Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer

Oncogene

Volumn 33, Issue 9, 2014, Pages 1181-1189

  Wang, J ^a   Tian, X ^a   Han, R ^a   Zhang, X ^a   Wang, X ^a   Shen, H ^a   Xue, L ^a   Liu, Y ^a   Yan, X ^a   Shen, J ^b   Mannoor, K ^b   Deepak, J ^b   Donahue, J M ^b   Stass, S A ^b   Xing, L ^a   Jiang, F ^b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

ARHGAP5; lung cancer; miR 486 5p; therapy; tumor suppressor gene

Indexed keywords

MICRORNA; MICRORNA 486 5P; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARHGAP5 GENE; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GROWTH RATE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; UPREGULATION;

MUS;

3' UNTRANSLATED REGIONS; CARCINOGENESIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; DOWN-REGULATION; GTPASE-ACTIVATING PROTEINS; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MICRORNAS; UP-REGULATION;

EID: 84896702937     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.42     Document Type: Article

References (32)

1. Tarver T. Cancer facts & figures 2012. American Cancer Society (ACS). J Consumer Health Internet 2012; 16: 366-367.
2. Ambros V. MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing. Cell 2003; 113: 673-676.
3. Yu L, Todd NW, Xing L, Xie Y, Zhang H, Liu Z et al. Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int J Cancer 2010; 127: 2870-2878.
4. Xing L, Todd NW, Yu L, Fang H, Jiang F. Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers. Mod Pathol 2010; 23: 1157-1164.
5. Shen J, Liu Z, Todd NW, Zhang H, Liao J, Yu L et al. Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers. BMC Cancer 2011; 11: 374.
6. Xiao C, Rajewsky K. MicroRNA control in the immune system: Basic principles. Cell 2009; 136: 26-36.
7. Saito Y, Jones PA. Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle 2006; 5: 2220-2222.
8. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435: 834-838.
9. Kent OA, Mendell JT. A small piece in the cancer puzzle: MicroRNAs as tumor suppressors and oncogenes. Oncogene 2006; 25: 6188-6196.
10. Jenkins DE, Oei Y, Hornig YS, Yu SF, Dusich J, Purchio T et al. Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis. Clin Exp Metastasis 2003; 20: 733-744.
11. Chakravarty G, Hadsell D, Buitrago W, Settleman J, Rosen JM. p190-B RhoGAP regulates mammary ductal morphogenesis. Mol Endocrinol 2003; 17: 1054-1065.
12. Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M et al. A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells. Cancer Lett 2009; 275: 27-34.
13. Tan X, Qin W, Zhang L, Hang J, Li B, Zhang C et al. A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis. Clin Cancer Res 2011; 17: 6802-6811.
14. Bansal A, Lee IH, Hong X, Anand V, Mathur SC, Gaddam S et al. Feasibility of mcroRNAs as biomarkers for Barrett's Esophagus progression: A pilot cross-sectional, phase 2 biomarker study. Am J Gastroenterol 2011; 106: 1055-1063.
15. Ragusa M, Majorana A, Statello L, Maugeri M, Salito L, Barbagallo D et al. Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment. Mol Cancer Ther 2010; 9: 3396-3409.
16. Oh HK, Tan AL, Das K, Ooi CH, Deng NT, Tan IB et al. Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer. Clin Cancer Res 2011; 17: 2657-2667.
17. Midorikawa Y, Yamamoto S, Tsuji S, Kamimura N, Ishikawa S, Igarashi H et al. Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis. Hepatology 2009; 49: 513-522.
18. Jiang F, Yin Z, Caraway NP, Li R, Katz RL. Genomic profiles in stage I primary non small cell lung cancer using comparative genomic hybridization analysis of cDNA microarrays. Neoplasia 2004; 6: 623-635.
19. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005; 433: 769-773.
20. Small EM, O'Rourke JR, Moresi V, Sutherland LB, McAnally J, Gerard RD et al. Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486. Proc Natl Acad Sci USA 2010; 107: 4218-4223.
21. Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y et al. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association. Cell 1999; 99: 323-334.
22. Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res 1997; 57: 5221-5225.
23. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15: 356-362.
24. Heckman-Stoddard BM, Vargo-Gogola T, McHenry PR, Jiang V, Herrick MP, Hilsenbeck SG et al. Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. Breast Cancer Res 2009; 11: R61.
25. Sordella R, Classon M, Hu KQ, Matheson SF, Brouns MR, Fine B et al. Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Dev Cell 2002; 2: 553-565.
26. McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM, Rybarczyk M et al. P190B RhoGAP has pro-Tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Res 2010; 12: R73.
27. Nakahara H, Mueller SC, Nomizu M, Yamada Y, Yeh Y, Chen WT. Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia. J Biol Chem 1998; 273: 9-12.
28. Gao SM, Xing CY, Chen CQ, Lin SS, Dong PH, Yu FJ. miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level. J Exp Clin Cancer Res 2011; 30: 110.
29. Fan T, Li R, Todd NW, Qiu Q, Fang HB, Wang H et al. Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target. Cancer Res 2007; 67: 7901-7906.
30. Mei YP, Liao JP, Shen J, Yu L, Liu BL, Liu L et al. Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis. Oncogene 2012; 31: 2794-2804.
31. Wang H, Zhang Z, Li R, Ang KK, Zhang H, Caraway NP et al. Overexpression of S100A2 protein as a prognostic marker for patients with stage I non small cell lung cancer. Int J Cancer 2005; 116: 285-290.
32. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.