Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of MicroRNA-92a

Circulation

Volumn 131, Issue 9, 2015, Pages 805-814

  Chen, Zhen ^a   Wen, Liang ^a   Martin, Marcy ^a,d   Hsu, Chien Yi ^f,g   Fang, Longhou ^a,c   Lin, Feng Mao ^h   Lin, Ting Yang ^a   Geary, McKenna J ^k   Geary, Greg G ⁱ   Zhao, Yongli ^j   Johnson, David A ^e   Chen, Jaw Wen ^f,g   Lin, Shing Jong ^f,g   Chien, Shu ^b   Huang, Hsien Da ^h   Miller, Yury I ^a   Huang, Po Hsun ^f,g   Shyy, John Y J ^a,j  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^g NATIONAL YANG MING UNIVERSITY   (Taiwan)

^h NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

ⁱ CALIFORNIA STATE UNIVERSITY   (United States)

^j XI'AN JIAOTONG UNIVERSITY   (China)

^k NONE

more..

Author keywords

Endothelium; Inflammasomes; MicroRNA 92; Oxidative stress; Sterol regulatory element binding protein 2

Indexed keywords

ANGIOTENSIN II; ENDOTHELIAL NITRIC OXIDE SYNTHASE; KRUPPEL LIKE FACTOR 2; KRUPPEL LIKE FACTOR 4; MICRORNA; MICRORNA 92A; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; EUK-134; HYBRID PROTEIN; HYDROGEN PEROXIDE; INFLAMMASOME; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN; MIRN92 MICRORNA, HUMAN; MIRN92 MICRORNA, MOUSE; MIRN92 MICRORNA, ZEBRAFISH; ORGANOMETALLIC COMPOUND; OXIDIZED LOW DENSITY LIPOPROTEIN; SALICYLIC ACID DERIVATIVE; SCAVENGER; ZEBRAFISH PROTEIN;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSACTIVATION; ZEBRA FISH; ANIMAL; BIOSYNTHESIS; BLOOD; CORONARY ARTERY DISEASE; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

AGED; ANGIOTENSIN II; ANIMALS; CORONARY DISEASE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; GENES, REPORTER; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; HYPERCHOLESTEROLEMIA; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPROTEINS, LDL; MALE; MICE; MICE, TRANSGENIC; MICRORNAS; MIDDLE AGED; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; RECOMBINANT FUSION PROTEINS; SALICYLATES; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTIONAL ACTIVATION; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84929514981     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.013675     Document Type: Article

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