메뉴 건너뛰기




Volumn 15, Issue 6, 2015, Pages 801-813

Recent advances of microRNA-based molecular diagnostics to reduce false-positive lung cancer imaging

Author keywords

Biomarkers; circulating microRNA; LDCT; lung cancer; Screening

Indexed keywords

MICRORNA; TUMOR MARKER;

EID: 84929869150     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2015.1041377     Document Type: Review
Times cited : (30)

References (124)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
    • Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136(5):E359-86
    • (2015) Int J Cancer , vol.136 , Issue.5 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3
  • 2
    • 34548457234 scopus 로고    scopus 로고
    • The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours
    • Goldstraw P, Crowley J, Chansky K, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2007;2: 706-14
    • (2007) J Thorac Oncol , vol.2 , pp. 706-714
    • Goldstraw, P.1    Crowley, J.2    Chansky, K.3
  • 3
    • 79961108629 scopus 로고    scopus 로고
    • Reduced lung-cancer mortality with low-dose computed tomographic screening
    • Aberle DR, Adams AM, Berg CD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011;365:395-409
    • (2011) N Engl J Med , vol.365 , pp. 395-409
    • Aberle, D.R.1    Adams, A.M.2    Berg, C.D.3
  • 4
    • 0001065684 scopus 로고
    • Survival and mortality from lung cancer in a screened population: The Johns Hopkins Study
    • Tockman MS. Survival and mortality from lung cancer in a screened population: the Johns Hopkins Study. Chest 1986;89: 324S-5S.
    • (1986) Chest , vol.89 , pp. 324S-5S
    • Tockman, M.S.1
  • 5
    • 0021154006 scopus 로고
    • Screening for early lung cancer. Results of the Memorial Sloan-Kettering study in New York
    • Melamed MR, Flehinger BJ, Zaman MB, et al. Screening for early lung cancer. Results of the Memorial Sloan-Kettering study in New York. Chest 1984;86:44-53
    • (1984) Chest , vol.86 , pp. 44-53
    • Melamed, M.R.1    Flehinger, B.J.2    Zaman, M.B.3
  • 7
    • 80355129626 scopus 로고    scopus 로고
    • Screening by chest radiograph and lung cancer mortality: The Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial
    • Oken MM, Hocking WG, Kvale PA, et al. Screening by chest radiograph and lung cancer mortality: the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial. JAMA 2011;306:1865-73
    • (2011) JAMA , vol.306 , pp. 1865-1873
    • Oken, M.M.1    Hocking, W.G.2    Kvale, P.A.3
  • 8
    • 84884908621 scopus 로고    scopus 로고
    • Screening for lung cancer: The US studies
    • Midthun DE, Jett JR. Screening for lung cancer: the US studies. J Surg Oncol 2013;108:275-9
    • (2013) J Surg Oncol , vol.108 , pp. 275-279
    • Midthun, D.E.1    Jett, J.R.2
  • 9
    • 84929857325 scopus 로고    scopus 로고
    • National Cancer Institute. Available from
    • National Cancer Institute. Available from: http://www.cancer.gov
  • 10
    • 0029805812 scopus 로고    scopus 로고
    • Peripheral lung cancer: Screening and detection with low-dose spiral CT versus radiography
    • Kaneko M, Eguchi K, Ohmatsu H, et al. Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography. Radiology 1996;201:798-802
    • (1996) Radiology , vol.201 , pp. 798-802
    • Kaneko, M.1    Eguchi, K.2    Ohmatsu, H.3
  • 11
    • 0032565365 scopus 로고    scopus 로고
    • Mass screening for lung cancer with mobile spiral computed tomography scanner
    • Sone S, Takashima S, Li F, et al. Mass screening for lung cancer with mobile spiral computed tomography scanner. Lancet 1998;351:1242-5
    • (1998) Lancet , vol.351 , pp. 1242-1245
    • Sone, S.1    Takashima, S.2    Li, F.3
  • 12
    • 0033542870 scopus 로고    scopus 로고
    • Early Lung Cancer Action Project: Overall design and findings from baseline screening
    • Henschke CI, McCauley DI, Yankelevitz DF, et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet 1999;354: 99-105
    • (1999) Lancet , vol.354 , pp. 99-105
    • Henschke, C.I.1    McCauley, D.I.2    Yankelevitz, D.F.3
  • 13
    • 33750315764 scopus 로고    scopus 로고
    • Survival of patients with stage i lung cancer detected on CT screening
    • Henschke CI, Yankelevitz DF, Libby DM, et al. Survival of patients with stage I lung cancer detected on CT screening. N Engl J Med 2006;355:1763-71
    • (2006) N Engl J Med , vol.355 , pp. 1763-1771
    • Henschke, C.I.1    Yankelevitz, D.F.2    Libby, D.M.3
  • 14
    • 10444244070 scopus 로고    scopus 로고
    • Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer
    • Gohagan JK, Marcus PM, Fagerstrom RM, et al. Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer. Lung Cancer 2005;47:9-15
    • (2005) Lung Cancer , vol.47 , pp. 9-15
    • Gohagan, J.K.1    Marcus, P.M.2    Fagerstrom, R.M.3
  • 15
    • 84874009586 scopus 로고    scopus 로고
    • Selection criteria for lung-cancer screening
    • Tammemagi MC, Katki HA, Hocking WG, et al. Selection criteria for lung-cancer screening. N Engl J Med 2013;368:728-36
    • (2013) N Engl J Med , vol.368 , pp. 728-736
    • Tammemagi, M.C.1    Katki, H.A.2    Hocking, W.G.3
  • 16
    • 73349107157 scopus 로고    scopus 로고
    • Management of lung nodules detected by volume CT scanning
    • van Klaveren RJ, Oudkerk M, Prokop M, et al. Management of lung nodules detected by volume CT scanning. N Engl J Med 2009;361:2221-9
    • (2009) N Engl J Med , vol.361 , pp. 2221-2229
    • Van Klaveren, R.J.1    Oudkerk, M.2    Prokop, M.3
  • 17
    • 84858796991 scopus 로고    scopus 로고
    • CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: Status after five annual screening rounds with low-dose CT
    • Saghir Z, Dirksen A, Ashraf H, et al. CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax 2012;67:296-301
    • (2012) Thorax , vol.67 , pp. 296-301
    • Saghir, Z.1    Dirksen, A.2    Ashraf, H.3
  • 18
    • 84859295557 scopus 로고    scopus 로고
    • Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial
    • Pastorino U, Rossi M, Rosato V, et al. Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial. Eur J Cancer Prev 2012;21:308-15
    • (2012) Eur J Cancer Prev , vol.21 , pp. 308-315
    • Pastorino, U.1    Rossi, M.2    Rosato, V.3
  • 19
    • 84866728837 scopus 로고    scopus 로고
    • Randomized study on early detection of lung cancer with MSCT in Germany: Study design and results of the first screening round
    • Becker N, Motsch E, Gross ML, et al. Randomized study on early detection of lung cancer with MSCT in Germany: study design and results of the first screening round. J Cancer Res Clin Oncol 2012;138: 1475-86
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 1475-1486
    • Becker, N.1    Motsch, E.2    Gross, M.L.3
  • 20
    • 84880924900 scopus 로고    scopus 로고
    • Four-year results of low-dose CT screening and nodule management in the ITALUNG trial
    • Lopes PA, Picozzi G, Falaschi F, et al. Four-year results of low-dose CT screening and nodule management in the ITALUNG trial. J Thorac Oncol 2013;8:866-75
    • (2013) J Thorac Oncol , vol.8 , pp. 866-875
    • Lopes, P.A.1    Picozzi, G.2    Falaschi, F.3
  • 21
    • 69249108174 scopus 로고    scopus 로고
    • A randomized study of lung cancer screening with spiral computed tomography: Three-year results from the DANTE trial
    • Infante M, Cavuto S, Lutman FR, et al. A randomized study of lung cancer screening with spiral computed tomography: three-year results from the DANTE trial. Am J Respir Crit Care Med 2009;180: 445-53
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 445-453
    • Infante, M.1    Cavuto, S.2    Lutman, F.R.3
  • 22
    • 34548565967 scopus 로고    scopus 로고
    • Baseline results of the Depiscan study: A French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR)
    • Blanchon T, Brechot JM, Grenier PA, et al. Baseline results of the Depiscan study: a French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR). Lung Cancer 2007;58:50-8
    • (2007) Lung Cancer , vol.58 , pp. 50-58
    • Blanchon, T.1    Brechot, J.M.2    Grenier, P.A.3
  • 23
    • 20144389751 scopus 로고    scopus 로고
    • CT screening for lung cancer: Five-year prospective experience
    • Swensen SJ, Jett JR, Hartman TE, et al. CT screening for lung cancer: five-year prospective experience. Radiology 2005;235: 259-65
    • (2005) Radiology , vol.235 , pp. 259-265
    • Swensen, S.J.1    Jett, J.R.2    Hartman, T.E.3
  • 24
    • 0037083316 scopus 로고    scopus 로고
    • Screening for lung cancer with low-dose helical computed tomography: Anti-lung cancer association project
    • Sobue T, Moriyama N, Kaneko M, et al. Screening for lung cancer with low-dose helical computed tomography: anti-lung cancer association project. J Clin Oncol 2002;20:911-20
    • (2002) J Clin Oncol , vol.20 , pp. 911-920
    • Sobue, T.1    Moriyama, N.2    Kaneko, M.3
  • 25
    • 0041464868 scopus 로고    scopus 로고
    • Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results
    • Pastorino U, Bellomi M, Landoni C, et al. Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results. Lancet 2003;362: 593-7
    • (2003) Lancet , vol.362 , pp. 593-597
    • Pastorino, U.1    Bellomi, M.2    Landoni, C.3
  • 26
    • 0036190266 scopus 로고    scopus 로고
    • Screening for early lung cancer with low-dose spiral CT: Prevalence in 817 asymptomatic smokers
    • Diederich S, Wormanns D, Semik M, et al. Screening for early lung cancer with low-dose spiral CT: prevalence in 817 asymptomatic smokers. Radiology 2002;222:773-81
    • (2002) Radiology , vol.222 , pp. 773-781
    • Diederich, S.1    Wormanns, D.2    Semik, M.3
  • 27
    • 33847691553 scopus 로고    scopus 로고
    • Computed tomography screening and lung cancer outcomes
    • Bach PB, Jett JR, Pastorino U, et al. Computed tomography screening and lung cancer outcomes. JAMA 2007;297:953-61.
    • (2007) JAMA , vol.297 , pp. 953-961
    • Bach, P.B.1    Jett, J.R.2    Pastorino, U.3
  • 28
    • 84884902938 scopus 로고    scopus 로고
    • European randomized lung cancer screening trials: Post NLST
    • Field JK, van KR, Pedersen JH, et al. European randomized lung cancer screening trials: Post NLST. J Surg Oncol 2013;108: 280-6
    • (2013) J Surg Oncol , vol.108 , pp. 280-286
    • Field, J.K.1    Van, K.R.2    Pedersen, J.H.3
  • 29
    • 84893557385 scopus 로고    scopus 로고
    • Overdiagnosis in low-dose computed tomography screening for lung cancer
    • Patz EF Jr, Pinsky P, Gatsonis C, et al. Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med 2014;174:269-74.
    • (2014) JAMA Intern Med , vol.174 , pp. 269-274
    • Patz, E.F.1    Pinsky, P.2    Gatsonis, C.3
  • 30
    • 80054893661 scopus 로고    scopus 로고
    • Cost-effectiveness of computed tomography screening for lung cancer in the United States
    • McMahon PM, Kong CY, Bouzan C, et al. Cost-effectiveness of computed tomography screening for lung cancer in the United States. J Thorac Oncol 2011;6:1841-8
    • (2011) J Thorac Oncol , vol.6 , pp. 1841-1848
    • McMahon, P.M.1    Kong, C.Y.2    Bouzan, C.3
  • 31
    • 84889573289 scopus 로고    scopus 로고
    • Lung cancer: CT screening for lung cancer-do we have an answer
    • Pastorino U, Sverzellati N. Lung cancer: CT screening for lung cancer-do we have an answer Nat Rev Clin Oncol 2013;10:672-3
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 672-673
    • Pastorino, U.1    Sverzellati, N.2
  • 32
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004;101:2999-3004
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 33
    • 34250013672 scopus 로고    scopus 로고
    • Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
    • Raveche ES, Salerno E, Scaglione BJ, et al. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood 2007;109:5079-86
    • (2007) Blood , vol.109 , pp. 5079-5086
    • Raveche, E.S.1    Salerno, E.2    Scaglione, B.J.3
  • 34
    • 46749147615 scopus 로고    scopus 로고
    • Genetic variants of miRNA sequences and non-small cell lung cancer survival
    • Hu Z, Chen J, Tian T, et al. Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest 2008;118:2600-8
    • (2008) J Clin Invest , vol.118 , pp. 2600-2608
    • Hu, Z.1    Chen, J.2    Tian, T.3
  • 35
    • 84862243555 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation
    • Iorio MV, Croce CM. Causes and consequences of microRNA dysregulation. Cancer J 2012;18:215-22
    • (2012) Cancer J , vol.18 , pp. 215-222
    • Iorio, M.V.1    Croce, C.M.2
  • 36
    • 84890572219 scopus 로고    scopus 로고
    • MiR-155-mediated loss of C/EBPbeta shifts the TGF-beta response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer
    • Johansson J, Berg T, Kurzejamska E, et al. MiR-155-mediated loss of C/EBPbeta shifts the TGF-beta response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene 2013;32:5614-24
    • (2013) Oncogene , vol.32 , pp. 5614-5624
    • Johansson, J.1    Berg, T.2    Kurzejamska, E.3
  • 37
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner U, Schubert J, Burk UC, et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 2009;11:1487-95
    • (2009) Nat Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3
  • 38
    • 77950665077 scopus 로고    scopus 로고
    • Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
    • Ma L, Reinhardt F, Pan E, et al. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol 2010;28:341-7
    • (2010) Nat Biotechnol , vol.28 , pp. 341-347
    • Ma, L.1    Reinhardt, F.2    Pan, E.3
  • 39
    • 77956339881 scopus 로고    scopus 로고
    • OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
    • Medina PP, Nolde M, Slack FJ. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 2010;467:86-90
    • (2010) Nature , vol.467 , pp. 86-90
    • Medina, P.P.1    Nolde, M.2    Slack, F.J.3
  • 40
  • 41
    • 84862211160 scopus 로고    scopus 로고
    • Role of microRNAs in lung cancer: MicroRNA signatures in cancer prognosis
    • Boeri M, Pastorino U, Sozzi G. Role of microRNAs in lung cancer: microRNA signatures in cancer prognosis. Cancer J 2012;18:268-74
    • (2012) Cancer J , Issue.18 , pp. 268-274
    • Boeri, M.1    Pastorino, U.2    Sozzi, G.3
  • 42
    • 79961025970 scopus 로고    scopus 로고
    • MicroRNAs in body fluids - The mix of hormones and biomarkers
    • Cortez MA, Bueso-Ramos C, Ferdin J, et al. MicroRNAs in body fluids-the mix of hormones and biomarkers. Nat Rev Clin Oncol 2011;8:467-77
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 467-477
    • Cortez, M.A.1    Bueso-Ramos, C.2    Ferdin, J.3
  • 45
    • 84867334962 scopus 로고    scopus 로고
    • Cell-to-cell miRNA transfer: From body homeostasis to therapy
    • Redis RS, Calin S, Yang Y, et al. Cell-to-cell miRNA transfer: from body homeostasis to therapy. Pharmacol Ther 2012;136:169-74
    • (2012) Pharmacol Ther , vol.136 , pp. 169-174
    • Redis, R.S.1    Calin, S.2    Yang, Y.3
  • 46
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • Kosaka N, Iguchi H, Yoshioka Y, et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 2010;285:17442-52
    • (2010) J Biol Chem , vol.285 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3
  • 47
    • 80053175966 scopus 로고    scopus 로고
    • Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
    • Yang M, Chen J, Su F, et al. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer 2011;10:117
    • (2011) Mol Cancer , vol.10 , pp. 117
    • Yang, M.1    Chen, J.2    Su, F.3
  • 48
    • 79959923298 scopus 로고    scopus 로고
    • MicroRNAs and lung cancer: From markers to targets
    • Sozzi G, Pastorino U, Croce CM. MicroRNAs and lung cancer: from markers to targets. Cell Cycle 2011;10:2045-6
    • (2011) Cell Cycle , vol.10 , pp. 2045-2046
    • Sozzi, G.1    Pastorino, U.2    Croce, C.M.3
  • 49
    • 84926618053 scopus 로고    scopus 로고
    • Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction
    • Fortunato O, Boeri M, Moro M, et al. Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction. Cell Death Dis 2014;5:e1564
    • (2014) Cell Death Dis , vol.5 , pp. e1564
    • Fortunato, O.1    Boeri, M.2    Moro, M.3
  • 50
    • 84911966357 scopus 로고    scopus 로고
    • Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
    • Melo SA, Sugimoto H, O'Connell JT, et al. Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. Cancer Cell 2014;26:707-21
    • (2014) Cancer Cell , vol.26 , pp. 707-721
    • Melo, S.A.1    Sugimoto, H.2    O'Connell, J.T.3
  • 51
    • 53349177819 scopus 로고    scopus 로고
    • Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases
    • Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008;18:997-1006
    • (2008) Cell Res , vol.18 , pp. 997-1006
    • Chen, X.1    Ba, Y.2    Ma, L.3
  • 52
    • 84916636025 scopus 로고    scopus 로고
    • MIRNA detection methods and clinical implications in lung cancer
    • Uso M, Jantus-Lewintre E, Sirera R, et al. miRNA detection methods and clinical implications in lung cancer. Future Oncol 2014;10:2279-92
    • (2014) Future Oncol , vol.10 , pp. 2279-2292
    • Uso, M.1    Jantus-Lewintre, E.2    Sirera, R.3
  • 53
    • 29144470346 scopus 로고    scopus 로고
    • Real-time quantification of microRNAs by stem-loop RT-PCR
    • Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005;33:e179
    • (2005) Nucleic Acids Res , vol.33 , pp. e179
    • Chen, C.1    Ridzon, D.A.2    Broomer, A.J.3
  • 54
    • 77649201708 scopus 로고    scopus 로고
    • Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available
    • Benes V, Castoldi M. Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available. Methods 2010;50:244-9
    • (2010) Methods , vol.50 , pp. 244-249
    • Benes, V.1    Castoldi, M.2
  • 55
    • 43449102192 scopus 로고    scopus 로고
    • Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
    • Lawrie CH, Gal S, Dunlop HM, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 2008;141:672-5
    • (2008) Br J Haematol , vol.141 , pp. 672-675
    • Lawrie, C.H.1    Gal, S.2    Dunlop, H.M.3
  • 56
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 2008;105: 10513-18.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3
  • 57
    • 77649205818 scopus 로고    scopus 로고
    • Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)
    • Kroh EM, Parkin RK, Mitchell PS, Tewari M. Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods 2010;50:298-301
    • (2010) Methods , vol.50 , pp. 298-301
    • Kroh, E.M.1    Parkin, R.K.2    Mitchell, P.S.3    Tewari, M.4
  • 58
    • 79953202200 scopus 로고    scopus 로고
    • Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
    • Arroyo JD, Chevillet JR, Kroh EM, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 2011;108:5003-8
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 5003-5008
    • Arroyo, J.D.1    Chevillet, J.R.2    Kroh, E.M.3
  • 59
    • 84876386633 scopus 로고    scopus 로고
    • Assessing sample and miRNA profile quality in serum and plasma or other biofluids
    • Blondal T, Jensby NS, Baker A, et al. Assessing sample and miRNA profile quality in serum and plasma or other biofluids. Methods 2013;59:S1-6
    • (2013) Methods , vol.59 , pp. S1-6
    • Blondal, T.1    Jensby, N.S.2    Baker, A.3
  • 60
    • 84867237573 scopus 로고    scopus 로고
    • Method for microRNA isolation from clinical serum samples
    • Li Y, Kowdley KV. Method for microRNA isolation from clinical serum samples. Anal Biochem 2012;431:69-75
    • (2012) Anal Biochem , vol.431 , pp. 69-75
    • Li, Y.1    Kowdley, K.V.2
  • 62
    • 33646178285 scopus 로고    scopus 로고
    • A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)
    • Castoldi M, Schmidt S, Benes V, et al. A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA 2006;12:913-20
    • (2006) RNA , vol.12 , pp. 913-920
    • Castoldi, M.1    Schmidt, S.2    Benes, V.3
  • 63
    • 33845876339 scopus 로고    scopus 로고
    • Direct and sensitive miRNA profiling from low-input total RNA
    • Wang H, Ach RA, Curry B. Direct and sensitive miRNA profiling from low-input total RNA. RNA 2007;13:151-9
    • (2007) RNA , vol.13 , pp. 151-159
    • Wang, H.1    Ach, R.A.2    Curry, B.3
  • 64
    • 77955290050 scopus 로고    scopus 로고
    • Many ways to generate microRNA-like small RNAs: Non-canonical pathways for microRNA production
    • Miyoshi K, Miyoshi T, Siomi H. Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production. Mol Genet Genomics 2010;284:95-103
    • (2010) Mol Genet Genomics , vol.284 , pp. 95-103
    • Miyoshi, K.1    Miyoshi, T.2    Siomi, H.3
  • 65
    • 84896853715 scopus 로고    scopus 로고
    • Robust global microRNA expression profiling using next-generation sequencing technologies
    • Tam S, de BR, Tsao MS, McPherson JD. Robust global microRNA expression profiling using next-generation sequencing technologies. Lab Invest 2014;94:350-8
    • (2014) Lab Invest , vol.94 , pp. 350-358
    • Tam, S.1    De Br Tsao, M.S.2    McPherson, J.D.3
  • 66
    • 84905241949 scopus 로고    scopus 로고
    • Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study
    • Mestdagh P, Hartmann N, Baeriswyl L, et al. Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat Methods 2014;11:809-15.
    • (2014) Nat Methods , vol.11 , pp. 809-815
    • Mestdagh, P.1    Hartmann, N.2    Baeriswyl, L.3
  • 67
    • 77951190661 scopus 로고    scopus 로고
    • Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression
    • Git A, Dvinge H, Salmon-Divon M, et al. Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression. RNA 2010;16: 991-1006
    • (2010) RNA , vol.16 , pp. 991-1006
    • Git, A.1    Dvinge, H.2    Salmon-Divon, M.3
  • 68
    • 79951771769 scopus 로고    scopus 로고
    • MIR-1254 and miR-574-5p: Serum-based microRNA biomarkers for early-stage nonsmall cell lung cancer
    • Foss KM, Sima C, Ugolini D, et al. miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage nonsmall cell lung cancer. J Thorac Oncol 2011;6:482-8
    • (2011) J Thorac Oncol , vol.6 , pp. 482-488
    • Foss, K.M.1    Sima, C.2    Ugolini, D.3
  • 69
    • 84856117899 scopus 로고    scopus 로고
    • Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer
    • Heegaard NH, Schetter AJ, Welsh JA, et al. Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer. Int J Cancer 2012;130:1378-86
    • (2012) Int J Cancer , vol.130 , pp. 1378-1386
    • Heegaard, N.H.1    Schetter, A.J.2    Welsh, J.A.3
  • 70
    • 77950498821 scopus 로고    scopus 로고
    • Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer
    • Hu Z, Chen X, Zhao Y, et al. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol 2010;28:1721-6
    • (2010) J Clin Oncol , vol.28 , pp. 1721-1726
    • Hu, Z.1    Chen, X.2    Zhao, Y.3
  • 71
    • 79953178293 scopus 로고    scopus 로고
    • Plasma microRNAs as potential biomarkers for non-small-cell lung cancer
    • Shen J, Todd NW, Zhang H, et al. Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. Lab Invest 2011; 91(4):579-87
    • (2011) Lab Invest , vol.91 , Issue.4 , pp. 579-587
    • Shen, J.1    Todd, N.W.2    Zhang, H.3
  • 72
    • 80055051965 scopus 로고    scopus 로고
    • Plasma microRNAs as novel biomarkers for early detection of lung cancer
    • Zheng D, Haddadin S, Wang Y, et al. Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int J Clin Exp Pathol 2011;4:575-86
    • (2011) Int J Clin Exp Pathol , Issue.4 , pp. 575-586
    • Zheng, D.1    Haddadin, S.2    Wang, Y.3
  • 73
    • 79953712598 scopus 로고    scopus 로고
    • Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival
    • Silva J, Garcia V, Zaballos A, et al. Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival. Eur Respir J 2011;37:617-23
    • (2011) Eur Respir J , Issue.37 , pp. 617-623
    • Silva, J.1    Garcia, V.2    Zaballos, A.3
  • 74
    • 72449187466 scopus 로고    scopus 로고
    • Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer
    • Xie Y, Todd NW, Liu Z, et al. Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer. Lung Cancer 2010;67(2):170-6
    • (2010) Lung Cancer , vol.67 , Issue.2 , pp. 170-176
    • Xie, Y.1    Todd, N.W.2    Liu, Z.3
  • 75
    • 77955516533 scopus 로고    scopus 로고
    • Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers
    • Yu L, Todd NW, Xing L, et al. Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int J Cancer 2010;127:2870-8
    • (2010) Int J Cancer , vol.127 , pp. 2870-2878
    • Yu, L.1    Todd, N.W.2    Xing, L.3
  • 76
    • 84862255365 scopus 로고    scopus 로고
    • Benefits and harms of CT screening for lung cancer: A systematic review
    • Bach PB, Mirkin JN, Oliver TK, et al. Benefits and harms of CT screening for lung cancer: a systematic review. JAMA 2012;307:2418-29
    • (2012) JAMA , vol.307 , pp. 2418-2429
    • Bach, P.B.1    Mirkin, J.N.2    Oliver, T.K.3
  • 77
    • 84977478146 scopus 로고    scopus 로고
    • MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer
    • Boeri M, Verri C, Conte D, et al. MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. Proc Natl Acad Sci USA 2011;108:3713-18
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3713-3718
    • Boeri, M.1    Verri, C.2    Conte, D.3
  • 78
    • 79960957682 scopus 로고    scopus 로고
    • A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer
    • Bianchi F, Nicassio F, Marzi M, et al. A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer. EMBO Mol Med 2011;3:495-503.
    • (2011) EMBO Mol Med , vol.3 , pp. 495-503
    • Bianchi, F.1    Nicassio, F.2    Marzi, M.3
  • 79
    • 84897015133 scopus 로고    scopus 로고
    • Clinical Utility of a Plasma-Based miRNA Signature Classifier Within Computed Tomography Lung Cancer Screening: A Correlative MILD Trial Study
    • Sozzi G, Boeri M, Rossi M, et al. Clinical Utility of a Plasma-Based miRNA Signature Classifier Within Computed Tomography Lung Cancer Screening: A Correlative MILD Trial Study. J Clin Oncol 2014;32: 768-73.
    • (2014) J Clin Oncol , vol.32 , pp. 768-773
    • Sozzi, G.1    Boeri, M.2    Rossi, M.3
  • 80
    • 43549126325 scopus 로고    scopus 로고
    • Lung cancer screening with low-dose computed tomography: A non-invasive diagnostic protocol for baseline lung nodules
    • Veronesi G, Bellomi M, Mulshine JL, et al. Lung cancer screening with low-dose computed tomography: a non-invasive diagnostic protocol for baseline lung nodules. Lung Cancer 2008;61:340-9
    • (2008) Lung Cancer , vol.61 , pp. 340-349
    • Veronesi, G.1    Bellomi, M.2    Mulshine, J.L.3
  • 81
    • 84929845363 scopus 로고    scopus 로고
    • MiRTest: A blood test for lung cancer early detection
    • Montani F, Marzi MJ, Dezi F, et al. miRTest: a blood test for lung cancer early detection. J Natl Cancer Inst 2015; 107(6): djv063
    • (2015) J Natl Cancer Inst , vol.107 , Issue.6 , pp. djv063
    • Montani, F.1    Marzi, M.J.2    Dezi, F.3
  • 82
    • 80052027132 scopus 로고    scopus 로고
    • Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers
    • Shen J, Liu Z, Todd NW, et al. Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers. BMC Cancer 2011;11:374
    • (2011) BMC Cancer , vol.11 , pp. 374
    • Shen, J.1    Liu, Z.2    Todd, N.W.3
  • 83
    • 84891833170 scopus 로고    scopus 로고
    • Analysis of MicroRNAs in sputum to improve computed tomography for lung cancer diagnosis
    • Shen J, Liao J, Guarnera MA, et al. Analysis of MicroRNAs in sputum to improve computed tomography for lung cancer diagnosis. J Thorac Oncol 2014;9:33-40
    • (2014) J Thorac Oncol , vol.9 , pp. 33-40
    • Shen, J.1    Liao, J.2    Guarnera, M.A.3
  • 84
    • 84920973525 scopus 로고    scopus 로고
    • Sputum microRNA Biomarkers for Identifying Lung Cancer in Indeterminate Solitary Pulmonary Nodules
    • Xing L, Su J, Guarnera MA, et al. Sputum microRNA Biomarkers for Identifying Lung Cancer in Indeterminate Solitary Pulmonary Nodules. Clin Cancer Res 2015;21:484-9
    • (2015) Clin Cancer Res , vol.21 , pp. 484-489
    • Xing, L.1    Su, J.2    Guarnera, M.A.3
  • 85
    • 84883373154 scopus 로고    scopus 로고
    • Micro RNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer
    • Cazzoli R, Buttitta F, Di NM, et al. microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. J Thorac Oncol 2013;8:1156-62
    • (2013) J Thorac Oncol , vol.8 , pp. 1156-1162
    • Cazzoli, R.1    Buttitta, F.2    Di, N.M.3
  • 86
    • 84896920819 scopus 로고    scopus 로고
    • Assessment of circulating microRNAs in plasma of lung cancer patients
    • Fortunato O, Boeri M, Verri C, et al. Assessment of circulating microRNAs in plasma of lung cancer patients. Molecules 2014;19:3038-54
    • (2014) Molecules , vol.19 , pp. 3038-3054
    • Fortunato, O.1    Boeri, M.2    Verri, C.3
  • 87
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics. MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy
    • Kasinski AL, Slack FJ. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer 2011;11:849-64
    • (2011) Nat Rev Cancer , vol.11 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 88
    • 84920261926 scopus 로고    scopus 로고
    • Therapeutic use of microRNAs in lung cancer
    • Fortunato O, Boeri M, Verri C, et al. Therapeutic Use of MicroRNAs in Lung Cancer. Biomed Res Int 2014;2014:756975
    • (2014) Biomed Res Int , vol.2014 , pp. 756975
    • Fortunato, O.1    Boeri, M.2    Verri, C.3
  • 89
    • 84929872225 scopus 로고    scopus 로고
    • Wordle. Available from
    • Wordle. Available from: www.wordle.net.
  • 90
    • 42749093490 scopus 로고    scopus 로고
    • MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer
    • Garofalo M, Quintavalle C, Di LG, et al. MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene 2008;27:3845-55
    • (2008) Oncogene , vol.27 , pp. 3845-3855
    • Garofalo, M.1    Quintavalle, C.2    Di, L.G.3
  • 91
    • 70949104622 scopus 로고    scopus 로고
    • MIR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
    • Garofalo M, Di LG, Romano G, et al. miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 2009;16:498-509
    • (2009) Cancer Cell , vol.16 , pp. 498-509
    • Garofalo, M.1    Di, L.G.2    Romano, G.3
  • 92
    • 78751582064 scopus 로고    scopus 로고
    • Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma
    • Bhatti I, Lee A, James V, et al. Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma. J Gastrointest Surg 2011;15:199-208
    • (2011) J Gastrointest Surg , vol.15 , pp. 199-208
    • Bhatti, I.1    Lee, A.2    James, V.3
  • 93
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008;27:2128-36
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3
  • 94
    • 77956061393 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)
    • Zhang JG, Wang JJ, Zhao F, et al. MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin Chim Acta 2010;411: 846-52
    • (2010) Clin Chim Acta , vol.411 , pp. 846-852
    • Zhang, J.G.1    Wang, J.J.2    Zhao, F.3
  • 95
    • 40249092910 scopus 로고    scopus 로고
    • MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
    • Zhu S, Wu H, Wu F, et al. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 2008;18:350-9
    • (2008) Cell Res , vol.18 , pp. 350-359
    • Zhu, S.1    Wu, H.2    Wu, F.3
  • 96
    • 39749163245 scopus 로고    scopus 로고
    • Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    • Xiao C, Srinivasan L, Calado DP, et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 2008;9:405-14
    • (2008) Nat Immunol , vol.9 , pp. 405-414
    • Xiao, C.1    Srinivasan, L.2    Calado, D.P.3
  • 97
    • 84883310620 scopus 로고    scopus 로고
    • MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways
    • Jin HY, Oda H, Lai M, et al. MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J 2013;32: 2377-91
    • (2013) EMBO J , vol.32 , pp. 2377-2391
    • Jin, H.Y.1    Oda, H.2    Lai, M.3
  • 98
    • 39749143354 scopus 로고    scopus 로고
    • Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters
    • Ventura A, Young AG, Winslow MM, et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 2008;132:875-86
    • (2008) Cell , vol.132 , pp. 875-886
    • Ventura, A.1    Young, A.G.2    Winslow, M.M.3
  • 99
    • 34447101200 scopus 로고    scopus 로고
    • Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92
    • Matsubara H, Takeuchi T, Nishikawa E, et al. Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene 2007;26:6099-105
    • (2007) Oncogene , vol.26 , pp. 6099-6105
    • Matsubara, H.1    Takeuchi, T.2    Nishikawa, E.3
  • 100
    • 84867745041 scopus 로고    scopus 로고
    • MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression
    • Zang YS, Zhong YF, Fang Z, et al. MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression. Cancer Gene Ther 2012;19:773-8
    • (2012) Cancer Gene Ther , vol.19 , pp. 773-778
    • Zang, Y.S.1    Zhong, Y.F.2    Fang, Z.3
  • 101
    • 34547458550 scopus 로고    scopus 로고
    • P53-mediated activation of miRNA34 candidate tumor-suppressor genes
    • Bommer GT, Gerin I, Feng Y, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 2007;17:1298-307
    • (2007) Curr Biol , vol.17 , pp. 1298-1307
    • Bommer, G.T.1    Gerin, I.2    Feng, Y.3
  • 102
    • 84879267458 scopus 로고    scopus 로고
    • MiR-34a/c-Dependent PDGFR-alpha/beta downregulation inhibits tumorigenesis and enhances TRAIL-induced apoptosis in lung cancer
    • Garofalo M, Jeon YJ, Nuovo GJ, et al. MiR-34a/c-Dependent PDGFR-alpha/beta downregulation inhibits tumorigenesis and enhances TRAIL-induced apoptosis in lung cancer. PLoS One 2013;8:e67581
    • (2013) PLoS One , vol.8 , pp. e67581
    • Garofalo, M.1    Jeon, Y.J.2    Nuovo, G.J.3
  • 103
    • 84868254278 scopus 로고    scopus 로고
    • MIRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma
    • Kasinski AL, Slack FJ. miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res 2012;72: 5576-87
    • (2012) Cancer Res , vol.72 , pp. 5576-5587
    • Kasinski, A.L.1    Slack, F.J.2
  • 104
    • 67650422613 scopus 로고    scopus 로고
    • MIR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer
    • Bandi N, Zbinden S, Gugger M, et al. miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res 2009;69:5553-9
    • (2009) Cancer Res , vol.69 , pp. 5553-5559
    • Bandi, N.1    Zbinden, S.2    Gugger, M.3
  • 105
    • 79955913660 scopus 로고    scopus 로고
    • MIR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner
    • Bandi N, Vassella E. miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. Mol Cancer 2011;10:55
    • (2011) Mol Cancer , vol.10 , pp. 55
    • Bandi, N.1    Vassella, E.2
  • 106
    • 77957280345 scopus 로고    scopus 로고
    • Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer
    • Ceppi P, Mudduluru G, Kumarswamy R, et al. Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res 2010;8:1207-16
    • (2010) Mol Cancer Res , vol.8 , pp. 1207-1216
    • Ceppi, P.1    Mudduluru, G.2    Kumarswamy, R.3
  • 107
    • 84902152865 scopus 로고    scopus 로고
    • ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism
    • Yang Y, Ahn YH, Chen Y, et al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest 2014;124:2696-708
    • (2014) J Clin Invest , vol.124 , pp. 2696-2708
    • Yang, Y.1    Ahn, Y.H.2    Chen, Y.3
  • 108
    • 77955270730 scopus 로고    scopus 로고
    • Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells
    • Takeyama Y, Sato M, Horio M, et al. Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Cancer Lett 2010;296:216-24
    • (2010) Cancer Lett , vol.296 , pp. 216-224
    • Takeyama, Y.1    Sato, M.2    Horio, M.3
  • 109
    • 70349142665 scopus 로고    scopus 로고
    • Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
    • Gibbons DL, Lin W, Creighton CJ, et al. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev 2009;23:2140-51
    • (2009) Genes Dev , vol.23 , pp. 2140-2151
    • Gibbons, D.L.1    Lin, W.2    Creighton, C.J.3
  • 110
    • 84879661245 scopus 로고    scopus 로고
    • The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells
    • Pacurari M, Addison JB, Bondalapati N, et al. The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells. Int J Oncol 2013;43:548-60
    • (2013) Int J Oncol , vol.43 , pp. 548-560
    • Pacurari, M.1    Addison, J.B.2    Bondalapati, N.3
  • 111
    • 84903879534 scopus 로고    scopus 로고
    • MIR-141 and miR-200c as markers of overall survival in early stage non-small cell lung cancer adenocarcinoma
    • Tejero R, Navarro A, Campayo M, et al. miR-141 and miR-200c as markers of overall survival in early stage non-small cell lung cancer adenocarcinoma. PLoS One 2014;9:e101899
    • (2014) PLoS One , vol.9 , pp. e101899
    • Tejero, R.1    Navarro, A.2    Campayo, M.3
  • 112
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 2007;104:15805-10
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3
  • 113
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell 2005;120: 635-47
    • (2005) Cell , vol.120 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 114
    • 34247565615 scopus 로고    scopus 로고
    • The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
    • Lee YS, Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev 2007;21: 1025-30
    • (2007) Genes Dev , vol.21 , pp. 1025-1030
    • Lee, Y.S.1    Dutta, A.2
  • 115
    • 35449003175 scopus 로고    scopus 로고
    • MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells
    • Sampson VB, Rong NH, Han J, et al. MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res 2007;67: 9762-70
    • (2007) Cancer Res , vol.67 , pp. 9762-9770
    • Sampson, V.B.1    Rong, N.H.2    Han, J.3
  • 116
    • 55549127406 scopus 로고    scopus 로고
    • Let-7 regulates Dicer expression and constitutes a negative feedback loop
    • Tokumaru S, Suzuki M, Yamada H, et al. let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis 2008;29:2073-7
    • (2008) Carcinogenesis , vol.29 , pp. 2073-2077
    • Tokumaru, S.1    Suzuki, M.2    Yamada, H.3
  • 117
    • 34548012848 scopus 로고    scopus 로고
    • The let-7 microRNA represses cell proliferation pathways in human cells
    • Johnson CD, Esquela-Kerscher A, Stefani G, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 2007;67:7713-22
    • (2007) Cancer Res , vol.67 , pp. 7713-7722
    • Johnson, C.D.1    Esquela-Kerscher, A.2    Stefani, G.3
  • 118
    • 84899558701 scopus 로고    scopus 로고
    • Identification of a tumor-suppressive human-specific microRNA within the FHIT tumor-suppressor gene
    • Hu B, Ying X, Wang J, et al. Identification of a tumor-suppressive human-specific microRNA within the FHIT tumor-suppressor gene. Cancer Res 2014;74:2283-94
    • (2014) Cancer Res , vol.74 , pp. 2283-2294
    • Hu, B.1    Ying, X.2    Wang, J.3
  • 119
    • 84896702937 scopus 로고    scopus 로고
    • Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer
    • Wang J, Tian X, Han R, et al. Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. Oncogene 2014;33(9):1181-9
    • (2014) Oncogene , vol.33 , Issue.9 , pp. 1181-1189
    • Wang, J.1    Tian, X.2    Han, R.3
  • 120
    • 84883826854 scopus 로고    scopus 로고
    • Insulin growth factor signaling is regulated by microRNA-486 an underexpressed microRNA in lung cancer
    • Peng Y, Dai Y, Hitchcock C, et al. Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer. Proc Natl Acad Sci USA 2013;110(37):15043-8
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.37 , pp. 15043-15048
    • Peng, Y.1    Dai, Y.2    Hitchcock, C.3
  • 121
    • 84934987915 scopus 로고    scopus 로고
    • Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer
    • Pang W, Tian X, Bai F, et al. Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer. Mol Cancer 2014;13:240
    • (2014) Mol Cancer , vol.13 , pp. 240
    • Pang, W.1    Tian, X.2    Bai, F.3
  • 122
    • 84861878901 scopus 로고    scopus 로고
    • MIR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A
    • Zhu X, Li H, Long L, et al. miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A. Acta Biochim Biophys Sin (Shanghai) 2012;44:519-26
    • (2012) Acta Biochim Biophys Sin (Shanghai) , vol.44 , pp. 519-526
    • Zhu, X.1    Li, H.2    Long, L.3
  • 123
    • 79954432422 scopus 로고    scopus 로고
    • MIR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5
    • Miko E, Margitai Z, Czimmerer Z, et al. miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5. FEBS Lett 2011;585:1191-6
    • (2011) FEBS Lett , vol.585 , pp. 1191-1196
    • Miko, E.1    Margitai, Z.2    Czimmerer, Z.3
  • 124
    • 73949116135 scopus 로고    scopus 로고
    • MIR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7
    • Sun Y, Bai Y, Zhang F, et al. miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7. Biochem Biophys Res Commun 2010;391: 1483-9
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1483-1489
    • Sun, Y.1    Bai, Y.2    Zhang, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.