Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Pang, Wenshuai ^a   Tian, Xin ^a   Bai, Fan ^a   Han, Ruiyu ^a   Wang, Juan ^a   Shen, Haitao ^a   Zhang, Xianghong ^a   Liu, Yueping ^a   Yan, Xia ^a   Jiang, Feng ^b   Xing, Lingxiao ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; GEFITINIB; INITIATION FACTOR 4E; MESSENGER RNA; MICRORNA; MICRORNA 486 5P; PROTEIN KINASE PIM 1; UNCLASSIFIED DRUG; MIRN486 MICRORNA, HUMAN; QUINAZOLINE DERIVATIVE;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADULT; ARTICLE; CANCER STAGING; CELL CYCLE PROGRESSION; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUCIFERASE ASSAY; LUNG CARCINOGENESIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN TARGETING; UPREGULATION; AGED; CELL CYCLE; CELL MOTION; CELL PROLIFERATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; TUMOR CELL LINE;

EUKARYOTA;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CISPLATIN; EUKARYOTIC INITIATION FACTOR-4E; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LUNG NEOPLASMS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM STAGING; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-PIM-1; QUINAZOLINES; TRANSCRIPTION, GENETIC;

EID: 84934987915     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-240     Document Type: Article

References (34)

1. Breuer M, Wientjens E, Verbeek S, Slebos R, Berns A: Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras. Cancer Res 1991, 51:958-963.
2. Van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Radaszkiewicz T, Berns A: Predisposition to lymphomagenesis in pim-1 transgenicmice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell 1, 56:673-682. 10.1016/0092-8674(89)90589-8
3. Nawijn MC, Alendar A, Berns A: For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer 1, 11:23-34. 10.1038/nrc2986
4. Amson R, Sigaux F, Przedborski S, Flandrin G, Givol D, Telerman A: The human protooncogene product p33pim is expressed during fetalhematopoiesisand in diverse leukemias. Proc Natl Acad Sci U S A 1, 86:8857-8861. 10.1073/pnas.86.22.8857
5. Dhanasekaran SM, Barrette TR, Ghosh D, Shah R, Varambally S, Kurachi K, Pienta KJ, Rubin MA, Chinnaiyan AM: Delineation of prognostic biomarkers in prostate cancer. Nature 1, 412:822-826. 10.1038/35090585
6. Peltola K, Hollmen M, Maula SM, Rainio E, Ristamäki R, Luukkaa M, Sandholm J, Sundvall M, Elenius K, Koskinen PJ, Grenman R, Jalkanen S: pim-1 Kinase expression predicts radiation response in squamocellularcarcinoma of head and neck and is under the control of epidermal growth factor receptor. Neoplasia 2009, 11:629-636.
7. Weirauch U, Beckmann N, Thomas M, Grünweller A, Huber K, Bracher F, Hartmann RK, Aigner A: Functional role and therapeutic potential of the Pim-1 kinase in colon carcinoma. Neoplasia 2013, 15:783-794.
8. Xu D, Allsop SA, Witherspoon SM, Snider JL, Yeh JJ, Fiordalisi JJ, White CD, Williams D, Cox AD, Baines AT: The oncogenic kinase Pim-1 is modulated by K-Rassignaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis 1, 32:488-495. 10.1093/carcin/bgr007
9. Zemskova M, Sahakian E, Bashkirova S, Lilly M: The pIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells. J Biol Chem 1, 283:20635-20644. 10.1074/jbc.M709479200
10. Hu XF, Li J, Vandervalk S, Wang Z, Magnuson NS, Xing PX: PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis. J Clin Invest 2009, 119:362-375.
11. Cen B, Mahajan S, Wang W, Kraft AS: Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1. Cancer Res 1, 73:3402-3411. 10.1158/0008-5472.CAN-12-4619
12. Siu A, Virtanen C, Jongstra J: PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells. Oncotarget 2011, 2:1134-1144.
13. Warnecke-Eberz U, Bollschweiler E, Drebber U, Pohl A, Baldus SE, Hoelscher AH, Metzger R: Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases. Oncol Rep 2008, 20:619-624.
14. Nasser MW, Datta J, Nuovo G, Kutay H, Motiwala T, Majumder S, Wang B, Suster S, Jacob ST, Ghoshal K: Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem 1, 283:33394-33405. 10.1074/jbc.M804788200
15. Jin Y, Tong DY, Chen JN, Feng ZY, Yang JY, Shao CK, Li JP: Overexpression of osteopontin, avb3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer. PLoS One 1, 7:e48575. 10.1371/journal.pone.0048575
16. Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell 1, 136:215-233. 10.1016/j.cell.2009.01.002
17. Eiring AM, Harb JG, Neviani P, Garton C, Oaks JJ, Spizzo R, Liu S, Schwind S, Santhanam R, Hickey CJ, Becker H, Chandler JC, Andino R, Cortes J, Hokland P, Huettner CS, Bhatia R, Roy DC, Liebhaber SA, Caligiuri MA, Marcucci G, Garzon R, Croce CM, Calin GA, Perrotti D: miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 1, 140:652-665. 10.1016/j.cell.2010.01.007
18. Thomas M, Lange-Grünweller K, Weirauch U, Gutsch D, Aigner A, Grünweller A, Hartmann RK: The proto-oncogene Pim-1 is a target of miR-33a. Oncogene 1, 31:918-928. 10.1038/onc.2011.278
19. Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ: Hypoxiainducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 1, 35:856-867. 10.1016/j.molcel.2009.09.006
20. Yu L, Todd NW, Xing L, Xie Y, Zhang H, Liu Z, Fang H, Zhang J, Katz RL, Jiang F: Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int J Cancer 1, 127:2870-2878. 10.1002/ijc.25289
21. Xing L, Todd NW, Yu L, Fang H, Jiang F: Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers. Mod Pathol 1, 23:1157-1164. 10.1038/modpathol.2010.111
22. Shen J, Todd NW, Zhang H, Yu L, Lingxiao X, Mei Y, Guarnera M, Liao J, Chou A, Lu CL, Jiang Z, Fang H, Katz RL, Jiang F: Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. Lab Invest 1, 91:579-587. 10.1038/labinvest.2010.194
23. Wang J, Tian X, Han R, Zhang X, Wang X, Shen H, Xue L, Liu Y, Yan X, Shen J, Mannoor K, Deepak J, Donahue JM, Stass SA, Xing L, Jiang F: Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. Oncogene 1, 33:1181-1189. 10.1038/onc.2013.42
24. Graff JR, Zimmer SG: Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs. Clin Exp Metastasis 1, 20:265-273. 10.1023/A:1022943419011
25. De Benedetti A, Graff JR: eIF-4E expression and its role in malignancies and metastases. Oncogene 1, 23:3189-3199. 10.1038/sj.onc.1207545
26. Hoover DS, Wingett DG, Zhang J, Reeves R, Magnuson NS: Pim-1 protein expression is regulated by its 5'-untranslated region and translation initiation factor elF-4E. Cell Growth Differ 1997, 8:1371-1380.
27. Qian KC, Wang L, Hickey ER, Studts J, Barringer K, Peng C, Kronkaitis A, Li J, White A, Mische S, Farmer B: Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. J Biol Chem 1, 280:6130-6137. 10.1074/jbc.M409123200
28. Tan X, Qin W, Zhang L, Hang J, Li B, Zhang C, Wan J, Zhou F, Shao K, Sun Y, Wu J, Zhang X, Qiu B, Li N, Shi S, Feng X, Zhao S, Wang Z, Zhao X, Chen Z, Mitchelson K, Cheng J, Guo Y, He J: A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis. Clin Cancer Res 1, 17:6802-6811. 10.1158/1078-0432.CCR-11-0419
29. Peng Y, Dai Y, Hitchcock C, Yang X, Kassis ES, Liu L, Luo Z, Sun HL, Cui R, Wei H, Kim T, Lee TJ, Jeon YJ, Nuovo GJ, Volinia S, He Q, Yu J, Nana-Sinkam P, Croce CM: Insulin growth factor signaling is regulated by microRNA-1, an underexpressed microRNA in lung cancer. Proc Natl Acad Sci U S A 2013, 110:15043-15048. 10.1073/pnas.1307107110
30. Li Y, Fan S, Koo J, Yue P, Chen ZG, Owonikoko TK, Ramalingam SS, Khuri FR, Sun SY: Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer. Cancer Biol Ther 1, 13:272-280. 10.4161/cbt.18923
31. Batra V, Maris JM, Kang MH, Reynolds CP, Houghton PJ, Alexander D, Kolb EA, Gorlick R, Keir ST, Carol H, Lock R, Billups CA, Smith MA: Initial testing (stage 1) of SGI-1, a PIM1 kinase inhibitor, by the pediatric preclinical testing program. Pediatr Blood Cancer 2012, 59:749-752. 10.1002/pbc.23364
32. Kim W, Youn H, Kwon T, Kang J, Kim E, Son B, Yang HJ, Jung Y, Youn B: PIM1 kinase inhibitors induce radiosensitization in non-small cell lung cancer cells. Pharmacol Res 1, 70:90-101. 10.1016/j.phrs.2013.01.005
33. Patel MR, Jay-Dixon J, Sadiq AA, Jacobson BA, Kratzke RA: Resistance to EGFR-TKI can be mediated through multiple signaling pathways converging upon cap-dependent translation in EGFR-wild type NSCLC. J Thorac Oncol 1, 8:1142-1147. 10.1097/JTO.0b013e31829ce963
34. Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, Tian W, Zhang Q, Wang C, Zhang Q, Zhuang SM, Zheng L, Liang A, Tao W, Cao X: Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 1, 19:232-243. 10.1016/j.ccr.2011.01.001