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Volumn 112, Issue 20, 2015, Pages 6383-6388

Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction

Author keywords

CBP; Ci; Gli; Hedgehog; Sufu

Indexed keywords

CUBITUS INTERRUPTUS PROTEIN; GLIOMA ASSOCIATED ONCOGENE HOMOLOG PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN SUPPRESSOR OF FUSED; UNCLASSIFIED DRUG; CI PROTEIN, DROSOPHILA; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; LUCIFERASE; ONCOPROTEIN; REPRESSOR PROTEIN; SUFU PROTEIN, DROSOPHILA; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR GLI1;

EID: 84929493246     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1421628112     Document Type: Article
Times cited : (54)

References (38)
  • 1
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J, Hui CC (2008) Hedgehog signaling in development and cancer. Dev Cell 15(6): 801-812.
    • (2008) Dev Cell , vol.15 , Issue.6 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 2
    • 84879414522 scopus 로고    scopus 로고
    • The mechanisms of Hedgehog signalling and its roles in development and disease
    • Briscoe J, Thérond PP (2013) The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 14(7):416-429.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , Issue.7 , pp. 416-429
    • Briscoe, J.1    Thérond, P.P.2
  • 3
    • 0026761497 scopus 로고
    • Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster
    • Préat T (1992) Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 132(3):725-736.
    • (1992) Genetics , vol.132 , Issue.3 , pp. 725-736
    • Préat, T.1
  • 4
    • 0032585515 scopus 로고    scopus 로고
    • Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
    • Ohlmeyer JT, Kalderon D (1998) Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396(6713):749-753.
    • (1998) Nature , vol.396 , Issue.6713 , pp. 749-753
    • Ohlmeyer, J.T.1    Kalderon, D.2
  • 5
    • 0033533714 scopus 로고    scopus 로고
    • Mouse Suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1
    • Ding Q, et al. (1999) Mouse Suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol 9(19):1119-1122.
    • (1999) Curr Biol , vol.9 , Issue.19 , pp. 1119-1122
    • Ding, Q.1
  • 6
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
    • Svärd J, et al. (2006) Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 10(2):187-197.
    • (2006) Dev Cell , vol.10 , Issue.2 , pp. 187-197
    • Svärd, J.1
  • 7
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in SUFU predispose to medulloblastoma
    • Taylor MD, et al. (2002) Mutations in SUFU predispose to medulloblastoma. Nat Genet 31(3):306-310.
    • (2002) Nat Genet , vol.31 , Issue.3 , pp. 306-310
    • Taylor, M.D.1
  • 8
    • 84866100107 scopus 로고    scopus 로고
    • Loss of SUFU function in familial multiple meningioma
    • Aavikko M, et al. (2012) Loss of SUFU function in familial multiple meningioma. Am J Hum Genet 91(3):520-526.
    • (2012) Am J Hum Genet , vol.91 , Issue.3 , pp. 520-526
    • Aavikko, M.1
  • 9
    • 0033582908 scopus 로고    scopus 로고
    • Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
    • Méthot N, Basler K (1999) Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96(6):819-831.
    • (1999) Cell , vol.96 , Issue.6 , pp. 819-831
    • Méthot, N.1    Basler, K.2
  • 10
    • 0033194243 scopus 로고    scopus 로고
    • Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of Gli-1
    • Kogerman P, et al. (1999) Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol 1(5):312-319.
    • (1999) Nat Cell Biol , vol.1 , Issue.5 , pp. 312-319
    • Kogerman, P.1
  • 11
    • 0034669178 scopus 로고    scopus 로고
    • Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus
    • Wang G, Amanai K, Wang B, Jiang J (2000) Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus. Genes Dev 14(22):2893-2905.
    • (2000) Genes Dev , vol.14 , Issue.22 , pp. 2893-2905
    • Wang, G.1    Amanai, K.2    Wang, B.3    Jiang, J.4
  • 12
    • 0038813753 scopus 로고    scopus 로고
    • Characterization of the physical interaction of Gli proteins with SUFU proteins
    • Dunaeva M, Michelson P, Kogerman P, Toftgard R (2003) Characterization of the physical interaction of Gli proteins with SUFU proteins. J Biol Chem 278(7):5116-5122.
    • (2003) J Biol Chem , vol.278 , Issue.7 , pp. 5116-5122
    • Dunaeva, M.1    Michelson, P.2    Kogerman, P.3    Toftgard, R.4
  • 13
    • 84896861295 scopus 로고    scopus 로고
    • Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapß2 in Hedgehog signaling
    • Shi Q, Han Y, Jiang J (2014) Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapß2 in Hedgehog signaling. J Cell Sci 127(Pt 5):1092-1103.
    • (2014) J Cell Sci , vol.127 , Issue.5 , pp. 1092-1103
    • Shi, Q.1    Han, Y.2    Jiang, J.3
  • 14
    • 84904117579 scopus 로고    scopus 로고
    • Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization
    • Szczepny A, et al. (2014) Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization. Biochem J 461(3):469-476.
    • (2014) Biochem J , vol.461 , Issue.3 , pp. 469-476
    • Szczepny, A.1
  • 16
    • 77950463564 scopus 로고    scopus 로고
    • The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    • Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 24(7):670-682.
    • (2010) Genes Dev , vol.24 , Issue.7 , pp. 670-682
    • Humke, E.W.1    Dorn, K.V.2    Milenkovic, L.3    Scott, M.P.4    Rohatgi, R.5
  • 17
    • 69249245332 scopus 로고    scopus 로고
    • Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
    • Chen MH, et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev 23(16):1910-1928.
    • (2009) Genes Dev , vol.23 , Issue.16 , pp. 1910-1928
    • Chen, M.H.1
  • 18
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
    • Zhang W, et al. (2005) Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell 8(2):267-278.
    • (2005) Dev Cell , vol.8 , Issue.2 , pp. 267-278
    • Zhang, W.1
  • 19
    • 1942518275 scopus 로고    scopus 로고
    • Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
    • Wang G, Jiang J (2004) Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms. Dev Biol 268(2):493-505.
    • (2004) Dev Biol , vol.268 , Issue.2 , pp. 493-505
    • Wang, G.1    Jiang, J.2
  • 20
    • 31744450041 scopus 로고    scopus 로고
    • Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    • Barnfield PC, Zhang X, Thanabalasingham V, Yoshida M, Hui CC (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73(8):397-405.
    • (2005) Differentiation , vol.73 , Issue.8 , pp. 397-405
    • Barnfield, P.C.1    Zhang, X.2    Thanabalasingham, V.3    Yoshida, M.4    Hui, C.C.5
  • 21
    • 0242624640 scopus 로고    scopus 로고
    • Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis
    • Fouix S, et al. (2003) Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis. Genes Cells 8(11):897-911.
    • (2003) Genes Cells , vol.8 , Issue.11 , pp. 897-911
    • Fouix, S.1
  • 22
    • 0037117611 scopus 로고    scopus 로고
    • Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
    • Cheng SY, Bishop JM (2002) Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc Natl Acad Sci USA 99(8):5442-5447.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.8 , pp. 5442-5447
    • Cheng, S.Y.1    Bishop, J.M.2
  • 23
    • 0032492995 scopus 로고    scopus 로고
    • Suppressor of fused links fused and Cubitus interruptus on the Hedgehog signalling pathway
    • Monnier V, Dussillol F, Alves G, Lamour-Isnard C, Plessis A (1998) Suppressor of fused links fused and Cubitus interruptus on the Hedgehog signalling pathway. Curr Biol 8(10):583-586.
    • (1998) Curr Biol , vol.8 , Issue.10 , pp. 583-586
    • Monnier, V.1    Dussillol, F.2    Alves, G.3    Lamour-Isnard, C.4    Plessis, A.5
  • 24
    • 0033789068 scopus 로고    scopus 로고
    • Suppressor of fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
    • Méthot N, Basler K (2000) Suppressor of fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 127(18):4001-4010.
    • (2000) Development , vol.127 , Issue.18 , pp. 4001-4010
    • Méthot, N.1    Basler, K.2
  • 25
    • 0032728958 scopus 로고    scopus 로고
    • Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
    • Wang G, Wang B, Jiang J (1999) Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev 13(21):2828-2837.
    • (1999) Genes Dev , vol.13 , Issue.21 , pp. 2828-2837
    • Wang, G.1    Wang, B.2    Jiang, J.3
  • 26
    • 84887702556 scopus 로고    scopus 로고
    • Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci
    • Zhang Y, et al. (2013) Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 4:2608.
    • (2013) Nat Commun , vol.4 , pp. 2608
    • Zhang, Y.1
  • 27
    • 84889832303 scopus 로고    scopus 로고
    • Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation
    • Cherry AL, et al. (2013) Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation. Acta Crystallogr D Biol Crystallogr 69(Pt 12):2563-2579.
    • (2013) Acta Crystallogr D Biol Crystallogr , vol.69 , Issue.12 , pp. 2563-2579
    • Cherry, A.L.1
  • 28
    • 33847660443 scopus 로고    scopus 로고
    • An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases
    • Bischof J, Maeda RK, Hediger M, Karch F, Basler K (2007) An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci USA 104(9):3312-3317.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.9 , pp. 3312-3317
    • Bischof, J.1    Maeda, R.K.2    Hediger, M.3    Karch, F.4    Basler, K.5
  • 29
    • 33646893705 scopus 로고    scopus 로고
    • A Hedgehog-induced BTB protein modulates Hedgehog signaling by degrading Ci/Gli transcription factor
    • Zhang Q, et al. (2006) A Hedgehog-induced BTB protein modulates Hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell 10(6):719-729.
    • (2006) Dev Cell , vol.10 , Issue.6 , pp. 719-729
    • Zhang, Q.1
  • 30
    • 0033859849 scopus 로고    scopus 로고
    • Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation
    • Wang QT, Holmgren RA (2000) Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development 127(14):3131-3139.
    • (2000) Development , vol.127 , Issue.14 , pp. 3131-3139
    • Wang, Q.T.1    Holmgren, R.A.2
  • 31
    • 78650751460 scopus 로고    scopus 로고
    • Inhibition of the nuclear import of Cubitus interruptus by Roadkill in the presence of strong Hedgehog signal
    • Seong KH, et al. (2010) Inhibition of the nuclear import of Cubitus interruptus by Roadkill in the presence of strong Hedgehog signal. PLoS ONE 5(12):e15365.
    • (2010) PLoS ONE , vol.5 , Issue.12 , pp. e15365
    • Seong, K.H.1
  • 32
    • 0030901264 scopus 로고    scopus 로고
    • Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling
    • Akimaru H, et al. (1997) Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 386(6626):735-738.
    • (1997) Nature , vol.386 , Issue.6626 , pp. 735-738
    • Akimaru, H.1
  • 33
    • 33645006077 scopus 로고    scopus 로고
    • Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains
    • Croker JA, Ziegenhorn SL, Holmgren RA (2006) Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains. Dev Biol 291(2):368-381.
    • (2006) Dev Biol , vol.291 , Issue.2 , pp. 368-381
    • Croker, J.A.1    Ziegenhorn, S.L.2    Holmgren, R.A.3
  • 34
    • 4544353067 scopus 로고    scopus 로고
    • Suppressor of fused regulates Gli activity through a dual binding mechanism
    • Merchant M, et al. (2004) Suppressor of fused regulates Gli activity through a dual binding mechanism. Mol Cell Biol 24(19):8627-8641.
    • (2004) Mol Cell Biol , vol.24 , Issue.19 , pp. 8627-8641
    • Merchant, M.1
  • 35
    • 0033583035 scopus 로고    scopus 로고
    • Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
    • Dai P, et al. (1999) Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem 274(12):8143-8152.
    • (1999) J Biol Chem , vol.274 , Issue.12 , pp. 8143-8152
    • Dai, P.1
  • 36
    • 33845219533 scopus 로고    scopus 로고
    • Mediator modulates Gli3-dependent Sonic hedgehog signaling
    • Zhou H, Kim S, Ishii S, Boyer TG (2006) Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol Cell Biol 26(23):8667-8682.
    • (2006) Mol Cell Biol , vol.26 , Issue.23 , pp. 8667-8682
    • Zhou, H.1    Kim, S.2    Ishii, S.3    Boyer, T.G.4
  • 37
    • 80054022786 scopus 로고    scopus 로고
    • Gli proteins in development and disease
    • Hui CC, Angers S (2011) Gli proteins in development and disease. Annu Rev Cell Dev Biol 27:513-537.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 513-537
    • Hui, C.C.1    Angers, S.2
  • 38
    • 84910677833 scopus 로고    scopus 로고
    • Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling
    • Lin C, et al. (2014) Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes Dev 28(22):2547-2563.
    • (2014) Genes Dev , vol.28 , Issue.22 , pp. 2547-2563
    • Lin, C.1


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