Focus on Molecules: The cystine/glutamate exchanger (System xc-)

Experimental Eye Research

Volumn 92, Issue 3, 2011, Pages 162-163

  Lim, Julie C ^a   Donaldson, Paul J ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Cystine glutamate exchange; Glutathione; Oxidative stress

Indexed keywords

AMINO ACID TRANSPORTER; CYSTINE; CYSTINE GLUTAMATE EXCHANGER; GLUTAMIC ACID; UNCLASSIFIED DRUG;

CATARACT; EYE DISEASE; HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RETINA MACULA AGE RELATED DEGENERATION; SHORT SURVEY;

AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; EYE DISEASES; GLUTATHIONE; HUMANS; MICE; OCULAR PHYSIOLOGICAL PHENOMENA; OXIDATIVE STRESS;

EID: 79952106857     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.05.007     Document Type: Short Survey

References (4)

1. -) in retinal ganglion cells and regulation by nitric oxide and oxidative stress. Cell Tissue Res. 2006, 324:189-202.
2. Lim J., Lorentzen K.A., Kistler J., Donaldson P.J. Molecular identification and characterisation of the glycine transporter (GLYT1) and the glutamine/glutamate transporter (ASCT2) in the rat lens. Exp. Eye Res. 2006, 83:447-455.
3. Lo M., Wang Y.Z., Gout P.W. The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases. J. Cell Physiol. 2008, 215:593-602. (Review).
4. Sato H., Shiiya A., Kimata M., Maebara K., Tamba M., Sakakura Y., Makino N., Sugiyama F., Yagami K., Moriguchi T., Takahashi S., Bannai S. Redox imbalance in cystine/glutamate transporter-deficient mice. J. Biol. Chem. 2005, 280:37423-37429.