Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism

PLoS Computational Biology

Volumn 11, Issue 4, 2015, Pages

  Rybakova, Katja N ^a   Bruggeman, Frank J ^a   Tomaszewska, Aleksandra ^b   Moné, Martijn J ^a   Carlberg, Carsten ^b   Westerhoff, Hans V ^a,c,d  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; CHEMICAL ACTIVATION; ORDINARY DIFFERENTIAL EQUATIONS; STOCHASTIC SYSTEMS; TIMING CIRCUITS; TRANSCRIPTION FACTORS;

ACTIVATION CYCLES; CHROMATIN MODIFICATION; COMPLEX ASSEMBLY; EUKARYOTICS; MODELLING FRAMEWORK; ORDINARY DIFFERENTIAL EQUATION MODELS; PROTEIN COMPLEXES; REGULATORY PROTEIN; STOCHASTICS; TRANSCRIPTIONAL ACTIVITY;

TRANSCRIPTION;

MESSENGER RNA; REGULATOR PROTEIN; TRANSCRIPTION FACTOR;

ANALYTIC METHOD; ARTICLE; BINDING KINETICS; CHROMATIN ASSEMBLY AND DISASSEMBLY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CYCLIC RATCHET MECHANISM; EUKARYOTE; GENE CONTROL; MATHEMATICAL MODEL; NONHUMAN; PROMOTER REGION; STATISTICAL MODEL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; BIOLOGICAL MODEL; BIOLOGICAL RHYTHM; COMPUTER SIMULATION; GENETIC TRANSCRIPTION; GENETICS;

EUKARYOTA;

BIOLOGICAL CLOCKS; COMPUTER SIMULATION; MODELS, GENETIC; MODELS, STATISTICAL; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84929494299     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004236     Document Type: Article

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