Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains

Developmental Biology

Volumn 291, Issue 2, 2006, Pages 368-381

  Croker, Jennifer A ^a,b   Ziegenhorn, Suzanne L ^a   Holmgren, Robert A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Cubitus interruptus; Drosophila; Hedgehog; Signal transduction

Indexed keywords

DNA; SERINE; SONIC HEDGEHOG PROTEIN; THYROXINE; TRANSCRIPTION FACTOR GLI1; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CYTOPLASM; DNA MODIFICATION; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EPIDERMIS; GENE ACTIVATION; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE INTERACTION; GENE TARGETING; GENETIC ANALYSIS; IMAGINAL DISC; LARVAL DEVELOPMENT; NONHUMAN; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REPRESSOR GENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALIA; CUBITUS INTERRUPTUS; ERINACEIDAE; VERTEBRATA;

EID: 33645006077     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2005.12.020     Document Type: Article

References (77)

1. J. Alcedo, M. Ayzenzon, T. Von Ohlen, M. Noll, and J.E. Hooper The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal Cell 86 1996 221 232
2. J. Alcedo, Y. Zou, and M. Noll Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system Mol. Cell 6 2000 457 465
3. C. Alexandre, A. Jacinto, and P. Ingham Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins Genes Dev. 10 1996 2003 2013
4. G. Alves, B. Limbourg-Bouchon, H. Tricoire, J. Brissard-Zahraoui, C. Lamour-Isnard, and D. Busson Modulation of Hedgehog target gene expression by the fused serine-threonine kinase in wing imaginal discs Mech. Dev. 78 1998 17 31
5. P. Aza-Blanc, F. Ramirez-Weber, M. Laget, C. Schwartz, and T. Kornberg Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor Cell 89 1997 1043 1053
6. P. Aza-Blanc, H.Y. Lin, A. Ruiz i Altaba, and T.B. Kornberg Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities Development 127 2000 4293 4301
7. S.S. Blair Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila Development 115 1992 21 33
8. A. Brand, and N. Perrimon Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 1993 401 415
9. J. Capdevila, M.P. Estrade, E. Sanchez-Herrero, and I. Guerrero The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development EMBO J. 13 1994 71 82
10. S. Carroll, and J. Whyte The role of the hairy gene during Drosophila morphogenesis: stripes in imaginal discs Genes Dev. 3 1989 905 916
11. C.H. Chen, D.P. von Kessler, W. Park, B. Wang, Y. Ma, and P.A. Beachy Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression Cell 98 1999 305 316
12. Y. Chen, and G. Struhl Dual roles for patched in sequestering and transducing Hedgehog Cell 87 1996 553 563
13. Y. Chen, and G. Struhl In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components on a Hedgehog receptor complex Development 125 1998 4943 4948
14. F.H. Crick, and P.A. Lawrence Compartments and polyclones in insect development Science 189 1975 340 347
15. C. Desplan, J. Theis, and P.H. O'Farrell The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity Nature 318 1985 630 635
16. M. Dominguez, M. Brunner, E. Hafen, and K. Basler Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus Science 272 1996 1621 1625
17. M. Dunaeva, P. Michelson, P. Kogerman, and R. Toftgard Characterization of the physical interaction of Gli proteins with SUFU proteins J. Biol. Chem. 278 2003 5116 5122
18. T. Durfee, O. Draper, J. Zupan, D.S. Conklin, and P.C. Zambryski New tools for protein linkage mapping and general two-hybrid screening Yeast 15 1999 1761 1768
19. S. Eaton, and T. Kornberg Repression of ciD in posterior compartments of Drosophila by engrailed Genes Dev. 4 1990 1068 1077
20. T. Fukumoto, R. Watanabe-Fukunaga, K. Fujisawa, S. Nagata, and R. Fukunaga The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells J. Biol. Chem. 276 2001 38441 38448
21. A. Garcia-Bellido, P. Ripoll, and G. Morata Developmental compartmentalisation of the wing disk of Drosophila Nat. Neuro-Biol. 245 1973 251 253
22. K.G. Golic, and S. Lindquist The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome Cell 59 1989 499 509
23. Y. Grau, and P. Simpson The segment polarity gene costal-2 in Drosophila Dev. Biol. 122 1987 186 200
24. K. Han, and J.L. Manley Functional domains of the Drosophila Engrailed protein EMBO J. 12 1993 2723 2733
25. J. Hepker, Q. Wang, C. Motzny, R. Holmgren, and T. Orenic Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes Development 124 1997 549 558
26. J. Hepker, R.K. Blackman, and R. Holmgren Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer Development 126 1999 3669 3677
27. J.E. Hooper Smoothened translates Hedgehog levels into distinct responses Development 130 2003 3951 3963
28. J.E. Hooper, and M.P. Scott Communicating with Hedgehogs Nat. Rev., Mol. Cell Biol. 6 2005 306 317
29. P.W. Ingham Segment polarity genes and cell patterning within the Drosophila body segment Curr. Opin. Genet. Devel. 1 1991 261 267
30. P.W. Ingham, and A.P. McMahon Hedgehog signaling in animal development: paradigms and principles Genes Dev. 23 2001 3059 3087
31. P.W. Ingham, A.M. Taylor, and Y. Nakano Role of the Drosophila patched gene in positional signalling Nature 353 1991 184 187
32. J. Jia, C. Tong, and J. Jiang Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail Genes Dev. 17 2003 2709 2720
33. K. Kinzler, and B. Vogelstein The GLI gene encodes a nuclear protein which binds specific sequences in the human genome Mol. Cell. Biol. 10 1990 634 642
34. N. Kudo, B. Wolff, T. Sekimoto, E.P. Schreiner, Y. Yoneda, M. Yanagida, S. Horinouchi, and M. Yoshida Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1 Exp. Cell. Res. 242 1998 540 547
35. J.J. Lee, D.P. von Kessler, S. Parks, and P.A. Beachy Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog Cell 71 1992 33 50
36. M.A. Lefers, Q.T. Wang, and R.A. Holmgren Genetic dissection of the Drosophila Cubitus interruptus signaling complex Dev. Biol. 236 2001 411 420
37. L. Lum, C. Zhang, S. Oh, R.K. Mann, D.P. von Kessler, J. Taipale, F. Weis-Garcia, R. Gong, B. Wang, and P.A. Beachy Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 Mol. Cell 12 2003 1261 1274
38. A. Martinez Arias, N.E. Baker, and P.W. Ingham Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo Development 103 1988 157 170
39. M. Merchant, F.F. Vajdos, M. Ultsch, H.R. Maun, U. Wendt, J. Cannon, W. Desmarais, R.A. Lazarus, A.M. de Vos, and F.J. de Sauvage Suppressor of fused regulates Gli activity through a dual binding mechanism Mol. Cell. Biol. 24 2004 8627 8641
40. N. Methot, and K. Basler Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus Cell 96 1999 819 831
41. N. Methot, and K. Basler Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus Development 127 2000 4001 4010
42. J. Mohler, and K. Vani Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila Development 115 1992 957 971
43. V. Monnier, F. Dussillol, G. Alves, C. Lamour-Isnard, and A. Plessis Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway Curr. Biol. 8 1998 583 586
44. V. Monnier, K. Ho, M. Sanial, M. Scott, and A. Plessis Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the Kinesin-related protein Costal2 BMC Dev. Biol. 2 2002 4
45. G. Morata, and P. Lawrence Control of compartment development by the engrailed gene of Drosophila Nature 255 1975 614 617
46. C.K. Motzny, and R. Holmgren The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways Mech. Dev. 52 1995 137 150
47. C. Nusslein-Volhard, E. Wieschaus, and H. Kluding Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster: I. Zygotic loci on the second chromosome Roux's Arch. Dev. Biol. 193 1984 267 282
48. S.K. Ogden, M. Ascano Jr., M.A. Stegman, L.M. Suber, J.E. Hooper, and D.J. Robbins Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2 Curr. Biol. 13 2003 1998 2003
49. T.V. Orenic, D.C. Slusarski, K.L. Kroll, and R.A. Holmgren Cloning and characterization of the segment polarity gene cubitus interruptus dominant of Drosophila Genes Dev. 4 1990 1053 1067
50. R.W. Padgett, R.D. St. Johnston, and W.M. Gelbart A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family Nature 325 1987 81 84
51. N.H. Patel, E. Martin-Blanco, K.G. Coleman, S.J. Poole, M.C. Ellis, T.B. Kornberg, and C.S. Goodman Expression of engrailed proteins in arthropods, annelids, and chordates Cell 58 1989 955 968
52. N.P. Pavletich, and C.O. Pabo Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers Science 261 1993 1701 1707
53. A. Pham, P. Therond, G. Alves, F.B. Tournier, D. Busson, C. Lamour-Isnard, B.C. Bouchon, T. Preat, and H. Tricoire The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment Genetics 140 1995 587 598
54. F. Pignoni, and S.L. Zipursky Induction of Drosophila eye development by decapentaplegic Development 124 1997 271 278
55. T. Preat Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster Genetics 132 1992 725 736
56. D.J. Robbins, K.E. Nybakken, R. Kobayashi, J.C. Sisson, J.M.T. Bishop, and P.P. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal-2 Cell 90 1997 225 234
57. L. Ruel, R. Rodriguez, A. Gallet, L. Lavenant-Staccini, and P.P. Therond Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog Nat. Cell Biol. 5 2003 907 913
58. J.M. Ruppert, B. Vogelstein, K. Arheden, and K. Kinzler GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity Mol. Cell. Biol. 10 1990 5408 5415
59. E. Sanchez-Herrero, J.P. Couso, J. Capdevila, and I. Guerrero The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs Mech. Dev. 55 1996 159 170
60. H. Sasaki, Y. Nishizaki, C. Hui, M. Nakafuku, and H. Kondoh Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling Development 126 1999 3915 3924
61. R.H. Schiestl, and R.D. Gietz High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier Curr. Genet. 16 1989 339 346
62. J.C. Sisson, K.S. Ho, D. Suyama, and M.P. Scott Costal2, a novel kinesin-related protein in the hedgehog signalling pathway Cell 90 1997 236 245
63. D.C. Slusarski, C.K. Motzny, and R. Holmgren Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster Genetics 139 1995 229 240
64. M.A. Stegman, J.A. Goetz, M. Ascano Jr., S.K. Ogden, K.E. Nybakken, and D.J. Robbins The kinesin related protein Costal2 associates with membranes in a hedgehog sensitive, smoothened independent manner J. Biol. Chem. 279 2004 7064 7071
65. T. Tabata, S. Eaton, and T.B. Kornberg The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation Genes Dev. 6 1992 2635 2645
66. A. Tanimura, S. Dan, and M. Yoshida Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome J. Virol. 72 1998 3958 3964
67. M. van den Heuvel, and P.W. Ingham Smoothened encodes a receptor-like serpentine protein required for hedgehog signaling Nature 382 1996 547 551
68. M. van den Heuvel, R. Nusse, P. Johnston, and P.A. Lawrence Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication Cell 59 1989 739 749
69. J.M. Van der Meer Optical clean and permanent whole mount preparations for phase contrast microscopy of cuticular structures of insect larvae Drosoph. Inf. Serv. 52 1977 160
70. C. von Mering, and K. Basler Distinct and regulated activities of human Gli proteins in Drosophila Curr. Biol. 9 1999 1319 1322
71. Q.T. Wang, and R.A. Holmgren The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels Development 126 1999 5097 5106
72. Q.T. Wang, and R.A. Holmgren Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation Development 127 2000 3131 3139
73. G. Wang, K. Amanai, B. Wang, and J. Jiang Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus Genes Dev. 14 2000 2893 2905
74. T. Xu, and G.M. Rubin Analysis of genetic mosaics in developing and adult Drosophila tissues Development 117 1993 1223 1237
75. D. Zarkower, and J. Hodgkin Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins Cell 70 1992 237 249
76. Y. Zhang, A. Ungar, C. Fresquez, and R. Holmgren Ectopic expression of either the Drosophila gooseberry-distal or proximal gene causes alterations of cell fate in the epidermis and central nervous system Development 120 1994 1151 1161
77. A.J. Zhu, L. Zheng, K. Suyama, and M.P. Scott Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction Genes Dev. 17 2003 1240 1252