Emerging roles for glial pathology in addiction

Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention

Volumn 9781493909742, Issue , 2014, Pages 397-418

  Reissner, Kathryn J ^a   Kalivas, Peter W ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Addiction; Astrocyte; Cocaine; Dopamine; Glutamate; Microglia; Oligodendrocyte

Indexed keywords

EID: 84929878366     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4939-0974-2_17     Document Type: Chapter

References (189)

1. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ (2010) Structure and function of the blood-brain barrier. Neurobiol Dis 37:13-25
2. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA (2006) International union of pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58:281-341
3. Agulhon C, Petravicz J, McMullen AB, Sweger EJ, Minton SK, Taves SR, Casper KB, Fiacco TA, McCarthy KD (2008) What is the role of astrocyte calcium in neurophysiology? Neuron 59:932-946
4. Airavaara M, Pickens CL, Stern AL, Wihbey KA, Harvey BK, Bossert JM, Liu QR, Hoffer BJ, Shaham Y (2011) Endogenous GDNF in ventral tegmental area and nucleus accumbens does not play a role in the incubation of heroin craving. Addict Biol 16:261-272
5. Albertson DN, Pruetz B, Schmidt CJ, Kuhn DM, Kapatos G, Bannon MJ (2004) Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem 88:1211-1219
6. Anderson CM, Swanson RA (2000) Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32:1-14
7. Anderson K V, Bokla L, Nusslein-Volhard C (1985) Establishment of dorsal-ventral polarity in the drosophila embryo: the induction of polarity by the toll gene product. Cell 42:791-798
8. Araque A, Parpura V, Sanzgiri RP, Haydon PG (1999) Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci 22:208-215
9. Baker DA, Shen H, Kalivas PW (2002a) Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration. Amino acids 23:161-162
10. Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW (2002b) The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci 22:9134-9141
11. Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, Kalivas PW (2003) Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 6:743-749
12. Banerjee S, Bhat MA (2007) Neuron-glial interactions in blood-brain barrier formation. Ann Rev Neurosci 30:235-258
13. Bannon M, Kapatos G, Albertson D (2005) Gene expression profiling in the brains of human cocaine abusers. Addict Biol 10:119-126
14. Barres BA (2008) The mystery and magic of glia: a perspective on their roles in health and disease. Neuron 60:430-440
15. Bartzokis G, Beckson M, Lu PH, Edwards N, Rapoport R, Wiseman E, Bridge P (2000) Agerelated brain volume reductions in amphetamine and cocaine addicts and normal controls: implications for addiction research. Psychiatry Res 98:93-102
16. Bartzokis G, Beckson M, Lu PH, Edwards N, Bridge P, Mintz J (2002) Brain maturation may be arrested in chronic cocaine addicts. Biol Psychiatry 51:605-611
17. Behrens PF, Franz P, Woodman B, Lindenberg KS, Landwehrmeyer GB (2002) Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain 125:1908-1922
18. Beitner-Johnson D, Guitart X, Nestler EJ (1993) Glial fibrillary acidic protein and the mesolimbic dopamine system: regulation by chronic morphine and Lewis-Fischer strain differences in the rat ventral tegmental area. J Neurochem 61:1766-1773
19. Belanger M, Allaman I, Magistretti PJ (2011) Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 14:724-738
20. Ben Achour S, Pascual O (2012) Astrocyte-neuron communication: functional consequences. Neurochem Res 37:2464-2473
21. Berk M, Malhi GS, Gray LJ, Dean OM (2013) The promise of N-acetylcysteine in neuropsychiatry. Trends Pharmacol Sci 34:167-177
22. Bezzi P, Volterra A (2001) A neuron-glia signalling network in the active brain. Curr Opin Neurobiol 11:387-394
23. Binns BC, Huang Y, Goettl VM, Hackshaw KV, Stephens RL Jr (2005) Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model. Brain Res 1041:38-47
24. Botreau F, Paolone G, Stewart J (2006) d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference. Behav Brain Res 172:173-178
25. Bowers MS, Kalivas PW (2003) Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration. Eur J Neurosci 17:1273-1278
26. Bradley SJ, Challiss RA (2012) G protein-coupled receptor signalling in astrocytes in health and disease: a focus on metabotropic glutamate receptors. Biochem Pharmacol 84:249-259
27. Brown RM, Short JL, Cowen MS, Ledent C, Lawrence AJ (2009) A differential role for the adenosine A2A receptor in opiate reinforcement vs opiate-seeking behavior. Neuropsychopharmacology 34:844-856
28. Buch S, Yao H, Guo M, Mori T, Mathias-Costa B, Singh V, Seth P, Wang J, Su TP (2012) Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms. Curr HIV Res 10:425-428
29. Buchanan MM, Hutchinson M, Watkins LR, Yin H (2010) Toll-like receptor 4 in CNS pathologies. J Neurochem 114:13-27
30. Cali C, Marchaland J, Spagnuolo P, Gremion J, Bezzi P (2009) Regulated exocytosis from astrocytes physiological and pathological related aspects. Int Rev Neurobiol 85:261-293
31. Carnicella S, Ron D (2009) GDNF-a potential target to treat addiction. Pharmacol Therap 122:9-18
32. Cata JP, Weng HR, Chen JH, Dougherty PM (2006) Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxelinduced hyperalgesia. Neuroscience 138:329-338
33. Chandler RK, Fletcher BW, Volkow ND (2009) Treating drug abuse and addiction in the criminal justice system: improving public health and safety. JAMA 301:183-190
34. Chen BT, Hopf FW, Bonci A (2010) Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse. Ann N Y Acad Sci 1187:129-139
35. Chen BT, Yau HJ, Hatch C, Kusumoto-Yoshida I, Cho SL, Hopf FW, Bonci A (2013) Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature 496:359-362
36. Chung WS, Barres BA (2012) The role of glial cells in synapse elimination. Curr Opin Neurobiol 22:438-445
37. Cooper ZD, Jones JD, Comer SD (2012) Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substances. Expert Opin Investig Drugs 21:169-178
38. Courtwright DT (2012) Addiction and the science of history. Addiction 107:486-492
39. Crews FT, Zou J, Qin L (2011) Induction of innate immune genes in brain create the neurobiology of addiction. Brain Behav Immun 25(Suppl 1):S4-S12
40. Cullen KM, Halliday GM (1994) Chronic alcoholics have substantial glial pathology in the forebrain and diencephalon. Alcohol Alcohol Suppl 2:253-257
41. Curcio L, Podda M V, Leone L, Piacentini R, Mastrodonato A, Cappelletti P, Sacchi S, Pollegioni L, Grassi C, D'Ascenzo M (2013) Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity. Brain 136:1216-1230
42. D'Ascenzo M, Fellin T, Terunuma M, Revilla-Sanchez R, Meaney DF, Auberson YP, Moss SJ, Haydon PG (2007) mGluR5 stimulates gliotransmission in the nucleus accumbens. Proc Natl Acad Sci U S A 104:1995-2000
43. Dackis C, O'Brien C (2005) Neurobiology of addiction: treatment and public policy ramifications. Nat Neurosci 8:1431-1436
44. Dahlin A, Xia L, Kong W, Hevner R, Wang J (2007) Expression and immunolocalization of the plasma membrane monoamine transporter in the brain. Neuroscience 146:1193-1211
45. Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1-105
46. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 85:5274-5278
47. Duarte EP, Curcio M, Canzoniero LM, Duarte CB (2012) Neuroprotection by GDNF in the ischemic brain. Growth Factors 30:242-257
48. Ersche KD, Jones PS, Williams GB, Robbins TW, Bullmore ET (2013) Cocaine dependence: a fast-track for brain ageing? Mol Psychiatry 18:134-135
49. Fattore L, Puddu MC, Picciau S, Cappai A, Fratta W, Serra GP, Spiga S (2002) Astroglial in vivo response to cocaine in mouse dentate gyrus: a quantitative and qualitative analysis by confocal microscopy. Neuroscience 110:1-6
50. Feltenstein MW, See RE (2008) The neurocircuitry of addiction: an overview. Br J Pharmacol 154:261-274
51. Fischer KD, Houston AC, Rebec GV (2013) Role of the major glutamate transporter GLT1 in nucleus accumbens core versus shell in cue-induced cocaine-seeking behavior. J Neurosci 33:9319-9327
52. Fischer-Smith KD, Houston AC, Rebec GV (2012) Differential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell. Neuroscience 210:333-339
53. Fletcher TL, Shain W (1993) Ethanol-induced changes in astrocyte gene expression during rat central nervous system development. Alcohol Clin Exp Res 17:993-1001
54. Fowler JS, Volkow ND, Kassed CA, Chang L (2007) Imaging the addicted human brain. Sci Pract Perspect 3:4-16
55. Franke H (1995) Influence of chronic alcohol treatment on the GFAP-immunoreactivity in astrocytes of the hippocampus in rats. Acta Histochem 97:263-271
56. Franklin TR, Acton PD, Maldjian JA, Gray JD, Croft JR, Dackis CA, O'Brien CP, Childress AR (2002) Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol Psychiatry 51:134-142
57. Friend DM, Keefe KA (2013) Glial reactivity in resistance to methamphetamine-induced neurotoxicity. J Neurochem 125:566-574
58. Fuente-Martin E, Garcia-Caceres C, Granado M, de Ceballos ML, Sanchez-Garrido MA, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizon P, Diaz F, Argente J, Horvath TL, Chowen JA (2012) Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. J Clinical Investig 122:3900-3913
59. Genoud C, Quairiaux C, Steiner P, Hirling H, Welker E, Knott GW (2006) Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex. PLoS Biol 4:e343
60. George O, Koob GF (2010) Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev 35:232-247
61. George O, Mandyam CD, Wee S, Koob GF (2008) Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology 33:2474-2482
62. Ghitza UE, Zhai H, Wu P, Airavaara M, Shaham Y, Lu L (2010) Role of BDNF and GDNF in drug reward and relapse: a review. Neurosci Biobehav Rev 35:157-171
63. Gipson CD, Reissner KJ, Kupchik YM, Smith AC, Stankeviciute N, Hensley-Simon ME, Kalivas PW (2013) Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc Natl Acad Sci U S A 110:9124-9129
64. Goldberg M, De Pitta M, Volman V, Berry H, Ben-Jacob E (2010) Nonlinear gap junctions enable long-distance propagation of pulsating calcium waves in astrocyte networks. PLoS Comp Biol 6:e1000909
65. Goldstein RZ, Volkow ND (2002) Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 159:1642-1652
66. Goldstein RZ, Volkow ND (2011) Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12:652-669
67. Goodlett CR, Leo JT, O'Callaghan JP, Mahoney JC, West JR (1993) Transient cortical astrogliosis induced by alcohol exposure during the neonatal brain growth spurt in rats. Brain Res Dev Brain Res 72:85-97
68. Gray KM, Carpenter MJ, Baker NL, DeSantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT (2012) A double-blind randomized controlled trial of N-acetylcysteine in cannabisdependent adolescents. Am J Psychiatry 169:805-812
69. Guilarte TR, Nihei MK, McGlothan JL, Howard AS (2003) Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticity. Neuroscience 122:499-513
70. Halassa MM, Haydon PG (2010) Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Ann Rev Physiol 72:335-355
71. Hanke ML, Kielian T (2011) Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci 121:367-387
72. Hauser KF, Fitting S, Dever SM, Podhaizer EM, Knapp PE (2012) Opiate drug use and the pathophysiology of neuroAIDS. Curr HIV Res 10:435-452
73. Haydon PG, Blendy J, Moss SJ, Rob Jackson F (2009) Astrocytic control of synaptic transmission and plasticity: a target for drugs of abuse? Neuropharmacology 56(Suppl 1):83-90
74. Hirst WD, Price GW, Rattray M, Wilkin GP (1998) Serotonin transporters in adult rat brain astrocytes revealed by [3H]5-HT uptake into glial plasmalemmal vesicles. Neurochem Int 33:11-22
75. Hutchinson MR, Shavit Y, Grace PM, Rice KC, Maier SF, Watkins LR (2011) Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev 63:772-810
76. Hutchinson MR et al (2012) Opioid activation of toll-like receptor 4 contributes to drug reinforcement. J Neurosci 32:11187-11200
77. Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction: the role of rewardrelated learning and memory. Ann Rev Neurosci 29:565-598
78. Inazu M, Kubota N, Takeda H, Zhang J, Kiuchi Y, Oguchi K, Matsumiya T (1999) Pharmacological characterization of dopamine transport in cultured rat astrocytes. Life Sci 64:2239-2245
79. Inazu M, Takeda H, Matsumiya T (2003) Expression and functional characterization of the extraneuronal monoamine transporter in normal human astrocytes. J Neurochem 84:43-52
80. Jacob CP, Koutsilieri E, Bartl J, Neuen-Jacob E, Arzberger T, Zander N, Ravid R, Roggendorf W, Riederer P, Grunblatt E (2007) Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease. J Alzheimers Dis 11:97-116
81. Jiang J, Amara SG (2011) New views of glutamate transporter structure and function: advances and challenges. Neuropharmacology 60:172-181
82. Kalivas PW (2009) The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci 10:561-572
83. Kalivas PW, Volkow ND (2005) The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162:1403-1413
84. Kalivas PW, Volkow ND (2011) New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry 16:974-986
85. Kalivas PW, Volkow N, Seamans J (2005) Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron 45:647-650
86. Karakaya S, Kipp M, Beyer C (2007) Oestrogen regulates the expression and function of dopamine transporters in astrocytes of the nigrostriatal system. J Neuroendocrinol 19:682-690
87. Kawai T, Akira S (2006) TLR signaling. Cell Death Differ 13:816-825
88. Kelamangalath L, Wagner JJ (2010) D-serine treatment reduces cocaine-primed reinstatement in rats following extended access to cocaine self-administration. Neuroscience 169:1127-1135
89. Khan ZU, Koulen P, Rubinstein M, Grandy DK, Goldman-Rakic PS (2001) An astroglia-linked dopamine D2-receptor action in prefrontal cortex. Proc Natl Acad Sci U S A 98:1964-1969
90. Kimelberg HK, Katz DM (1985) High-affinity uptake of serotonin into immunocytochemically identified astrocytes. Science 228:889-891
91. Kittel-Schneider S, Kenis G, Schek J, van den Hove D, Prickaerts J, Lesch KP, Steinbusch H, Reif A (2012) Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytes. Front Psychiatry 3:33
92. Knackstedt LA, La Rowe S, Mardikian P, Malcolm R, Upadhyaya H, Hedden S, Markou A, Kalivas PW (2009) The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biol Psychiatry 65:841-845
93. Knackstedt LA, Melendez RI, Kalivas PW (2010) Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol Psychiatry 67:81-84
94. Koob GF, Nestler EJ (1997) The neurobiology of drug addiction. J Neuropsychiatry Clin Neurosci 9:482-497
95. Koob GF, Volkow ND (2010) Neurocircuitry of addiction. Neuropsychopharmacology 35:217-238
96. Kousik SM, Napier TC, Carvey PM (2012) The effects of psychostimulant drugs on blood brain barrier function and neuroinflammation. Front Pharmacol 3:121
97. Kovalevich J, Corley G, Yen W, Rawls SM, Langford D (2012) Cocaine-induced loss of white matter proteins in the adult mouse nucleus accumbens is attenuated by administration of a betalactam antibiotic during cocaine withdrawal. Am J Pathol 181:1921-1927
98. Kristiansen LV, Bannon MJ, Meador-Woodruff JH (2009) Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. Neurochem Res 34:46-54
99. Krueger M, Bechmann I (2010) CNS pericytes: concepts, misconceptions, and a way out. Glia 58:1-10
100. Lalumiere RT, Kalivas PW (2007) Reward and drugs of abuse. In: Kesner RP, Martinez JL (eds) Neurobiology of learning and memory. Academic, New York, pp 459-482
101. Lane SD, Steinberg JL, Ma L, Hasan KM, Kramer LA, Zuniga EA, Narayana PA, Moeller FG (2010) Diffusion tensor imaging and decision making in cocaine dependence. PLoS ONE 5:e11591
102. La Rowe SD, Myrick H, Hedden S, Mardikian P, Saladin M, McRae A, Brady K, Kalivas PW, Malcolm R (2007) Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry 164:1115-1117
103. La Rowe SD, Kalivas PW, Nicholas JS, Randall PK, Mardikian PN, Malcolm RJ (2013) A doubleblind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am J Addict 22:443-452
104. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H (2001) Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 13:534-546
105. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA (1996) The dorsoventral regulatory gene cassette spatzle/toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-983
106. Leshner AI (1997) Addiction is a brain disease, and it matters. Science 278:45-47
107. Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P (2013) The cystine/glutamate antiporter system x (c) (-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal 18:522-555
108. Lim JC, Donaldson PJ (2011) Focus on molecules: the cystine/glutamate exchanger (System x (c) (-)). Exp Eye Res 92:162-163
109. Lim KO, Choi SJ, Pomara N, Wolkin A, Rotrosen JP (2002) Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. Biol Psychiatry 51:890-895
110. Lim KO, Wozniak JR, Mueller BA, Franc DT, Specker SM, Rodriguez CP, Silverman AB, Rotrosen JP (2008) Brain macrostructural and microstructural abnormalities in cocaine dependence. Drug Alcohol Depend 92:164-172
111. Lu L, Wang X, Wu P, Xu C, Zhao M, Morales M, Harvey BK, Hoffer BJ, Shaham Y (2009) Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving. Biol Psychiatry 66:137-145
112. Luscher C, Malenka RC (2011) Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron 69:650-663
113. Mameli M, Luscher C (2011) Synaptic plasticity and addiction: learning mechanisms gone awry. Neuropharmacology 61:1052-1059
114. Mameli M, Halbout B, Creton C, Engblom D, Parkitna JR, Spanagel R, Luscher C (2009) Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci 12:1036-1041
115. Mann K, Kiefer F, Spanagel R, Littleton J (2008) Acamprosate: recent findings and future research directions. Alcohol Clin Exp Res 32:1105-1110
116. Martinez D, Narendran R (2010) Imaging neurotransmitter release by drugs of abuse. Curr Top Behav Neurosci 3:219-245
117. Masliah E, Alford M, DeTeresa R, Mallory M, Hansen L (1996) Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann Neurol 40:759-766
118. McFarland K, Lapish CC, Kalivas PW (2003) Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 23:3531-3537
119. McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, Espana RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S (2011) Emerging, reemerging, and forgotten brain areas of the reward circuit: notes from the 2010 motivational neural networks conference. Behav Brain Res 225:348-357
120. Melendez RI, Hicks MP, Cagle SS, Kalivas PW (2005) Ethanol exposure decreases glutamate uptake in the nucleus accumbens. Alcohol Clin Exp Res 29:326-333
121. Miguel-Hidalgo JJ (2005) Lower packing density of glial fibrillary acidic protein-immunoreactive astrocytes in the prelimbic cortex of alcohol-naive and alcohol-drinking alcohol-preferring rats as compared with alcohol-nonpreferring and Wistar rats. Alcohol Clin Exp Res 29:766-772
122. Miyazaki I, Asanuma M, Diaz-Corrales FJ, Miyoshi K, Ogawa N (2004) Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia. Brain Res 1029:120-123
123. Mookherjee P, Green PS, Watson GS, Marques MA, Tanaka K, Meeker KD, Meabon JS, Li N, Zhu P, Olson VG, Cook DG (2011) GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model. J Alzheimers Dis 26:447-455
124. Morgello S, Uson RR, Schwartz EJ, Haber RS (1995) The human blood-brain barrier glucose transporter (GLUT1) is a glucose transporter of gray matter astrocytes. Glia 14:43-54
125. Moussawi K, Kalivas PW (2010) Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction. Eur J Pharmacol 639:115-122
126. Moussawi K, Riegel A, Nair S, Kalivas PW (2011) Extracellular glutamate: functional compartments operate in different concentration ranges. Front Syst Neurosci 5:94
127. Myers KM, Carlezon WA, Jr. (2012) D-cycloserine effects on extinction of conditioned responses to drug-related cues. Biol Psychiatry 71:947-955
128. Nagasawa K, Kawasaki F, Tanaka A, Nagai K, Fujimoto S (2007) Characterization of guanine and guanosine transport in primary cultured rat cortical astrocytes and neurons. Glia 55:1397-1404
129. Najlerahim A, Francis PT, Bowen DM (1990) Age-related alteration in excitatory amino acid neurotransmission in rat brain. Neurobiol Aging 11:155-158
130. Narayana PA, Ahobila-Vajjula P, Ramu J, Herrera J, Steinberg JL, Moeller FG (2009) Diffusion tensor imaging of cocaine-treated rodents. Psychiatry Res 171:242-251
131. Navarrete M, Araque A (2008) Endocannabinoids mediate neuron-astrocyte communication. Neuron 57:883-893
132. Navarrete M, Araque A (2010) Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes. Neuron 68:113-126
133. Nestler EJ, Aghajanian GK (1997) Molecular and cellular basis of addiction. Science 278:58-63
134. O'Malley EK, Sieber BA, Black IB, Dreyfus CF (1992) Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture. Brain Res 582:65-70
135. O'Neill CE, Le Tendre ML, Bachtell RK (2012) Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. Neuropsychopharmacology 37:1245-1256
136. Ohno M, Watanabe S (1996) D-cycloserine, a glycine site agonist, reverses working memory failure by hippocampal muscarinic receptor blockade in rats. Eur J Pharmacol 318:267-271
137. Olive MF, Cleva RM, Kalivas PW, Malcolm RJ (2012) Glutamatergic medications for the treatment of drug and behavioral addictions. Pharmacol Biochem Behav 100:801-810
138. Ossipov MH, Lai J, King T, Vanderah TW, Porreca F (2005) Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers 80:319-324
139. Paolone G, Botreau F, Stewart J (2009) The facilitative effects of D-cycloserine on extinction of a cocaine-induced conditioned place preference can be long lasting and resistant to reinstatement. Psychopharmacology (Berl) 202:403-409
140. Parpura V, Heneka MT, Montana V, Oliet SH, Schousboe A, Haydon PG, Stout RF, Jr., Spray DC, Reichenbach A, Pannicke T, Pekny M, Pekna M, Zorec R, Verkhratsky A (2012) Glial cells in (patho) physiology. J Neurochem 121:4-27
141. Pekny M, Nilsson M (2005) Astrocyte activation and reactive gliosis. Glia 50:427-434
142. Pfefferbaum A, Lim KO, Zipursky RB, Mathalon DH, Rosenbloom MJ, Lane B, Ha CN, Sullivan EV (1992) Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol Clin Exp Res 16:1078-1089
143. Pierce RC, Bari AA (2001) The role of neurotrophic factors in psychostimulant-induced behavioral and neuronal plasticity. Rev Neurosci 12:95-110
144. Pierre K, Pellerin L (2005) Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 94:1-14
145. Pochon NA, Menoud A, Tseng JL, Zurn AD, Aebischer P (1997) Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization. Eur J Neurosci 9:463-471
146. Porter JT, McCarthy KD (1997) Astrocytic neurotransmitter receptors in situ and in vivo. Prog Neurobiol 51:439-455
147. Potier B, Billard JM, Riviere S, Sinet PM, Denis I, Champeil-Potokar G, Grintal B, Jouvenceau A, Kollen M, Dutar P (2010) Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats. Aging Cell 9:722-735
148. Qrunfleh AM, Alazizi A, Sari Y (2013) Ceftriaxone, a beta-lactam antibiotic, attenuates relapselike ethanol-drinking behavior in alcohol-preferring rats. J Psychopharmacol 27:541-549
149. Radzishevsky I, Sason H, Wolosker H (2013) D-serine: physiology and pathology. Curr Opin Clin Nutr Metab Care 16:72-75
150. Reissner KJ, Kalivas PW (2010) Using glutamate homeostasis as a target for treating addictive disorders. Behav Pharmacol 21:514-522
151. Reissner KJ, Kalivas PW (2013) Cellular and molecular mechanisms of addiction. In: Charney DS, Buxbaum JD, Sklar P, Nestler EJ (eds) Neurobiology of mental illness, 4th edn. Oxford University Press, Ch 51, pp 683-695
152. Reissner KJ, Brown RM, Spencer S, Tran SK, Thomas CA, Kalivas PW (2014) Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1 dependent mechanism. Neuropsychopharmacology 39(2):499-506
153. Rintala J, Jaatinen P, Kiianmaa K, Riikonen J, Kemppainen O, Sarviharju M, Hervonen A (2001) Dose-dependent decrease in glial fibrillary acidic protein-immunoreactivity in rat cerebellum after lifelong ethanol consumption. Alcohol 23:1-8
154. Rippeth JD, Heaton RK, Carey CL, Marcotte TD, Moore DJ, Gonzalez R, Wolfson T, Grant I, Group H (2004) Methamphetamine dependence increases risk of neuropsychological impairment in HIV infected persons. J Int Neuropsychol Soc 10:1-14
155. Rothstein JD, Patel S, Regan MR, Haenggeli C, Huang YH, Bergles DE, Jin L, Dykes Hoberg M, Vidensky S, Chung DS, Toan SV, Bruijn LI, Su ZZ, Gupta P, Fisher PB (2005) Betalactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433:73-77
156. Saransaari P, Oja SS (1995) Age-related changes in the uptake and release of glutamate and aspartate in the mouse brain. Mech Ageing Dev 81:61-71
157. Sari Y, Smith KD, Ali PK, Rebec GV (2009) Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. J Neurosci 29:9239-9243
158. Sari Y, Sreemantula SN, Lee MR, Choi DS (2013) Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats. J Mol Neurosci 51:779-787
159. Schaar DG, Sieber BA, Dreyfus CF, Black IB (1993) Regional and cell-specific expression of GDNF in rat brain. Exp Neurol 124:368-371
160. Schlaepfer TE, Lancaster E, Heidbreder R, Strain EC, Kosel M, Fisch HU, Pearlson GD (2006) Decreased frontal white-matter volume in chronic substance abuse. Int J Neuropsychopharmacol 9:147-153
161. Shao W, Zhang SZ, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB, Huang YY, Liu YJ, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN, Hu G, Zhou JW (2013) Suppression of neuroinflammation by astrocytic dopamine D2 receptors via alphaB-crystallin. Nature 494:90-94
162. Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS (2012) TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci 15:70-80
163. Sim ME, Lyoo IK, Streeter CC, Covell J, Sarid-Segal O, Ciraulo DA, Kim MJ, Kaufman MJ, Yurgelun-Todd DA, Renshaw PF (2007) Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects. Neuropsychopharmacology 32:2229-2237
164. Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB, Function MRCC, Ageing Neuropathology Study G (2010) Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. Neurobiol Aging 31:578-590
165. Sofroniew MV (2009) Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 32:638-647
166. Sofroniew M V, Vinters HV (2010) Astrocytes: biology and pathology. Acta Neuropathol 119:7-35
167. Song P, Zhao ZQ (2001) The involvement of glial cells in the development of morphine tolerance. Neurosci Res 39:281-286
168. Sorg SF, Taylor MJ, Alhassoon OM, Gongvatana A, Theilmann RJ, Frank LR, Grant I (2012) Frontal white matter integrity predictors of adult alcohol treatment outcome. Biol Psychiatry 71:262-268
169. Soria G, Castane A, Ledent C, Parmentier M, Maldonado R, Valverde O (2006) The lack of A2A adenosine receptors diminishes the reinforcing efficacy of cocaine. Neuropsychopharmacology 31:978-987
170. Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A (2010) Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Curr Top Behav Neurosci 3:3-27
171. Tagliaferro P, Vega MD, Evrard SG, Ramos AJ, Brusco A (2002) Alcohol exposure during adulthood induces neuronal and astroglial alterations in the hippocampal CA-1 area. Ann N Y Acad Sci 965:334-342
172. Takeda H, Inazu M, Matsumiya T (2002) Astroglial dopamine transport is mediated by norepinephrine transporter. Naunyn Schmiedebergs Arch Pharmacol 366:620-623
173. Tawfik VL, Regan MR, Haenggeli C, Lacroix-Fralish ML, Nutile-McMenemy N, Perez N, Rothstein JD, DeLeo JA (2008) Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. Neuroscience 152:1086-1092
174. Thanos PK, Bermeo C, Wang GJ, Volkow ND (2009) D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice. Behav Brain Res 199:345-349
175. Turner JR, Ecke LE, Briand LA, Haydon PG, Blendy JA (2013) Cocaine-related behaviors in mice with deficient gliotransmission. Psychopharmacology (Berl) 226:167-176
176. Tzingounis AV, Wadiche JI (2007) Glutamate transporters: confining runaway excitation by shaping synaptic transmission. Nat Rev Neurosci 8:935-947
177. Van den Oever MC, Spijker S, Smit AB (2012) The synaptic pathology of drug addiction. Adv Exp Med Biol 970:469-491
178. Vatassery GT, Lai JC, Smith WE, Quach HT (1998) Aging is associated with a decrease in synaptosomal glutamate uptake and an increase in the susceptibility of synaptosomal vitamin E to oxidative stress. Neurochem Res 23:121-125
179. Vongvatcharanon U, Mukem S, Udomuksorn W, Kumarsit E, Vongvatcharanon S (2010) Alcohol administration during adulthood induces alterations of parvalbumin and glial fibrillary acidic protein immunoreactivity in rat hippocampus and cingulate cortex. Acta Histochem 112:392-401
180. Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M (2006) Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo. Nat Neurosci 9:816-823
181. Watkins LR, Hutchinson MR, Johnston IN, Maier SF (2005) Glia: novel counter-regulators of opioid analgesia. Trends Neurosci 28:661-669
182. Watkins LR, Hutchinson MR, Rice KC, Maier SF (2009) The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci 30:581-591
183. Wheeler DD, Ondo JG (1986) Time course of the aging of the high affinity L-glutamate transporter in rat cortical synaptosomes. Exp Gerontol 21:159-168
184. Witcher MR, Kirov SA, Harris KM (2007) Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus. Glia 55:13-23
185. Wlaz P, Rolinski Z, Czuczwar SJ (1996) Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice. Epilepsia 37:610-617
186. Woltjer RL, Duerson K, Fullmer JM, Mookherjee P, Ryan AM, Montine TJ, Kaye JA, Quinn JF, Silbert L, Erten-Lyons D, Leverenz JB, Bird TD, Pow DV, Tanaka K, Watson GS, Cook DG (2010) Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease. J Neuropathol Exp Neurol 69:667-676
187. Xu J, DeVito EE, Worhunsky PD, Carroll KM, Rounsaville BJ, Potenza MN (2010) White matter integrity is associated with treatment outcome measures in cocaine dependence. Neuropsychopharmacology 35:1541-1549
188. Yang FY, Lee YS, Cherng CG, Cheng LY, Chang WT, Chuang JY, Kao GS, Yu L (2013) D-cycloserine, sarcosine and D-serine diminish the expression of cocaine-induced conditioned place preference. J Psychopharmacol 27:550-558
189. Zorec R, Araque A, Carmignoto G, Haydon PG, Verkhratsky A, Parpura V (2012) Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route. ASN Neuro 4:e00080