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Volumn 83, Issue 4, 2015, Pages 221-231

Premature adrenarche -A common condition with variable presentation

Author keywords

Adrenal androgens; Adrenal hyperandrogenism; Adrenarche; Birth weight; Growth; Metabolic syndrome; Ovarian hyperandrogenism; Prepubertal children; Pubarche

Indexed keywords

INSULIN SENSITIZING AGENT; METFORMIN; PRASTERONE; PRASTERONE SULFATE;

EID: 84929955695     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000369458     Document Type: Review
Times cited : (95)

References (76)
  • 1
    • 0017239621 scopus 로고
    • Serum androgens in normal prepubertal and pubertal children and in children with precocious adrenarche
    • Korth-Schutz S, Levine LS, New MI: Serum androgens in normal prepubertal and pubertal children and in children with precocious adrenarche. J Clin Endocrinol Metab 1976; 42: 117-124.
    • (1976) J Clin Endocrinol Metab , vol.42 , pp. 117-124
    • Korth-Schutz, S.1    Levine, L.S.2    New, M.I.3
  • 2
    • 0020635997 scopus 로고
    • Benign premature adrenarche: Clinical features and serum steroid levels
    • Voutilainen R, Perheentupa J, Apter D: Benign premature adrenarche: clinical features and serum steroid levels. Acta Paediatr Scand 1983; 72: 707-711.
    • (1983) Acta Paediatr Scand , vol.72 , pp. 707-711
    • Voutilainen, R.1    Perheentupa, J.2    Apter, D.3
  • 3
    • 64549102567 scopus 로고    scopus 로고
    • Continuum of phenotypes and sympathoadrenal function in premature adrenarche
    • Utriainen P, Voutilainen R, Jääskeläinen J: Continuum of phenotypes and sympathoadrenal function in premature adrenarche. Eur J Endocrinol 2009; 160: 657-665.
    • (2009) Eur J Endocrinol , vol.160 , pp. 657-665
    • Utriainen, P.1    Voutilainen, R.2    Jääskeläinen, J.3
  • 5
    • 84915784049 scopus 로고    scopus 로고
    • Premature adrenarche: Etiology, clinical findings, and consequences
    • Voutilainen R, Jääskeläinen J: Premature adrenarche: etiology, clinical findings, and consequences. J Steroid Biochem Mol Biol 2015; 145C:226-236.
    • (2015) J Steroid Biochem Mol Biol , vol.145 C , pp. 226-236
    • Voutilainen, R.1    Jääskeläinen, J.2
  • 6
    • 0000255618 scopus 로고
    • Precocious growth of sexual hair without other secondary sexual development: 'premature pubarche' a constitutional variation of adolescence
    • Silverman S, Migeon C, Rosemberg E, Wilkins L: Precocious growth of sexual hair without other secondary sexual development: 'premature pubarche' a constitutional variation of adolescence. Pediatrics 1952; 10: 426-432.
    • (1952) Pediatrics , vol.10 , pp. 426-432
    • Silverman, S.1    Migeon, C.2    Rosemberg, E.3    Wilkins, L.4
  • 7
    • 0028830625 scopus 로고
    • Decreased insulin sensitivity in prepubertal girls with premature adrenarche and acanthosis nigricans
    • Oppenheimer E, Linder B, DiMartino-Nardi J: Decreased insulin sensitivity in prepubertal girls with premature adrenarche and acanthosis nigricans. J Clin Endocrinol Metab 1995; 80: 614-618.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 614-618
    • Oppenheimer, E.1    Linder, B.2    Dimartino-Nardi, J.3
  • 8
    • 0031827641 scopus 로고    scopus 로고
    • Hyperinsulinaemia, dyslipaemia and cardiovascular risk in girls with a history of premature pubarche
    • Ibanez L, Potau N, Chacon P, Pascual C, Carrascosa A: Hyperinsulinaemia, dyslipaemia and cardiovascular risk in girls with a history of premature pubarche. Diabetologia 1998; 41: 1057-1063.
    • (1998) Diabetologia , vol.41 , pp. 1057-1063
    • Ibanez, L.1    Potau, N.2    Chacon, P.3    Pascual, C.4    Carrascosa, A.5
  • 9
    • 0033305392 scopus 로고    scopus 로고
    • The roles of insulin sensitivity, insulin-like growth factor i (IGF-I), and IGF-binding protein-1 and -3 in the hyperandrogenism of African-American and Caribbean Hispanic girls with premature adrenarche
    • Vuguin P, Linder B, Rosenfeld RG, Saenger P, DiMartino-Nardi J: The roles of insulin sensitivity, insulin-like growth factor I (IGF-I), and IGF-binding protein-1 and -3 in the hyperandrogenism of African-American and Caribbean Hispanic girls with premature adrenarche. J Clin Endocrinol Metab 1999; 84: 2037-2042.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2037-2042
    • Vuguin, P.1    Linder, B.2    Rosenfeld, R.G.3    Saenger, P.4    Dimartino-Nardi, J.5
  • 11
    • 0344177202 scopus 로고    scopus 로고
    • Fat distribution in nonobese girls with and without precocious pubarche: Central adiposity related to insulinaemia and androgenaemia from prepuberty to postmenarche
    • Ibanez L, Ong K, de Zegher F, Marcos MV, del Rio L, Dunger DB: Fat distribution in nonobese girls with and without precocious pubarche: central adiposity related to insulinaemia and androgenaemia from prepuberty to postmenarche. Clin Endocrinol 2003; 58: 372-379.
    • (2003) Clin Endocrinol , vol.58 , pp. 372-379
    • Ibanez, L.1    Ong, K.2    De Zegher, F.3    Marcos, M.V.4    Del Rio, L.5    Dunger, D.B.6
  • 14
  • 15
    • 0342602068 scopus 로고    scopus 로고
    • Girls diagnosed with premature pubarche show an exaggerated ovarian androgen synthesis from the early stages of puberty: Evidence from gonadotropin-releasing hormone agonist testing
    • Ibáñez L, Potau N, Zampolli M, Street ME, Carrascosa A: Girls diagnosed with premature pubarche show an exaggerated ovarian androgen synthesis from the early stages of puberty: evidence from gonadotropin-releasing hormone agonist testing. Fertil Steril 1997; 67: 849-855.
    • (1997) Fertil Steril , vol.67 , pp. 849-855
    • Ibáñez, L.1    Potau, N.2    Zampolli, M.3    Street, M.E.4    Carrascosa, A.5
  • 16
    • 0031769471 scopus 로고    scopus 로고
    • Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: Relation to reduced fetal growth
    • Ibáñez L, Potau N, Francois I, de Zegher F: Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth. J Clin Endocrinol Metab 1998; 83: 3558-3562.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3558-3562
    • Ibáñez, L.1    Potau, N.2    Francois, I.3    De Zegher, F.4
  • 17
    • 52549085934 scopus 로고    scopus 로고
    • Adrenarche: Postnatal adrenal zonation and hormonal and metabolic regulation
    • Belgorosky A, Baquedano MS, Guercio G, Rivarola MA: Adrenarche: postnatal adrenal zonation and hormonal and metabolic regulation. Horm Res 2008; 70: 257-267.
    • (2008) Horm Res , vol.70 , pp. 257-267
    • Belgorosky, A.1    Baquedano, M.S.2    Guercio, G.3    Rivarola, M.A.4
  • 18
    • 62449213811 scopus 로고    scopus 로고
    • Androgen synthesis in adrenarche
    • Miller WL: Androgen synthesis in adrenarche. Rev Endocr Metab Disord 2009; 10: 3-17.
    • (2009) Rev Endocr Metab Disord , vol.10 , pp. 3-17
    • Miller, W.L.1
  • 19
    • 84866275590 scopus 로고    scopus 로고
    • The steroid metabolome of adrenarche
    • Rege J, Rainey WE: The steroid metabolome of adrenarche. J Endocrinol 2012; 214: 133-143
    • (2012) J Endocrinol , vol.214 , pp. 133-143
    • Rege, J.1    Rainey, W.E.2
  • 21
    • 0033304847 scopus 로고    scopus 로고
    • Exaggerated adrenarche and hyperinsulinism in adolescent girls born small for gestational age
    • Ibanez L, Potau N, Marcos MV, de Zegher F: Exaggerated adrenarche and hyperinsulinism in adolescent girls born small for gestational age. J Clin Endocrinol Metab 1999; 84: 4739-4741.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4739-4741
    • Ibanez, L.1    Potau, N.2    Marcos, M.V.3    De Zegher, F.4
  • 23
    • 33644839552 scopus 로고    scopus 로고
    • Early puberty-menarche after precocious pubarche: Relation to prenatal growth
    • Ibanez L, Jimenez R, de Zegher F: Early puberty-menarche after precocious pubarche: relation to prenatal growth. Pediatrics 2006; 117: 117-121.
    • (2006) Pediatrics , vol.117 , pp. 117-121
    • Ibanez, L.1    Jimenez, R.2    De Zegher, F.3
  • 24
    • 0030926557 scopus 로고    scopus 로고
    • Developmental and functional biology of the primate fetal adrenal cortex
    • Mesiano S, Jaffe RB: Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev 1997; 18: 378-403.
    • (1997) Endocr Rev , vol.18 , pp. 378-403
    • Mesiano, S.1    Jaffe, R.B.2
  • 25
    • 0033031741 scopus 로고    scopus 로고
    • Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: Implications for growth and remodeling
    • Spencer SJ, Mesiano S, Lee JY, Jaffe RB: Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling. J Clin Endocrinol Metab 1999; 84: 1110-1115.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1110-1115
    • Spencer, S.J.1    Mesiano, S.2    Lee, J.Y.3    Jaffe, R.B.4
  • 27
    • 17844368603 scopus 로고    scopus 로고
    • Urinary markers of adrenarche: Reference values in healthy subjects, aged 3-18 years
    • Remer T, Boye KR, Hartmann MF, Wudy SA: Urinary markers of adrenarche: reference values in healthy subjects, aged 3-18 years. J Clin Endocrinol Metab 2005; 90: 2015-2021.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2015-2021
    • Remer, T.1    Boye, K.R.2    Hartmann, M.F.3    Wudy, S.A.4
  • 30
    • 84858064955 scopus 로고    scopus 로고
    • Increased activation of the alternative 'backdoor' pathway in patients with 21-hydroxylase deficiency: Evidence from urinary steroid hormone analysis
    • Kamrath C, Hochberg Z, Hartmann MF, Remer T, Wudy SA: Increased activation of the alternative 'backdoor' pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis. J Clin Endocrinol Metab 2012; 97:E367-E375.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E367-E375
    • Kamrath, C.1    Hochberg, Z.2    Hartmann, M.F.3    Remer, T.4    Wudy, S.A.5
  • 31
    • 0030996897 scopus 로고    scopus 로고
    • Diminished adrenal androgen secretion in familial glucocorticoid deficiency implicates a significant role for ACTH in the induction of adrenarche
    • Weber A, Clark AJL, Perry LA, Honour JW, Savage MO: Diminished adrenal androgen secretion in familial glucocorticoid deficiency implicates a significant role for ACTH in the induction of adrenarche. Clin Endocrinol 1997; 46: 431-437.
    • (1997) Clin Endocrinol , vol.46 , pp. 431-437
    • Weber, A.1    Ajl, C.2    Perry, L.A.3    Honour, J.W.4    Savage, M.O.5
  • 32
    • 84880570986 scopus 로고    scopus 로고
    • Absent adrenarche in children with hypopituitarism: A study based on urinary steroid metabolomics
    • Boettcher C, Hartman MF, de Laffolie J, Zimmer KP, Wudy SA: Absent adrenarche in children with hypopituitarism: a study based on urinary steroid metabolomics. Horm Res Paediatr 2013; 79: 356-360.
    • (2013) Horm Res Paediatr , vol.79 , pp. 356-360
    • Boettcher, C.1    Hartman, M.F.2    De Laffolie, J.3    Zimmer, K.P.4    Wudy, S.A.5
  • 33
    • 0036798276 scopus 로고    scopus 로고
    • Increased adrenocortical and adrenomedullary hormonal activity in 12-year-old children born small for gestational age
    • Tenhola S, Martikainen A, Rahiala E, Parviainen M, Halonen P, Voutilainen R: Increased adrenocortical and adrenomedullary hormonal activity in 12-year-old children born small for gestational age. J Pediatr 2002; 141: 477-482.
    • (2002) J Pediatr , vol.141 , pp. 477-482
    • Tenhola, S.1    Martikainen, A.2    Rahiala, E.3    Parviainen, M.4    Halonen, P.5    Voutilainen, R.6
  • 34
    • 2942633569 scopus 로고    scopus 로고
    • Avon Longitudinal Study of Parents and Children Study Team: Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls
    • Ong KK, Potau N, Petry CJ, Jones R, Ness AR, Honour JW, de Zegher F, Ibáñez L, Dunger DB; Avon Longitudinal Study of Parents and Children Study Team: Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls. J Clin Endocrinol Metab 2004; 89: 2647-2651.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2647-2651
    • Ong, K.K.1    Potau, N.2    Petry, C.J.3    Jones, R.4    Ness, A.R.5    Honour, J.W.6    De Zegher, F.7    Ibáñez, L.8    Dunger, D.B.9
  • 35
    • 14844297433 scopus 로고    scopus 로고
    • Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity
    • Neville KA, Walker JL: Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity. Arch Dis Child 2005; 90: 258-261.
    • (2005) Arch Dis Child , vol.90 , pp. 258-261
    • Neville, K.A.1    Walker, J.L.2
  • 36
    • 1242351792 scopus 로고    scopus 로고
    • Premature pubarche as an indicator of how body weight influences the onset of adrenarche
    • Charkaluk M-L, Trivin C, Brauner R: Premature pubarche as an indicator of how body weight influences the onset of adrenarche. Eur J Pediatr 2004; 163: 89-93.
    • (2004) Eur J Pediatr , vol.163 , pp. 89-93
    • Charkaluk, M.-L.1    Trivin, C.2    Brauner, R.3
  • 38
    • 67349179971 scopus 로고    scopus 로고
    • Girls with premature adrenarche have accelerated early childhood growth
    • Utriainen P, Voutilainen R, Jääskeläinen J: Girls with premature adrenarche have accelerated early childhood growth. J Pediatr 2009; 154: 882-887.
    • (2009) J Pediatr , vol.154 , pp. 882-887
    • Utriainen, P.1    Voutilainen, R.2    Jääskeläinen, J.3
  • 40
    • 70350651571 scopus 로고    scopus 로고
    • Body fat and animal protein intakes are associated with adrenal androgen secretion in children
    • Shi L, Wudy SA, Buyken AE, Hartmann MF, Remer T: Body fat and animal protein intakes are associated with adrenal androgen secretion in children. Am J Clin Nutr 2009; 90: 1321-1328.
    • (2009) Am J Clin Nutr , vol.90 , pp. 1321-1328
    • Shi, L.1    Wudy, S.A.2    Buyken, A.E.3    Hartmann, M.F.4    Remer, T.5
  • 41
    • 0035064234 scopus 로고    scopus 로고
    • Candidate gene analysis in premature pubarche and adolescent hyperandrogenism
    • Witchel SF, Smith R, Tomboc M, Aston CE: Candidate gene analysis in premature pubarche and adolescent hyperandrogenism. Fertil Steril 2001; 75: 724-730.
    • (2001) Fertil Steril , vol.75 , pp. 724-730
    • Witchel, S.F.1    Smith, R.2    Tomboc, M.3    Aston, C.E.4
  • 42
    • 84885202828 scopus 로고    scopus 로고
    • A diagnosis not to be missed: Nonclassic steroid 11β-hydroxylase deficiency presenting with premature adrenarche and hirsutism
    • Reisch N, Högler W, Parajes S, Rose IT, Dhir V, Götzinger J, Arlt W, Krone N: A diagnosis not to be missed: nonclassic steroid 11β-hydroxylase deficiency presenting with premature adrenarche and hirsutism. J Clin Endocrinol Metab 2013; 98:E1620-E1625.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1620-E1625
    • Reisch, N.1    Högler, W.2    Parajes, S.3    Rose, I.T.4    Dhir, V.5    Götzinger, J.6    Arlt, W.7    Krone, N.8
  • 51
    • 59449088244 scopus 로고    scopus 로고
    • Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index
    • Rosenfield RL, Lipton RB, Drum ML: Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index. Pediatrics 2009; 123: 84-88.
    • (2009) Pediatrics , vol.123 , pp. 84-88
    • Rosenfield, R.L.1    Lipton, R.B.2    Drum, M.L.3
  • 52
  • 53
    • 0033794672 scopus 로고    scopus 로고
    • Adrenal hyperandrogenism in adolescent girls with a history of low birthweight and precocious pubarche
    • Ibáñez L, Potau N, Marcos MV, De Zegher F: Adrenal hyperandrogenism in adolescent girls with a history of low birthweight and precocious pubarche. Clin Endocrinol 2000; 53: 523-527.
    • (2000) Clin Endocrinol , vol.53 , pp. 523-527
    • Ibáñez, L.1    Potau, N.2    Marcos, M.V.3    De Zegher, F.4
  • 55
    • 0036146435 scopus 로고    scopus 로고
    • Elevated free IGF-I levels in prepubertal Hispanic girls with premature adrenarche: Relationship with hyperandrogenism and insulin sensitivity
    • Silfen ME, Manibo AM, Ferin M, McMahon DJ, Levine LS, Oberfield SE: Elevated free IGF-I levels in prepubertal Hispanic girls with premature adrenarche: relationship with hyperandrogenism and insulin sensitivity. J Clin Endocrinol Metab 2002; 87: 398-403.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 398-403
    • Silfen, M.E.1    Manibo, A.M.2    Ferin, M.3    McMahon, D.J.4    Levine, L.S.5    Oberfield, S.E.6
  • 57
    • 0034575063 scopus 로고    scopus 로고
    • Increased bone mineral density and serum leptin in non-obese girls with precocious pubarche: Relation to low birthweight and hyperinsulinism
    • Ibáñez L, Potau N, Ong K, Dunger DB, De Zegher F: Increased bone mineral density and serum leptin in non-obese girls with precocious pubarche: relation to low birthweight and hyperinsulinism. Horm Res 2000; 54: 192-197.
    • (2000) Horm Res , vol.54 , pp. 192-197
    • Ibáñez, L.1    Potau, N.2    Ong, K.3    Dunger, D.B.4    De Zegher, F.5
  • 59
    • 70449104252 scopus 로고    scopus 로고
    • Body composition and bone mineral density in children with premature adrenarche and the association of LRP5 gene polymorphisms with bone mineral density
    • Utriainen P, Jääskeläinen J, Saarinen A, Vanninen E, Mäkitie O, Voutilainen R: Body composition and bone mineral density in children with premature adrenarche and the association of LRP5 gene polymorphisms with bone mineral density. J Clin Endocrinol Metab 2009; 94: 4144-4151.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4144-4151
    • Utriainen, P.1    Jääskeläinen, J.2    Saarinen, A.3    Vanninen, E.4    Mäkitie, O.5    Voutilainen, R.6
  • 60
    • 0032953381 scopus 로고    scopus 로고
    • Biopsychological and cognitive differences in children with premature vs on-time adrenarche
    • Dorn LD, Hitt SF, Rotenstein D: Biopsychological and cognitive differences in children with premature vs. on-time adrenarche. Arch Pediatr Adolesc Med 1999; 153: 137-146.
    • (1999) Arch Pediatr Adolesc Med , vol.153 , pp. 137-146
    • Dorn, L.D.1    Hitt, S.F.2    Rotenstein, D.3
  • 62
    • 79955682098 scopus 로고    scopus 로고
    • Isolated premature pubarche: Report of anthropometric and metabolic profile of a Brazilian cohort of girls
    • de Ferran K, Paiva IA, Garcia Ldos S, Gama Mde P, Guimarães MM: Isolated premature pubarche: report of anthropometric and metabolic profile of a Brazilian cohort of girls. Horm Res Paediatr 2011; 75: 367-373.
    • (2011) Horm Res Paediatr , vol.75 , pp. 367-373
    • De Ferran, K.1    Paiva, I.A.2    Garcia Ldos, S.3    Gama Mde, P.4    Guimarães, M.M.5
  • 63
    • 0036152665 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 in girls with precocious pubarche: A premenarcheal marker for polycystic ovary syndrome?
    • Ibáñez L, Aulesa C, Potau N, Ong K, Dunger DB, de Zegher F: Plasminogen activator inhibitor-1 in girls with precocious pubarche: a premenarcheal marker for polycystic ovary syndrome? Pediatr Res 2002; 51: 244-248.
    • (2002) Pediatr Res , vol.51 , pp. 244-248
    • Ibáñez, L.1    Aulesa, C.2    Potau, N.3    Ong, K.4    Dunger, D.B.5    De Zegher, F.6
  • 65
    • 0036067399 scopus 로고    scopus 로고
    • Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism
    • Mathew RP, Najjar JL, Lorenz RA, Mayes DE, Russell WE: Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism. J Pediatr 2002; 141: 91-98.
    • (2002) J Pediatr , vol.141 , pp. 91-98
    • Mathew, R.P.1    Najjar, J.L.2    Lorenz, R.A.3    Mayes, D.E.4    Russell, W.E.5
  • 66
    • 0028039771 scopus 로고
    • Familial influences on the adrenal androgen excretion rate during the adrenarche
    • Pratt JH, Manatunga AK, Li W: Familial influences on the adrenal androgen excretion rate during the adrenarche. Metabolism 1994; 43: 186-189.
    • (1994) Metabolism , vol.43 , pp. 186-189
    • Pratt, J.H.1    Manatunga, A.K.2    Li, W.3
  • 67
    • 41349101611 scopus 로고    scopus 로고
    • ACTH receptor promoter polymorphism associates with the severity of premature adrenarche and modulates hypothalamo-pituitary-adrenal axis in children
    • Lappalainen S, Utriainen P, Kuulasmaa T, Voutilainen R, Jääskeläinen J: ACTH receptor promoter polymorphism associates with the severity of premature adrenarche and modulates hypothalamo-pituitary-adrenal axis in children. Pediatr Res 2008; 63: 410-414.
    • (2008) Pediatr Res , vol.63 , pp. 410-414
    • Lappalainen, S.1    Utriainen, P.2    Kuulasmaa, T.3    Voutilainen, R.4    Jääskeläinen, J.5
  • 69
    • 84865487648 scopus 로고    scopus 로고
    • Polymorphism of POR, SULT2A1 and HSD11B1 in children with premature adrenarche
    • Utriainen P, Laakso S, Jääskeläinen J, Voutilainen R: Polymorphism of POR, SULT2A1 and HSD11B1 in children with premature adrenarche. Metabolism 2012; 61: 1215-1219.
    • (2012) Metabolism , vol.61 , pp. 1215-1219
    • Utriainen, P.1    Laakso, S.2    Jääskeläinen, J.3    Voutilainen, R.4
  • 72
    • 42049088721 scopus 로고    scopus 로고
    • Androgen receptor gene CAG repeat polymorphism and X-chromosome inactivation in children with premature adrenarche
    • Lappalainen S, Utriainen P, Kuulasmaa T, Voutilainen R, Jääskeläinen J: Androgen receptor gene CAG repeat polymorphism and X-chromosome inactivation in children with premature adrenarche. J Clin Endocrinol Metab 2008; 93: 1304-1309.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1304-1309
    • Lappalainen, S.1    Utriainen, P.2    Kuulasmaa, T.3    Voutilainen, R.4    Jääskeläinen, J.5
  • 73
    • 34547655600 scopus 로고    scopus 로고
    • Association of the GAA1013->GAG polymorphism of the insulin-like growth factor-1 receptor ( IGF1R) gene with premature pubarche
    • Roldan MB, White C, Witchel SF: Association of the GAA1013->GAG polymorphism of the insulin-like growth factor-1 receptor ( IGF1R) gene with premature pubarche. Fertil Steril 2007; 88: 410-417.
    • (2007) Fertil Steril , vol.88 , pp. 410-417
    • Roldan, M.B.1    White, C.2    Witchel, S.F.3
  • 74
    • 80052960916 scopus 로고    scopus 로고
    • Adrenarche and middle childhood
    • Campbell BC: Adrenarche and middle childhood. Hum Nat 2011; 22: 327-349.
    • (2011) Hum Nat , vol.22 , pp. 327-349
    • Campbell, B.C.1
  • 76
    • 79961225521 scopus 로고    scopus 로고
    • Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence
    • Ibáñez L, Lopez-Bermejo A, Diaz M, Marcos MV, de Zegher F: Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence. J Clin Endocrinol Metab 2011; 96:E1262-E1267.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. E1262-E1267
    • Ibáñez, L.1    Lopez-Bermejo, A.2    Diaz, M.3    Marcos, M.V.4    De Zegher, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.