Girls diagnosed with premature pubarche show an exaggerated ovarian androgen synthesis from the early stages of puberty: Evidence from gonadotropin-releasing hormone agonist testing

Fertility and Sterility

Volumn 67, Issue 5, 1997, Pages 849-855

  Ibáñflez, Lourdes ^a   Street, Maria E ^c   Potau, Neus ^b   Carrascosa, Antonio ^a   Zampolli, Maria ^b  

^a HOSPITAL MATERNO INFANTIL VALL D HEBRON   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

GnRH a testing; ovarian cytochrome P450c17 dysregulation; ovarian steroid hyper responsiveness; Premature pubarche

Indexed keywords

17 HYDROXYPREGNENOLONE; ANDROGEN; ANDROSTENEDIONE; CORTICOTROPIN; CYTOCHROME P450; ESTRADIOL; GONADORELIN AGONIST; GONADOTROPIN; HYDROCORTISONE; HYDROXYPROGESTERONE; LEUPRORELIN; PRASTERONE; PRASTERONE SULFATE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE;

ADOLESCENT; ADRENAL GLAND; ADULT; ANDROGEN SYNTHESIS; ARTICLE; CHILD; CLINICAL PROTOCOL; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; HUMAN; HYPERANDROGENISM; HYPOPHYSIS GONAD SYSTEM; LUTEINIZING HORMONE RELEASE; MAJOR CLINICAL STUDY; MENARCHE; OVARY DEVELOPMENT; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0342602068     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(97)81396-9     Document Type: Article

References (25)

1. Ehrmann DA, Rosenfield RL, Barnes RB, Brigell DF, Sheikh Z. Detection of functional ovarian hyperandrogenism in women with androgen excess. N Engl J Med 1992;327:157-62.
2. Rosenfield RL, Barnes RB, Ehrmann DA. Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1994;79:1686-92.
3. Ehrmann DA, Barnes RB, Rosenfield RL. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev 1995; 16:322-53.
4. Ibañez L, Potau N, Zampolli M, Prat N, Gussinyé M, Saenger P, et al. Source localization of androgen excess in adolescent girls. J Clin Endocrinol Metab 1994;79:1778-84.
5. Rosenfield RL, Barnes RB, Cara JF, Lucky AW. Dysregulation of cytochrome P450cl7α as the cause of polycystic ovarian syndrome. Fertil Steril 1990;53:785-91.
6. Rosenfield RL. Hyperandrogenism in peripubertal girls. In: Mahoney CP, editor. Current issues in pediatric and adolescent endocrinology. Philadelphia: Saunders, 1990:1233-58.
7. Ibañez L, Potau N, Virdis R, Zampolli M, Terzi C, Gussinyé M, et al. Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1993;76:1599-603.
8. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in girls. Arch Dis Child 1969;44:291-303.
9. Rosenfield RL, Rich BH, Lucky AW. Adrenarche as a cause of benign pseudopuberty in boys. J Pediatr 1982; 101:10059.
10. New MI, Lorenzen F, Lerner AJ, Kohn B, Oberfield SE, Pollack MS, et al. Genotyping steroid 21-hydroxylase deficiency: hormonal reference data. J Clin Endocrinol Metab 1983; 56: 320-5.
11. Chang YT, Zhang L, Alkaddour HS, Mason JI, Ling K, Yang X, et al. Absence of molecular defect in the type II 3β-hydroxysteroid dehydrogenase (3β-HSD) gene in premature pubarche children and hirsute female patients with moderately decreased adrenal 3β-HSD activity. Pediatr Res 1995; 37:8204.
12. Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440-7.
13. Ibáñez L, Potau N, Georgopoulos N, Prat N, Gussinyé M, Carrascosa A. Growth hormone, insulin-like growth factor-I axis, and insulin secretion in hyperandrogenic adolescents. Fertil Steril 1995;64:1113-9.
14. Ghai K, Rosenfield RL. Maturation of the normal pituitary-testicular axis, as assessed by gonadotropm-releasing hormone agonist challenge. J Clin Endocrinol Metab 1994;78: 1336-40.
15. Rosenfield RL, Burstein S, Cutler L, Cara JF, Levitsky LL, Barnes RB, et al. Use of nafarelin for testing pituitary-ovarian function. J Reprod Med 1989; 34(Suppl 12):1044-50.
16. Barnes RB, Rosenfield RL, Burstein S, Ehrmann DA. Pituitary-ovarian responses to nafarelin in the polycystic ovary syndrome. N Engl J Med 1989;320:559-65.
17. Rich BH, Rosenfield RL, Lucky AW, Helke JC, Otto P. Adrenarche: changing adrenal response to adrenocorticotropin. J Clin Endocrinol Metab 1981;52:1129-36.
18. Lucky AW, Rosenfield RL, McGuire J, Rudy S, Helke J. Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche. J Clin Endocrinol Metab 1986; 62:840-8.
19. Likitmaskul S, Cowell CT, Donaghue K, Kreutzmann DJ, Howard NJ, Blades B, et al."Exaggerated adrenarche" in children presenting with premature adrenarche. Clin Endocrinol (Oxf) 1995;42:265-72.
20. Hillier S, Ross GT. Effects of exogenous testosterone on ovarian weight, follicular morphology, and intraovarian progesterone concentration in estrogen-primed hypophysectomized immature female rats. Biol Reprod 1979;20:261-8.
21. Cara JF, Rosenfield RL. Insulin-like growth factor-I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian theca-interstitial cells. Endocrinology 1988; 123:733-9.
22. Nobels F, Dewailly D. Puberty and polycystic ovarian syndrome: the insulin/insulin-like growth factor I hypothesis. Fertil Steril 1992; 58:655-66.
23. Willis D, Mason H, Gilling-Smith C, Franks S. Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries. J Clin Endocrinol Metab 1996;81:302-9.
24. Rosenfield RL. Evidence that idiopathic functional adrenal hyperandrogenism is caused by dysregulation of adrenal steroidogenesis and that hyperinsulinemia may be involved [editorial]. J Clin Endocrinol Metab 1996;81:878-80.
25. Ibáñez L, Potau N, Zampolli M, Prat N, Virdis R, Vicens-Calvet E, et al. Hyperinsulinemia in postpubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1996;81:123743.