Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 8, 2011, Pages

  Ibáñez, Lourdes ^a,e   López Bermejo, Abel ^b   Diáz, Marta ^a,e   Marcos, Maria Victoria ^c,e   De Zegher, Francis ^d  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL JOSEP TRUETA   (Spain)

^c HOSPITAL DE TERRASSA   (Spain)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; C REACTIVE PROTEIN; METFORMIN;

ABDOMINAL FAT; ABDOMINAL OBESITY; ADOLESCENT; AGE; ARTICLE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY HEIGHT; BODY WEIGHT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; FEMALE; FOLLICULAR PHASE; FOLLOW UP; HIRSUTISM; HUMAN; INTRAABDOMINAL FAT; LIVER; LOW BIRTH WEIGHT; MENSTRUAL CYCLE; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGOMENORRHEA; OVARY; OVARY POLYCYSTIC DISEASE; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM; SCREENING TEST; SPAIN;

ADOLESCENT; CHILD; FEMALE; FOLLOW-UP STUDIES; HIRSUTISM; HUMANS; HYPERANDROGENISM; HYPOGLYCEMIC AGENTS; MENARCHE; METFORMIN; OLIGOMENORRHEA; POLYCYSTIC OVARY SYNDROME; PREVALENCE; PUBERTY, PRECOCIOUS; RISK FACTORS; TREATMENT OUTCOME;

EID: 79961225521     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0555     Document Type: Article

References (25)

1. de Zegher F, Lopez-Bermejo A, Ibáñez L 2009 Adipose tissue expandabilityand the early origins of polycystic ovary syndrome. Trends Endocrinol Metab 20:418-423
2. Ibáñez L, Potau N, Francois I, de Zegher F 1998 Precociouspubarche, hyperinsulinism and ovarian hyperandrogenism in girls: relation to reduced fetal growth. J Clin Endocrinol Metab 83:3558-3662
3. Ibáñez L, Jiménez R, de Zegher F 2006 Early puberty-menarche afterprecocious pubarche: relation to prenatal growth. Pediatrics 117:117-121 (Pubitemid 46050527)
4. Ibáñez L, de Zegher F, Potau N 1999 Anovulation after precociouspubarche: early markers and time course in adolescence. J Clin Endocrinol Metab 84:2691-2695 (Pubitemid 30641994)
5. Ibáñez L, Valls C, Potau N, Marcos MV, de Zegher F 2001 Polycysticovary syndrome after precocious pubarche: ontogeny of the low birthweight effect. Clin Endocrinol (Oxf) 55:667-672 (Pubitemid 34204450)
6. Ibáñez L, Ong K, Valls C, Marcos MV, Dunger DB, de Zegher F 2006 Metformin treatment to prevent early puberty in girls with precocious pubarche. J Clin Endocrinol Metab 91:2888-2891 (Pubitemid 44271731)
7. Ibáñez L, López-Bermejo A, Díaz M, Marcos MV, de Zegher F 2008Metformin treatment for 4 yr to reduce total and visceral fat in low-birthweight girls with precocious pubarche. J Clin Endocrinol Metab 93:1841-1845 (Pubitemid 351656527)
8. Ibáñez L, Lopez-Bermejo A, Diaz M, Marcos MV, de Zegher F 2010 Pubertal metformin therapy to reduce total, visceral and hepatic adiposity. J Pediatr 156:98.e1-102.e1
9. Ibáñez L, Lopez-Bermejo A, Diaz M, Marcos MV, de Zegher F 2011 Early metformin therapy to delay menarche and augment height in girls with precocious pubarche. Fertil Steril 95:727-730
10. Ibáñez L, Valls C, Marcos MV, Ong K, Dunger DB, de Zegher F 2004 Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: effects of prepubertal initiation and postpubertal discontinuation of metformin. J Clin Endocrinol Metab 89:4331-4337 (Pubitemid 39244434)
11. Ibáñez L, Suárez L, Lopez-Bermejo A, Diaz M, Valls C, de ZegherF 2008 Early development of visceral fat excess following spontaneous catch-up growth in children with low birthweight. J Clin Endocrinol Metab 93:925-928 (Pubitemid 351398575)
12. Balen AH, Laven JSE, Tan SL, Dewailly D 2003 Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update 9:505-514 (Pubitemid 38072143)
13. Zawadski JK, Dunaif A 1992 Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic ovary syndrome. Boston: Blackwell Scientific Publications; 377-384
14. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF 2009 The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 91:456-488
15. McCartney CR, Prendergast KA, Chhabra S, Eagleson CA, Yoo R, Chang RJ, Foster CM, Marshall JC 2006 The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J Clin Endocrinol Metab 91:1714-1722
16. McCartney CR, Blank SK, Prendergast KA, Chhabra S, Eagleson CA, Helm KD, Yoo R, Chang RJ, Foster CM, Caprio S, Marshall JC 2007 Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls. J Clin Endocrinol Metab 92:430-436
17. Hart R, Doherty DA, Norman RJ, Franks S, Dickinson JE, Hickey M, Sloboda DM 2010 Serum antimullerian hormone (AMH) levels are elevated in adolescent girls with polycystic ovaries and the polycystic ovarian syndrome (PCOS). Fertil Steril 94:1118-1121
18. Park AS, Lawson MA, Chuan SS, Oberfield SE, Hoeger KM, Witchel SF, Chang RJ 2010 Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. J Clin Endocrinol Metab 95:1786-1792
19. Ibáñez L, Potau N, Enriquez G, de Zegher F 2000 Reduced uterineand ovarian size in adolescent girls born small for gestational age. Pediatr Res 47:575-577 (Pubitemid 30249842)
20. Ibáñez L, Potau N, Enriquez G, Marcos MV, de Zegher F 2003 Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age. Hum Reprod 18:1565-1569 (Pubitemid 36966015)
21. Ibáñez L, Jaramillo A, Enríquez G, Miró E, López-Bermejo A,Dunger D, de Zegher F 2007 Polycystic ovaries after precocious pubarche: relation to prenatal growth. Hum Reprod 22:395-400 (Pubitemid 46152558)
22. Ibáñez L, López-Bermejo A, Callejo J, Torres A, Cabré S, Dunger D,de Zegher F 2008 Polycystic ovaries in nonobese adolescents and young women with ovarian androgen excess: relation to prenatal growth. J Clin Endocrinol Metab 93:196-199
23. Legro RS, Roller RL, Dodson WC, Stetter CM, Kunselman AR, Dunaif A 2010 Associations of birthweight and gestational age with reproductive and metabolic phenotypes in women with polycystic ovarian syndrome and their first-degree relatives. J Clin Endocrinol Metab 95:789-799
24. de Zegher F, Ibáñez L 2009 Early origins of polycystic ovary syndrome:hypotheses may change without notice. J Clin Endocrinol Metab 94:3682-3685
25. Mannerås-Holm L, Leonhardt H, Kullberg J, Jennische E, Odén A,Holm G, Hellström M, Lönn L, Olivecrona G, Stener-Victorin E,Lönn M2 011 Adipose tissue has aberrant morphology and functionin PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance. J Clin Endocrinol Metab 96:E304-E311