FA, Ashford W, Ernesto C, et al. The severe impairment battery: concurrent validity and the assessment of longitudinal change in Alzheimer's disease. Alzheimer Dis Assoc Disord 1997;11(suppl 2):S51-S56.
    • (1997) Alzheimer Dis Assoc Disord , vol.11 , Issue.SUPPL. 2
    • Schmitt, F.A.1    Ashford, W.2    Ernesto, C.3
  • 15
    • 78651295101 scopus 로고    scopus 로고
    • Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative
    • Alzheimer's Disease Neuroimaging Initiative.
    • Schneider LS, Insel PS, Weiner MW; Alzheimer's Disease Neuroimaging Initiative. Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative. Arch Neurology 2011;68(1):58-66.
    • (2011) Arch Neurology , vol.68 , Issue.1 , pp. 58-66
    • Schneider, L.S.1    Insel, P.S.2    Weiner, M.W.3
  • 16
    • 45149132039 scopus 로고    scopus 로고
    • Safety and efficacy of galantamine in subjects with mild cognitive impairment
    • Winblad B, Gauthier S, Scinto L, et al. Safety and efficacy of galantamine in subjects with mild cognitive impairment. Neurology 2008;70(22):2024-2035.
    • (2008) Neurology , vol.70 , Issue.22 , pp. 2024-2035
    • Winblad, B.1    Gauthier, S.2    Scinto, L.3
  • 17
    • 34248372938 scopus 로고    scopus 로고
    • Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: The InDDEx study
    • Feldman HH, Ferris S, Winblad B, et al. Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol 2007;6(6):501-512.
    • (2007) Lancet Neurol , vol.6 , Issue.6 , pp. 501-512
    • Feldman, H.H.1    Ferris, S.2    Winblad, B.3
  • 18
    • 20344381835 scopus 로고    scopus 로고
    • Vitamin e and donepezil for the treatment of mild cognitive impairment
    • Petersen RC, Thomas RG, Grundman M, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005;352(23):2379-2388.
    • (2005) N Engl J Med , vol.352 , Issue.23 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3
  • 19
    • 36849078870 scopus 로고    scopus 로고
    • Cholinesterase inhibitors in mild cognitive impairment: A systematic review of randomised trials
    • Raschetti R, Albanese E, Vanacore N, Maggini M. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials. PLoS Med 2007; 4(11):e338.
    • (2007) PLoS Med , vol.4 , Issue.11
    • Raschetti, R.1    Albanese, E.2    Vanacore, N.3    Maggini, M.4
  • 21
    • 0037417238 scopus 로고    scopus 로고
    • Memantine in moderate-to-severe Alzheimer's disease
    • Reisberg B, Doody R, Stoffler A, et al. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med 2003;348(14):1333-1341.
    • (2003) N Engl J Med , vol.348 , Issue.14 , pp. 1333-1341
    • Reisberg, B.1    Doody, R.2    Stoffler, A.3
  • 22
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
    • Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 2004;291(3):317-324.
    • (2004) JAMA , vol.291 , Issue.3 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3
  • 23
    • 34249873186 scopus 로고    scopus 로고
    • A 24-week randomized, controlled trial of memantine in patients with moderate-to-severe Alzheimer disease
    • van Dyck CH, Tariot PN, Meyers B, et al. A 24-week randomized, controlled trial of memantine in patients with moderate-to-severe Alzheimer disease. Alzheimer Dis Assoc Disord 2007;21(2): 136-143.
    • (2007) Alzheimer Dis Assoc Disord , vol.21 , Issue.2 , pp. 136-143
    • Van Dyck, C.H.1    Tariot, P.N.2    Meyers, B.3
  • 24
    • 33746924907 scopus 로고    scopus 로고
    • Memantine treatment in mild to moderate Alzheimer disease: A 24-week randomized, controlled trial
    • Peskind ER, Potkin SG, Pomara N, et al. Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial. Am J Geriatr Psychiatry 2006;14(8):704-715.
    • (2006) Am J Geriatr Psychiatry , vol.14 , Issue.8 , pp. 704-715
    • Peskind, E.R.1    Potkin, S.G.2    Pomara, N.3
  • 25
    • 40549106116 scopus 로고    scopus 로고
    • Memantine treatment in patients with mild to moderate Alzheimer's disease: Results of a randomised, double-blind, placebo-controlled 6-month study
    • Bakchine S, Loft H. Memantine treatment in patients with mild to moderate Alzheimer's disease: results of a randomised, double-blind, placebo-controlled 6-month study. J Alzheimers Dis 2008;13(1):97-107.
    • (2008) J Alzheimers Dis , vol.13 , Issue.1 , pp. 97-107
    • Bakchine, S.1    Loft, H.2
  • 26
    • 42149142899 scopus 로고    scopus 로고
    • Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: A randomized, double-blind, placebo-controlled trial
    • Porsteinsson AP, Grossberg GT, Mintzer J, et al. Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial. Curr Alzheimer Res 2008;5(1):83-89.
    • (2008) Curr Alzheimer Res , vol.5 , Issue.1 , pp. 83-89
    • Porsteinsson, A.P.1    Grossberg, G.T.2    Mintzer, J.3
  • 28
    • 79959389773 scopus 로고    scopus 로고
    • Lack of evidence for the efficacy of memantine in mild Alzheimer disease
    • Schneider LS, Dagerman KS, Higgins JPT, McShane R. Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol 2011;68(8):991-998.
    • (2011) Arch Neurol , vol.68 , Issue.8 , pp. 991-998
    • Schneider, L.S.1    Dagerman, K.S.2    Higgins, J.P.T.3    McShane, R.4
  • 29
    • 0032810628 scopus 로고    scopus 로고
    • Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices
    • Frankiewicz T, Parsons CG. Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices. Neuropharmacology 1999;38(9):1253-1259.
    • (1999) Neuropharmacology , vol.38 , Issue.9 , pp. 1253-1259
    • Frankiewicz, T.1    Parsons, C.G.2
  • 30
    • 76149120867 scopus 로고    scopus 로고
    • Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice
    • Martinez-Coria H, Green KN, Billings LM, et al. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol 2010;176(2): 870-880.
    • (2010) Am J Pathol , vol.176 , Issue.2 , pp. 870-880
    • Martinez-Coria, H.1    Green, K.N.2    Billings, L.M.3
  • 31
    • 66149095869 scopus 로고    scopus 로고
    • Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    • Lopez OL, Becker JT, Wahed AS, et al. Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease. J Neurol Neurosurg Psychiatry 2009;80(6):600-607.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , Issue.6 , pp. 600-607
    • Lopez, O.L.1    Becker, J.T.2    Wahed, A.S.3
  • 32
    • 77951874698 scopus 로고    scopus 로고
    • Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease
    • Rountree SD, Chan W, Pavlik VN, et al. Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease. Alzheimers Res Ther 2009;1(2):7.
    • (2009) Alzheimers Res Ther , vol.1 , Issue.2 , pp. 7
    • Rountree, S.D.1    Chan, W.2    Pavlik, V.N.3
  • 33
    • 30344444750 scopus 로고    scopus 로고
    • A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease
    • Reisberg B, Doody R, Stoffler A, et al. A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease. Arch Neurol 2006;63(1): 49-54.
    • (2006) Arch Neurol , vol.63 , Issue.1 , pp. 49-54
    • Reisberg, B.1    Doody, R.2    Stoffler, A.3
  • 34
    • 33745865937 scopus 로고    scopus 로고
    • Open-label extension studies and misinformation
    • author reply 1036-1037
    • Schneider LS. Open-label extension studies and misinformation. Arch Neurol 2006;63(7):1036; author reply 1036-1037.
    • (2006) Arch Neurol , vol.63 , Issue.7 , pp. 1036
    • Schneider, L.S.1
  • 35
    • 79960016354 scopus 로고    scopus 로고
    • Combination treatment in Alzheimer's disease: Results of a randomized controlled trial with cerebrolysin and donepezil
    • Alvarez XA, Cacabelos R, Sampedro C, et al. Combination treatment in Alzheimer's disease: results of a randomized, controlled trial with cerebrolysin and donepezil. Curr Alzheimer Res 2011;8(5):583-591.
    • (2011) Curr Alzheimer Res , vol.8 , Issue.5 , pp. 583-591
    • Alvarez, X.A.1    Cacabelos, R.2    Sampedro, C.3
  • 36
    • 56649098949 scopus 로고    scopus 로고
    • Ginkgo biloba extract and preventing Alzheimer disease
    • Schneider LS. Ginkgo biloba extract and preventing Alzheimer disease. JAMA 2008;300(19):2306-2308.
    • (2008) JAMA , vol.300 , Issue.19 , pp. 2306-2308
    • Schneider, L.S.1
  • 38
    • 28244446721 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type
    • Schneider LS, DeKosky ST, Farlow MR, et al. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. Curr Alzheimer Res 2005; 2(5):541-551.
    • (2005) Curr Alzheimer Res , vol.2 , Issue.5 , pp. 541-551
    • Schneider, L.S.1    Dekosky, S.T.2    Farlow, M.R.3
  • 39
    • 49449087355 scopus 로고    scopus 로고
    • Ginkgo biloba for mild to moderate dementia in a community setting: A pragmatic, randomised, parallel-group, double-blind, placebo-controlled trial
    • McCarney R, Fisher P, Iliffe S, et al. Ginkgo biloba for mild to moderate dementia in a community setting: a pragmatic, randomised, parallel-group, double-blind, placebo-controlled trial. Int J Geriatr Psychiatry 2008;23(12):1222-1230
    • (2008) Int J Geriatr Psychiatry , vol.23 , Issue.12 , pp. 1222-1230
    • McCarney, R.1    Fisher, P.2    Iliffe, S.3
  • 40
    • 84876372183 scopus 로고    scopus 로고
    • Institute for Quality and Efficiency in Health Care, Updated April 30, 2010. Accessed January 3, 2013
    • Institute for Quality and Efficiency in Health Care. Alzheimer's disease: only a few therapies provide proof of benefit to patients. www.iqwig.de/index. 948.en. html?random=667c6a. Updated April 30, 2010. Accessed January 3, 2013.
    • Alzheimer's Disease: Only A Few Therapies Provide Proof of Benefit to Patients
  • 41
    • 56649112752 scopus 로고    scopus 로고
    • Ginkgo biloba for prevention of dementia: A randomized controlled trial
    • DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 2008;300(19):2253- 2262.
    • (2008) JAMA , vol.300 , Issue.19 , pp. 2253-2262
    • Dekosky, S.T.1    Williamson, J.D.2    Fitzpatrick, A.L.3
  • 42
    • 33750576826 scopus 로고    scopus 로고
    • The GuidAge study: Methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761(R) for prevention of Alzheimer disease in patients over 70 with a memory complaint
    • Vellas B, Andrieu S, Ousset PJ, et al. The GuidAge study: Methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761(R) for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology 2006; 67(9 suppl 3):S6-S11.
    • (2006) Neurology , vol.67 , Issue.9 SUPPL. 3
    • Vellas, B.1    Andrieu, S.2    Ousset, P.J.3
  • 43
    • 42149166010 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of Ginkgo biloba for the prevention of cognitive decline
    • Dodge HH, Zitzelberger T, Oken BS, et al. A randomized placebo-controlled trial of Ginkgo biloba for the prevention of cognitive decline. Neurology 2008;70(19 pt 2): 1809-1817.
    • (2008) Neurology , vol.70 , Issue.19 PART 2 , pp. 1809-1817
    • Dodge, H.H.1    Zitzelberger, T.2    Oken, B.S.3
  • 44
    • 84856779629 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration, Updated July 27, 2011. Accessed February 8, 2013
    • U.S. Food and Drug Administration. Guidance for industry: frequently asked questions about medical foods. www.fda. gov/Food/ GuidanceComplianceRegulatory Information/GuidanceDocuments/MedicalFoods/ ucm054048.htm. Updated July 27, 2011. Accessed February 8, 2013.
    • Guidance for Industry: Frequently Asked Questions about Medical Foods
  • 45
    • 69449085062 scopus 로고    scopus 로고
    • Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: A randomized, double-blind, placebo-controlled, multicenter trial
    • Henderson ST, Vogel JL, Barr LJ, et al. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr Metab (Lond) 2009; 6(1):31.
    • (2009) Nutr Metab (Lond) , vol.6 , Issue.1 , pp. 31
    • Henderson, S.T.1    Vogel, J.L.2    Barr, L.J.3
  • 46
    • 84863946102 scopus 로고    scopus 로고
    • Efficacy of Souvenaid in mild Alzheimer's disease: Results from a randomized, controlled trial
    • Scheltens P, Twisk JWR, Blesa R, et al. Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. J Alzheimers Dis 2012;31(1): 225-236.
    • (2012) J Alzheimers Dis , vol.31 , Issue.1 , pp. 225-236
    • Scheltens, P.1    Twisk, J.W.R.2    Blesa, R.3
  • 47
    • 41049111771 scopus 로고    scopus 로고
    • Effectiveness of cholinesterase inhibitors and memantine for treating dementia: Evidence review for a clinical practice guideline
    • Raina P, Santaguida P, Ismaila A, et al. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 2008;148(5): 379-397.
    • (2008) Ann Intern Med , vol.148 , Issue.5 , pp. 379-397
    • Raina, P.1    Santaguida, P.2    Ismaila, A.3
  • 48
    • 31344435588 scopus 로고    scopus 로고
    • A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease
    • Takeda A, Loveman E, Clegg A, et al. A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease. Int J Geriatr Psychiatry 2006;21(1):17-28.
    • (2006) Int J Geriatr Psychiatry , vol.21 , Issue.1 , pp. 17-28
    • Takeda, A.1    Loveman, E.2    Clegg, A.3
  • 49
    • 33644658662 scopus 로고    scopus 로고
    • The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease
    • ix-xi, 1-160
    • Loveman E, Green C, Kirby J, et al. The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease. Health Technol Assess 2006;10(1):iii-iv, ix-xi, 1-160.
    • (2006) Health Technol Assess , vol.10 , Issue.1
    • Loveman, E.1    Green, C.2    Kirby, J.3
  • 52
    • 84884894746 scopus 로고    scopus 로고
    • Development, optimization and use of preclinical behavioral models to maximize the productivity of drug discovery for Alzheimer's disease
    • McArthur RA, Borsini F, eds, San Diego, CA: Academic Press
    • Lindner MD, McArthur RA, Deadwyler S, et al. Development, optimization and use of preclinical behavioral models to maximize the productivity of drug discovery for Alzheimer's disease. In: McArthur RA, Borsini F, eds. Animal and translational models for CNS drug discovery. San Diego, CA: Academic Press, 2008:93-157.
    • (2008) Animal and Translational Models for CNS Drug Discovery , pp. 93-157
    • Lindner, M.D.1    McArthur, R.A.2    Deadwyler, S.3
  • 53
    • 33645906519 scopus 로고    scopus 로고
    • Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: A randomized controlled trial
    • Rockwood K, Fay S, Song X, et al. Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: a randomized controlled trial. CMAJ 2006;174(8):1099-1105.
    • (2006) CMAJ , vol.174 , Issue.8 , pp. 1099-1105
    • Rockwood, K.1    Fay, S.2    Song, X.3
  • 54
    • 52649127458 scopus 로고    scopus 로고
    • Long-term course and effectiveness of combination therapy in Alzheimer disease
    • Atri A, Shaughnessy L, Locascio JJ, et al. Long-term course and effectiveness of combination therapy in Alzheimer disease. Alzheimer Dis Assoc Disord 2008;22(3): 209-221.
    • (2008) Alzheimer Dis Assoc Disord , vol.22 , Issue.3 , pp. 209-221
    • Atri, A.1    Shaughnessy, L.2    Locascio, J.J.3
  • 55
    • 0037707465 scopus 로고    scopus 로고
    • Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease
    • Geldmacher DS, Provenzano G, McRae T, et al. Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease. J Am Geriatr Soc 2003; 51(7):937-944.
    • (2003) J Am Geriatr Soc , vol.51 , Issue.7 , pp. 937-944
    • Geldmacher, D.S.1    Provenzano, G.2    McRae, T.3
  • 56
    • 2942746512 scopus 로고    scopus 로고
    • Delay in nursing home placement with donepezil
    • Schneider LS, Qizilbash N. Delay in nursing home placement with donepezil. J Am Geriatr Soc 2004;52(6):1024-1026.
    • (2004) J Am Geriatr Soc , vol.52 , Issue.6 , pp. 1024-1026
    • Schneider, L.S.1    Qizilbash, N.2
  • 57
    • 84555197337 scopus 로고    scopus 로고
    • Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian imaging biomarkers and lifestyle (AIBL) study of ageing
    • Sona A, Zhang P, Ames D, et al. Predictors of rapid cognitive decline in Alzheimer's disease: results from the Australian imaging, biomarkers and lifestyle (AIBL) study of ageing. Int Psychogeriatr 2011;24(2):1-8.
    • (2011) Int Psychogeriatr , vol.24 , Issue.2 , pp. 1-8
    • Sona, A.1    Zhang, P.2    Ames, D.3
  • 58
    • 3242775357 scopus 로고    scopus 로고
    • The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease
    • Holmes C, Wilkinson D, Dean C, et al. The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease. Neurology 2004;63(2):214-219.
    • (2004) Neurology , vol.63 , Issue.2 , pp. 214-219
    • Holmes, C.1    Wilkinson, D.2    Dean, C.3
  • 59
    • 21444438776 scopus 로고    scopus 로고
    • Drug persistency patterns for patients treated with rivastigmine or donepezil in usual care settings
    • Mauskopf JA, Paramore C, Lee WC, Snyder EH. Drug persistency patterns for patients treated with rivastigmine or donepezil in usual care settings. J Manag Care Pharm 2005;11(3):231-251.
    • (2005) J Manag Care Pharm , vol.11 , Issue.3 , pp. 231-251
    • Mauskopf, J.A.1    Paramore, C.2    Lee, W.C.3    Snyder, E.H.4
  • 60
    • 84863229484 scopus 로고    scopus 로고
    • Donepezil and memantine for moderate-to-severe Alzheimer's disease
    • Howard R, McShane R, Lindesay J, et al. Donepezil and memantine for moderate-to-severe Alzheimer's disease. N Engl J Med 2012;366(10):893-903.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 893-903
    • Howard, R.1    McShane, R.2    Lindesay, J.3
  • 61
    • 84857848793 scopus 로고    scopus 로고
    • Discontinuing donepezil or starting memantine for Alzheimer's disease
    • Schneider LS. Discontinuing donepezil or starting memantine for Alzheimer's disease. N Engl J Med 2012;366(10):957-959.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 957-959
    • Schneider, L.S.1
  • 62
    • 70350517148 scopus 로고    scopus 로고
    • Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine
    • Rodda J, Morgan S, Walker Z. Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. Int Psychogeriatr 2009;21(5):813-824.
    • (2009) Int Psychogeriatr , vol.21 , Issue.5 , pp. 813-824
    • Rodda, J.1    Morgan, S.2    Walker, Z.3
  • 63
    • 60749130048 scopus 로고    scopus 로고
    • Impact of cholinesterase inhibitors on behavioral and psychological symptoms of Alzheimer's disease: A meta-analysis
    • Campbell N, Ayub A, Boustani MA, et al. Impact of cholinesterase inhibitors on behavioral and psychological symptoms of Alzheimer's disease: a meta-analysis. Clin Interv Aging 2008;3(4):719-728.
    • (2008) Clin Interv Aging , vol.3 , Issue.4 , pp. 719-728
    • Campbell, N.1    Ayub, A.2    Boustani, M.A.3
  • 64
    • 34948834261 scopus 로고    scopus 로고
    • Donepezil for the treatment of agitation in Alzheimer's disease
    • Howard RJ, Juszczak E, Ballard CG, et al. Donepezil for the treatment of agitation in Alzheimer's disease. N Engl J Med 2007; 357(14):1382-1392.
    • (2007) N Engl J Med , vol.357 , Issue.14 , pp. 1382-1392
    • Howard, R.J.1    Juszczak, E.2    Ballard, C.G.3
  • 65
    • 84860509122 scopus 로고    scopus 로고
    • Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial
    • Fox C, Crugel M, Maidment I, et al. Efficacy of memantine for agitation in Alzheimer's dementia: a randomised double-blind placebo controlled trial. PLoS One 2012; 7(5):e35185.
    • (2012) PLoS One , vol.7 , Issue.5
    • Fox, C.1    Crugel, M.2    Maidment, I.3
  • 66
    • 84884840827 scopus 로고    scopus 로고
    • Issues in design and conduct of clinical trials for cognitive-enhancing drugs
    • McArthur RA, Borsini F, eds, San Diego, CA: Academic Press
    • Schneider LS. Issues in design and conduct of clinical trials for cognitive-enhancing drugs. In: McArthur RA, Borsini F, eds. Animal and translational models for CNS drug discovery. San Diego, CA: Academic Press, 2008:21-76.
    • (2008) Animal and Translational Models for CNS Drug Discovery , pp. 21-76
    • Schneider, L.S.1
  • 67
    • 0030814418 scopus 로고    scopus 로고
    • Development of cognitive instruments for use in clinical trials of antidementia drugs: Additions to the Alzheimer's Disease Assessment Scale that broaden its scope
    • The Alzheimer's Disease Cooperative Study
    • Mohs RC, Knopman D, Petersen RC, et al. Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997;11(suppl 2): S13-S21.
    • (1997) Alzheimer Dis Assoc Disord , vol.11 , Issue.SUPPL. 2
    • Mohs, R.C.1    Knopman, D.2    Petersen, R.C.3
  • 68
    • 78751692575 scopus 로고    scopus 로고
    • Anti-A therapeutics in Alzheimer's disease: The need for a paradigm shift
    • Golde TE, Schneider LS, Koo EH. Anti-A therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron 2011; 69(2):203-213.
    • (2011) Neuron , vol.69 , Issue.2 , pp. 203-213
    • Golde, T.E.1    Schneider, L.S.2    Koo, E.H.3
  • 69
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12(10):383-388.
    • (1991) Trends Pharmacol Sci , vol.12 , Issue.10 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 70
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297(5580):353- 356.
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 71
    • 79959772357 scopus 로고    scopus 로고
    • Human apoE isoforms differentially regulate brain amyloid-α peptide clearance
    • Castellano JM, Kim J, Stewart FR, et al. Human apoE isoforms differentially regulate brain amyloid-α peptide clearance. Sci Transl Med 2011;3(89):89ra57.
    • (2011) Sci Transl Med , vol.3 , Issue.89
    • Castellano, J.M.1    Kim, J.2    Stewart, F.R.3
  • 72
    • 47149112621 scopus 로고    scopus 로고
    • Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase i trial
    • Holmes C, Boche D, Wilkinson D, et al. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 2008;372(9634):216-223.
    • (2008) Lancet , vol.372 , Issue.9634 , pp. 216-223
    • Holmes, C.1    Boche, D.2    Wilkinson, D.3
  • 73
    • 77949300796 scopus 로고    scopus 로고
    • 11C-PiB PET assessment of change in fibrillar amyloid-[beta] load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2 double-blind placebo-controlled ascending-dose study
    • Rinne JO, Brooks DJ, Rossor MN, et al. 11C-PiB PET assessment of change in fibrillar amyloid-[beta] load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 2010;9(4):363-372.
    • (2010) Lancet Neurol , vol.9 , Issue.4 , pp. 363-372
    • Rinne, J.O.1    Brooks, D.J.2    Rossor, M.N.3
  • 74
    • 20944448555 scopus 로고    scopus 로고
    • Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    • Gilman S, Koller M, Black RS, et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005;64(9):1553-1562.
    • (2005) Neurology , vol.64 , Issue.9 , pp. 1553-1562
    • Gilman, S.1    Koller, M.2    Black, R.S.3
  • 75
    • 73349091534 scopus 로고    scopus 로고
    • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
    • Salloway S, Sperling R, Gilman S, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009;73(24): 2061-2070.
    • (2009) Neurology , vol.73 , Issue.24 , pp. 2061-2070
    • Salloway, S.1    Sperling, R.2    Gilman, S.3
  • 76
    • 84863115941 scopus 로고    scopus 로고
    • Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab
    • Ostrowitzki S, Deptula D, Thurfjell L, et al. Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab. Arch Neurol 2011;69(2): 198-207.
    • (2011) Arch Neurol , vol.69 , Issue.2 , pp. 198-207
    • Ostrowitzki, S.1    Deptula, D.2    Thurfjell, L.3
  • 77
    • 0014313861 scopus 로고
    • The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
    • Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968; 114(512):797-811.
    • (1968) Br J Psychiatry , vol.114 , Issue.512 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.E.2    Roth, M.3
  • 78
    • 79958110883 scopus 로고    scopus 로고
    • Alzheimer's pathogenesis: Is there neuron-to-neuron propagation?
    • Braak H, Del Tredici K. Alzheimer's pathogenesis: is there neuron-to-neuron propagation? Acta Neuropathol 2011; 121(5):589-595.
    • (2011) Acta Neuropathol , vol.121 , Issue.5 , pp. 589-595
    • Braak, H.1    Del Tredici, K.2
  • 80
    • 80051741276 scopus 로고    scopus 로고
    • A clinical perspective: Anti taus treatment in Alzheimer's disease
    • Fuentes P, Catalan J. A clinical perspective: anti taus treatment in Alzheimer's disease. Curr Alzheimer Res 2011;8(6): 686-688.
    • (2011) Curr Alzheimer Res , vol.8 , Issue.6 , pp. 686-688
    • Fuentes, P.1    Catalan, J.2


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