Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Journal of Biological Chemistry

Volumn 282, Issue 25, 2007, Pages 18129-18140

  Xia, Yin ^a   Yu, Paul B ^a   Sidis, Yisrael ^a   Beppu, Hideyuki ^a   Bloch, Kenneth D ^a   Schneyer, Alan L ^a   Lin, Herbert Y ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Simches Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEINS (BMP); RECEPTOR EXPRESSION; THREONINE KINASE RECEPTORS;

BONE; GROWTH KINETICS; LIGANDS; MUSCLE; RNA; SIGNAL TRANSDUCTION;

PROTEINS;

ACTIVIN RECEPTOR 2; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR; LIGAND; MEMBRANE PROTEIN; REPULSIVE GUIDANCE MOLECULE PROTEIN A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTERY MUSCLE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; GRANULOSA CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; ISOTOPE LABELING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ACTIVIN RECEPTORS, TYPE II; ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; FEMALE; GRANULOSA CELLS; HUMANS; KINETICS; MEMBRANE PROTEINS; MICE; MUSCLE, SMOOTH; NERVE TISSUE PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 34547124340     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701679200     Document Type: Article

References (33)

1. Derynck, R., and Zhang, Y. E. (2003) Nature 425, 577-584
2. Massagué, J., and Chen, Y. G. (2000) Genes Dev. 14, 627-644
3. Shi, Y., and Massagué, J. (2003) Cell 113, 685-700
4. Aspenberg, P., Jeppsson, C., and Economides, A. N. (2001) J. Bone Miner. Res. 16, 497-500
5. Balemans, W., and Van Hul, W. (2002) Dev. Biol. 250, 231-250
6. Canalis, E., Economides, A. N., and Gazzerro, E. (2003) Endocr. Rev. 24, 218-235
7. Lin, J., Patel, S. R., Cheng, X., Cho, E. A., Levitan, I., Ullenbruch, M., Phan, S. H., Park, J. M., and Dressler, G. R. (2005) Nat. Med. 11, 387-393
8. Brown, C. B., Boyer, A. S., Runyan, R. B., and Barnett, J. V. (1999) Science 283, 2080-2082
9. del Re, E., Babitt, J. L., Pirani, A., Schneyer, A. L., and Lin, H. Y. (2004) J. Biol. Chem. 279, 22765-22772
10. Lewis, K. A., Gray, P. C., Blount, A. L., MacConell, L. A., Wiater, E., Bilezikjian, L. M., and Vale, W. (2000) Nature 404, 411-414
11. Wiater, E., and Vale, W. (2003) J. Biol. Chem. 278, 7934-7941
12. Yeo, C., and Whitman, M. (2001) Mol. Cell 7, 949-957
13. Babbit, J. L., Huang, F. W., Wrighting, D. W., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R., Schneyer, A., Woolf, C. J., Andrews, N. C., and Lin, H. Y. (2006) Nat. Genet. 38, 531-539
14. Babbit, J. L., Zhang, Y., Samad, T. A., Xia, Y., Tang, J., Schneyer, A., Woolf, C. J., and Lin, H. Y. (2005) J. Biol. Chem. 280, 29820-29827
15. Samad, T. A., Rebbapragada, A., Bell, E., Zhang, Y., Sidis, Y., Jeong, S. J., Campagna, J. A., Perusini, S., Fabrizio, D. A., Schneyer, A. L., Lin, H. Y., Brivanlou, A. H., Attisano, L., and Woolf, C. J. (2005) J. Biol. Chem. 280, 14122-14129
16. Monnier, P. P., Sierra, A., Macchi, P., Deitinghoff, L., Andersen, J. S., Mann, M., Flad, M., Hornberger, M. R., Stahl, B., Bonhoeffer, F., and Mueller, B. K. (2002) Nature 419, 392-395
17. Niederkofler, V., Salie, R., Sigrist, M., and Arber, S. (2004) J. Neurosci. 24, 808-818
18. Samad, T. A., Srinivasan, A., Karchewski, L. A., Jeong, S. J., Campagna, J. A., Ji, R. R., Fabrizio, D. A., Zhang, Y., Lin, H. Y., Bell, E., and Woolf, C. J. (2004) J. Neurosci. 24, 2027-2036
19. Schmidtmer, J., and Engelkamp, D. (2004) Gene Expr. Patterns 4, 105-110
20. Rajagopalan, S., Deitinghoff, L., Davis, D., Conrad, S., Skutella, T., Chedotal, A., Mueller, B. K., and Strittmatter, S. M. (2004) Nat. Cell Biol. 6, 756-762
21. Xia, Y., Sidis, Y., Mukherjee, A., Samad, T. A., Brenner, G., Woolf, C. J., Lin, H. Y., and Schneyer, A. (2005) Endocrinology 146, 3614-3621
22. Rodriguez Martinez, A., Niemela, O., and Parkkila, S. (2004) Haematologica 89, 1441-1445
23. Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L., Franchini, P. L., Dubé, M., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., Nemeth, E., Thompson, J., Risler, J. K., Zaborowska, C., Babakaiff, R., Radomski, C. C., Pape, T. D., Davidas, O., Christakis, J., Brissot, P., Lockitch, G., Ganz, T., Hayden, M. R., and Goldberg, Y. P. (2004) Nat. Genet. 36, 77-82
24. Yu, P. B., Beppu, H., Kawai, N., Li, E., and Bloch, K. D. (2005) J. Biol. Chem. 280, 24443-24450
25. Welt, C. K., Lambert-Messerlian, G. M., Zheng, W., Crowley, W. F., Jr., and Schneyer, A. L. (1997) J. Clin. Endocrinol. Metab. 82, 3720-3727
26. Szabo, A., Perou, C. M., Karaca, M., Perreard, L., Quackenbush, J. F., and Bernard, P. S. (2004) Genome Biol. 5, R59
27. Korchynskyi, O., and ten Dijke, P. (2002) J. Biol. Chem. 277, 4883-4891
28. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) EMBO J. 17, 3091-3100
29. Frolik, C. A., Wakefield, L. M., Smith, D. M., and Sporn, M. B. (1984) J. Biol. Chem. 259, 10995-11000
30. Liu, F., Ventura, F., Doody, J., and Massagué, J. (1995) Mol. Cell. Biol. 15, 3479-3486
31. Nohno, T., Ishikawa, T., Saito, T., Hosokawa, K., Noji, S., Wolsing, D. H., and Rosenbaum, J. S. (1995) J. Biol. Chem. 270, 22522-22526
32. Rosenzweig, B. L., Imamura, T., Okadome, T., Cox, G. N., Yamashita, H., ten Dijke, P., Heldin, C. H., and Miyazono, K. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7632-7636
33. Mazerbourg, S., Sangkuhl, K., Luo, C.-W., Sudo, S., Klein, C., and Hsueh, A. J. W. (2005) J. Biol. Chem. 280, 32122-32132