The american geriatrics society/national institute on aging bedside-to-bench conference: Research agenda on delirium in older adults

Journal of the American Geriatrics Society

Volumn 63, Issue 5, 2015, Pages 843-852

  Mikhailovich, A ^a  

^a American Geriatrics Society   (United States)

Author keywords

cognition; delirium; Geriatric syndromes; interventions; measurement; pathophysiology

Indexed keywords

BIOLOGICAL MARKER;

ARTICLE; BRAIN MICROCIRCULATION; COGNITION; DELIRIUM; DEMENTIA; GERIATRIC DISORDER; GERIATRICS; HUMAN; IMMUNOLOGY; INTERVENTION STUDY; LENGTH OF STAY; MICTURITION DISORDER; NATIONAL HEALTH ORGANIZATION; NONHUMAN; PATHOPHYSIOLOGY; PHENOMENOLOGY; PHYSIOLOGY; PSYCHOPHYSIOLOGY; QUALITY CONTROL; SLEEP DISORDER; STRESS; URINE INCONTINENCE; AGED; COMPLICATION; FORECASTING; MEDICAL RESEARCH; MEDICAL SOCIETY; TRENDS; UNITED STATES;

AGED; BIOMEDICAL RESEARCH; DELIRIUM; DEMENTIA; FORECASTING; GERIATRICS; HUMANS; NATIONAL INSTITUTE ON AGING (U.S.); SOCIETIES, MEDICAL; UNITED STATES;

EID: 84929656156     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.13406     Document Type: Article

References (100)

1. Diagnostic and Statistical Manual of Mental Disorders, 5th Ed. New York: American Psychiatric Association Publishing, 2013.
2. Inouye SK, van Dyck CH, Alessi CA, et al., Clarifying confusion: The Confusion Assessment Method. A new method for detection of delirium. Ann Intern Med 1990; 113: 941-948.
3. Han JH, Wilson A, Vasilevskis EE, et al., Diagnosing delirium in older emergency department patients: Validity and reliability of the Delirium Triage Screen and the brief Confusion Assessment Method. Ann Emerg Med 2013; 62: 457-465.
4. Smith HA, Boyd J, Fuchs DC, et al., Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med 2011; 39: 150-157.
5. Guenther U, Popp J, Koecher L, et al., Validity and reliability of the CAM-ICU Flowsheet to diagnose delirium in surgical ICU patients. J Crit Care 2010; 25: 144-151.
6. Silverstein JH, Deiner SG,. Perioperative delirium and its relationship to dementia. Prog Neuropsychopharmacol Biol Psychiatry 2012; 43C: 108-115.
7. Inouye SK, Studenski S, Tinetti ME, et al., Geriatric syndromes: Clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 2007; 55: 780-791.
8. VazFragoso CA, Gill TM,. Sleep complaints in community-living older persons: A multifactorial geriatric syndrome. J Am Geriatr Soc 2007; 55: 1853-1866.
9. Bellapart J, Boots R,. Potential use of melatonin in sleep and delirium in the critically ill. Br J Anaesth 2012; 108: 572-580.
10. Watson PL, Ceriana P, Fanfulla F,. Delirium: Is sleep important? Best Pract Res Clin Anaesthesiol 2012; 26: 355-366.
11. Inouye SK,. Delirium in older persons. N Engl J Med 2006; 354: 1157-1165.
12. Flink BJ, Rivelli SK, Cox EA, et al., Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly. Anesthesiology 2012; 116: 788-796.
13. Zaubler TS, Murphy K, Rizzuto L, et al., Quality improvement and cost savings with multicomponent delirium interventions: Replication of the Hospital Elder Life Program in a community hospital. Psychosomatics 2013; 54: 219-226.
14. Inouye SK, Bogardus ST Jr, Baker DI, et al., The Hospital Elder Life Program: A model of care to prevent cognitive and functional decline in older hospitalized patients. Hospital Elder Life Program. J Am Geriatr Soc 2000; 48: 1697-1706.
15. Kamdar BB, King LM, Collop NA, et al., The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med 2013; 41: 800-809.
16. Tadic SD, Tannenbaum C, Resnick NM, et al., Brain responses to bladder filling in older women without urgency incontinence. Neurourol Urodyn 2013; 32: 435-440.
17. Kuchel GA, Moscufo N, Guttmann CR, et al., Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2009; 64A: 902-909.
18. Wagg A, Gibson W, Ostaszkiewicz J, et al., Urinary incontinence in frail elderly persons: Report from the 5th International Consultation on Incontinence. Neurourol Urodyn 2014; doi: 10.1002/nau.22602.
19. Waardenburg IE,. Delirium caused by urinary retention in elderly people: A case report and literature review on the "cystocerebral syndrome." J Am Geriatr Soc 2008; 56: 2371-2372.
20. American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc 2012; 2012: 616-631.
21. Paquette A, Gou P, Tannenbaum C,. Systematic review and meta-analysis: Do clinical trials testing antimuscarinic agents for overactive bladder adequately measure central nervous system adverse events? J Am Geriatr Soc 2011; 59: 1332-1339.
22. Quinlan N, Marcantonio ER, Inouye SK, et al., Vulnerability: The crossroads of frailty and delirium. J Am Geriatr Soc 2011; 59: S262-S268.
23. Leung JM, Tsai TL, Sands LP,. Brief report: Preoperative frailty in older surgical patients is associated with early postoperative delirium. Anesth Analg 2011; 112: 1199-1201.
24. Pol RA, van Leeuwen BL, Visser L, et al., Standardised frailty indicator as predictor for postoperative delirium after vascular surgery: A prospective cohort study. Eur J Vasc Endovasc Surg 2011; 42: 824-830.
25. Saczynski JS, Marcantonio ER, Quach L, et al., Cognitive trajectories after postoperative delirium. N Engl J Med 2012; 367: 30-39.
26. McCusker J, Cole M, Dendukuri N, et al., Delirium in older medical inpatients and subsequent cognitive and functional status: A prospective study. Can Med Assoc J 2001; 165: 575-583.
27. Pandharipande PP, Girard TD, Ely EW,. Long-term cognitive impairment after critical illness. N Engl J Med 2014; 370: 185-186.
28. Marcantonio ER, Flacker JM, Michaels M, et al., Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc 2000; 48: 618-624.
29. Kiely DK, Jones RN, Bergmann MA, et al., Association between delirium resolution and functional recovery among newly admitted postacute facility patients. J Gerontol A Biol Sci Med Sci 2006; 61A: 204-208.
30. Rudolph JL, Inouye SK, Jones RN, et al., Delirium: An independent predictor of functional decline after cardiac surgery. J Am Geriatr Soc 2010; 58: 643-649.
31. Ely EW, Shintani A, Truman B, et al., Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291: 1753-1762.
32. Robinson TN, Raeburn CD, Tran ZV, et al., Motor subtypes of postoperative delirium in older adults. Arch Surg 2011; 146: 295-300.
33. Walston J, Hadley EC, Ferrucci L, et al., Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006; 54: 991-1001.
34. Walston J, Fedarko N, Yang H, et al., The physical and biological characterization of a frail mouse model. J Gerontol A Biol Sci Med Sci 2008; 63A: 391-398.
35. Maldonado JR,. Neuropathogenesis of delirium: Review of current etiologic theories and common pathways. Am J Geriatr Psychiatry 2013; 21: 1190-1222.
36. Taffet G,. Homeostenosis [on-line]. Available at http://www.ouhsc.edu/geriatricmedicine/Education/Homeostenosis/Homeostenosis.htm Accessed June 26, 2010.
37. Konsman JP, Parnet P, Dantzer R,. Cytokine-induced sickness behaviour: Mechanisms and implications. Trends Neurosci 2002; 25: 154-159.
38. Cunningham C, Maclullich AM,. At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response. Brain Behav Immun 2013; 28: 1-13.
39. van den Boogaard M, Kox M, Quinn KL, et al., Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients. Crit Care 2011; 15: R297.
40. van Munster BC, Korse CM, de Rooij SE, et al., Markers of cerebral damage during delirium in elderly patients with hip fracture. BMC Neurol 2009; 9: 21. doi: 10.1186/1471-2377-9-21.
41. Hughes CG, Morandi A, Girard TD, et al., Association between endothelial dysfunction and acute brain dysfunction during critical illness. Anesthesiology 2013; 118: 631-639.
42. vanGool WA, van de Beek D, Eikelenboom P,. Systemic infection and delirium: When cytokines and acetylcholine collide. Lancet 2010; 375: 773-775.
43. Field RH, Gossen A, Cunningham C,. Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: Reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci 2012; 32: 6288-6294.
44. Dugan LL, Ali SS, Shekhtman G, et al., IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase. PLoS ONE 2009; 4: e5518.
45. Westhoff D, Witlox J, Koenderman L, et al., Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients. J Neuroinflammation 2013; 10: 122.
46. Griffin EW, Skelly DT, Murray CL, et al., Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction. J Neurosci 2013; 33: 15248-15258.
47. Pandharipande P, Shintani A, Peterson J, et al., Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006; 104: 21-26.
48. Stewart DE, Yuen T,. A systematic review of resilience in the physically ill. Psychosomatics 2011; 52: 199-209.
49. Jones RN, Fong TG, Metzger E, et al., Aging, brain disease, and reserve: Implications for delirium. Am J Geriatr Psychiatry 2010; 18: 117-127.
50. Barnett JH, Salmond CH, Jones PB, et al., Cognitive reserve in neuropsychiatry. Psychol Med 2006; 36: 1053-1064.
51. Jeste DV, Savla GN, Thompson WK, et al., Association between older age and more successful aging: Critical role of resilience and depression. Am J Psychiatry 2013; 170: 188-196.
52. Murray C, Sanderson DJ, Barkus C, et al., Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging 2012; 33: 603-616.
53. Cunningham C, Wilcockson DC, Campion S, et al., Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci 2005; 25: 9275-9284.
54. Strimbu K, Tavel JA,. What are biomarkers? Curr Opin HIV AIDS 2010; 5: 463-466.
55. Xie Z, McAuliffe S, Swain CA, et al., Cerebrospinal fluid aβ to tau ratio and postoperative cognitive change. Ann Surg 2013; 258: 364-369.
56. Alexander SA, Ren D, Gunn SR, et al., Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. Am J Crit Care 2014; 23: 49-57.
57. Ely EW, Girard TD, Shintani AK, et al., Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med 2007; 35: 112-117.
58. Leung JM, Sands LP, Wang Y, et al., Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology 2007; 107: 406-411.
59. Adamis D, Van Munster BC, Macdonald AJ,. The genetics of deliria. Int Rev Psychiatry 2009; 21: 20-29.
60. Brown EN, Purdon PL,. The aging brain and anesthesia. Curr Opin Anaesthesiol 2013; 26: 414-419.
61. Morandi A, McCurley J, Vasilevskis EE, et al., Tools to detect delirium superimposed on dementia: A systematic review. J Am Geriatr Soc 2012; 60: 2005-2013.
62. Alsop DC, Fearing MA, Johnson K, et al., The role of neuroimaging in elucidating delirium pathophysiology. J Gerontol A Biol Sci Med Sci 2006; 61A: 1287-1293.
63. Gunther ML, Morandi A, Krauskopf E, et al., The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: The VISIONS cohort magnetic resonance imaging study . Crit Care Med 2012; 40: 2022-2032.
64. Sharshar T, Carlier R, Bernard F, et al., Brain lesions in septic shock: A magnetic resonance imaging study. Intensive Care Med 2007; 33: 798-806.
65. Shioiri A, Kurumaji A, Takeuchi T, et al., White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging. Am J Geriatr Psychiatry 2010; 18: 743-753.
66. Hanyu H, Sato T, Hirao K, et al., The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: A longitudinal SPECT study. J Neurol Sci 2010; 290: 96-101.
67. Yokota H, Ogawa S, Kurokawa A, et al., Regional cerebral blood flow in delirium patients. Psychiatry Clin Neurosci 2003; 57: 337-339.
68. Choi SH, Lee H, Chung TS, et al., Neural network functional connectivity during and after an episode of delirium. Am J Psychiatry 2012; 169: 498-507.
69. Jackson JC, Hopkins RO, Miller RR, et al., Acute respiratory distress syndrome, sepsis, and cognitive decline: A review and case study. South Med J 2009; 102: 1150-1157.
70. Morandi A, Rogers BP, Gunther ML, et al., The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: The VISIONS prospective cohort magnetic resonance imaging study . Crit Care Med 2012; 40: 2182-2189.
71. Semmler A, Hermann S, Mormann F, et al., Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. J Neuroinflammation 2008; 5: 38.
72. Inouye SK, Viscoli CM, Horwitz RI, et al., A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Ann Intern Med 1993; 119: 474-481.
73. Inouye SK, Zhang Y, Jones RN, et al., Risk factors for delirium at discharge: Development and validation of a predictive model. Arch Intern Med 2007; 167: 1406-1413.
74. Khan BA, Zawahiri M, Campbell NL, et al., Delirium in hospitalized patients: Implications of current evidence on clinical practice and future avenues for research-a systematic evidence review. J Hosp Med 2012; 7: 580-589.
75. Davis DH, Skelly DT, Murray C, et al., Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium. Am J Geriatr Psychiatry 2014;pii: S1064-7481(14)00230-9. doi: 10.1016/j.jagp.2014.08.005.
76. Witlox J, Slor CJ, Jansen RW, et al., The neuropsychological sequelae of delirium in elderly patients with hip fracture three months after hospital discharge. Int Psychogeriatr 2013; 25: 1521-1531.
77. Davis DH, Muniz Terrera G, Keage H, et al., Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study. Brain 2012; 135: 2809-2816.
78. Gross AL, Jones RN, Habtemariam DA, et al., Delirium and long-term cognitive trajectory among persons with dementia. Arch Intern Med 2012; 172: 1324-1331.
79. Pandharipande PP, Girard TD, Jackson JC, et al., Long-term cognitive impairment after critical illness. N Engl J Med 2013; 369: 1306-1316.
80. Friedman JI, Soleimani L, McGonigle DP, et al., Pharmacological treatments of non-substance-withdrawal delirium: A systematic review of prospective trials. Am J Psychiatry 2014; 171: 151-159.
81. Inouye SK, Marcantonio ER, Metzger ED,. Doing damage in delirium: The hazards of antipsychotic treatment in elderly persons. Lancet Psychiatry 2014; 1: 312-315.
82. Inouye SK, Bogardus ST Jr, Charpentier PA, et al., A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 1999; 340: 669-676.
83. Bergmann MA, Murphy KM, Kiely DK, et al., A model for management of delirious postacute care patients. J Am Geriatr Soc 2005; 53: 1817-1825.
84. Milisen K, Lemiengre J, Braes T, et al., Multicomponent intervention strategies for managing delirium in hospitalized older people: Systematic review. J Adv Nurs 2005; 52: 79-90.
85. Silver JK, Baima J,. Cancer prehabilitation: An opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes. Am J Phys Med Rehabil 2013; 92: 715-727.
86. Young J, Murthy L, Westby M, et al., Diagnosis, prevention, and management of delirium: Summary of NICE guidance. BMJ 2010; 341: c3704.
87. Kolanowski AM, Fick DM, Clare L, et al., Pilot study of a nonpharmacological intervention for delirium superimposed on dementia. Res Gerontol Nurs 2011; 4: 161-167.
88. Davis DH, Kreisel SH, Muniz Terrera G, et al., The epidemiology of delirium: Challenges and opportunities for population studies. Am J Geriatr Psychiatry 2013; 21: 1173-1189.
89. Vasilevskis EE, Han JH, Hughes CG, et al., Epidemiology and risk factors for delirium across hospital settings. Best Pract Res Clin Anaesthesiol 2012; 26: 277-287.
90. Adamis D,. Statistical methods for analysing longitudinal data in delirium studies. Int Rev Psychiatry 2009; 21: 74-85.
91. Al-Qadheeb NS, Balk EM, Fraser GL, et al., Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: A systematic review and meta-analysis. Crit Care Med 2014; 42: 1442-1454.
92. Inouye SK, Kosar CM, Tommet D, et al., The CAM-S: Development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med 2014; 160: 526-533.
93. Yang FM, Jones RN, Inouye SK, et al., Selecting optimal screening items for delirium: An application of item response theory. BMC Med Res Methodol 2013; 13: 8.
94. Marana E, Colicci S, Meo F, et al., Neuroendocrine stress response in gynecological laparoscopy: TIVA with propofol versus sevoflurane anesthesia. J Clin Anesth 2010; 22: 250-255.
95. Cerejeira J, Batista P, Nogueira V, et al., The stress response to surgery and postoperative delirium: Evidence of hypothalamic-pituitary-adrenal axis hyper responsiveness and decreased suppression of the GH/IGF-1 Axis. J Geriatr Psychiatry Neurol 2013; 26: 185-194.
96. Zhang H, Lu Y, Liu M, et al., Strategies for prevention of postoperative delirium: A systematic review and meta-analysis of randomized trials. Crit Care 2013; 17: R47.
97. Maclullich AM, Ferguson KJ, Miller T, et al., Unravelling the pathophysiology of delirium: A focus on the role of aberrant stress responses. J Psychosom Res 2008; 65: 229-238.
98. Shavit Y, Fridel K, Beilin B,. Postoperative pain management and proinflammatory cytokines: Animal and human studies. J Neuroimmune Pharmacol 2006; 1: 443-451.
99. Rasmussen LS, Johnson T, Kuipers HM, et al., Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand 2003; 47: 260-266.
100. Westfall JM, Mold J, Fagnan L,. Practice-based research-"Blue Highways" on the NIH roadmap. JAMA 2007; 297: 403-406.