The neurobiology of drug addiction

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 9, Issue 3, 1997, Pages 482-497

  Koob, George F ^a   Nestler, Eric J ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ADRENERGIC RECEPTOR STIMULATING AGENT; ALCOHOL; AMPHETAMINE; COCAINE; DOPAMINE; GLUTAMIC ACID; NEUROTRANSMITTER; NICOTINE; OPIATE PEPTIDE; SEROTONIN;

AMYGDALOID NUCLEUS; DOPAMINERGIC SYSTEM; DRUG DEPENDENCE; DRUG WITHDRAWAL; HUMAN; NEUROBIOLOGY; NEUROCHEMISTRY; NEUROTRANSMISSION; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; REINFORCEMENT; RELAPSE; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030758555     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.9.3.482     Document Type: Review

References (169)

1. World Health Organization: International Statistical Classification of Diseases and Related Health Problems, 10th revision. Geneva, World Health Organization, 1990
2. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Washington, DC, American Psychiatric Association, 1994
3. Institute of Medicine: Pathways of Addiction. Washington, DC, National Academy Press, 1996
4. Markou A, Weiss F, Gold LH, et al: Animal models of drug craving. Psychopharmacology (Berl) 1993; 112:163-182
5. White FJ, Wolf ME: Psychomotor stimulants, in The Biological Bases of Drug Tolerance and Dependence, edited by Pratt JA. London, Academic Press, 1991, pp 153-197
6. Koob GF: Dopamine, addiction and reward. Seminars in the Neurosciences 1992; 4:139-148
7. Stewart J, Badiani A: Tolerance and sensitization to the behavioral effects of drugs. Behav Pharmacol 1993; 4:289-312
8. Koob GF, Bloom FE: Cellular and molecular mechanisms of drug dependence. Science 1988; 242:715-723
9. Wikler A: Dynamics of drug dependence: implications of a conditioning theory for research and treatment. Arch Gen Psychiatry 1973; 28:611-616
10. Koob GF, Markou A, Weiss F, et al: Opponent process and drug dependence: neurobiological mechanisms. Seminars in the Neurosciences 1993; 5:351-358
11. Nestler EJ, Fitzgerald LW, Self DW: Substance abuse: neurobiology, in The American Psychiatric Press Review of Psychiatry, vol 14, edited by Oldham JM, Riba MB. Washington, DC, American Psychiatric Press, 1995, pp 51-81
12. Tabakoff B, Hoffman PL: Alcohol: neurobiology, in Substance Abuse: A Comprehensive Textbook, edited by Lowinson JH, Ruiz P, Millman RB. Baltimore, Williams and Wilkins, 1992, pp 152-185
13. Olds J, Milner P: Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. Journal of Comparative and Physiological Psychology 1954; 47:419-427
14. Stein L: Chemistry of reward and punishment, in Psychopharmacology: A Review of Progress (1957-1967) (US Public Health Service publ no 1836), edited by Efron DH. Washington, DC, US Government Printing Office, 1968, pp 105-123
15. Nauta WJH, Haymaker W: Hypothalamic nuclei and fiber connections, in The Hypothalamus, edited by Haymaker W, Anderson E, Nauta WJH. Springfield, IL, Charles C Thomas, 1969, pp 136-209
16. Liebman JL, Cooper SJ: The Neuropharmacological Basis of Reward. Oxford, Clarendon, 1989
17. Valenstein ES, Campbell JF: Medial forebrain bundle-lateral hypothalamic area and reinforcing brain stimulation. Am J Physiol 1966; 210:270-274
18. Koob GF: Drugs of abuse: anatomy, pharmacology, and function of reward pathways. Trends Pharmacol Sci 1992; 13:177-184
19. Kilty JE, Lorang D, Amara SG: Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science 1991; 254:578-579
20. Blakely RD, Berson HE, Fremeau RT, et al: Cloning and expression of a functional serotonin transporter from rat brain. Nature 1991; 354:66-70
21. Giros B, El Mestikawy S, Bertrand L, et al: Cloning and functional characterization of a cocaine-sensitive dopamine transporter. FEBS Lett 1991; 295:149-154
22. Rudnick G, Clark J: From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim Biophys Acta 1993; 1144:249-263
23. O'Callaghan JP, Miller DB: Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse. J Pharmacol Exp Ther 1994; 270:741-751
24. Angrist B, Sudilovsky A: Central nervous system stimulants: historical aspects and clinical effects, in Handbook of Psychopharmacology, vol 11, edited by Iversen LL, Iversen SD, Snyder SH. New York, Plenum, 1976, pp 99-165
25. Fischman MW, Schuster CR, Hatano Y: A comparison of the subjective and cardiovascular effects of cocaine and lidocaine in humans. Pharmacol Biochem Behav 1983; 18:123-127
26. Groppetti A, Zambotti F, Biazzi A, et al: Amphetamine and cocaine on amine turnover, in Frontiers in Catecholamine Research, edited by Usdin E, Snyder SH. New York, Pergamon, 1973, pp 917-925
27. Spealman RD, Goldberg SR, Kelleher RT, et al: Some effects of cocaine and two cocaine analogs on schedule-controlled behavior of squirrel monkeys. J Pharmacol Exp Ther 1977; 202:500-509
28. Kornetsky C, Esposito RU: Reward and detection thresholds for brain stimulation: dissociative effects of cocaine. Brain Res 1981; 209:496-500
29. Kornetsky C, Esposito RU: Euphorigenic drugs: effects on the reward pathways of the brain. Federation Proceedings 1979; 38:2473-2476
30. Mucha RF, van der Kooy D, O'Shaughnessy M, et al: Drug reinforcement studied by the use of place conditioning in rat. Brain Res 1982; 243:91-105
31. Carr GD, Fibiger HC, Phillips AG: Conditioned place preference as a measure of drug reward, in The Neuropharmacological Basis of Reward, edited by Liebman JM, Cooper SJ. New York, Oxford University Press, 1989, pp 264-319
32. Koob GF, Vaccarino FJ, Amalric M, et al: Positive reinforcement properties of drugs: search for neural substrates, in Brain Reward Systems and Abuse, edited by Engel J, Oreland L. New York, Raven, 1987, pp 35-50
33. Kelly PH, Seviour PW, Iversen SD: Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 1975; 94:507-522
34. Kelly PH, Iversen SD: Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats. Eur J Pharmacol 1976; 40:45-55
35. Pijnenburg AJJ, Honig WMM, Van Rossum JM: Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat. Psychopharmacologia 1975; 41:87-95
36. Yokel RA, Wise RA: Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward. Science 1975; 187:547-549
37. Ettenberg A, Pettit HO, Bloom FE, et al: Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems. Psychopharmacology (Berl) 1982; 78:204-209
38. Caine SB, Koob GF: Pretreatment with the dopamine agonist 7-OH-DPAT shifts the cocaine self-administration dose-effect function to the left under different schedules in the rat. Behav Pharmacol 1995; 6:333-347
39. 1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat. Neurosci Lett 1987; 79:315-320
40. 2 dopamine antagonist on behavior maintained by cocaine or food. Pharmacol Biochem Behav 1989; 32:691-697
41. 2 antagonists. Behav Pharmacol 1990; 1:355-363
42. Caine SB, Koob GF: Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. Science 1993; 260:1814-1816
43. Roberts DCS, Koob GF, Klonoff P, et al: Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacol Biochem Behav 1980; 12:781-787
44. Lyness WH, Friedle NM, Moore KE: Destruction of dopaminergic nerve terminals in nucleus accumbens: effect of d-amphetamine self-administration. Pharmacol Biochem Behav 1979; 11:553-556
45. Caine SB, Koob GF: Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food. J Exp Anal Behav 1994; 61:213-221
46. Schuster CR, Thompson T: Self administration of and behavioral dependence on drugs. Annu Rev Pharmacol 1969; 9:483-502
47. Deneau G, Yanagita T, Seevers MH: Self-administration of psychoactive substances by the monkey: a measure of psychological-dependence. Psychopharmacologia 1969; 16:30-48
48. Koob GF, Pettit HO, Ettenberg A, et al: Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat. J Pharmacol Exp Ther 1984; 229:481-486
49. Goldberg SR, Woods JH, Schuster CR: Nalorphine-induced changes in morphine self-administration in rhesus monkeys. J Pharmacol Exp Ther 1971; 176:464-471
50. 1 and naloxone. Prostaglandins 1976; 12:11-19
51. Vaccarino FJ, Pettit HO, Bloom FE, et al: Effects of intracerebroventricular administration of methyl naloxonium chloride on heroin self-administration in the rat. Pharmacol Biochem Behav 1985; 23:495-498
52. Negus SS, Henriksen SJ, Mattox SR, et al: Effects of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats. J Pharmacol Exp Ther 1993; 265:1245-1252
53. Britt MD, Wise RA: Ventral tegmental site of opiate reward: antagonism by a hydrophilic opiate receptor blocker. Brain Res 1983; 258:105-108
54. Vaccarino FJ, Bloom FE, Koob GF: Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat. Psychopharmacology (Berl) 1985; 86:37-42
55. Schroeder RL, Weinger MB, Vakassian L, et al: Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection. Neurosci Lett 1991; 121:173-177
56. Goeders NE, Lane JD, Smith JE: Self-administration of methionine enkephalin into the nucleus accumbens. Pharmacol Biochem Behav 1984; 20:451-455
57. Pettit HO, Ettenberg A, Bloom FE, et al: Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology (Berl) 1984; 84:167-173
58. Stinus L, Cador M, Le Moal M: Interaction between endogenous opioids and dopamine within the nucleus accumbens. Ann NY Acad Sci 1992; 654:254-273
59. West TE: The effects of nucleus accumbens injections of receptor-selective opiate agonists on brain stimulation reward. Doctoral dissertation, Concordia University, Montreal, Quebec, Canada, 1991
60. Pert A, Sivit C: Neuroanatomical focus for morphine and enkephalin-induced hypermotility. Nature 1977; 265:645-647
61. Di Chiara G, Imperato A: Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther 1988; 244:1067-1080
62. Hemby SE, Martin TJ, Co C, et al: The effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis. J Pharmacol Exp Ther 1995; 273:591-598
63. Bozarth MA, Wise RA: Intracranial self-administration of morphine into the ventral tegmental area in rats. Life Sci 1981; 28:551-555
64. Di Chiara G, North RA: Neurobiology of opiate abuse. Trends Pharmacol Sci 1992; 13:185-193
65. Stinus L, Nadaud D, Deminiere JM, et al: Chronic flupentixol treatment potentiates the reinforcing properties of systemic heroin administration. Biol Psychiatry 1989; 26:363-371
66. Spyraki C, Fibiger HC, Phillips AG: Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system. Psychopharmacology (Berl) 1983; 79:278-283
67. Shippenberg TS, Herz A, Spanagel R, et al: Conditioning of opioid reinforcement: neuroanatomical and neurochemical substrates. Ann NY Acad Sci 1992; 654:347-356
68. Sepinwall J, Cook L: Behavioral pharmacology of anti-anxiety drugs, in Handbook of Psychopharmacology, vol 13, edited by Iversen LL, Iversen SD, Snyder SH. London, Plenum, 1978, pp 345-393
69. Richards G, Schoch P, Haefely W: Benzodiazepine receptors: new vistas. Seminars in the Neurosciences 1991; 3:191-203
70. Suzdak PD, Glowa JR, Crawley JN, et al: A selective imidazoben-zodiazepine antagonist of ethanol in the rat. Science 1986; 234:1243-1247
71. Koob GF, Britton KT: Neurobiological substrates for the ana-anxiety effects of ethanol, in The Pharmacology of Alcohol and Alcohol Dependence, edited by Begleiter H, Kissin B. New York, Oxford University Press, 1996, pp 477-506
72. Frye GD, Breese GR: GABAergic modulation of ethanol-induced motor impairment. J Pharmacol Exp Ther 1982; 223:750-756
73. Liljequist S, Engel J: Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes. Psychopharmacology (Berl) 1982; 78:71-75
74. Samson HH, Tolliver GA, Pfeffer AO, et al: Oral ethanol reinforcement in the rat: effect of the partial inverse benzodiazepine agonist Ro 15-4513. Pharmacol Biochem Behav 1987; 27:517-519
75. Rassnick S, D'Amico E, Riley E, et al: GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol. Alcohol Clin Exp Res 1993; 17:124-130
76. Fitzgerald LW, Nestler EJ: Molecular and cellular adaptations in signal transduction pathways following ethanol exposure. Clin Neurosci 1995; 3:165-173
77. Hoffman PL, Rabe C, Moses F, et al: W-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J Neurochem 1989; 52:1937-1940
78. Lovinger DM, White C, Weight FF: Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 1989; 243:1721-1724
79. Tsai G, Gastfriend DR, Coyle JT: The glutamatergic basis of human alcoholism. Am J Psychiatry 1995; 152:332-340
80. Pfeffer AO, Samson HH: Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats. Pharmacol Biochem Behav 1988; 29:343-350
81. Weiss F, Lorang MT, Bloom FE, et al: Ethanol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 1993; 267:250-258
82. Rassnick S, Stinus L, Koob GF: The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain Res 1993; 623:16-24
83. Engel JA, Enerback C, Fahlke C, et al: Serotonergic and dopaminergic involvement in ethanol intake, in Novel Pharmacological Interventions for Alcoholism, edited by Naranjo CA, Sellers EM. New York, Springer, 1992, pp 68-82
84. Sellars EM, Higgins GA, Sobell MB: 5-HT and alcohol abuse trends. Pharmacol Sci 1992; 13:69-75
85. Naranjo C, Kadlec K, Sanhueza P, et al: Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers. Clin Pharmacol Ther 1990; 47:490-498
86. Hubbell CL, Marglin SH, Spitalnic SJ, et al: Opioidergic, serotonergic, and dopaminergic manipulations and rats′ intake of a sweetened alcoholic beverage. Alcohol 1991; 8:355-367
87. Hyytia P: Involvement of μ-opioid receptors in alcohol drinking by alcohol-preferring AA rats. Pharmacol Biochem Behav 1993; 45:697-701
88. O'Malley SS, Jaffe AJ, Chang G, et al: Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch Gen Psychiatry 1992; 49:881-887
89. Volpicelli JR, Alterman AI, Hayashida M, et al: Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 1992; 49:876-880
90. Malin DH, Lake JR, Carter VA, et al: Naloxone precipitates nicotine abstinence syndrome in the rat. Psychopharmacology (Berl) 1993; 112:339-342
91. Malin DH, Lake JR, Carter VA, et al: The nicotine antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat. Psychopharmacology (Berl) 1994; 115:180-184
92. Corrigall WA, Franklin KBJ, Coen KM, et al: The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology (Berl) 1992; 107:285-289
93. Alheid GF, Heimer L: New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience 1988; 27:1-39
94. Johnston JB: Further contributions to the study of the evolution of the forebrain. J Comp Neurol 1923; 35:337-481
95. Heimer L, Alheid G: Piecing together the puzzle of basal forebrain anatomy, in The Basal Forebrain: Anatomy to Function, edited by Napier TC, Kalivas PW, Hanin I. New York, Plenum, 1991, pp 1-42
96. Heimer L, Zahm DS, Churchill L, et al: Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience 1991; 41:89-125
97. Caine SB, Heinrichs SC, Coffin VL, et al: Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Res 1995; 692:47-56
98. Pontieri FE, Tanda G, Di Chiara G: Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proc Natl Acad Sci USA 1995; 92:12304-12308
99. A receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 1995; 283:151-159
100. Heyser CJ, Roberts AJ, Schulteis G, et al: Central administration of an opiate antagonist decreases oral ethanol self-administration in rats (abstract). Society for Neuroscience Abstracts 1995; 21:1698
101. Pich EM, Lorang M, Yeganeh M, et al: Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J Neurosci 1995; 15:5439-5447
102. Aghajanian GK: Tolerance of locus coeruleus neurons to morphine and suppression of withdrawal response by clonidine. Nature 1978; 276:186-188
103. Taylor JR, Elsworth JD, Garcia EJ, et al: Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal. Psychopharmacology (Berl) 1988; 96:121-134
104. Maldonado R, Stinus L, Gold LH, et al: Role of different brain structures in the expression of the physical morphine withdrawal syndrome. J Pharmacol Exp Ther 1992; 261:669-677
105. Grant KA, Valverius P, Hudspith M, et al: Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol 1990; 176:289-296
106. Littleton J, Little H, Laverty R: Role of neuronal calcium channels in ethanol dependence: from cell cultures to the intact animal. Ann NY Acad Sci 1992; 654:324-334
107. Gawin FH, Kleber HD: Abstinence symptomatology and psychiatric diagnosis in cocaine abusers: clinical observations. Arch Gen Psychiatry 1986; 43:107-113
108. Weddington WW, Brown BS, Haertzen CA, et al: Changes in mood, craving, and sleep during short-term abstinence reported by male cocaine addicts: a controlled, residential study. Arch Gen Psychiatry 1990; 47:861-868
109. Esposito RU, Motola AHD, Kornetsky C: Cocaine: acute effects on reinforcement thresholds for self-stimulation behavior to the medial forebrain bundle. Pharmacol Biochem Behav 1978; 8:437-439
110. Kokkinidis L, Zacharko RM, Predy PA: Post-amphetamine depression of self-stimulation responding from the substantia nigra: reversal by tricyclic antidepressants. Pharmacol Biochem Behav 1980; 13:379-383
111. Kokkinidis L, Zacharko RM, Anisman H: Amphetamine withdrawal: a behavioral evaluation. Life Sci 1986; 38:1617-1623
112. Frank RA, Martz S, Pommering T: The effect of chronic cocaine on self-stimulation train-duration thresholds. Pharmacol Biochem Behav 1988; 29:755-758
113. Schaefer GJ, Michael RP: Changes in response rates and reinforcement thresholds for intracranial self-stimulation during morphine withdrawal. Pharmacol Biochem Behav 1986; 25:1263-1269
114. Schulteis G, Markou A, Cole M, et al: Decreased brain reward produced by ethanol withdrawal. Proc Natl Acad Sci USA 1995; 92:5880-5884
115. Hubner CB, Kornetsky C: Heroin, 6-acetylmorphine, and morphine effects on threshold for rewarding and aversive brain stimulation. J Pharmacol Exp Ther 1992; 260:562-567
116. Huston-Lyons D, Kornetsky C: Effects of nicotine on the threshold for rewarding brain stimulation in rats. Pharmacol Biochem Behav 1992; 41:755-759
117. Bauco P, Wise RA: Potentiation of lateral hypothalamic and midline mesencephalic brain stimulation reinforcement by nicotine: examination of repeated treatment. J Pharmacol Exp Ther 1994; 271:294-301
118. Kornetsky C, Moolten M, Bain G: Ethanol and rewarding brain stimulation, in Neuropharmacology of Ethanol, edited by Meyer RE, Koob GF, Lewis MJ, et al. Boston, Birkhauser, 1991, pp 179-199
119. Schulteis G, Markou A, Cole M, et al: Decreased brain reward produced by ethanol withdrawal. Proc Natl Acad Sci USA 1995; 92:5880-5884
120. Leith NJ, Barrett RJ: Amphetamine and the reward system: evidence for tolerance and post-drug depression. Psychopharmacologia 1976; 46:19-25
121. Parsons LH, Koob GF, Weiss F: Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine. J Pharmacol Exp Ther 1995; 274:1182-1191
122. Markou A, Koob GF: Post-cocaine anhedonia: an animal model of cocaine withdrawal. Neuropsychopharmacology 1991; 4:17-26
123. Markou A, Koob GF: Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations. Physiol Behav 1992; 51:111-119
124. Legault M, Wise RA: Effects of withdrawal from nicotine on intracranial self-stimulation (abstract). Society for Neuroscience Abstracts 1994; 20:1032
125. Koob GF: Drug addiction: the yin and yang of hedonic homeostasis. Neuron 1996; 16:893-896
126. Robinson TE, Berridge KC: The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 1993; 18:247-291
127. Solomon RL, Corbit JD: An opponent-process theory of motivation, I: temporal dynamics of affect. Psychol Rev 1974; 81:119-145
128. Siegel S: Evidence from rats that morphine tolerance is a learned response. Journal of Comparative and Physiological Psychology 1975; 89:498-506
129. Poulos CX, Cappell H: Homeostatic theory of drug tolerance: a general model of physiological adaptation. Psychol Rev 1991; 98:390-408
130. Weiss F, Markou A, Lorang MT, et al: Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain Res 1992; 593:314-318
131. Stinus L, Le Moal M, Koob GF: Nucleus accumbens and amygdala as possible substrates for the aversive stimulus effects of opiate withdrawal. Neuroscience 1990; 37:767-773
132. Roberts AJ, Cole M, Koob GF: Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. Alcohol Clin Exp Res 1996; 20:1289-1298
133. Weiss F, Parsons LH, Schulteis G, et al: Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. J Neurosci 1996; 16:3474-3485
134. Collins AC, Bhat RV, Pauly JR, et al: Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists, in The Biology of Nicotine Dependence, edited by Bock G, Marsh J. New York, Wiley, 1990, pp 87-105
135. Dani JA, Heinemann S: Molecular and cellular aspects of nicotine abuse. Neuron 1996; 16:905-908
136. Koob GF, Heinrichs SC, Menzaghi F, et al: Corticotropin-releasing factor, stress and behavior. Seminars in the Neurosciences 1994; 7:221-229
137. Piazza PV, Le Moal M: Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annu Rev Pharmacol Toxicol 1996; 36:359-378
138. 1 dopamine receptor sensitivity within the rat nucleus accumbens. J Pharmacol Exp Ther 1991; 258:882-890
139. Maldonado R, Koob GF: Destruction of the locus coeruleus decreases physical signs of opiate withdrawal. Brain Res 1993; 605:128-138
140. Rasmussen K, Beitner-Johnson DB, Krystal JH, et al: Opiate withdrawal and rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. J Neurosci 1990; 10:2308-2317
141. Koob GF, Maldonado R, Stinus L: Neural substrates of opiate withdrawal. Trends Neurosci 1992; 15:186-191
142. Gold MS, Redmond DE, Kleber HD: Clonidine blocks acute opiate-withdrawal symptoms. Lancet 1978; 2:599-602
143. Nestler EJ: Molecular mechanisms of drug addiction. J Neurosci 1992; 12:2439-2450
144. Nestler EJ, Hope BT, Widnell KL: Drug addiction: a model for the molecular basis of neural plasticity. Neuron 1993; 11:995-1006
145. Collier HOJ: Cellular site of opiate dependence. Nature 1980; 283:625-629
146. Nestler EJ: Under siege: The brain on opiates. Neuron 1996; 16:897-900
147. Sharrna SK, Klee WA, Nirenberg M: Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. Proc Natl Acad Sci USA 1975; 72:3092-3096
148. Alreja M, Aghajanian GK: Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus coeruleus neurons. J Neurosci 1993; 13:3525-3532
149. Widnell KL, Russell D, Nestler EJ: Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proc Natl Acad Sci USA 1994; 91:10947-10951
150. Maldonado R, Blendy JA, Tzavara E, et al: Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science 1996; 273:657-659
151. Rasmussen K, Aghajanian GK: Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesion of the nucleus paragigantocellularis. Brain Res 1989; 505:346-350
152. Akaoka H, Aston-Jones G: Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory acid input. J Neurosci 1991; 11:3830-3839
153. Self DW, Nestler EJ: Molecular mechanisms of drug reinforcement and addiction. Annu Rev Neurosci 1995; 18:463-495
154. Nestler EJ: Molecular neurobiology of drug addiction. Neuropsychopharmacology 1994; 11:77-87
155. Hope BT, Nye HE, Kelz MB, et al: Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 1994; 13:1235-1244
156. Hyman SE: Addiction to cocaine and amphetamine. Neuron 1996; 16:901-904
157. Widnell K, Self DW, Lane SB, et al: Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. J Pharmacol Exp Ther 1996; 276:306-315
158. Li DH, Depoortere RY, Emmett-Oglesby MW: Tolerance to the reinforcing effects of cocaine in a progressive ratio paradigm. Psychopharmacology (Berl) 1994; 116:326-332
159. Young AM, Goudie AJ: Adaptive processes regulating tolerance to the behavioral effects of drugs, in Psychopharmacology: The Fourth Generation of Progress, edited by Bloom FE, Kupfer DJ. New York, Raven, 1995, pp 733-742
160. Trujillo KA, Akil H: Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 1991; 251:85-87
161. Kovoor A, Henry DJ, Chavkin C: Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1). J Biol Chem 1995; 270:589-595
162. Koob GF: Animal models of drug addiction, in Psychopharmacology: The Fourth Generation of Progress, edited by Bloom FE, Kupfer DJ. New York, Raven, 1995, pp 759-772
163. deWit H, Stewart J: Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology (Berl) 1981; 75:134-143
164. Stewart J, deWit H: Reinstatement of drug-taking behavior as a method of assessing incentive motivational properties of drugs, in Methods of Assessing the Reinforcing Properties of Abused Drugs, edited by Bozarth MA. New York, Springer-Verlag, 1987, pp 211-227
165. O'Brien CP, Eckardt MJ, Linnoila VMI: Pharmacotherapy of alcoholism, in Psychopharmacology: The Fourth Generation of Progress, edited by Bloom FE, Kupfer DJ. New York, Raven, 1995, pp 1745-1755
166. Heyser CJ, Schulteis G, Durbin P, et al: Chronic acamprosate decreases deprivation-induced ethanol self-administration in rats. Neuropsychopharmacology (in press)
167. Sass H, Soyka M, Mann K, et al: Relapse prevention by acamprosate: results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry 1996; 53:673-680
168. Volpicelli JR, Davis MA, Olgin JE: Naltrexone blocks the post-shock increase of ethanol consumption. Life Sci 1986; 38:841-847
169. 2-like dopamine receptor agonists. Science 1996; 271:1586-1589