-
1
-
-
0029973474
-
Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy
-
Mizutani M, Kern TS, Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest. 1996;97:2883-2890.
-
(1996)
J Clin Invest
, vol.97
, pp. 2883-2890
-
-
Mizutani, M.1
Kern, T.S.2
Lorenzi, M.3
-
2
-
-
0032529103
-
Neural apoptosis in the retina during experimental and human diabetes: Early onset and effect of insulin
-
Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW. Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin. J Clin Invest. 1998;102:783-791.
-
(1998)
J Clin Invest
, vol.102
, pp. 783-791
-
-
Barber, A.J.1
Lieth, E.2
Khin, S.A.3
Antonetti, D.A.4
Buchanan, A.G.5
Gardner, T.W.6
-
3
-
-
0033753702
-
Response of capillary cell death to aminoguanidine predicts the development of retinopathy: Comparison of diabetes and galactosemia
-
Kern TS, Tang J, Mizutani M, Kowluru R, Nagraj R, Lorenzi M. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci. 2000;41:3972-3978.
-
(2000)
Invest Ophthalmol Vis Sci
, vol.41
, pp. 3972-3978
-
-
Kern, T.S.1
Tang, J.2
Mizutani, M.3
Kowluru, R.4
Nagraj, R.5
Lorenzi, M.6
-
4
-
-
0142221070
-
Diabetes-induced mitochondrial dysfunction in the retina
-
Kowluru RA, Abbas SN. Diabetes-induced mitochondrial dysfunction in the retina. Invest Ophthalmol Vis Sci. 2003;44:5327-5334.
-
(2003)
Invest Ophthalmol Vis Sci
, vol.44
, pp. 5327-5334
-
-
Kowluru, R.A.1
Abbas, S.N.2
-
5
-
-
43449109783
-
Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy
-
Behl Y, Krothapalli P, Desta T, DiPiazza A, Roy S, Graves DT. Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy. Am J Pathol. 2008; 172:1411-1418.
-
(2008)
Am J Pathol
, vol.172
, pp. 1411-1418
-
-
Behl, Y.1
Krothapalli, P.2
Desta, T.3
Dipiazza, A.4
Roy, S.5
Graves, D.T.6
-
6
-
-
48249083387
-
Role of the polyol pathway in high glucose-induced apoptosis of retinal pericytes and proliferation of endothelial cells
-
Takamura Y, Tomomatsu T, Kubo E, Tsuzuki S, Akagi Y. Role of the polyol pathway in high glucose-induced apoptosis of retinal pericytes and proliferation of endothelial cells. Invest Ophthalmol Vis Sci. 2008;49:3216-3223.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, pp. 3216-3223
-
-
Takamura, Y.1
Tomomatsu, T.2
Kubo, E.3
Tsuzuki, S.4
Akagi, Y.5
-
7
-
-
73149121384
-
Metabolic memory in diabetes-from in vitro oddity to in vivo problem: Role of apoptosis
-
Kowluru RA, Chan PS. Metabolic memory in diabetes-from in vitro oddity to in vivo problem: role of apoptosis. Brain Res Bull. 2010;81:297-302.
-
(2010)
Brain Res Bull
, vol.81
, pp. 297-302
-
-
Kowluru, R.A.1
Chan, P.S.2
-
8
-
-
68149131912
-
TNF-α mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations
-
Joussen AM, Doehmen S, Le ML, et al. TNF-α mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations. Mol Vis. 2009;15:1418-1425.
-
(2009)
Mol Vis
, vol.15
, pp. 1418-1425
-
-
Joussen, A.M.1
Doehmen, S.2
Le, M.L.3
-
9
-
-
0035136213
-
Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development
-
Esteban LM, Vicario-Abejon C, Fernandez-Salguero P, et al. Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol Cell Biol. 2001;21:1444-1452.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1444-1452
-
-
Esteban, L.M.1
Vicario-Abejon, C.2
Fernandez-Salguero, P.3
-
10
-
-
33846207546
-
Deregulated Ras signaling in developmental disorders: New tricks for an old dog
-
Schubbert S, Bollag G, Shannon K. Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Curr Opin Genet Dev. 2007;17:15-22.
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 15-22
-
-
Schubbert, S.1
Bollag, G.2
Shannon, K.3
-
11
-
-
33750615090
-
Zinc induces ERK-dependent cell death through a specific Ras isoform
-
Klein C, Creach K, Irintcheva V, et al. Zinc induces ERK-dependent cell death through a specific Ras isoform. Apoptosis. 2006;11: 1933-1944.
-
(2006)
Apoptosis
, vol.11
, pp. 1933-1944
-
-
Klein, C.1
Creach, K.2
Irintcheva, V.3
-
12
-
-
1442276545
-
Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats
-
Kowluru RA, Kowluru A, Chakrabarti S, Khan Z. Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats. Diabetes. 2004;53:775-783.
-
(2004)
Diabetes
, vol.53
, pp. 775-783
-
-
Kowluru, R.A.1
Kowluru, A.2
Chakrabarti, S.3
Khan, Z.4
-
13
-
-
34447508212
-
Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes
-
Kowluru RA, Kowluru A, Kanwar M. Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes. Mol Cell Biochem. 2007;296:69-76.
-
(2007)
Mol Cell Biochem
, vol.296
, pp. 69-76
-
-
Kowluru, R.A.1
Kowluru, A.2
Kanwar, M.3
-
14
-
-
53649090339
-
Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy
-
Kanwar M, Kowluru RA. Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy. Microvasc Res. 2008;76:189-193.
-
(2008)
Microvasc Res
, vol.76
, pp. 189-193
-
-
Kanwar, M.1
Kowluru, R.A.2
-
15
-
-
34250787073
-
Ras as a therapeutic target in hematologic malignancies
-
Alvarado Y, Giles FJ. Ras as a therapeutic target in hematologic malignancies. Expert Opin Emerg Drugs. 2007;12:271-284.
-
(2007)
Expert Opin Emerg Drugs
, vol.12
, pp. 271-284
-
-
Alvarado, Y.1
Giles, F.J.2
-
16
-
-
68249116568
-
Translocation of H-Ras and its implications in the development of diabetic retinopathy
-
Kowluru RA, Kanwar M. Translocation of H-Ras and its implications in the development of diabetic retinopathy. Biochem Biophys Res Commun. 2009;387:461-466.
-
(2009)
Biochem Biophys Res Commun
, vol.387
, pp. 461-466
-
-
Kowluru, R.A.1
Kanwar, M.2
-
17
-
-
54049107708
-
Role of the hemopexin domain of matrix metalloproteinases in cell migration
-
Dufour A, Sampson NS, Zucker S, Cao J. Role of the hemopexin domain of matrix metalloproteinases in cell migration. J Cell Physiol. 2008;217:643-651.
-
(2008)
J Cell Physiol
, vol.217
, pp. 643-651
-
-
Dufour, A.1
Sampson, N.S.2
Zucker, S.3
Cao, J.4
-
18
-
-
0038059516
-
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)
-
Van den Steen PE, Dubois B, Nelissen I, Rudd PM, Dwek RA, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol. 2002;37:375-536.
-
(2002)
Crit Rev Biochem Mol Biol
, vol.37
, pp. 375-536
-
-
van den Steen, P.E.1
Dubois, B.2
Nelissen, I.3
Rudd, P.M.4
Dwek, R.A.5
Opdenakker, G.6
-
19
-
-
0034615550
-
Tissue inhibitors of metalloproteinases: Evolution, structure and function
-
Brew K, Dinakarpandian D, Nagase H. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta. 2000;1477:267-283.
-
(2000)
Biochim Biophys Acta
, vol.1477
, pp. 267-283
-
-
Brew, K.1
Dinakarpandian, D.2
Nagase, H.3
-
20
-
-
47749131954
-
The relationship between plasma MMP-9 and TIMP-2 levels and intraocular pressure elevation in diabetic patients after intravitreal triamcinolone injection
-
Yildirim N, Sahin A, Erol N, Kara S, Uslu S, Topbas S. The relationship between plasma MMP-9 and TIMP-2 levels and intraocular pressure elevation in diabetic patients after intravitreal triamcinolone injection. J Glaucoma. 2008;17:253-256.
-
(2008)
J Glaucoma
, vol.17
, pp. 253-256
-
-
Yildirim, N.1
Sahin, A.2
Erol, N.3
Kara, S.4
Uslu, S.5
Topbas, S.6
-
21
-
-
0035124888
-
Matrix metalloproteinases in human diabetic and nondiabetic vitreous
-
Jin M, Kashiwagi K, Iizuka Y, Tanaka Y, Imai M, Tsukahara S. Matrix metalloproteinases in human diabetic and nondiabetic vitreous. Retina. 2001;21:28-33.
-
(2001)
Retina
, vol.21
, pp. 28-33
-
-
Jin, M.1
Kashiwagi, K.2
Iizuka, Y.3
Tanaka, Y.4
Imai, M.5
Tsukahara, S.6
-
22
-
-
18744362465
-
Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier
-
Giebel SJ, Menicucci G, McGuire PG, Das A. Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier. Lab Invest. 2005;85:567-607.
-
(2005)
Lab Invest
, vol.85
, pp. 567-607
-
-
Giebel, S.J.1
Menicucci, G.2
McGuire, P.G.3
Das, A.4
-
23
-
-
34249002311
-
Matrix metalloproteinase-2 expression and apoptogenic activity in retinal pericytes: Implications in diabetic retinopathy
-
Yang R, Liu H, Williams I, Chaqour B. Matrix metalloproteinase-2 expression and apoptogenic activity in retinal pericytes: implications in diabetic retinopathy. Ann N Y Acad Sci. 2007;1103:196-201.
-
(2007)
Ann N Y Acad Sci
, vol.1103
, pp. 196-201
-
-
Yang, R.1
Liu, H.2
Williams, I.3
Chaqour, B.4
-
24
-
-
0032955659
-
Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor
-
Das A, McLamore A, Song W, McGuire PG. Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor. Arch Ophthalmol. 1999;117:498-503.
-
(1999)
Arch Ophthalmol
, vol.117
, pp. 498-503
-
-
Das, A.1
McLamore, A.2
Song, W.3
McGuire, P.G.4
-
25
-
-
67349209321
-
Oxidative stress and the development of diabetic retinopathy: Contributory role of matrix metalloproteinase-2
-
Kowluru RA, Kanwar M. Oxidative stress and the development of diabetic retinopathy: contributory role of matrix metalloproteinase-2. Free Rad Biol Med. 2009;46:1677-1685.
-
(2009)
Free Rad Biol Med
, vol.46
, pp. 1677-1685
-
-
Kowluru, R.A.1
Kanwar, M.2
-
26
-
-
34248352031
-
Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation
-
Dai Y, Khanna P, Chen S, Pei XY, Dent P, Grant S. Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation. Blood. 2007;109:4415-4423.
-
(2007)
Blood
, vol.109
, pp. 4415-4423
-
-
Dai, Y.1
Khanna, P.2
Chen, S.3
Pei, X.Y.4
Dent, P.5
Grant, S.6
-
27
-
-
0033618337
-
Matrix metalloproteinases
-
Nagase H, Woessner JJF. Matrix metalloproteinases. J Biol Chem. 1999;274:21491-21494.
-
(1999)
J Biol Chem
, vol.274
, pp. 21491-21494
-
-
Nagase, H.1
Woessner, J.J.F.2
-
28
-
-
31744445961
-
Matrix metalloproteinases (MMPs) in health and disease: An overview
-
Malemud CJ. Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci. 2006;11:1696-1701.
-
(2006)
Front Biosci
, vol.11
, pp. 1696-1701
-
-
Malemud, C.J.1
-
29
-
-
0028944962
-
Hyperglycemia and microvascular and macrovascular disease in diabetes
-
Klein R. Hyperglycemia and microvascular and macrovascular disease in diabetes. Diabetes Care. 1995;18:258-268.
-
(1995)
Diabetes Care
, vol.18
, pp. 258-268
-
-
Klein, R.1
-
30
-
-
0037235904
-
Role of nitric oxide in matrix remodeling in diabetes and heart failure
-
Tyagi SC, Hayden MR. Role of nitric oxide in matrix remodeling in diabetes and heart failure. Heart Fail Rev. 2003;8:23-28.
-
(2003)
Heart Fail Rev
, vol.8
, pp. 23-28
-
-
Tyagi, S.C.1
Hayden, M.R.2
-
31
-
-
63449086757
-
Matrix metalloproteinases: Their potential role in the pathogenesis of diabetic nephropathy
-
Thrailkill KM, Clay Bunn R, Fowlkes JL. Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy. Endocrine. 2009;35:1-10.
-
(2009)
Endocrine
, vol.35
, pp. 1-10
-
-
Thrailkill, K.M.1
Clay, B.R.2
Fowlkes, J.L.3
-
32
-
-
34548397756
-
Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
-
Navaratna D, McGuire PG, Menicucci G, Das A. Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes. Diabetes. 2007;56:2380-2387.
-
(2007)
Diabetes
, vol.56
, pp. 2380-2387
-
-
Navaratna, D.1
McGuire, P.G.2
Menicucci, G.3
Das, A.4
-
33
-
-
52449119107
-
Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia
-
Moshal KS, Tipparaju SM, Vacek TP, et al. Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol. 2008; 295:H890-H897.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.295
-
-
Moshal, K.S.1
Tipparaju, S.M.2
Vacek, T.P.3
-
34
-
-
33748489508
-
H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-K{green}B: An implication for invasive phenotype in rat liver epithelial cells
-
Lee KW, Kim MS, Kang NJ, et al. H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-K{green}B: an implication for invasive phenotype in rat liver epithelial cells. Int J Cancer. 2006;119:1767-1775.
-
(2006)
Int J Cancer
, vol.119
, pp. 1767-1775
-
-
Lee, K.W.1
Kim, M.S.2
Kang, N.J.3
-
35
-
-
0032979479
-
Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes
-
Das A, McGuire PG, Eriqat C, et al. Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes. Invest Ophthalmol Vis Sci. 1999;40:809-813.
-
(1999)
Invest Ophthalmol Vis Sci
, vol.40
, pp. 809-813
-
-
Das, A.1
McGuire, P.G.2
Eriqat, C.3
-
36
-
-
45449114005
-
Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy
-
Beránek M, Kolar P, Tschoplova S, Kankova K, Vasku A. Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy. Mol Vis. 2008;14:1114-1121.
-
(2008)
Mol Vis
, vol.14
, pp. 1114-1121
-
-
Beránek, M.1
Kolar, P.2
Tschoplova, S.3
Kankova, K.4
Vasku, A.5
-
37
-
-
61449138733
-
Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis
-
Kolaczkowska E, Grzybek W, van Rooijen N, et al. Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis. J Leukoc Biol. 2009;85:374-381.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 374-381
-
-
Kolaczkowska, E.1
Grzybek, W.2
van Rooijen, N.3
-
38
-
-
33845200847
-
Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression
-
Yoon SO, Shin S, Lee HL, Chun HK, Chung AS. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther. 2006;5:2666-2675.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2666-2675
-
-
Yoon, S.O.1
Shin, S.2
Lee, H.L.3
Chun, H.K.4
Chung, A.S.5
-
39
-
-
34447549291
-
Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells
-
Zhu TN, He HJ, Kole S, et al. Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells. J Biol Chem. 2007;282:14816-14826.
-
(2007)
J Biol Chem
, vol.282
, pp. 14816-14826
-
-
Zhu, T.N.1
He, H.J.2
Kole, S.3
-
40
-
-
0031915048
-
Overview of matrix metalloproteinase expression in cultured human cells
-
Giambernardi TA, Grant GM, Taylor GP, et al. Overview of matrix metalloproteinase expression in cultured human cells. Matrix Biol. 1998;16:483-496.
-
(1998)
Matrix Biol
, vol.16
, pp. 483-496
-
-
Giambernardi, T.A.1
Grant, G.M.2
Taylor, G.P.3
-
41
-
-
14844334649
-
Farnesyltransferase inhibitor SCH-66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration
-
Desrosiers RR, Cusson MH, Turcotte S, Béliveau R. Farnesyltransferase inhibitor SCH-66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration. Int J Cancer. 2005; 114:702-712.
-
(2005)
Int J Cancer
, vol.114
, pp. 702-712
-
-
Desrosiers, R.R.1
Cusson, M.H.2
Turcotte, S.3
Béliveau, R.4
-
42
-
-
67649380732
-
Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras
-
Kang S, Kim ES, Moon A. Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009;21:1317-1322.
-
(2009)
Oncol Rep
, vol.21
, pp. 1317-1322
-
-
Kang, S.1
Kim, E.S.2
Moon, A.3
-
43
-
-
11144357238
-
Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes
-
Miyahara S, Kiryu J, Yamashiro K, et al. Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes. Am J Pathol. 2004;164: 1697-1706.
-
(2004)
Am J Pathol
, vol.164
, pp. 1697-1706
-
-
Miyahara, S.1
Kiryu, J.2
Yamashiro, K.3
-
44
-
-
48249088030
-
Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy
-
Al-Shabrawey M, Bartoli M, El-Remessy AB, et al. Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008;49:3231-3238.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, pp. 3231-3238
-
-
Al-Shabrawey, M.1
Bartoli, M.2
El-Remessy, A.B.3
-
45
-
-
77954195454
-
Simvastatin protects diabetic rats against kidney injury through the suppression of renal matrix metalloproteinase-9 expression
-
In press
-
Yao XM, Ye S, Zai ZM, et al. Simvastatin protects diabetic rats against kidney injury through the suppression of renal matrix metalloproteinase-9 expression. J Endocrinol Invest. In press.
-
J Endocrinol Invest
-
-
Yao, X.M.1
Ye, S.2
Zai, Z.M.3
-
46
-
-
34547588531
-
Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue
-
Evans J, Powell JT, Schwalbe E, Loftus IM, Thompson MM. Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue. Eur J Vasc Endovasc Surg. 2007;34:302-303.
-
(2007)
Eur J Vasc Endovasc Surg
, vol.34
, pp. 302-303
-
-
Evans, J.1
Powell, J.T.2
Schwalbe, E.3
Loftus, I.M.4
Thompson, M.M.5
|