-
1
-
-
0032488666
-
5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer
-
DOI 10.1074/jbc.273.6.3158
-
Auchus RJ, Lee TC, Miller WL 1998 Cytochrome b5 augments the 17,20 lyase activity of human P450c17 without direct electron transfer. J Biol Chem 273:3158-3165 (Pubitemid 28109723)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.6
, pp. 3158-3165
-
-
Auchus, R.J.1
Lee, T.C.2
Miller, W.L.3
-
2
-
-
0042384482
-
The 17, 20-lyase activity of cytochrome P450c17 from human fetal testis favors the Δ5 steroidogenic pathway
-
Flü ck CE, Miller WL, Auchus RJ 2003 The 17, 20-lyase activity of cytochrome P450c17 from human fetal testis favors the Δ5 steroidogenic pathway. J Clin Endocrinol Metab 88:3762-3766
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3762-3766
-
-
Flück, C.E.1
Miller, W.L.2
Auchus, R.J.3
-
3
-
-
0035528888
-
The role of 5α-reduction in steroid hormone physiology
-
Wilson JD 2001 The role of 5α-reduction in steroid hormone physiology. Reprod Fertil Dev 13:673-678 (Pubitemid 34240215)
-
(2001)
Reproduction, Fertility and Development
, vol.13
, Issue.7-8
, pp. 673-678
-
-
Wilson, J.D.1
-
4
-
-
7444233759
-
The backdoor pathway to dihydrotestosterone
-
DOI 10.1016/j.tem.2004.09.004, PII S1043276004002140
-
Auchus RJ 2004 The backdoor pathway to dihydrotestosterone. Trends Endocrinol Metab 15:432-438 (Pubitemid 39440726)
-
(2004)
Trends in Endocrinology and Metabolism
, vol.15
, Issue.9
, pp. 432-438
-
-
Auchus, R.J.1
-
5
-
-
0037317265
-
5α-androstane-3α,17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane-3α,17α- diol-20-one as a key intermediate
-
DOI 10.1210/en.2002-220721
-
Wilson JD, Auchus RJ, Leihy MW, Guryev OL, Estabrook RW, Osborn SM, Shaw G, Renfree MB 2003 5α-Androstane-3α,17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane- 3α,17α-diol-20-one as a key intermediate. Endocrinology 144:575-580 (Pubitemid 36205230)
-
(2003)
Endocrinology
, vol.144
, Issue.2
, pp. 575-580
-
-
Wilson, J.D.1
Auchus, R.J.2
Leihy, M.W.3
Guryev, O.L.4
Estabrook, R.W.5
Osborn, S.M.6
Shaw, G.7
Renfree, M.B.8
-
7
-
-
3142530379
-
Steroid 5α-reductase 1 promotes 5α-androstane-3α, 17β-diol synthesis in immature mouse testes by two pathways
-
DOI 10.1016/j.mce.2004.04.009, PII S0303720704001674
-
Mahendroo M, Wilson JD, Richardson JA, Auchus RJ 2004 Steroid 5α-reductase 1 promotes 5α-androstane-3α,17β-diol synthesis in immature mouse testes by two pathways. Mol Cell Endocrinol 222: 113-120 (Pubitemid 38900820)
-
(2004)
Molecular and Cellular Endocrinology
, vol.222
, Issue.1-2
, pp. 113-120
-
-
Mahendroo, M.1
Wilson, J.D.2
Richardson, J.A.3
Auchus, R.J.4
-
8
-
-
0015239404
-
Partial characterization of the nuclear reduced nicotinamide adenine dinucleotide phosphate: Δ 4-3-ketosteroid 5α-oxidoreductase of rat prostate
-
Frederiksen DW, Wilson JD 1971 Partial characterization of the nuclear reduced nicotinamide adenine dinucleotide phosphate: Δ 4-3-ketosteroid 5α-oxidoreductase of rat prostate. J Biol Chem 246:2584-2593
-
(1971)
J Biol Chem
, vol.246
, pp. 2584-2593
-
-
Frederiksen, D.W.1
Wilson, J.D.2
-
9
-
-
0034454269
-
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
-
DOI 10.1210/er.21.3.245
-
White PC, Speiser PW 2000 Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Endocr Rev 21:245-291 (Pubitemid 32275589)
-
(2000)
Endocrine Reviews
, vol.21
, Issue.3
, pp. 245-291
-
-
White, P.C.1
Speiser, P.W.2
-
10
-
-
3042613405
-
Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: Analytical study
-
DOI 10.1016/S0140-6736(04)16503-3, PII S0140673604165033
-
Arlt W, Walker EA, Draper N, Ivison HE, Ride JP, Hammer F, Chalder SM, Borucka-Mankiewicz M, Hauffa BP, Malunowicz EM, Stewart PM, Shackleton CH 2004 Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study. Lancet 363:2128-2135 (Pubitemid 38844154)
-
(2004)
Lancet
, vol.363
, Issue.9427
, pp. 2128-2135
-
-
Arlt, W.1
Walker, E.A.2
Draper, N.3
Ivison, H.E.4
Ride, J.P.5
Hammer, F.6
Chalder, S.M.7
Borucka-Mankiewicz, M.8
Hauffa, B.P.9
Malunowicz, E.M.10
Stewart, P.M.11
Shackleton, C.H.L.12
-
11
-
-
77956588420
-
Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: An Endocrine Society Clinical Practice Guideline
-
Speiser PW, Azziz R, Baskin LS, Ghizzoni L, Hensle TW, Merke DP, Meyer-Bahlburg HF, Miller WL, Montori VM, Oberfield SE, Ritzen M, White PC 2010 Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 95:4133-4160
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 4133-4160
-
-
Speiser, P.W.1
Azziz, R.2
Baskin, L.S.3
Ghizzoni, L.4
Hensle, T.W.5
Merke, D.P.6
Meyer-Bahlburg, H.F.7
Miller, W.L.8
Montori, V.M.9
Oberfield, S.E.10
Ritzen, M.11
White, P.C.12
-
12
-
-
0034099721
-
Hormonal diagnosis of 21-hydroxylase deficiency in plasma and urine of neonates using benchtop gas chromatography-mass spectrometry
-
Wudy SA, Hartmann M, Homoki J 2000 Hormonal diagnosis of 21-hydroxylase deficiency in plasma and urine of neonates using bench top gas chromatography-mass spectrometry. J Endocrinol 165:679-683 (Pubitemid 30407696)
-
(2000)
Journal of Endocrinology
, vol.165
, Issue.3
, pp. 679-683
-
-
Wudy, S.A.1
Hartmann, M.2
Homoki, J.3
-
13
-
-
77955417131
-
Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)
-
Krone N, Hughes BA, Lavery GG, Stewart PM, Arlt W, Shackleton CH 2010 Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS). J Steroid Biochem Mol Biol 121:496-504
-
(2010)
J Steroid Biochem Mol Biol
, vol.121
, pp. 496-504
-
-
Krone, N.1
Hughes, B.A.2
Lavery, G.G.3
Stewart, P.M.4
Arlt, W.5
Shackleton, C.H.6
-
14
-
-
3142682710
-
Profiling steroids by gas chromatography- mass spectrometry: Clinical applications
-
Ranke MB, ed. Basel, Switzerland: Karger
-
Wudy SA and Homoki J 2003 Profiling steroids by gas chromatography- mass spectrometry: clinical applications. In: Ranke MB, ed. Diagnostics of endocrine function in children and adolescents. Basel, Switzerland: Karger; 427-449
-
(2003)
Diagnostics of Endocrine Function in Children and Adolescents
, pp. 427-449
-
-
Wudy, S.A.1
Homoki, J.2
-
15
-
-
17844368603
-
Urinary markers of adrenarche: Reference values in healthy subjects, aged 3-18 years
-
DOI 10.1210/jc.2004-1571
-
Remer T, Boye KR, Hartmann MF, Wudy SA 2005 Urinary markers of adrenarche: reference values in healthy subjects, aged 3-18 years. J Clin Endocrinol Metab 90:2015-2021 (Pubitemid 40586233)
-
(2005)
Journal of Clinical Endocrinology and Metabolism
, vol.90
, Issue.4
, pp. 2015-2021
-
-
Remer, T.1
Boye, K.R.2
Hartmann, M.F.3
Wudy, S.A.4
-
16
-
-
0027414682
-
Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research
-
Shackleton CHL 1993 Mass spectrometry in the diagnosis of steroid related disorders and in hypertension research. J Steroid Biochem Molec Biol 45:127-140 (Pubitemid 23123154)
-
(1993)
Journal of Steroid Biochemistry and Molecular Biology
, vol.45
, Issue.1-3
, pp. 127-140
-
-
Shackleton, C.H.L.1
-
17
-
-
2142653123
-
Adrenarche and bone modeling and remodeling at the proximal radius: Weak androgens make stronger cortical bone in healthy children
-
DOI 10.1359/jbmr.2003.18.8.1539
-
Remer T, Boye KR, Hartmann M, Neu CM, Schoenau E, Manz F, Wudy SA 2003 Adrenarche and bone modeling and remodeling at the proximal radius: weak androgens make stronger cortical bone in healthy children. J Bone Miner Res 18:1539-1546 (Pubitemid 41070809)
-
(2003)
Journal of Bone and Mineral Research
, vol.18
, Issue.8
, pp. 1539-1546
-
-
Remer, T.1
Boye, K.R.2
Hartmann, M.3
Neu, C.M.4
Schoenau, E.5
Manz, F.6
Wudy, S.A.7
-
18
-
-
0002845980
-
Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages
-
Schmidt M, Kreutz M, Löffler G, Schölmerich J, Straub RH 2000 Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. J Endocrinol 164:161-169 (Pubitemid 30114663)
-
(2000)
Journal of Endocrinology
, vol.164
, Issue.2
, pp. 161-169
-
-
Schmidt, M.1
Kreutz, M.2
Loffler, G.3
Scholmerich, J.4
Straub, R.H.5
-
19
-
-
41549141663
-
17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites
-
Shackleton CH, Neres MS, Hughes BA, Stewart PM, Kater CE 2008 17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites. Steroids 73:652-656
-
(2008)
Steroids
, vol.73
, pp. 652-656
-
-
Shackleton, C.H.1
Neres, M.S.2
Hughes, B.A.3
Stewart, P.M.4
Kater, C.E.5
-
20
-
-
33745790703
-
Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: Implication for the backdoor pathway to dihydrotestosterone
-
DOI 10.1210/jc.2005-2460
-
Homma K, Hasegawa T, Nagai T, Adachi M, Horikawa R, Fujiwara I, Tajima T, Takeda R, Fukami M, Ogata T 2006 Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: implication for the backdoor pathway to dihydrotestosterone. J Clin Endocrinol Metab 91:2643-2649 (Pubitemid 44024631)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.7
, pp. 2643-2649
-
-
Homma, K.1
Hasegawa, T.2
Nagai, T.3
Adachi, M.4
Horikawa, R.5
Fujiwara, I.6
Tajima, T.7
Takeda, R.8
Fukami, M.9
Ogata, T.10
-
21
-
-
0027234897
-
Tissue distribution and ontogeny of steroid 5α-reductase isozyme expression
-
Thigpen AE, Silver RI, Guileyardo JM, Casey ML, McConnell JD, Russell DW 1993 Tissue distribution and ontogeny of steroid 5α-reductase isozyme expression. J Clin Invest 92:903-910 (Pubitemid 23262413)
-
(1993)
Journal of Clinical Investigation
, vol.92
, Issue.2
, pp. 903-910
-
-
Thigpen, A.E.1
Silver, R.I.2
Guileyardo, J.M.3
Casey, M.L.4
McConnell, J.D.5
Russell, D.W.6
-
22
-
-
80051664435
-
Why boys will be boys: Two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation
-
Flück CE, Meyer-Böni M, Pandey AV, Kempná P, Miller WL, Schoenle EJ, Biason-Lauber A 2011 Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. Am J Hum Genet 89:201-218
-
(2011)
Am J Hum Genet
, vol.89
, pp. 201-218
-
-
Flück, C.E.1
Meyer-Böni, M.2
Pandey, A.V.3
Kempná, P.4
Miller, W.L.5
Schoenle, E.J.6
Biason-Lauber, A.7
-
23
-
-
0034287545
-
Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
-
Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K 2000 Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochem J 351:67-77
-
(2000)
Biochem J
, vol.351
, pp. 67-77
-
-
Penning, T.M.1
Burczynski, M.E.2
Jez, J.M.3
Hung, C.F.4
Lin, H.K.5
Ma, H.6
Moore, M.7
Palackal, N.8
Ratnam, K.9
-
24
-
-
0035093784
-
Human types 1 and 3 3α-hydroxysteroid dehydrogenases: Differential lability and tissue distribution
-
DOI 10.1210/jc.86.2.841
-
Dufort I, Labrie F, Luu-The V 2001 Human types 1 and 3 3α-hydroxysteroid dehydrogenases: differential lability and tissue distribution. J Clin Endocrinol Metab 86:841-846 (Pubitemid 32208285)
-
(2001)
Journal of Clinical Endocrinology and Metabolism
, vol.86
, Issue.2
, pp. 841-846
-
-
Dufort, I.1
Labrie, F.2
Luu-The, V.3
-
25
-
-
0001429526
-
Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase
-
DOI 10.1210/en.140.2.568
-
Dufort I, Rheault P, Huang XF, Soucy P, Luu-The V 1999 Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase. Endocrinology 140:568-574 (Pubitemid 29058186)
-
(1999)
Endocrinology
, vol.140
, Issue.2
, pp. 568-574
-
-
Dufort, I.1
Rheault, P.2
Huang, X.-F.3
Soucy, P.4
Luu-The, V.5
-
26
-
-
0035931117
-
Type 5 17β-hydroxysteroid dehydrogenase: Its role in the formation of androgens in women
-
DOI 10.1016/S0303-7207(00)00425-1, PII S0303720700004251
-
Luu-The V, Dufort I, Pelletier G, Labrie F 2001 Type 5 17β-hydroxysteroid dehydrogenase: its role in the formation of androgens in women. Mol Cell Endocrinol 171:77-82 (Pubitemid 32098200)
-
(2001)
Molecular and Cellular Endocrinology
, vol.171
, Issue.1-2
, pp. 77-82
-
-
Luu-The, V.1
Dufort, I.2
Pelletier, G.3
Labrie, F.4
-
27
-
-
34249800682
-
Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3α-hydroxysteroids in human tissues
-
DOI 10.1210/en.2006-1491
-
Belyaeva OV, Chetyrkin SV, Clark AL, Kostereva NV, SantaCruz KS, Chronwall BM, Kedishvili NY 2007 Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3α-hydroxysteroids in human tissues. Endocrinology 148:2148-2156 (Pubitemid 46997028)
-
(2007)
Endocrinology
, vol.148
, Issue.5
, pp. 2148-2156
-
-
Belyaeva, O.V.1
Chetyrkin, S.V.2
Clark, A.L.3
Kostereva, N.V.4
SantaCruz, K.S.5
Chronwall, B.M.6
Kedishvili, N.Y.7
-
28
-
-
17144426051
-
5 and by serine phosphorylation of P450c17
-
DOI 10.1074/jbc.M414673200
-
Pandey AV, Miller WL 2005 Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. J Biol Chem 280:13265-13271 (Pubitemid 40517210)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 13265-13271
-
-
Pandey, A.V.1
Miller, W.L.2
|