Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model

Circulation

Volumn 128, Issue 10, 2013, Pages 1066-1075

  Hinkel, Rabea ^a   Penzkofer, Daniela ^b   Zühlke, Stefanie ^a   Fischer, Ariane ^b   Husada, Wira ^a   Xu, Quan Fu ^b   Baloch, Elisabeth ^a   Van Rooij, Eva ^c   Zeiher, Andreas M ^b,d   Kupatt, Christian ^a   Dimmeler, Stefanie ^b,d  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c MiRagen Therapeutics   (United States)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

apoptosis; infarction; inflammation; ischemia; microRNAs; reperfusion

Indexed keywords

COMPLEMENTARY RNA; LOCKED NUCLEIC ACID; LOCKED NUCLEIC ACID MODIFIED ANTISENSE MIR 92A; MICRORNA; MICRORNA 92A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CAPILLARY DENSITY; CATHETER; CELL DEATH; CELL HYPOXIA; CELL PROTECTION; CELL TRANSPORT; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG MEGADOSE; EXPERIMENTAL MODEL; HEART EJECTION FRACTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HEART PROTECTION; HISTOCHEMISTRY; IN VITRO STUDY; INHIBITION KINETICS; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REOXYGENATION; REPERFUSION INJURY; SWINE;

APOPTOSIS; INFARCTION; INFLAMMATION; ISCHEMIA; MICRORNAS; REPERFUSION;

ANIMALS; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICRORNAS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; OLIGONUCLEOTIDES, ANTISENSE; SWINE;

EID: 84883654580     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.001904     Document Type: Article

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