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Volumn , Issue , 2014, Pages 259-289

Aging and remodeling of the ras and raas and related pathways: Implications for heart failure therapy

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EID: 84929383051     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4939-0268-2     Document Type: Chapter
Times cited : (5)

References (268)
  • 1
    • 84862674729 scopus 로고    scopus 로고
    • Prevention of heart failure in the elderly: When, where and how to begin
    • Jugdutt BI. Prevention of heart failure in the elderly: when, where and how to begin. Heart Fail Rev. 2012. 15:531-44.
    • (2012) Heart Fail Rev , vol.15 , pp. 531-544
    • Jugdutt, B.I.1
  • 3
    • 0000253067 scopus 로고    scopus 로고
    • The aging heart: Structure, function, and disease
    • Braunwald E, editor, Philadelphia, PA: Saunders
    • Lakatta EG, Gerstenblith G, Weisfeldt ML. The aging heart: structure, function, and disease. In: Braunwald E, editor. Heart disease. Philadelphia, PA: Saunders. 1997. p. 1687-700.
    • (1997) Heart Disease , pp. 1687-1700
    • Lakatta, E.G.1    Gerstenblith, G.2    Weisfeldt, M.L.3
  • 4
    • 0037422592 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises
    • Aging arteries: a “set up” for vascular disease
    • Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part I. Aging arteries: a “set up” for vascular disease. Circulation. 2003. 107:139-46.
    • (2003) Circulation , vol.107 , pp. 139-146
    • Lakatta, E.G.1    Levy, D.2
  • 5
    • 0037458070 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises
    • Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part II. Circulation. 2003. 107:346-54.
    • (2003) Circulation , vol.107 , pp. 346-354
    • Lakatta, E.G.1
  • 6
    • 42949129182 scopus 로고    scopus 로고
    • Aging and remodeling during healing of the wounded heart: Current therapies and novel drug targets
    • Jugdutt BI. Aging and remodeling during healing of the wounded heart: current therapies and novel drug targets. Curr Drug Targets. 2008. 9:325-44.
    • (2008) Curr Drug Targets , vol.9 , pp. 325-344
    • Jugdutt, B.I.1
  • 7
    • 41149107026 scopus 로고    scopus 로고
    • Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction
    • Bujak M, Kweon HJ, Chatila K, et al. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Col! Cardiol. 2008. 51:1384-92.
    • (2008) J am Col! Cardiol , vol.51 , pp. 1384-1392
    • Bujak, M.1    Kweon, H.J.2    Chatila, K.3
  • 8
    • 41149175634 scopus 로고    scopus 로고
    • Aging and defective healing, adverse remodeling and blunted postconditioning in the reperfused wounded heart
    • Jugdutt BI, Jelani A. Aging and defective healing, adverse remodeling and blunted postconditioning in the reperfused wounded heart. J Am Coll Cardiol. 2008. 51:1399-403.
    • (2008) J am Coll Cardiol , vol.51 , pp. 1399-1403
    • Jugdutt, B.I.1    Jelani, A.2
  • 9
    • 77955175733 scopus 로고    scopus 로고
    • Aging- related early changes in markers of ventricular and matrix remodeling after reperfused st-segment elevation myocardial infarction in the canine model. Effect of early therapy with an angiotensin ii type 1 receptor blocker
    • Jugdutt BI, Jelani A, Palaniyappan A, et al. Aging- related early changes in markers of ventricular and matrix remodeling after reperfused ST-segment elevation myocardial infarction in the canine model. Effect of early therapy with an angiotensin II type 1 receptor blocker. Circulation. 2010. 122:341-51.
    • (2010) Circulation , vol.122 , pp. 341-351
    • Jugdutt, B.I.1    Jelani, A.2    Palaniyappan, A.3
  • 10
    • 77955713353 scopus 로고    scopus 로고
    • Stemi and heart failure in the elderly: Role of adverse remodeling
    • Jelani A, Jugdutt BI. STEMI and heart failure in the elderly: role of adverse remodeling. Heart Fail Rev. 2010. 15:513-21.
    • (2010) Heart Fail Rev , vol.15 , pp. 513-521
    • Jelani, A.1    Jugdutt, B.I.2
  • 11
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2010 update: A report from the american heart association statistics committee and stroke statistics subcommittee
    • Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics - 2010 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2010. 121:e46-215.
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1    Adams, R.J.2    Brown, T.M.3
  • 12
    • 19544381765 scopus 로고    scopus 로고
    • Public health and aging: Trends in aging: United states and worldwide
    • 18 Aug 2011
    • Centers for Disease Control and Prevention. Public health and aging: trends in aging: United States and worldwide. MMRW Morb Mortal Wkly Rep. 2003. 52:101-6. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5206a2.htm. Accessed 18 Aug 2011.
    • (2003) MMRW Morb Mortal Wkly Rep , vol.52 , pp. 101-106
  • 13
    • 84949053804 scopus 로고    scopus 로고
    • Dec
    • World Health Organization (WHO). Definition of an older or elderly person. http://www.who.int/health- info/survey/ageingdefnolder/en/print.html. Accessed 30 Dec 2009.
    • (2009) Definition of an Older Or Elderly Person , vol.30
  • 14
    • 77955718033 scopus 로고    scopus 로고
    • Aging and heart failure: Changing demographics and implications for therapy in the elderly
    • Jugdutt BI. Aging and heart failure: changing demographics and implications for therapy in the elderly. Heart Fail Rev. 2010. 15:401-5.
    • (2010) Heart Fail Rev , vol.15 , pp. 401-405
    • Jugdutt, B.I.1
  • 15
    • 84938048679 scopus 로고
    • When does old age begin? The evolution of the english definition
    • Roebuck J. When does old age begin? The evolution of the English definition. J Soc Hist. 1979. 12:416-28.
    • (1979) J Soc Hist , vol.12 , pp. 416-428
    • Roebuck, J.1
  • 16
    • 0004326980 scopus 로고
    • A history of modern germany - 18401945
    • Holborn, H. A history of modern Germany - 18401945. Princeton University Press. 1969. p. 291-3.
    • (1969) Princeton University Press , pp. 291-293
    • Holborn, H.1
  • 17
    • 77952142435 scopus 로고    scopus 로고
    • Heart failure in the elderly: Advances and challenges
    • Jugdutt BI. Heart failure in the elderly: advances and challenges. Expert Rev Cardiovasc Ther. 2010. 8: 695-715.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , pp. 695-715
    • Jugdutt, B.I.1
  • 18
    • 28744446343 scopus 로고    scopus 로고
    • Acc/aha 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: A report of the american college of cardiology/american heart association task force on practice guidelines (writing committee to update the 2001 guidelines for the evaluation and management of heart failure
    • Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to update the 2001 guidelines for the evaluation and management of heart failure). Circulation. 2005. 112:e154-235.
    • (2005) Circulation , vol.112 , pp. e154-e235
    • Hunt, S.A.1    Abraham, W.T.2    Chin, M.H.3
  • 19
    • 65549154913 scopus 로고    scopus 로고
    • 2009 focused update: Accf/aha guidelines for the diagnosis and management of heart failure in adults: A report of the american college of cardiology foundation/american heart association task force on practice guidelines: Developed in collaboration with the international society for heart and lung transplantation
    • Jessup M, Abraham WT, Casey DE, et al. 2009 focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009. 119:1977-2016.
    • (2009) Circulation , vol.119 , pp. 1977-2016
    • Jessup, M.1    Abraham, W.T.2    Casey, D.E.3
  • 20
    • 0038629347 scopus 로고    scopus 로고
    • On the rise: The current and projected future burden of congestive heart failure hospitalization in canada
    • Johansen H, Strauss B, Arnold MO, Moe G, Liu P. On the rise: the current and projected future burden of congestive heart failure hospitalization in Canada. Can J Cardiol. 2003. 19:430-5.
    • (2003) Can J Cardiol , vol.19 , pp. 430-435
    • Johansen, H.1    Strauss, B.2    Arnold, M.O.3    Moe, G.4    Liu, P.5
  • 21
    • 33644554148 scopus 로고    scopus 로고
    • Canadian cardiovascular society consensus conference recommendations on heart failure 2006: Diagnosis and treatment
    • Arnold MO, Liu P, Demers C, et al. Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosis and treatment. Can J Cardiol. 2006. 22:23-45.
    • (2006) Can J Cardiol , vol.22 , pp. 23-45
    • Arnold, M.O.1    Liu, P.2    Demers, C.3
  • 22
    • 53549085406 scopus 로고    scopus 로고
    • Esc guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the european society of cardiology
    • Dickstein K, Cohen-Solal A, Filippatos G, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Eur J Heart Fail. 2008. 10:933-89.
    • (2008) Eur J Heart Fail , vol.10 , pp. 933-989
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3
  • 23
    • 84864477617 scopus 로고    scopus 로고
    • Esc guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 - the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the european society of cardiology. Developed in collaboration with the heart failure association (hfa) of the esc
    • McMurray J, Adamopoulos S, Anker S, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 - the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2012. 14:803-69.
    • (2012) Eur J Heart Fail , vol.14 , pp. 803-869
    • McMurray, J.1    Adamopoulos, S.2    Anker, S.3
  • 24
    • 79955827214 scopus 로고    scopus 로고
    • Accf/aha 2011 expert consensus document on hypertension in the elderly
    • Aronow WS, Fleg JL, Pepine CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly. J Am Coll Cardiol. 2011. 57:2037-114.
    • (2011) J am Coll Cardiol , vol.57 , pp. 2037-2114
    • Aronow, W.S.1    Fleg, J.L.2    Pepine, C.J.3
  • 26
    • 84902566522 scopus 로고    scopus 로고
    • Aging and markers of adverse remodeling after myocardial infarction
    • Jugdutt BI, Dhalla NS, editors, New York: Springer
    • Jugdutt BI, Jelani A. Aging and markers of adverse remodeling after myocardial infarction. In: Jugdutt BI, Dhalla NS, editors. Cardiac remodeling.Molecular mechanisms. New York: Springer. 2013. p. 487-512.
    • (2013) Cardiac Remodeling , pp. 487-512
    • Jugdutt, B.I.1    Jelani, A.2
  • 27
    • 84948971457 scopus 로고    scopus 로고
    • Aging and remodeling of the renin- angiotensin-system post infarction
    • Kimchi A, editor, Bologna, Italy: Medimond
    • Jugdutt BI. Aging and remodeling of the renin- angiotensin-system post infarction. In: Kimchi A, editor. Proceedings 15th World congress on Heart Disease, Vancouver 2010. Bologna, Italy: Medimond. 2010. p. 87-91.
    • (2010) Proceedings 15Th World Congress on Heart Disease, Vancouver , vol.2010 , pp. 87-91
    • Jugdutt, B.I.1
  • 28
    • 34248646263 scopus 로고    scopus 로고
    • American heart association council on clinical cardiology. Society of geriatric cardiology. Acute coronary care in the elderly, part ii. St-segment- elevation myocardial infarction. A scientific statement for healthcare professionals from the american heart association council for clinical cardiology
    • Alexander KP, Newby LK, Armstrong PW, et al. American Heart Association Council on Clinical Cardiology. Society of Geriatric Cardiology. Acute coronary care in the elderly, Part II. ST-segment- elevation myocardial infarction. A scientific statement for healthcare professionals from the American Heart Association Council for Clinical Cardiology. Circulation. 2007. 115:2570-89.
    • (2007) Circulation , vol.115 , pp. 2570-2589
    • Alexander, K.P.1    Newby, L.K.2    Armstrong, P.W.3
  • 29
    • 33744979327 scopus 로고    scopus 로고
    • Valsartan in the treatment of heart attack survivors
    • Jugdutt BI. Valsartan in the treatment of heart attack survivors. Vasc Health Risk Manag. 2006. 2:125-38.
    • (2006) Vasc Health Risk Manag , vol.2 , pp. 125-138
    • Jugdutt, B.I.1
  • 30
    • 0031765829 scopus 로고    scopus 로고
    • Cardiac senescence is associated with enhanced expression of angiotensin ii receptor subtypes
    • Heymes C, Silvestre JS, Llorens-Cortes C, et al. Cardiac senescence is associated with enhanced expression of angiotensin II receptor subtypes. Endocrinology. 1998. 139:2579-87.
    • (1998) Endocrinology , vol.139 , pp. 2579-2587
    • Heymes, C.1    Silvestre, J.S.2    Llorens-Cortes, C.3
  • 31
    • 67849135106 scopus 로고    scopus 로고
    • Alteration of messenger rna and protein levels of cardiac alpha(1)-adrenergic receptor and angiotensin ii receptor subtypes during aging in rats
    • Cao XJ, Li YF. Alteration of messenger RNA and protein levels of cardiac alpha(1)-adrenergic receptor and angiotensin II receptor subtypes during aging in rats. Can J Cardiol. 2009. 25:415-20.
    • (2009) Can J Cardiol , vol.25 , pp. 415-420
    • Cao, X.J.1    Li, Y.F.2
  • 32
    • 64049115544 scopus 로고    scopus 로고
    • Angiotensin ii, mitochondria, cytoskeletal, and extracellular matrix connections: An integrating viewpoint
    • De Cavanagh EM, Ferder M, Inserra F, Ferder L. Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint. Am J Physiol Heart Circ Physiol. 2009. 296:H550-8.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296 , pp. H550-H558
    • De Cavanagh, E.M.1    Ferder, M.2    Inserra, F.3    Ferder, L.4
  • 33
    • 65349128571 scopus 로고    scopus 로고
    • Disruption of the ang ii type 1 receptor promotes longevity in mice
    • Benigni A, Corna D, Zoja C, et al. Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest. 2009. 119:524-30.
    • (2009) J Clin Invest , vol.119 , pp. 524-530
    • Benigni, A.1    Corna, D.2    Zoja, C.3
  • 34
    • 62749132947 scopus 로고    scopus 로고
    • Normal aging of the cardiovascular system
    • Aronow WS, Fleg JL, Rich MW, editors, 4th ed. New York, NY: Informa
    • Fleg JL, Lakatta EG. Normal aging of the cardiovascular system. In: Aronow WS, Fleg JL, Rich MW, editors. Cardiovascular disease in the elderly. 4th ed. New York, NY: Informa. 2008. p. 1-43.
    • (2008) Cardiovascular Disease in the Elderly , pp. 1-43
    • Fleg, J.L.1    Lakatta, E.G.2
  • 35
    • 18244395103 scopus 로고    scopus 로고
    • Outcomes and prognostic factors of systolic as compared with diastolic heart failure in urban america
    • McCullough PA, Khandelwal AK, McKinnon JE, et al. Outcomes and prognostic factors of systolic as compared with diastolic heart failure in urban America. Congest Heart Fail. 2005. 11:6-11.
    • (2005) Congest Heart Fail , vol.11 , pp. 6-11
    • McCullough, P.A.1    Khandelwal, A.K.2    McKinnon, J.E.3
  • 36
    • 40849083824 scopus 로고    scopus 로고
    • Diastolic heart failure in the elderly: Underlying mechanisms and clinical relevance
    • McDonald K. Diastolic heart failure in the elderly: underlying mechanisms and clinical relevance. Int J Cardiol. 2008. 125:197-202.
    • (2008) Int J Cardiol , vol.125 , pp. 197-202
    • McDonald, K.1
  • 37
    • 33748305725 scopus 로고    scopus 로고
    • Extracellular matrix and cardiac remodeling
    • Villarreal FJ, editor, New York, NY: Springer
    • Jugdutt BI. Extracellular matrix and cardiac remodeling. In: Villarreal FJ, editor. Interstitial fibrosis in heart failure. New York, NY: Springer. 2004. p. 23-55.
    • (2004) Interstitial Fibrosis in Heart Failure , pp. 23-55
    • Jugdutt, B.I.1
  • 38
    • 84902566521 scopus 로고    scopus 로고
    • Regulation of fibrosis after myocardial infarction: Implications for ventricular remodeling
    • Jugdutt BI, Dhalla NS, editors, New York, NY: Springer
    • Jugdutt BI. Regulation of fibrosis after myocardial infarction: implications for ventricular remodeling. In: Jugdutt BI, Dhalla NS, editors. Cardiac remodeling. Molecular mechanisms. New York, NY: Springer. 2013. p. 525-45.
    • (2013) Cardiac Remodeling. Molecular Mechanisms , pp. 525-545
    • Jugdutt, B.I.1
  • 39
    • 0001823731 scopus 로고    scopus 로고
    • Angiotensin ii, receptor blockers
    • Crawford MH, editor, Philadelphia, PA: W.B. Saunders
    • Jugdutt BI. Angiotensin II, receptor blockers. In: Crawford MH, editor. Cardiology clinics annual of drug therapy, vol. 2. Philadelphia, PA: W.B. Saunders. 1998. p. 1-17.
    • (1998) Cardiology Clinics Annual of Drug Therapy , vol.2 , pp. 1-17
    • Jugdutt, B.I.1
  • 40
    • 0027285976 scopus 로고
    • Tissue renin-angiotensin system in myocardial hypertrophy and failure
    • Dzau VJ. Tissue renin-angiotensin system in myocardial hypertrophy and failure. Arch Intern Med. 1993. 153:937-42.
    • (1993) Arch Intern Med , vol.153 , pp. 937-942
    • Dzau, V.J.1
  • 41
    • 0035048905 scopus 로고    scopus 로고
    • Theodore cooper lecture: Tissue angiotensin and pathobiology of vascular disease: A unifying hypothesis
    • Dzau VJ. Theodore Cooper lecture: tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension. 2001. 37:1047-52.
    • (2001) Hypertension , vol.37 , pp. 1047-1052
    • Dzau, V.J.1
  • 43
    • 0031831020 scopus 로고    scopus 로고
    • Does blockade of angiotensin ii receptors offer clinical benefits over inhibition of angiotensin-converting enzyme?
    • de Gasparo M, Levens N. Does blockade of angiotensin II receptors offer clinical benefits over inhibition of angiotensin-converting enzyme? Pharmacol Toxicol. 1998. 82:257-71.
    • (1998) Pharmacol Toxicol , vol.82 , pp. 257-271
    • De Gasparo, M.1    Levens, N.2
  • 44
    • 0035853402 scopus 로고    scopus 로고
    • Enhanced angiotensin ii activity in heart failure: Reevaluation of the counterregulatory hypothesis of receptor subtypes
    • Opie LH, Sack MN. Enhanced angiotensin II activity in heart failure: reevaluation of the counterregulatory hypothesis of receptor subtypes. Circ Res. 2001. 88:654-8.
    • (2001) Circ Res , vol.88 , pp. 654-658
    • Opie, L.H.1    Sack, M.N.2
  • 45
    • 0028133516 scopus 로고
    • Endothelial dysfunction in heart failure and potential for reversal by ace inhibition
    • Drexler H. Endothelial dysfunction in heart failure and potential for reversal by ACE inhibition. Br Heart J. 1994. 72(3 Suppl):S11-4.
    • (1994) Br Heart J , vol.72 , pp. S11-S14
    • Drexler, H.1
  • 46
    • 0029065411 scopus 로고
    • Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation
    • Seyedi N, Xu X, Nasjletti A, et al. Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension. 1995. 26: 164-70.
    • (1995) Hypertension , vol.26 , pp. 164-170
    • Seyedi, N.1    Xu, X.2    Nasjletti, A.3
  • 47
    • 0031003230 scopus 로고    scopus 로고
    • Effects of angiotensin-converting enzyme inhibitors and angiotensin ii type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin ii type 2 receptors
    • Liu YH, Yang XP, Sharov VG, et al. Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors. J Clin Invest. 1997. 99:1926-35.
    • (1997) J Clin Invest , vol.99 , pp. 1926-1935
    • Liu, Y.H.1    Yang, X.P.2    Sharov, V.G.3
  • 48
    • 1942452358 scopus 로고    scopus 로고
    • Role of angiotensin ii type 2 receptors and kinins in the cardioprotective effect of angiotensin ii type 1 receptor antagonists in rats with heart failure
    • Liu YH, Yang XP, Shesely EG, Sankey SS, Carretero OA. Role of angiotensin II type 2 receptors and kinins in the cardioprotective effect of angiotensin II type 1 receptor antagonists in rats with heart failure. J Am Coll Cardiol. 2004. 43:1473-80.
    • (2004) J am Coll Cardiol , vol.43 , pp. 1473-1480
    • Liu, Y.H.1    Yang, X.P.2    Shesely, E.G.3    Sankey, S.S.4    Carretero, O.A.5
  • 49
    • 34548849523 scopus 로고    scopus 로고
    • Tissue kallikrein is involved in the cardioprotective effect of at1-receptor blockade in acute myocardial ischemia
    • Messadi-Laribi E, Griol-Charhbill V, Pizard A, et al. Tissue kallikrein is involved in the cardioprotective effect of AT1-receptor blockade in acute myocardial ischemia. J Pharmacol Exp Ther. 2007. 323:210-6.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 210-216
    • Messadi-Laribi, E.1    Griol-Charhbill, V.2    Pizard, A.3
  • 50
    • 0034211294 scopus 로고    scopus 로고
    • Effect of up269-6 and losartan on at1 and at2-receptor expression and ip3 receptor and pkce proteins
    • Cardioprotection after angiotensin II type 1 blockade involves angiotensin II type 2 receptor expression and activation of protein kinase C-epsilon in acutely reperfused myocardial infarction in the dog
    • Xu Y, Menon V, Jugdutt BI. Cardioprotection after angiotensin II type 1 blockade involves angiotensin II type 2 receptor expression and activation of protein kinase C-epsilon in acutely reperfused myocardial infarction in the dog. Effect of UP269-6 and losartan on AT1 and AT2-receptor expression and IP3 receptor and PKCe proteins. J Renin Angiotensin Aldosterone Syst. 2000. 1:184-95.
    • (2000) J Renin Angiotensin Aldosterone Syst , vol.1 , pp. 184-195
    • Xu, Y.1    Menon, V.2    Jugdutt, B.I.3
  • 51
    • 0035533452 scopus 로고    scopus 로고
    • Enhanced regional at2-receptor and pkce expression during cardioprotection induced by at1-receptor blockade after reperfused myocardial infarction
    • Jugdutt BI, Balghith M. Enhanced regional AT2-receptor and PKCe expression during cardioprotection induced by AT1-receptor blockade after reperfused myocardial infarction. J Renin Angiotensin Aldosterone Syst. 2001. 2:134-40.
    • (2001) J Renin Angiotensin Aldosterone Syst , vol.2 , pp. 134-140
    • Jugdutt, B.I.1    Balghith, M.2
  • 52
    • 4644288423 scopus 로고    scopus 로고
    • At1 receptor blockade limits myocardial injury and upregulates at2 receptors during reperfused myocardial infarction
    • Jugdutt BI, Menon V. AT1 receptor blockade limits myocardial injury and upregulates AT2 receptors during reperfused myocardial infarction. Mol Cell Biochem. 2004. 260:111-8.
    • (2004) Mol Cell Biochem , vol.260 , pp. 111-118
    • Jugdutt, B.I.1    Menon, V.2
  • 53
    • 3042771034 scopus 로고    scopus 로고
    • Valsartan-inducedcardioprotection involves angiotensin ii type 2 receptor upreg- ulation in dog and rat in vivo models of reperfused myocardial infarction
    • Jugdutt BI, Menon V. Valsartan-induced cardioprotection involves angiotensin II type 2 receptor upreg- ulation in dog and rat in vivo models of reperfused myocardial infarction. J Cardiac Fail. 2004. 10:74-82.
    • J Cardiac Fail. 2004 , vol.10 , pp. 74-82
    • Jugdutt, B.I.1    Menon, V.2
  • 54
    • 84861348764 scopus 로고    scopus 로고
    • The kallikrein-kinin system as a regulator of cardiovascular and renal function
    • Rhaleb N-E, Yang X-P, Carretero OA. The kallikrein-kinin system as a regulator of cardiovascular and renal function. Compr Physiol. 2011. 1:971-93.
    • (2011) Compr Physiol , vol.1 , pp. 971-993
    • Rhaleb, N.-E.1    Yang, X.-P.2    Carretero, O.A.3
  • 55
    • 0025598309 scopus 로고
    • Identification of a highly specific chy- mase as the major angiotensin il-forming enzyme in the human heart
    • Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A. Identification of a highly specific chy- mase as the major angiotensin Il-forming enzyme in the human heart. J Biol Chem. 1990. 265:22348-57.
    • (1990) J Biol Chem , vol.265 , pp. 22348-22357
    • Urata, H.1    Kinoshita, A.2    Misono, K.S.3    Bumpus, F.M.4    Husain, A.5
  • 56
    • 0025239660 scopus 로고
    • Angiotensin il-forming pathways in normal and failing human hearts
    • Urata H, Healy B, Stewart RW, Bumpus FM, Husain A. Angiotensin Il-forming pathways in normal and failing human hearts. Circ Res. 1990. 66:883-90.
    • (1990) Circ Res , vol.66 , pp. 883-890
    • Urata, H.1    Healy, B.2    Stewart, R.W.3    Bumpus, F.M.4    Husain, A.5
  • 57
    • 0026737777 scopus 로고
    • Circulating angiotensin ii levels under repeated administration of lisinopril in normal subjects
    • Kawamura M, Imanashi M, Matsushima Y, et al. Circulating angiotensin II levels under repeated administration of lisinopril in normal subjects. Clin Exp Pharmacol Physiol. 1992. 19:547-53.
    • (1992) Clin Exp Pharmacol Physiol , vol.19 , pp. 547-553
    • Kawamura, M.1    Imanashi, M.2    Matsushima, Y.3
  • 58
    • 0033995775 scopus 로고    scopus 로고
    • Maximally recommended doses of angiotensin-converting enzyme (Ace) inhibitors do not completely prevent ace- mediated formation of angiotensin ii in chronic heart failure
    • Jorde UP, Ennezat PV, Lisker J, et al. Maximally recommended doses of angiotensin-converting enzyme (ACE) inhibitors do not completely prevent ACE- mediated formation of angiotensin II in chronic heart failure. Circulation. 2000. 101:844-6.
    • (2000) Circulation , vol.101 , pp. 844-846
    • Jorde, U.P.1    Ennezat, P.V.2    Lisker, J.3
  • 59
    • 0031017144 scopus 로고    scopus 로고
    • Functional and biochemical analysis of angiotensin ii-forming pathways in the human heart
    • Wolny A, Clozel JP, Rein J, et al. Functional and biochemical analysis of angiotensin II-forming pathways in the human heart. Circ Res. 1997. 80: 219-27.
    • (1997) Circ Res , vol.80 , pp. 219-227
    • Wolny, A.1    Clozel, J.P.2    Rein, J.3
  • 60
    • 2642575030 scopus 로고    scopus 로고
    • Combined blockade of the renin- angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin ii type 1 receptor antagonists
    • Azizi M, Menard J. Combined blockade of the renin- angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists. Circulation. 2004. 109:2492-9.
    • (2004) Circulation , vol.109 , pp. 2492-2499
    • Azizi, M.1    Menard, J.2
  • 61
    • 0030846832 scopus 로고    scopus 로고
    • Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systems
    • Spinale FG, de Gasparo M, Whitebread S, et al. Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systems. Circulation. 1997. 96:2385-96.
    • (1997) Circulation , vol.96 , pp. 2385-2396
    • Spinale, F.G.1    De Gasparo, M.2    Whitebread, S.3
  • 62
    • 0033514910 scopus 로고    scopus 로고
    • Addition of angiotensin ii receptor blockade to maximal angiotensin-converting enzyme inhibition improves exercise capacity in patients with severe congestive heart failure
    • Hamroff G, Katz SD, Mancini D, et al. Addition of angiotensin II receptor blockade to maximal angiotensin-converting enzyme inhibition improves exercise capacity in patients with severe congestive heart failure. Circulation. 1999. 99:990-2.
    • (1999) Circulation , vol.99 , pp. 990-992
    • Hamroff, G.1    Katz, S.D.2    Mancini, D.3
  • 63
    • 0034806667 scopus 로고    scopus 로고
    • Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction
    • Yu CM, Tipoe GL, Wing-Hon Lai K, et al. Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction. J Am Coll Cardiol. 2001. 38:1207-15.
    • (2001) J am Coll Cardiol , vol.38 , pp. 1207-1215
    • Yu, C.M.1    Tipoe, G.L.2    Wing-Hon Lai, K.3
  • 64
  • 65
    • 0037017384 scopus 로고    scopus 로고
    • Evidence for a role of mast cells in the evolution to congestive heart failure
    • Hara M, Ono K, Hwang MW, et al. Evidence for a role of mast cells in the evolution to congestive heart failure. J Exp Med. 2002. 195:375-81.
    • (2002) J Exp Med , vol.195 , pp. 375-381
    • Hara, M.1    Ono, K.2    Hwang, M.W.3
  • 66
    • 0037512313 scopus 로고    scopus 로고
    • Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure
    • Matsumoto T, Wada A, Tsutamoto T, et al. Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure. Circulation. 2003. 107:2555-8.
    • (2003) Circulation , vol.107 , pp. 2555-2558
    • Matsumoto, T.1    Wada, A.2    Tsutamoto, T.3
  • 68
    • 0242542497 scopus 로고    scopus 로고
    • Impact of chymase inhibitor on cardiac function and survival after myocardial infarction
    • Jin D, Takai S, Yamada M, et al. Impact of chymase inhibitor on cardiac function and survival after myocardial infarction. Cardiovasc Res. 2003. 60:413-20.
    • (2003) Cardiovasc Res , vol.60 , pp. 413-420
    • Jin, D.1    Takai, S.2    Yamada, M.3
  • 69
    • 67649881400 scopus 로고    scopus 로고
    • Chymase plays an important role in left ventricular remodeling influenced by intermittent hypoxia in mice
    • Matsumoto C, Hayashi T, Kitada K, et al. Chymase plays an important role in left ventricular remodeling influenced by intermittent hypoxia in mice. Hypertension. 2009. 54:164-71.
    • (2009) Hypertension , vol.54 , pp. 164-171
    • Matsumoto, C.1    Hayashi, T.2    Kitada, K.3
  • 70
    • 80053144553 scopus 로고    scopus 로고
    • Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion
    • Oyamada S, Bianchi C, Takai S, Chu LM, Selke FW. Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion. J Pharmacol Exp Ther. 2011. 339:143-51.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 143-151
    • Oyamada, S.1    Bianchi, C.2    Takai, S.3    Chu, L.M.4    Selke, F.W.5
  • 71
    • 77951171609 scopus 로고    scopus 로고
    • Mast cell chymase limits the cardiac efficacy of ang i-converting enzyme inhibitor therapy in rodents
    • Wei CC, Hase N, Inoue Y, et al. Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest. 2010. 120:1229-39.
    • (2010) J Clin Invest , vol.120 , pp. 1229-1239
    • Wei, C.C.1    Hase, N.2    Inoue, Y.3
  • 72
    • 77958511663 scopus 로고    scopus 로고
    • Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and lv torsion angle in dogs with isolated mitral regurgitation
    • Pat B, Chen Y, Killingsworth C, Gladden JD, et al. Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation. Circulation. 2011. 122:1488-95.
    • (2011) Circulation , vol.122 , pp. 1488-1495
    • Pat, B.1    Chen, Y.2    Killingsworth, C.3    Gladden, J.D.4
  • 73
    • 4143051373 scopus 로고    scopus 로고
    • Human chymase degrades human fibronectin
    • Okumura K, Takai S, Muramatsu M, et al. Human chymase degrades human fibronectin. Clin Chim Acta. 2004. 347:223-5.
    • (2004) Clin Chim Acta , vol.347 , pp. 223-225
    • Okumura, K.1    Takai, S.2    Muramatsu, M.3
  • 74
  • 75
    • 0034449856 scopus 로고    scopus 로고
    • High cardiac angiotensin-ii-forming activity in infarcted and non- infarcted human myocardium
    • Ihara M, Urata H, Shirai K, et al. High cardiac angiotensin-II-forming activity in infarcted and non- infarcted human myocardium. Cardiology. 2000. 94: 247-53.
    • (2000) Cardiology , vol.94 , pp. 247-253
    • Ihara, M.1    Urata, H.2    Shirai, K.3
  • 76
    • 0033054630 scopus 로고    scopus 로고
    • Increased chymase-dependent angiotensin ii formation in human atherosclerotic aorta
    • Ihara M, Urata H, Kinoshita A, et al. Increased chymase-dependent angiotensin II formation in human atherosclerotic aorta. Hypertension. 1999. 33: 1399-405.
    • (1999) Hypertension , vol.33 , pp. 1399-1405
    • Ihara, M.1    Urata, H.2    Kinoshita, A.3
  • 77
    • 0033770425 scopus 로고    scopus 로고
    • Hypothesis regarding the pathophysiological role of alternative pathways of angiotensin ii formation in atherosclerosis
    • Arakawa K, Urata H. Hypothesis regarding the pathophysiological role of alternative pathways of angiotensin II formation in atherosclerosis. Hypertension. 2000. 36:638-41.
    • (2000) Hypertension , vol.36 , pp. 638-641
    • Arakawa, K.1    Urata, H.2
  • 78
    • 0033977168 scopus 로고    scopus 로고
    • Increased chy- mase activity in internal thoracic artery of patients with hypercholesterolemia
    • Uehara Y, Urata H, Sasaguri M, et al. Increased chy- mase activity in internal thoracic artery of patients with hypercholesterolemia. Hypertension. 2000. 35:55-60.
    • (2000) Hypertension , vol.35 , pp. 55-60
    • Uehara, Y.1    Urata, H.2    Sasaguri, M.3
  • 79
    • 0036054853 scopus 로고    scopus 로고
    • Chymase inhibition suppresses high-cholesterol diet-induced lipid accumulation in the hamster aorta
    • Uehara Y, Urata H, Ideishi M, Arakawa K, Saku K. Chymase inhibition suppresses high-cholesterol diet-induced lipid accumulation in the hamster aorta. Cardiovasc Res. 2002. 55:870-6.
    • (2002) Cardiovasc Res , vol.55 , pp. 870-876
    • Uehara, Y.1    Urata, H.2    Ideishi, M.3    Arakawa, K.4    Saku, K.5
  • 80
    • 33645746010 scopus 로고    scopus 로고
    • Advanced glyca- tion end products activate a chymase-dependent angiotensin ii-generating pathway in diabetic complications
    • Koka V, Wang W, Huang XR, et al. Advanced glyca- tion end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications. Circulation. 2006. 113:1353-60.
    • (2006) Circulation , vol.113 , pp. 1353-1360
    • Koka, V.1    Wang, W.2    Huang, X.R.3
  • 81
    • 41749123049 scopus 로고    scopus 로고
    • Activation of the intracellular renin angiotensin system in cardiac fibroblasts by high glucose: Role in extracellular matrix production
    • Singh VP, Baker KM, Kumar R. Activation of the intracellular renin angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production. Am J Physiol. 2008. 294:H1675-84.
    • (2008) Am J Physiol , vol.294 , pp. H1675-H1684
    • Singh, V.P.1    Baker, K.M.2    Kumar, R.3
  • 82
    • 0034687165 scopus 로고    scopus 로고
    • Effects of combined angiotensin ii and endothelin receptor blockade with developing heart failure: Effects on left ventricular performance
    • New RB, Sampson AC, King MK, et al. Effects of combined angiotensin II and endothelin receptor blockade with developing heart failure: effects on left ventricular performance. Circulation. 2000. 102:1447-53.
    • (2000) Circulation , vol.102 , pp. 1447-1453
    • New, R.B.1    Sampson, A.C.2    King, M.K.3
  • 83
    • 0033178254 scopus 로고    scopus 로고
    • Interactions between endothelin-1 and the renin- angiotensin-aldosterone system
    • Rossi GP, Sacchetto A, Cesari M, Pessina AC. Interactions between endothelin-1 and the renin- angiotensin-aldosterone system. Cardiovasc Res. 1999. 43:300-7.
    • (1999) Cardiovasc Res , vol.43 , pp. 300-307
    • Rossi, G.P.1    Sacchetto, A.2    Cesari, M.3    Pessina, A.C.4
  • 84
    • 0034619523 scopus 로고    scopus 로고
    • Endothelins and endothelin receptor antagonists: Therapeutic considerations for a novel class of cardiovascular drugs
    • Luscher TF, Barton M. Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs. Circulation. 2000. 102:2434-40.
    • (2000) Circulation , vol.102 , pp. 2434-2440
    • Luscher, T.F.1    Barton, M.2
  • 85
    • 33644878609 scopus 로고    scopus 로고
    • Endothelins: Pathophysiology and treatment implications in chronic heart failure
    • Teerlink JR. Endothelins: pathophysiology and treatment implications in chronic heart failure. Curr Heart Fail Rep. 2005. 2:191-7.
    • (2005) Curr Heart Fail Rep , vol.2 , pp. 191-197
    • Teerlink, J.R.1
  • 86
    • 1642576176 scopus 로고    scopus 로고
    • Endothelin a receptor antagonism in experimental congestive heart failure results in augmentation of the renin- angiotensin system and sustained sodium retention
    • Schirger JA, Chen HH, Jougasaki M, et al. Endothelin A receptor antagonism in experimental congestive heart failure results in augmentation of the renin- angiotensin system and sustained sodium retention. Circulation. 2004. 109:249-54.
    • (2004) Circulation , vol.109 , pp. 249-254
    • Schirger, J.A.1    Chen, H.H.2    Jougasaki, M.3
  • 87
    • 3242810591 scopus 로고    scopus 로고
    • Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the endothelin a receptor antagonist trial in heart failure (Earth): Randomised, double-blind, placebo-controlled trial
    • Anand I, McMurray J, Cohn JN, et al. Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the Endothelin A Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial. Lancet. 2004. 364:347-54.
    • (2004) Lancet , vol.364 , pp. 347-354
    • Anand, I.1    McMurray, J.2    Cohn, J.N.3
  • 88
    • 0034601744 scopus 로고    scopus 로고
    • Secondary pulmonary hypertension in chronic heart failure: The role of the endothelium in pathophysiology and management
    • Moraes DL, Colucci WS, Givertz MM. Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management. Circulation. 2000. 102:1718-23.
    • (2000) Circulation , vol.102 , pp. 1718-1723
    • Moraes, D.L.1    Colucci, W.S.2    Givertz, M.M.3
  • 89
    • 79953728180 scopus 로고    scopus 로고
    • Bosentan does not improve pulmonary hypertension and lung remodeling in heart failure
    • Jiang BH, Tardif J-C, Shi Y, Dupuis J. Bosentan does not improve pulmonary hypertension and lung remodeling in heart failure. Eur Respir J. 2011. 37:578-86.
    • Eur Respir J. 2011 , vol.37 , pp. 578-586
    • Jiang, B.H.1    Tardif, J.-C.2    Shi, Y.3    Dupuis, J.4
  • 90
    • 84864924644 scopus 로고    scopus 로고
    • World health organization pulmonary hypertension group 2: Pulmonary hypertension due to left heart disease in the adult - a summary statement from the pulmonary hypertension council of the international society for heart and lung transplantation
    • Fang JC, DeMarco T, Givertz MM, et al. World Health Organization Pulmonary Hypertension group 2: pulmonary hypertension due to left heart disease in the adult - a summary statement from the Pulmonary Hypertension Council of the International Society for heart and Lung Transplantation. J Heart Lung Transplant. 2012. 31:913-33.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 913-933
    • Fang, J.C.1    De Marco, T.2    Givertz, M.M.3
  • 91
    • 0034721906 scopus 로고    scopus 로고
    • A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril- insensitive carboxypeptidase
    • Tipnis SR, Hooper NM, Hyde R, et al. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril- insensitive carboxypeptidase. J Biol Chem. 2000. 275:33238-43.
    • (2000) J Biol Chem , vol.275 , pp. 33238-33243
    • Tipnis, S.R.1    Hooper, N.M.2    Hyde, R.3
  • 92
    • 0038053724 scopus 로고    scopus 로고
    • A novel angiotensin-converting enzyme-related carboxypeptidase (Ace2) converts angiotensin i to angiotensin 1-9
    • Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000. 87:E1-9.
    • (2000) Circ Res , vol.87 , pp. E1-E9
    • Donoghue, M.1    Hsieh, F.2    Baronas, E.3
  • 93
    • 0037142101 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 as an essential regulator of heart function
    • Crackower MA, Sarao R, Oudit GY, et al. Angiotensin-converting enzyme 2 as an essential regulator of heart function. Nature. 2002. 417:822-8.
    • (2002) Nature , vol.417 , pp. 822-828
    • Crackower, M.A.1    Sarao, R.2    Oudit, G.3
  • 94
    • 28144445338 scopus 로고    scopus 로고
    • Advances in biochemical and functional roles of angiotensinconverting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function
    • Ferrario CM, Trask AJ, Jessup JA. Advances in biochemical and functional roles of angiotensinconverting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. Am J Physiol. 2005. 289:H2281-90.
    • (2005) Am J Physiol , vol.289 , pp. H2281-H2290
    • Ferrario, C.M.1    Trask, A.J.2    Jessup, J.A.3
  • 95
    • 28144432331 scopus 로고    scopus 로고
    • Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects
    • Iwata M, Cowling RT, Gurantz D, et al. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol. 2005. 289:H2356-63.
    • (2005) Am J Physiol , vol.289 , pp. H2356-H2363
    • Iwata, M.1    Cowling, R.T.2    Gurantz, D.3
  • 96
    • 19644384705 scopus 로고    scopus 로고
    • Effect of angiotensin-converting enzyme inhibition and angiotensin ii receptor blockers on cardiac angiotensin-converting enzyme 2
    • Ferrario CM, Jessup J, Chappell MC, et al. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005. 111:2605-10.
    • Circulation. 2005 , vol.111 , pp. 2605-2610
    • Ferrario, C.M.1    Jessup, J.2    Chappell, M.C.3
  • 97
    • 2342620869 scopus 로고    scopus 로고
    • Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin ii receptors
    • Ishiyama Y, Gallagher PE, Averill DB, et al. Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension. 2004. 43:970-6.
    • (2004) Hypertension , vol.43 , pp. 970-976
    • Ishiyama, Y.1    Gallagher, P.E.2    Averill, D.B.3
  • 98
    • 0037007055 scopus 로고    scopus 로고
    • Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats
    • Loot AE, Roks AJ, Henning RH, et al. Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats. Circulation. 2002. 105:1548-50.
    • (2002) Circulation , vol.105 , pp. 1548-1550
    • Loot, A.E.1    Roks, A.J.2    Henning, R.H.3
  • 99
    • 33750589885 scopus 로고    scopus 로고
    • Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
    • Ocaranza MP, Godoy I, Jalil JE, et al. Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat. Hypertension. 2006. 48:572-8.
    • (2006) Hypertension , vol.48 , pp. 572-578
    • Ocaranza, M.P.1    Godoy, I.2    Jalil, J.E.3
  • 100
    • 78650170861 scopus 로고    scopus 로고
    • Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ace2 and profiling-1 expression
    • Zhong JC, Ye JY, Jin HY, et al. Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profiling-1 expression. Regul Pept. 2011. 166:90-7.
    • (2011) Regul Pept , vol.166 , pp. 90-97
    • Zhong, J.C.1    Ye, J.Y.2    Jin, H.Y.3
  • 101
    • 84948990375 scopus 로고    scopus 로고
    • Role of ace2 and ang (1-7) in limiting fibrosis and remodeling during healing after reperfused myocardial infarction
    • Jugdutt B, Palaniyappan A, Idikio H. Role of ACE2 and Ang (1-7) in limiting fibrosis and remodeling during healing after reperfused myocardial infarction. J Mol Cell Cardiol. 2009. 57:S24 (Abstract).
    • (2009) J Mol Cell Cardiol , vol.57 , pp. S24
    • Jugdutt, B.1    Palaniyappan, A.2    Idikio, H.3
  • 102
    • 84948988249 scopus 로고    scopus 로고
    • The ace2/ang-(1-7) pathway in cardiac fibroblasts as a potential target for cardiac remodeling
    • Jugdutt BI, Dhalla NS, editors, New York, NY: Springer
    • Cowling RT, Goldberg BH. The ACE2/Ang-(1-7) pathway in cardiac fibroblasts as a potential target for cardiac remodeling. In: Jugdutt BI, Dhalla NS, editors. Cardiac remodeling. Molecular mechanisms. New York, NY: Springer. 2013. p. 547-57.
    • (2013) Cardiac Remodeling. Molecular Mechanisms , pp. 547-557
    • Cowling, R.T.1    Goldberg, B.H.2
  • 103
    • 84862648459 scopus 로고    scopus 로고
    • Role of ace2 in diastolic and systolic heart failure
    • Wang W, Bodiga S, Das SK, et al. Role of ACE2 in diastolic and systolic heart failure. Heart Fail Rev. 2012. 17:683-9.
    • (2012) Heart Fail Rev , vol.17 , pp. 683-689
    • Wang, W.1    Bodiga, S.2    Das, S.K.3
  • 104
    • 0141988865 scopus 로고    scopus 로고
    • Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: Evidence for upregulation of the angiotensin-converting enzyme homologueace2
    • Zisman LS, Keller RS, Weaver B, et al. Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2. Circulation. 2003. 108:1707-12.
    • (2003) Circulation , vol.108 , pp. 1707-1712
    • Zisman, L.S.1    Keller, R.S.2    Weaver, B.3
  • 105
    • 78649337583 scopus 로고    scopus 로고
    • Ace2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction
    • Zhao YX, Yin HQ, Yu QT, et al. ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction. Hum Gene Ther. 2010. 21:1545-54.
    • (2010) Hum Gene Ther , vol.21 , pp. 1545-1554
    • Zhao, Y.X.1    Yin, H.Q.2    Yu, Q.T.3
  • 106
    • 68849105984 scopus 로고    scopus 로고
    • Soluble angiotensin-converting enzyme 2 in human heart failure: Relation with myocardial function and clinical outcomes
    • Epelman S, Shrestha K, Troughton RW, et al. Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes. J Card Fail. 2009. 15:565-71.
    • (2009) J Card Fail , vol.15 , pp. 565-571
    • Epelman, S.1    Shrestha, K.2    Troughton, R.W.3
  • 107
    • 75349101263 scopus 로고    scopus 로고
    • Plasma ace2 activity is an independent prognostic marker in chagas’ disease and equally potent as bnp
    • Wang Y, Moreira Mda C, Heringer-Walther S, et al. Plasma ACE2 activity is an independent prognostic marker in Chagas’ disease and equally potent as BNP. J Card Fail. 2010. 16:157-63.
    • (2010) J Card Fail , vol.16 , pp. 157-163
    • Wang, Y.1    Moreira Mda, C.2    Heringer-Walther, S.3
  • 108
    • 33645238126 scopus 로고    scopus 로고
    • Age- and gender- related difference of ace2 expression in a rat lung
    • Xie X, Chen J, Wang X, et al. Age- and gender- related difference of ACE2 expression in a rat lung. Life Sci. 2006. 78:2166-71.
    • (2006) Life Sci , vol.78 , pp. 2166-2171
    • Xie, X.1    Chen, J.2    Wang, X.3
  • 109
    • 34548248723 scopus 로고    scopus 로고
    • Different responses to angiotensin-(1-7) in young, aged and diabetic rabbit corpus cavernosum
    • Yousif MH, Kehinde EO, Benter IF. Different responses to angiotensin-(1-7) in young, aged and diabetic rabbit corpus cavernosum. Pharmacol Res. 2007. 56:209-16.
    • (2007) Pharmacol Res , vol.56 , pp. 209-216
    • Yousif, M.H.1    Kehinde, E.O.2    Benter, I.F.3
  • 110
    • 84948967057 scopus 로고    scopus 로고
    • Effect of age on expression of at1 and at2 receptors and ace-2 and angiotensin (1-7), ac-sdkp and smad-2 proteins after acute reperfused st-segment myocardial infarction
    • Palaniyappan A, Idikio H, Jugdutt BI. Effect of age on expression of AT1 and AT2 receptors and ACE-2 and Angiotensin (1-7), Ac-SDKP and Smad-2 proteins after acute reperfused ST-segment myocardial infarction. Circulation. 2008. 118 Suppl 2:S547 (Abstract).
    • (2008) Circulation , vol.118
    • Palaniyappan, A.1    Idikio, H.2    Jugdutt, B.I.3
  • 111
    • 0035569026 scopus 로고    scopus 로고
    • Bradykinin potentiation by angiotensin-(1-7) and ace inhibitors correlates with ace c- and n-domain blockade
    • Tom B, de Vries R, Saxena PR, et al. Bradykinin potentiation by angiotensin-(1-7) and ACE inhibitors correlates with ACE C- and N-domain blockade. Hypertension. 2001. 38:95-9.
    • (2001) Hypertension , vol.38 , pp. 95-99
    • Tom, B.1    De Vries, R.2    Saxena, P.R.3
  • 112
    • 12844288884 scopus 로고    scopus 로고
    • Losartan increases bradykinin levels in hypertensive humans
    • Campbell DJ, Krum H, Esler MD. Losartan increases bradykinin levels in hypertensive humans. Circulation. 2005. 111:315-20.
    • (2005) Circulation , vol.111 , pp. 315-320
    • Campbell, D.J.1    Krum, H.2    Esler, M.D.3
  • 113
    • 33750147612 scopus 로고    scopus 로고
    • Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system
    • Nagata S, Kato J, Sasaki K, et al. Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system. Biochem Biophys Res Commun. 2006. 350:1026-31.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 1026-1031
    • Nagata, S.1    Kato, J.2    Sasaki, K.3
  • 114
    • 49249116079 scopus 로고    scopus 로고
    • Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normoten- sive rats
    • Jessup JA, Trask AJ, Chappell MC, et al. Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normoten- sive rats. Am J Physiol. 2008. 294:H2614-8.
    • (2008) Am J Physiol , vol.294 , pp. H2614-H2618
    • Jessup, J.A.1    Trask, A.J.2    Chappell, M.C.3
  • 115
    • 44949253157 scopus 로고    scopus 로고
    • Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart
    • Trask AJ, Jessup JA, Chappell MC, Ferrario CM. Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol. 2008. 294:H2242-7.
    • (2008) Am J Physiol , vol.294 , pp. H2242-H2247
    • Trask, A.J.1    Jessup, J.A.2    Chappell, M.C.3    Ferrario, C.M.4
  • 116
    • 66249098883 scopus 로고    scopus 로고
    • Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy
    • Ferrario C, Varagic J, Hanini J, et al. Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol. 2009. 296:H1184-92.
    • (2009) Am J Physiol , vol.296 , pp. H1184-H1192
    • Ferrario, C.1    Varagic, J.2    Hanini, J.3
  • 117
    • 62349100153 scopus 로고    scopus 로고
    • Cardiac chymase converts rat proangiotensin-12 (Pa12) to angiotensin ii: Effects of pa12 upon cardiac haemodynamics
    • Prosser HC, Forster ME, Richards AM, Pemberton CJ. Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics. Cardiovasc Res. 2009. 82:40-50.
    • Cardiovasc Res. 2009 , vol.82 , pp. 40-50
    • Prosser, H.C.1    Forster, M.E.2    Richards, A.M.3    Pemberton, C.J.4
  • 118
    • 83255175529 scopus 로고    scopus 로고
    • Chymase- dependent generation of angiotensin ii from angio- tensin-(1-12) in human atrial tissue
    • Ahmad S, Simmons T, Varagic J, et al. Chymase- dependent generation of angiotensin II from angio- tensin-(1-12) in human atrial tissue. PLoS One. 2011. 6:e28501.
    • (2011) Plos One , vol.6
    • Ahmad, S.1    Simmons, T.2    Varagic, J.3
  • 119
    • 84875370725 scopus 로고    scopus 로고
    • Chymase mediates angiotensin-(1-12) metabolism in human hearts
    • Ahmad S, Wei CC, Tallaj J, et al. Chymase mediates angiotensin-(1-12) metabolism in human hearts. J Am Soc Hypertens. 2013. 7:128-36.
    • (2013) J am Soc Hypertens , vol.7 , pp. 128-136
    • Ahmad, S.1    Wei, C.C.2    Tallaj, J.3
  • 120
    • 84949053805 scopus 로고    scopus 로고
    • Chymase- mediated angiotensin ii generation from angioten- sin-(1-12) in left ventricular tissue of normal and diseased human subjects
    • Moniwa N, Wei C-C, dell’Italia LJ, et al. Chymase- mediated angiotensin II generation from angioten- sin-(1-12) in left ventricular tissue of normal and diseased human subjects. J Clin Hypertens (Greenwich). 2012. 14 Suppl 1:149 (Abstract).
    • (2012) J Clin Hypertens (Greenwich) , vol.1 , Issue.149
    • Moniwa, N.1    Wei, C.-C.2    Dell’ Italia, L.J.3
  • 121
    • 0023266532 scopus 로고
    • Effects of enalapril on mortality in severe congestive heart failure: Results of the cooperative north scandinavian enalapril survival study (consensus)
    • The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med. 1987. 316:1429-35.
    • (1987) N Engl J Med , vol.316 , pp. 1429-1435
  • 122
    • 0024591826 scopus 로고    scopus 로고
    • Short- and long-acting angiotensin-converting enzyme inhibitors: A randomized trial of lisinopril versus captopril in the treatment of congestive heart failure. The multicenter lisinopril-captopril congestive heart failure study group
    • Giles TD, Katz R, Sullivan JM, et al. Short- and long-acting angiotensin-converting enzyme inhibitors: a randomized trial of lisinopril versus captopril in the treatment of congestive heart failure. The Multicenter Lisinopril-Captopril Congestive Heart Failure Study Group. J Am Coll Cardiol. 1989. 13:1240-7.
    • J am Coll Cardiol. 1989 , vol.13 , pp. 1240-1247
    • Giles, T.D.1    Katz, R.2    Sullivan, J.M.3
  • 123
    • 0025913812 scopus 로고
    • Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
    • The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991. 325:293-302.
    • (1991) N Engl J Med , vol.325 , pp. 293-302
  • 124
    • 0026785561 scopus 로고
    • Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions
    • The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992. 327:685-91.
    • (1992) N Engl J Med , vol.327 , pp. 685-691
  • 125
    • 0033694573 scopus 로고    scopus 로고
    • Efficacy and safety of high-dose lisinopril in chronic heart failure patients at high cardiovascular risk, including those with diabetes mellitus. Results from the atlas trial
    • Ryden L, Armstrong PW, Cleland JG, et al. Efficacy and safety of high-dose lisinopril in chronic heart failure patients at high cardiovascular risk, including those with diabetes mellitus. Results from the ATLAS trial. Eur Heart J. 2000. 21:1967-78.
    • (2000) Eur Heart J , vol.21 , pp. 1967-1978
    • Ryden, L.1    Armstrong, P.W.2    Cleland, J.G.3
  • 126
    • 33748988737 scopus 로고    scopus 로고
    • The pepchf investigators, et al. The perindopril in elderly people with chronic heart failure (pep-chf) study
    • Cleland JG, Tendera M, Adamus J, The PEPCHF Investigators, et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J. 2006. 27:2338-45.
    • (2006) Eur Heart J , vol.27 , pp. 2338-2345
    • Cleland, J.G.1    Tendera, M.2    Adamus, J.3
  • 127
    • 0030902115 scopus 로고    scopus 로고
    • Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of losartan in the elderly study, elite)
    • Pitt B, Segal R, Martinez FA, et al. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet. 1997. 349:747-52.
    • (1997) Lancet , vol.349 , pp. 747-752
    • Pitt, B.1    Segal, R.2    Martinez, F.A.3
  • 128
    • 0033533456 scopus 로고    scopus 로고
    • Comparison of candesartan, enalapril, and their combination in congestive heart failure: Randomized evaluation of strategies for left ventricular dysfunction (resolvd) pilot study. The resolvd pilot study investigators
    • McKelvie RS, Yusuf S, Pericak D, et al. Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators. Circulation. 1999. 100:1056-64.
    • (1999) Circulation , vol.100 , pp. 1056-1064
    • McKelvie, R.S.1    Yusuf, S.2    Pericak, D.3
  • 129
    • 0034612118 scopus 로고    scopus 로고
    • Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: Randomised trial-the losartan heart failure survival study elite ii
    • Pitt B, Poole-Wilson PA, Segal R, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial-the Losartan Heart Failure Survival Study ELITE II. Lancet. 2000. 355:1582-7.
    • (2000) Lancet , vol.355 , pp. 1582-1587
    • Pitt, B.1    Poole-Wilson, P.A.2    Segal, R.3
  • 130
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of angiotensin receptor blocker valsartan in chronic heart failure
    • Cohn JN, Tognoni G, Valsartan Heart Failure Trial Investigators. A randomized trial of angiotensin receptor blocker valsartan in chronic heart failure. N Engl J Med. 2001. 345:1667-75.
    • (2001) N Engl J Med , vol.345 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 131
    • 0042410539 scopus 로고    scopus 로고
    • Charm investigators and committees. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: The charm-overall programme
    • Pfeffer MA, Swedberg K, Granger CB, et al. CHARM Investigators and Committees. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003. 362:759-66.
    • (2003) Lancet , vol.362 , pp. 759-766
    • Pfeffer, M.A.1    Swedberg, K.2    Granger, C.B.3
  • 132
    • 0041408235 scopus 로고    scopus 로고
    • Charm investigators and committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The charm-added trial
    • McMurray JJ, Ostergren J, Swedberg K, et al. CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003. 362:767-71.
    • (2003) Lancet , vol.362 , pp. 767-771
    • McMurray, J.J.1    Ostergren, J.2    Swedberg, K.3
  • 133
    • 0041909380 scopus 로고    scopus 로고
    • Charm investigators and committees. Effects of candesar- tan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: The charm- alternative trial
    • Granger CB, McMurray JJ, Yusuf S, et al. CHARM Investigators and Committees. Effects of candesar- tan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM- Alternative trial. Lancet. 2003. 362:772-6.
    • (2003) Lancet , vol.362 , pp. 772-776
    • Granger, C.B.1    McMurray, J.J.2    Yusuf, S.3
  • 134
    • 0041408234 scopus 로고    scopus 로고
    • Charm investigators and committees. Effects of candesar- tan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The charm-preserved trial
    • Yusuf S, Pfeffer MA, Swedberg K, et al. CHARM Investigators and Committees. Effects of candesar- tan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-preserved trial. Lancet. 2003. 362:777-81.
    • (2003) Lancet , vol.362 , pp. 777-781
    • Yusuf, S.1    Pfeffer, M.A.2    Swedberg, K.3
  • 135
    • 33644876849 scopus 로고    scopus 로고
    • Mortality and morbidity remain high despite captopril and/or valsartan therapy in elderly patients with left ventricular systolic dysfunction, heart failure, or both after acute myocardial infarction: Results of the valsartan in acute myocardial infarction trial (valiant)
    • White HD, Aylward PE, Huang Z, et al. Mortality and morbidity remain high despite captopril and/or valsartan therapy in elderly patients with left ventricular systolic dysfunction, heart failure, or both after acute myocardial infarction: results of the Valsartan in Acute Myocardial Infarction Trial (VALIANT). Circulation. 2005. 112:3391-9.
    • (2005) Circulation , vol.112 , pp. 3391-3399
    • White, H.D.1    Aylward, P.E.2    Huang, Z.3
  • 136
    • 57349142933 scopus 로고    scopus 로고
    • I-preserve investigators. Irbesartan in patients with heart failure and preserved ejection fraction
    • Massie BM, Carson PE, McMurray JJ, et al. I-PRESERVE Investigators. Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med. 2008. 359:2456-67.
    • (2008) N Engl J Med , vol.359 , pp. 2456-2467
    • Massie, B.M.1    Carson, P.E.2    McMurray, J.J.3
  • 137
    • 0025832708 scopus 로고
    • The discovery of a new class of highly specific nonpeptide angiotensin ii receptor antagonists
    • Timmermans PB, Carini DJ, Chiu AT, et al. The discovery of a new class of highly specific nonpeptide angiotensin II receptor antagonists. Am J Hypertens. 1991. 4:275S-81.
    • (1991) Am J Hypertens , vol.4 , pp. 275S-281S
    • Timmermans, P.B.1    Carini, D.J.2    Chiu, A.T.3
  • 138
    • 0015506533 scopus 로고
    • Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases
    • Buhler FR, Laragh JH, Baer L, et al. Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases. N Engl J Med. 1972. 287:1209-14.
    • (1972) N Engl J Med , vol.287 , pp. 1209-1214
    • Buhler, F.R.1    Laragh, J.H.2    Baer, L.3
  • 139
    • 0035841607 scopus 로고    scopus 로고
    • Esler m
    • Campbell DJ, Aggarwal A, Esler M, et al. p-blockers, angiotensin II, and ACE inhibitors in patients with heart failure. Lancet. 2001. 358:1609-10.
    • (2001) Lancet , vol.358 , pp. 1609-1610
    • Campbell, D.J.1    Aggarwal, A.2
  • 140
    • 0033549348 scopus 로고    scopus 로고
    • Benefit ofbeta-blockers for heart failure: Proven in 1999
    • Sharpe N. Benefit ofbeta-blockers for heart failure: proven in 1999. Lancet. 1999. 353:1988-9.
    • (1999) Lancet , vol.353 , pp. 1988-1989
    • Sharpe, N.1
  • 141
    • 0030980604 scopus 로고    scopus 로고
    • Valsartan, a new angiotensin ii receptor antagonist: A double-blind study comparing the incidence of cough with lisinopril and hydrochlorothiazide
    • Benz J, Oshrain C, Henry D, et al. Valsartan, a new angiotensin II receptor antagonist: a double-blind study comparing the incidence of cough with lisinopril and hydrochlorothiazide. J Clin Pharmacol. 1997. 37:101-7.
    • (1997) J Clin Pharmacol , vol.37 , pp. 101-107
    • Benz, J.1    Oshrain, C.2    Henry, D.3
  • 142
    • 0036196771 scopus 로고    scopus 로고
    • Can angiotensin receptor antagonists be used safely in patients with previous ace inhibitor-induced angioedema?
    • Howes LG, Tran D. Can angiotensin receptor antagonists be used safely in patients with previous ACE inhibitor-induced angioedema? Drug Saf. 2002. 25:73-6.
    • (2002) Drug Saf , vol.25 , pp. 73-76
    • Howes, L.G.1    Tran, D.2
  • 143
    • 0242490542 scopus 로고    scopus 로고
    • Valsartan in acute myocardial infarction trial investigators. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    • Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan in Acute Myocardial Infarction Trial Investigators. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003. 349:1893-906.
    • (2003) N Engl J Med , vol.349 , pp. 1893-1906
    • Pfeffer, M.A.1    McMurray, J.J.2    Velazquez, E.J.3
  • 144
    • 0347423198 scopus 로고    scopus 로고
    • Joint national committee on prevention, detection, evaluation, and treatment of high blood pressure
    • National Heart, Lung, and Blood Institute. National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure
    • Chobanian AV, Bakris GL, Black HR, et al. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute. National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003. 42:1206-52.
    • (2003) Hypertension , vol.42 , pp. 1206-1252
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 145
    • 0038460302 scopus 로고    scopus 로고
    • National heart, lung, and blood institute joint national committee on prevention, detection, evaluation, and treatment of high blood pressure
    • National High Blood Pressure Education Program Coordinating Committee. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report
    • Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National High Blood Pressure Education Program Coordinating Committee. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003. 289:2560-72.
    • (2003) JAMA , vol.289 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 146
    • 34249655660 scopus 로고    scopus 로고
    • American heart association council for high blood pressure research
    • American Heart Association Council on Clinical Cardiology. American Heart Association Council on Epidemiology and Prevention. Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention
    • Rosendorff C, Black HR, Cannon CP, et al. American Heart Association Council for High Blood Pressure Research. American Heart Association Council on Clinical Cardiology. American Heart Association Council on Epidemiology and Prevention. Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention. Circulation. 2007. 115:2761-88.
    • (2007) Circulation , vol.115 , pp. 2761-2788
    • Rosendorff, C.1    Black, H.R.2    Cannon, C.P.3
  • 147
    • 34547615709 scopus 로고    scopus 로고
    • Guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the european society of hypertension (esh) and of the european society of cardiology (esc)
    • Mancia G, De Backer G, Dominiczak A, et al. Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2007. 28:1462-536.
    • (2007) Eur Heart J , vol.28 , pp. 1462-1536
    • Mancia, G.1    De Backer, G.2    Dominiczak, A.3
  • 148
    • 0026786643 scopus 로고
    • Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The save investigators
    • Pfeffer MA, Braunwald E, Moye LA, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med. 1992. 327:669-77.
    • (1992) N Engl J Med , vol.327 , pp. 669-677
    • Pfeffer, M.A.1    Braunwald, E.2    Moye, L.A.3
  • 149
    • 0042330455 scopus 로고    scopus 로고
    • The european trial on reduction of cardiac events with perindopril in stable coronary artery disease investigators
    • Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)
    • Fox KM, The EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet. 2003. 362:782-8.
    • (2003) Lancet , vol.362 , pp. 782-788
    • Fox, K.M.1
  • 150
    • 0035328174 scopus 로고    scopus 로고
    • Quiet study group
    • The QUinapril Ischemic Event Trial (QUIET): evaluation of chronic ACE inhibitor therapy in patients with ischemic heart disease and preserved left ventricular function
    • Pitt B, O’Neill B, Feldman R, et al. QUIET Study Group. The QUinapril Ischemic Event Trial (QUIET): evaluation of chronic ACE inhibitor therapy in patients with ischemic heart disease and preserved left ventricular function. Am J Cardiol. 2001. 87:1058-63.
    • Am J Cardiol. 2001 , vol.87 , pp. 1058-1063
    • Pitt, B.1    O’ Neill, B.2    Feldman, R.3
  • 151
    • 84948989922 scopus 로고    scopus 로고
    • Peace trial investigators. Angiotensin-convertingenzyme inhibition in stable coronary artery disease
    • Braunwald E, Domanski MJ, Fowler SE, et al. PEACE Trial Investigators. Angiotensin-convertingenzyme inhibition in stable coronary artery disease. N Engl J Med. 2003. 362:782-8.
    • (2003) N Engl J Med , vol.362 , pp. 782-788
    • Braunwald, E.1    Domanski, M.J.2    Fowler, S.E.3
  • 152
    • 33746863179 scopus 로고    scopus 로고
    • Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: A combined analysis of three trials
    • Dagenais GR, Pogue J, Fox K, Simoons ML, Yusuf S. Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials. Lancet. 2006. 368:581-8.
    • (2006) Lancet , vol.368 , pp. 581-588
    • Dagenais, G.R.1    Pogue, J.2    Fox, K.3    Simoons, M.L.4    Yusuf, S.5
  • 153
    • 0034700790 scopus 로고    scopus 로고
    • Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: Results of the hope study and microhope substudy
    • Heart Outcomes Prevention Evaluation Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICROHOPE substudy. Lancet. 2000. 355:253-9.
    • (2000) Lancet , vol.355 , pp. 253-259
  • 154
    • 0034688194 scopus 로고    scopus 로고
    • Hope/hope- too study investigators
    • Effects of an angiotensinconverting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S, Sleight P, Pogue J, et al. HOPE/HOPE- TOO Study Investigators. Effects of an angiotensinconverting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000. 342:145-53.
    • (2000) N Engl J Med , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3
  • 155
    • 0027517659 scopus 로고
    • The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The collaborative study group
    • Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med. 1993. 329:1456-62.
    • (1993) N Engl J Med , vol.329 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rohde, R.D.4
  • 156
    • 24644510705 scopus 로고    scopus 로고
    • Hope/hope_too study investigators. Long-term effects of ramipril on cardiovascular events and on diabetes: Results of the hope study extension
    • Bosch J, Lonn E, Pogue J, et al. HOPE/HOPE_TOO Study Investigators. Long-term effects of ramipril on cardiovascular events and on diabetes: results of the HOPE study extension. Circulation. 2005. 112: 1339-46.
    • (2005) Circulation , vol.112 , pp. 1339-1346
    • Bosch, J.1    Lonn, E.2    Pogue, J.3
  • 157
    • 34548420712 scopus 로고    scopus 로고
    • Advance collaborative group. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the advance trial): A randomised controlled trial
    • Patel A, MacMahon S, Chalmers J, et al. ADVANCE Collaborative Group. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. 2007. 370: 829-40.
    • (2007) Lancet , vol.370 , pp. 829-840
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3
  • 158
    • 27944470071 scopus 로고    scopus 로고
    • Targeting the renin-angiotensin system for the reduction of cardiovascular outcomes in hypertension: Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers
    • Kjeldsen SE, Lyle PA, Tershakovec AM, et al. Targeting the renin-angiotensin system for the reduction of cardiovascular outcomes in hypertension: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Expert Opin Emerg Drugs. 2005. 10:729-45.
    • (2005) Expert Opin Emerg Drugs , vol.10 , pp. 729-745
    • Kjeldsen, S.E.1    Lyle, P.A.2    Tershakovec, A.M.3
  • 159
    • 33747767282 scopus 로고    scopus 로고
    • Angiotensin receptor blockers may increase risk of myocardial infarction: Unraveling the arb-mi paradox
    • Strauss MH, Hall AS. Angiotensin receptor blockers may increase risk of myocardial infarction: unraveling the ARB-MI paradox. Circulation. 2006. 114:838-54.
    • Circulation. 2006 , vol.114 , pp. 838-854
    • Strauss, M.H.1    Hall, A.S.2
  • 160
    • 9044220224 scopus 로고    scopus 로고
    • Comparison of the angiotensin ii antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension
    • Tikkanen I, Omvik P, Jensen HA. Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension. J Hypertens. 1995. 13:1343-51.
    • J Hypertens. 1995 , vol.13 , pp. 1343-1351
    • Tikkanen, I.1    Omvik, P.2    Jensen, H.A.3
  • 161
    • 0029775814 scopus 로고    scopus 로고
    • Valsartan, a new angiotensin ii antagonist for the treatment of essential hypertension: Efficacy and safety compared with placebo and enalapril
    • Holwerda NJ, Fogari R, Angeli P, et al. Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy and safety compared with placebo and enalapril. J Hypertens. 1996. 14:1147-51.
    • J Hypertens. 1996 , vol.14 , pp. 1147-1151
    • Holwerda, N.J.1    Fogari, R.2    Angeli, P.3
  • 162
    • 0030896946 scopus 로고    scopus 로고
    • Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough
    • Chan P, Tomlinson B, Huang TY, et al. Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. J Clin Pharmacol. 1997. 37:253-7.
    • (1997) J Clin Pharmacol , vol.37 , pp. 253-257
    • Chan, P.1    Tomlinson, B.2    Huang, T.Y.3
  • 163
    • 0037160968 scopus 로고    scopus 로고
    • Life study group. Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (life): A randomised trial against atenolol
    • Dahlof B, Devereux RB, Kjeldsen SE, et al. LIFE Study Group. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet. 2002. 359:995-1003.
    • (2002) Lancet , vol.359 , pp. 995-1003
    • Dahlof, B.1    Devereux, R.B.2    Kjeldsen, S.E.3
  • 164
    • 0037036971 scopus 로고    scopus 로고
    • Optimaal steering committee of the optimaal study group. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: The optimaal randomised trial
    • Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan
    • Dickstein K, Kjekshus J, OPTIMAAL Steering Committee of the OPTIMAAL Study Group. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan. Lancet. 2002. 360:752-60.
    • (2002) Lancet , vol.360 , pp. 752-760
    • Dickstein, K.1    Kjekshus, J.2
  • 165
    • 27944470102 scopus 로고    scopus 로고
    • Angiotensin ii receptor blockers and myocardial infarction: Deeds and misdeeds
    • Volpe M, Mancia G, Trimarco B. Angiotensin II receptor blockers and myocardial infarction: deeds and misdeeds. J Hypertens. 2005. 23:2113-8.
    • (2005) J Hypertens , vol.23 , pp. 2113-2118
    • Volpe, M.1    Mancia, G.2    Trimarco, B.3
  • 166
    • 42049107348 scopus 로고    scopus 로고
    • Ontarget investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events
    • Yusuf S, Teo KK, Pogue J, et al. ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008. 358:1547-59.
    • (2008) N Engl J Med , vol.358 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.K.2    Pogue, J.3
  • 167
    • 52249116778 scopus 로고    scopus 로고
    • Profess study group. Telmisartan to prevent recurrent stroke and cardiovascular events
    • Yusuf S, Diener HC, Sacco RL, et al. PROFESS Study Group. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med. 2008. 359:1225-37.
    • (2008) N Engl J Med , vol.359 , pp. 1225-1237
    • Yusuf, S.1    Diener, H.C.2    Sacco, R.L.3
  • 168
    • 62849083736 scopus 로고    scopus 로고
    • Telmisartan randomised assessment study in ace intolerant subjects with cardiovascular disease (Transcend) investigators
    • Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial
    • Yusuf S, Teo K, Anderson C, et al. Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial. Lancet. 2008. 372:1174-83.
    • (2008) Lancet , vol.372 , pp. 1174-1183
    • Yusuf, S.1    Teo, K.2    Erson, C.3
  • 169
    • 70349972814 scopus 로고    scopus 로고
    • Ontarget/transcend investigators. Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the ongoing telmisartan alone and in combination with ramipril global end point trial and the telmisartan randomized assessment study in ace intolerant subjects with cardiovascular disease
    • Verdecchia P, Sleight P, Mancia G, et al. ONTARGET/TRANSCEND Investigators. Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global End point Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease. Circulation. 2009. 120: 1380-9.
    • (2009) Circulation , vol.120 , pp. 1380-1389
    • Verdecchia, P.1    Sleight, P.2    Mancia, G.3
  • 170
    • 0037377574 scopus 로고    scopus 로고
    • Differential response of cardiac fibroblasts from young and senescent rats to ang ii
    • Shivakumar K, Dostal DE, Boheler K, et al. Differential response of cardiac fibroblasts from young and senescent rats to ANG II. Am J Physiol Heart Circ Physiol. 2003. 284:H1454-9.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284 , pp. H1454-H1459
    • Shivakumar, K.1    Dostal, D.E.2    Boheler, K.3
  • 171
    • 34548414599 scopus 로고    scopus 로고
    • Protective effect of long-term angiotensin ii inhibition
    • Basso N, Cini R, Pietrelli A, et al. Protective effect of long-term angiotensin II inhibition. Am J Physiol Heart Circ Physiol. 2007. 293:H1351-8.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H1351-H1358
    • Basso, N.1    Cini, R.2    Pietrelli, A.3
  • 172
    • 0142043899 scopus 로고    scopus 로고
    • Predictors of late development of heart failure in stable survivors of myocardial infarction: The care study
    • Lewis EF, Moye LA, Rouleau JL, et al. Predictors of late development of heart failure in stable survivors of myocardial infarction: the CARE study. J Am Coll Cardiol. 2003. 42:1446-53.
    • (2003) J am Coll Cardiol , vol.42 , pp. 1446-1453
    • Lewis, E.F.1    Moye, L.A.2    Rouleau, J.L.3
  • 173
    • 0000531635 scopus 로고    scopus 로고
    • Cardiovascular death and left ventricular remodeling two years after myocardial infarction: Baseline predictors and impact of long-term use of captopril: Information from the survival and ventricular enlargement (save) trial
    • St John Sutton M, Pfeffer MA, Moye L, et al. Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial. Circulation. 1997. 96:3294-9.
    • Circulation. 1997 , vol.96 , pp. 3294-3299
    • St John Sutton, M.1    Pfeffer, M.A.2    Moye, L.3
  • 174
    • 0027428865 scopus 로고
    • Age-related increase in mortality among patients with first myocardial infarctions treated with thrombolysis. The investigators of the gruppo italiano per lo studio della supravvivenza nell’infarcto miocardico (gissi-2)
    • Maggioni AP, Maseri A, Fresco C, et al. Age-related increase in mortality among patients with first myocardial infarctions treated with thrombolysis. The investigators of the gruppo Italiano per lo Studio della supravvivenza nell’Infarcto Miocardico (GISSI-2). N Engl J Med. 1993. 329:1442-8.
    • (1993) N Engl J Med , vol.329 , pp. 1442-1448
    • Maggioni, A.P.1    Maseri, A.2    Fresco, C.3
  • 175
    • 0000724991 scopus 로고    scopus 로고
    • Prevention of ventricular remodeling after myocardial infarction and in congestive heart failure
    • Jugdutt BI. Prevention of ventricular remodeling after myocardial infarction and in congestive heart failure. Heart Fail Rev. 1996. 1:115-29.
    • (1996) Heart Fail Rev , vol.1 , pp. 115-129
    • Jugdutt, B.I.1
  • 176
    • 0141653901 scopus 로고    scopus 로고
    • Ventricular remodeling post-infarction and the extracellular collagen matrix. When is enough enough?
    • Jugdutt BI. Ventricular remodeling post-infarction and the extracellular collagen matrix. When is enough enough? Circulation. 2003. 108:1395-403.
    • (2003) Circulation , vol.108 , pp. 1395-1403
    • Jugdutt, B.I.1
  • 177
    • 0037372536 scopus 로고    scopus 로고
    • Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways
    • Jugdutt BI. Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways. Curr Drug Targets Cardiovasc Haematol Disord. 2003. 3:1-30.
    • (2003) Curr Drug Targets Cardiovasc Haematol Disord , vol.3 , pp. 1-30
    • Jugdutt, B.I.1
  • 179
    • 0037195160 scopus 로고    scopus 로고
    • Left ventricular remodeling after primary coronary angioplasty: Patterns of left ventricular dilation and long-term prognostic implications
    • Bolognese L, Neskovic AN, Parodi G, et al. Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications. Circulation. 2002. 106:2351-7.
    • (2002) Circulation , vol.106 , pp. 2351-2357
    • Bolognese, L.1    Neskovic, A.N.2    Parodi, G.3
  • 180
    • 1542409911 scopus 로고    scopus 로고
    • Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction
    • Bolognese L, Carrabba N, Parodi G, et al. Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction. Circulation. 2004. 109:1121-6.
    • (2004) Circulation , vol.109 , pp. 1121-1126
    • Bolognese, L.1    Carrabba, N.2    Parodi, G.3
  • 181
    • 33645469422 scopus 로고    scopus 로고
    • Results of the randomized perindopril and remodeling elderly with acute myocardial infarction (Preami) study
    • Ferrari R, for the PREAMI Investigators. Effects of angiotensin-converting enzyme inhibition with peri- dopril on left ventricular remodeling and clinical outcome. Results of the randomized Perindopril and Remodeling Elderly with Acute Myocardial Infarction (PREAMI) study. Arch Intern Med. 2006. 166:659-66.
    • Arch Intern Med. 2006 , vol.166 , pp. 659-666
    • Ferrari, R.1
  • 182
    • 59449106597 scopus 로고    scopus 로고
    • Role of healing-specific-matricellular proteins and matrix metalloproteinases in age-related enhanced early remodeling after reperfused stemi in dogs
    • Jugdutt BI, Palaniyappan A, Uwiera RRE, Idikio H. Role of healing-specific-matricellular proteins and matrix metalloproteinases in age-related enhanced early remodeling after reperfused STEMI in dogs. Mol Cell Biochem. 2009. 322:25-36.
    • (2009) Mol Cell Biochem , vol.322 , pp. 25-36
    • Jugdutt, B.I.1    Palaniyappan, A.2    Uwiera, R.3    Idikio, H.4
  • 183
    • 84948968699 scopus 로고    scopus 로고
    • Secretory leucocyte protease inhibitor and matricellular protein modulation of post reperfused myocardial infarction healing, fibrosis and remodeling in rat model
    • Circulation
    • Palaniyappan A, Idikio H, Jugdutt BI. Secretory leucocyte protease inhibitor and matricellular protein modulation of post reperfused myocardial infarction healing, fibrosis and remodeling in rat model. Effect of candesartan and omapatrilat. Circulation. 2009. 120 Suppl 2:S837 (Abstract).
    • (2009) Effect of Candesartan and Omapatrilat , vol.120 , pp. S837
    • Palaniyappan, A.1    Idikio, H.2    Jugdutt, B.I.3
  • 184
    • 34250862176 scopus 로고    scopus 로고
    • Angiotensin receptors and aging
    • Carey RM. Angiotensin receptors and aging. Hypertension. 2007. 50:33-4.
    • (2007) Hypertension , vol.50 , pp. 33-34
    • Carey, R.M.1
  • 185
    • 34250796304 scopus 로고    scopus 로고
    • Paradoxical role of angiotensin ii type 2 receptors in resistance arteries of old rats
    • Pinaud F, Bocquet A, Dumont O, et al. Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats. Hypertension. 2007. 50:96-102.
    • (2007) Hypertension , vol.50 , pp. 96-102
    • Pinaud, F.1    Bocquet, A.2    Dumont, O.3
  • 186
    • 33846427712 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients
    • Savoia C, Touyz RM, Volpe M, Schiffrin EL. Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension. 2007. 49:341-6.
    • (2007) Hypertension , vol.49 , pp. 341-346
    • Savoia, C.1    Touyz, R.M.2    Volpe, M.3    Schiffrin, E.L.4
  • 187
    • 77955709345 scopus 로고    scopus 로고
    • The role of inflammatory and fibrogenic pathways in heart failure associated with aging
    • Chen W, Frangogiannis NG. The role of inflammatory and fibrogenic pathways in heart failure associated with aging. Heart Fail Rev. 2010. 15:415-22.
    • (2010) Heart Fail Rev , vol.15 , pp. 415-422
    • Chen, W.1    Frangogiannis, N.G.2
  • 188
    • 77955698907 scopus 로고    scopus 로고
    • Modulation of p-adrenergic receptor signaling in heart failure and longevity: Targeting adenyl cyclase type 5
    • Ho D, Yan L, Iwatsubo K, Vatner DE, Varner SF. Modulation of p-adrenergic receptor signaling in heart failure and longevity: targeting adenyl cyclase type 5. Heart Fail Rev. 2010. 15:495-512.
    • (2010) Heart Fail Rev , vol.15 , pp. 495-512
    • Ho, D.1    Yan, L.2    Iwatsubo, K.3    Vatner, D.E.4    Varner, S.F.5
  • 189
    • 84862638785 scopus 로고    scopus 로고
    • The role of mineralocorticoid receptor antagonists (Mras) in very old patients with heart failure
    • Pitt B. The role of mineralocorticoid receptor antagonists (MRAs) in very old patients with heart failure. Heart Fail Rev. 2012. 17:573-9.
    • (2012) Heart Fail Rev , vol.17 , pp. 573-579
    • Pitt, B.1
  • 190
    • 0023122783 scopus 로고
    • Benefits and potential harm of lowering high blood pressure
    • Cruickshank JM, Thorp JM, Zacharias FJ. Benefits and potential harm of lowering high blood pressure. Lancet. 1987. 1(8533):581-4.
    • (1987) Lancet , vol.1 , Issue.8533 , pp. 581-584
    • Cruickshank, J.M.1    Thorp, J.M.2    Zacharias, F.J.3
  • 191
    • 0026343631 scopus 로고
    • Intravenous nitroglycerin unloading in acute myocardial infarction
    • Jugdutt BI. Intravenous nitroglycerin unloading in acute myocardial infarction. Am J Cardiol. 1991. 68(14):52D-63.
    • (1991) Am J Cardiol , vol.68 , Issue.14 , pp. 52D-63D
    • Jugdutt, B.I.1
  • 192
    • 9744237279 scopus 로고    scopus 로고
    • Angiotensin receptor blockers and myocardial infarction
    • Verma S, Strauss M. Angiotensin receptor blockers and myocardial infarction. BMJ. 2004. 329:1248-9.
    • (2004) BMJ , vol.329 , pp. 1248-1249
    • Verma, S.1    Strauss, M.2
  • 193
    • 33645004041 scopus 로고    scopus 로고
    • The role of angiotensin ii type 1 receptor antagonists in elderly patients with hypertension
    • Thomas GN, Chan P, Tomlinson B. The role of angiotensin II type 1 receptor antagonists in elderly patients with hypertension. Drugs Aging. 2006. 23:131-55.
    • Drugs Aging. 2006 , vol.23 , pp. 131-155
    • Thomas, G.N.1    Chan, P.2    Tomlinson, B.3
  • 194
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999. 341:709-17.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 195
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: Insights from the randomized aldactone evaluation study (rales)
    • Rales Investigators
    • Zannad F, Alla F, Dousset B, Perez A, Pitt B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators. Circulation. 2000. 102:2700-6.
    • (2000) Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 196
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone postacute myocardial infarction heart failure efficacy and survival study investigators
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F, et al. Eplerenone PostAcute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003. 348:1309-21.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 197
    • 22844437062 scopus 로고    scopus 로고
    • Ephesus investigators
    • Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure
    • Pitt B, White H, Nicolau J, et al. EPHESUS Investigators. Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol. 2005. 46:425-31.
    • (2005) J am Coll Cardiol , vol.46 , pp. 425-431
    • Pitt, B.1    White, H.2    Nicolau, J.3
  • 198
    • 70349990209 scopus 로고    scopus 로고
    • Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone
    • Mak GJ, Ledwidge MT, Watson CJ, et al. Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone. J Am Coll Cardiol. 2009. 54:1674-82.
    • (2009) J am Coll Cardiol , vol.54 , pp. 1674-1682
    • Mak, G.J.1    Ledwidge, M.T.2    Watson, C.J.3
  • 199
    • 78650399880 scopus 로고    scopus 로고
    • Eplerenone in patients with systolic heart failure and mild symptoms
    • Zannad F, McMurray JJ, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011. 364:11-21.
    • (2011) N Engl J Med , vol.364 , pp. 11-21
    • Zannad, F.1    McMurray, J.J.2    Krum, H.3
  • 200
    • 85047687352 scopus 로고    scopus 로고
    • Impact of mineralocorticoid receptor antagonists on changes in cardiac structure and function of left ventricular dysfunction. A metaanalysis of randomized controlled trials
    • Li X, Qi Y, Li Y, et al. Impact of mineralocorticoid receptor antagonists on changes in cardiac structure and function of left ventricular dysfunction. A metaanalysis of randomized controlled trials. Circ Heart Fail. 2013. 6:156-65.
    • (2013) Circ Heart Fail , vol.6 , pp. 156-165
    • Li, X.1    Qi, Y.2    Li, Y.3
  • 202
    • 44349166506 scopus 로고    scopus 로고
    • Age- dependent decrease 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-hsd2) activity in hypertensive patients
    • Henschkowski J, Stuck AE, Frey BM, et al. Age- dependent decrease 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) activity in hypertensive patients. Am J Hypertens. 2008. 21:644-9.
    • (2008) Am J Hypertens , vol.21 , pp. 644-649
    • Henschkowski, J.1    Stuck, A.E.2    Frey, B.M.3
  • 203
    • 0023743171 scopus 로고
    • Mineralocorticoid action: Target-tissue specificity is enzyme, not receptor mediated
    • Funder JW, Pearce P, Smith R, Smith AL. Mineralocorticoid action: target-tissue specificity is enzyme, not receptor mediated. Science. 1988. 242: 583-5.
    • (1988) Science , vol.242 , pp. 583-585
    • Funder, J.W.1    Pearce, P.2    Smith, R.3    Smith, A.L.4
  • 204
    • 0023761690 scopus 로고
    • Localization of 11 beta-hydroxysteroid dehydrogenase-tissue specific receptor of the mineralocorticoid receptor
    • Edwards CR, Stewart PM, Burt D, et al. Localization of 11 beta-hydroxysteroid dehydrogenase-tissue specific receptor of the mineralocorticoid receptor. Lancet. 1988. 2:986-9.
    • (1988) Lancet , vol.2 , pp. 986-989
    • Edwards, C.R.1    Stewart, P.M.2    Burt, D.3
  • 206
    • 59849118673 scopus 로고    scopus 로고
    • Reconsidering the roles of the mineralocorticoid receptor
    • Funder WF. Reconsidering the roles of the mineralocorticoid receptor. Hypertension. 2008. 53(Pt 2): 286-90.
    • (2008) Hypertension , vol.53 , pp. 286-290
    • Funder, W.F.1
  • 207
    • 12144288823 scopus 로고    scopus 로고
    • Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension
    • Bocchi B, Kenouch S, Lamarre-Cliche M, et al. Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension. Hypertension. 2004. 43:803-8.
    • (2004) Hypertension , vol.43 , pp. 803-808
    • Bocchi, B.1    Kenouch, S.2    Lamarre-Cliche, M.3
  • 208
    • 33751404901 scopus 로고    scopus 로고
    • Why are mineralocorticoid receptor antagonists cardioprotective?
    • Chai W, Danser AHJ. Why are mineralocorticoid receptor antagonists cardioprotective? Naunyn Schmiedebergs Arch Pharmacol. 2006. 374:153-62.
    • (2006) Naunyn Schmiedebergs Arch Pharmacol , vol.374 , pp. 153-162
    • Chai, W.1    Danser, A.2
  • 209
    • 77952958303 scopus 로고    scopus 로고
    • Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways
    • Krug AW, Allenhofer L, Monticone R, et al. Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways. Hypertension. 2010. 55:1476-83.
    • (2010) Hypertension , vol.55 , pp. 1476-1483
    • Krug, A.W.1    Allenhofer, L.2    Monticone, R.3
  • 210
    • 41149110120 scopus 로고    scopus 로고
    • Association of leucocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: The framingham heart study
    • Vasan RS, Demisse S, Kimura M, et al. Association of leucocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study. Circulation. 2008. 117:1138-44.
    • (2008) Circulation , vol.117 , pp. 1138-1144
    • Vasan, R.S.1    Demisse, S.2    Kimura, M.3
  • 212
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4e-left ventricular hypertrophy study
    • Pitt B, Reichek N, Willenbrock R, et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation. 2003. 108:1831-8.
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 213
    • 3543099842 scopus 로고    scopus 로고
    • Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure
    • Mottram PM, Haluska B, Leano R, et al. Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure. Circulation. 2004. 110:558-65.
    • (2004) Circulation , vol.110 , pp. 558-565
    • Mottram, P.M.1    Haluska, B.2    Leano, R.3
  • 214
    • 38549140081 scopus 로고    scopus 로고
    • Selective mineralocorticoid receptor blocker eplere- none reduces resistance artery stiffness in hypertensive patients
    • Savoia C, Touyz RM, Amiri F, Schiffrin EL. Selective mineralocorticoid receptor blocker eplere- none reduces resistance artery stiffness in hypertensive patients. Hypertension. 2008. 51:432-9.
    • (2008) Hypertension , vol.51 , pp. 432-439
    • Savoia, C.1    Touyz, R.M.2    Amiri, F.3    Schiffrin, E.L.4
  • 215
    • 78651297483 scopus 로고    scopus 로고
    • Role of plasma aldosterone concentration in regression of left- ventricular mass following antihypertensive medication
    • Yoshida C, Goda A, Naito Y, et al. Role of plasma aldosterone concentration in regression of left- ventricular mass following antihypertensive medication. J Hypertens. 2011. 29:357-63.
    • (2011) J Hypertens , vol.29 , pp. 357-363
    • Yoshida, C.1    Goda, A.2    Naito, Y.3
  • 216
    • 84874367056 scopus 로고    scopus 로고
    • Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: The aldo-dhf randomized controlled trial
    • Edelmann F, Wachter R, Schmidt AG, et al. Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. JAMA. 2013. 309:781-91.
    • (2013) JAMA , vol.309 , pp. 781-791
    • Edelmann, F.1    Wachter, R.2    Schmidt, A.G.3
  • 217
    • 84877259591 scopus 로고    scopus 로고
    • Baseline characteristics of patients in the treatment of preserved cardiac function with an aldosterone antagonist trial
    • Shah SJ, Heitner JF, Sweitzer NK, et al. Baseline characteristics of patients in the treatment of preserved cardiac function with an aldosterone antagonist trial. Circ Heart Fail. 2013. 6:184-92.
    • (2013) Circ Heart Fail , vol.6 , pp. 184-192
    • Shah, S.J.1    Heitner, J.F.2    Sweitzer, N.K.3
  • 218
    • 33748141662 scopus 로고    scopus 로고
    • Plasma aldosterone is independently associated with the metabolic syndrome
    • Bochud M, Nussberger J, Bovet P, et al. Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension. 2006. 48:239-45.
    • (2006) Hypertension , vol.48 , pp. 239-245
    • Bochud, M.1    Nussberger, J.2    Bovet, P.3
  • 219
    • 49649085000 scopus 로고    scopus 로고
    • The aggravating mechanisms of aldosterone on kidney fibrosis
    • Remuzzi G, Cattaneo D, Perico N. The aggravating mechanisms of aldosterone on kidney fibrosis. J Am Soc Nephrol. 2008. 19:1459-62.
    • (2008) J am Soc Nephrol , vol.19 , pp. 1459-1462
    • Remuzzi, G.1    Cattaneo, D.2    Perico, N.3
  • 220
    • 33847193562 scopus 로고    scopus 로고
    • Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension
    • Pratt-Ubanama MN, Nishizaka MK, Boedefeld RL, et al. Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension. Chest. 2007. 131:453-9.
    • (2007) Chest , vol.131 , pp. 453-459
    • Pratt-Ubanama, M.N.1    Nishizaka, M.K.2    Boedefeld, R.L.3
  • 221
    • 77952395275 scopus 로고    scopus 로고
    • Plasma aldoste rone levels are associated with increased cardiovascular mortality: The ludwigshafen risk and cardiovascular (luric) health study
    • Tomaschitz A, Pilz S, Ritz E, et al. Plasma aldoste rone levels are associated with increased cardiovascular mortality: the Ludwigshafen Risk and Cardiovascular (LURIC) health study. Eur Heart J. 2010. 31:1237-47.
    • (2010) Eur Heart J , vol.31 , pp. 1237-1247
    • Tomaschitz, A.1    Pilz, S.2    Ritz, E.3
  • 222
    • 84856143583 scopus 로고    scopus 로고
    • Aldosterone, mortality, and acute ischemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure
    • Ivanes F, Susen S, Mouquet F, et al. Aldosterone, mortality, and acute ischemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure. Eur Heart J. 2012. 33:191-202.
    • (2012) Eur Heart J , vol.33 , pp. 191-202
    • Ivanes, F.1    Susen, S.2    Mouquet, F.3
  • 223
    • 67651048925 scopus 로고    scopus 로고
    • Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: A randomized controlled trial
    • Edwards NC, Steeds RP, Stewart PM, et al. Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial. J Am Coll Cardiol. 2009. 54:505-12.
    • (2009) J am Coll Cardiol , vol.54 , pp. 505-512
    • Edwards, N.C.1    Steeds, R.P.2    Stewart, P.M.3
  • 224
    • 77950510305 scopus 로고    scopus 로고
    • Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome
    • Fujita T. Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. Hypertension. 2010. 55:813-8.
    • (2010) Hypertension , vol.55 , pp. 813-818
    • Fujita, T.1
  • 225
    • 34748888358 scopus 로고    scopus 로고
    • A possible association between primary aldosteronism and a lower beta-cell function
    • Mosso LM, Carvajal CA, Maiz A, et al. A possible association between primary aldosteronism and a lower beta-cell function. Hypertension. 2007. 25:2125-30.
    • Hypertension. 2007 , vol.25 , pp. 2125-2130
    • Mosso, L.M.1    Carvajal, C.A.2    Maiz, A.3
  • 226
    • 33846963787 scopus 로고    scopus 로고
    • Aldosterone impairs vascular reactivity by decreasing glucose-6- phosphate dehydrogenase activity
    • Leopold JA, Dam A, Maron BA, et al. Aldosterone impairs vascular reactivity by decreasing glucose-6- phosphate dehydrogenase activity. Nat Med. 2007. 13:189-97.
    • (2007) Nat Med , vol.13 , pp. 189-197
    • Leopold, J.A.1    Dam, A.2    Maron, B.A.3
  • 227
    • 0037024518 scopus 로고    scopus 로고
    • The pathophysiology of aldosterone in the cardiovascular system
    • Rocha R, Funder JW. The pathophysiology of aldosterone in the cardiovascular system. Ann NY Acad Sci. 2002. 970:89-100.
    • (2002) Ann NY Acad Sci , vol.970 , pp. 89-100
    • Rocha, R.1    Funder, J.W.2
  • 228
    • 15744377168 scopus 로고    scopus 로고
    • Aldosterone activates vascular p38map kinase and nadph oxidase via c-src
    • Callera GE, Touyz RM, Tostes RC, et al. Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension. 2005. 45:773-9.
    • (2005) Hypertension , vol.45 , pp. 773-779
    • Callera, G.E.1    Touyz, R.M.2    Tostes, R.C.3
  • 229
    • 77956388193 scopus 로고    scopus 로고
    • Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice
    • Usher MG, Duan SZ, Ivaschenko CY, et al. Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest. 2010. 120:3350-64.
    • J Clin Invest. 2010 , vol.120 , pp. 3350-3364
    • Usher, M.G.1    Duan, S.Z.2    Ivaschenko, C.Y.3
  • 230
    • 27644585370 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients
    • Keidar S, Gamliel-Lazarovich A, Kaplan M, et al. Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients. Circ Res. 2005. 97: 946-53.
    • (2005) Circ Res , vol.97 , pp. 946-953
    • Keidar, S.1    Gamliel-Lazarovich, A.2    Kaplan, M.3
  • 231
    • 48749108107 scopus 로고    scopus 로고
    • Aldosterone, but not angiotensin ii, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rats cardiomyocytes
    • Yamamuro M, Yoshimura M, Nakayama M, et al. Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rats cardiomyocytes. Circ J. 2008. 72:1346-50.
    • (2008) Circ J , vol.72 , pp. 1346-1350
    • Yamamuro, M.1    Yoshimura, M.2    Nakayama, M.3
  • 232
    • 84860309326 scopus 로고    scopus 로고
    • Emphasis-hf study investigators. Eplerenone and atrial fibrillation in mild systolic heart failure: Results from the emphasis-hf (eplerenone in mild patients hospitalization and survival study in heart failure) study
    • Swedberg K, Zannad F, McMurray JJ, et al. EMPHASIS-HF Study Investigators. Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (eplerenone in mild patients hospitalization and survival study in heart failure) study. J Am Coll Cardiol. 2012. 59: 1598-603.
    • (2012) J am Coll Cardiol , vol.59 , pp. 1598-1603
    • Swedberg, K.1    Zannad, F.2    McMurray, J.J.3
  • 233
    • 33846443625 scopus 로고    scopus 로고
    • Podocyte as the target for aldosterone: Roles of oxidative stress and sgk1
    • Shibata S, Nagase M, Yoshida S, Kawachi H, Fujita T. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension. 2007. 49: 355-64.
    • (2007) Hypertension , vol.49 , pp. 355-364
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3    Kawachi, H.4    Fujita, T.5
  • 234
    • 79954571357 scopus 로고    scopus 로고
    • Mineralocorticoid receptor-mediated dna damage in kidneys of doca-salt hypertensive rats
    • Schupp N, Kolkhof P, Queisser N, et al. Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats. FASEB J. 2011. 25:968-78.
    • (2011) FASEB J , vol.25 , pp. 968-978
    • Schupp, N.1    Kolkhof, P.2    Queisser, N.3
  • 235
    • 58149360318 scopus 로고    scopus 로고
    • Blockades of angiotensin and aldosterone reduce osteopontin expression and interstitial fibrosis infiltration in rats with myocardial infarction
    • Zhang Y-L, Zhou S-X, Lei J, Yuan G-Y, Wang J-F. Blockades of angiotensin and aldosterone reduce osteopontin expression and interstitial fibrosis infiltration in rats with myocardial infarction. Chin Med J. 2008. 121:2192-6.
    • (2008) Chin Med J , vol.121 , pp. 2192-2196
    • Zhang, Y.-L.1    Zhou, S.-X.2    Lei, J.3    Yuan, G.-Y.4    Wang, J.-F.5
  • 236
    • 0037488488 scopus 로고    scopus 로고
    • Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure
    • Qin W, Rudolph AE, Bond BR, et al. Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. Circ Res. 2003. 93:69-76.
    • (2003) Circ Res , vol.93 , pp. 69-76
    • Qin, W.1    Rudolph, A.E.2    Bond, B.R.3
  • 237
    • 68549109739 scopus 로고    scopus 로고
    • Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density
    • Messaoudi S, Milliez P, Samuel JL, Delcayre C. Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density. FASEB J. 2009. 23: 2176-85.
    • (2009) FASEB J , vol.23 , pp. 2176-2185
    • Messaoudi, S.1    Milliez, P.2    Samuel, J.L.3    Delcayre, C.4
  • 238
    • 79953224745 scopus 로고    scopus 로고
    • Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function
    • Lother A, Berger S, Gilsbach R, et al. Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension. 2011. 57:746-54.
    • (2011) Hypertension , vol.57 , pp. 746-754
    • Lother, A.1    Berger, S.2    Gilsbach, R.3
  • 239
    • 3442888821 scopus 로고    scopus 로고
    • Managing hyperkalemia caused by inhibition of the nin-angiotensin-aldosterone system
    • Palmer BF. Managing hyperkalemia caused by inhibition of the nin-angiotensin-aldosterone system. N Engl J Med. 2004. 351:585-92.
    • (2004) N Engl J Med , vol.351 , pp. 585-592
    • Palmer, B.F.1
  • 240
    • 79953720277 scopus 로고    scopus 로고
    • The pearl-hf investigators
    • Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial
    • Pitt B, Anker SD, Bushinsky DA, Kitzman DW, Zannad F, Huang IZ, the PEARL-HF investigators. Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial. Eur Heart J. 2011. 32:820-8.
    • (2011) Eur Heart J , vol.32 , pp. 820-828
    • Pitt, B.1    Anker, S.D.2    Bushinsky, D.A.3    Kitzman, D.W.4    Zannad, F.5    Huang, I.Z.6
  • 241
    • 84863807562 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: A meta-analysis of randomized clinical trials of renin-angiotensin- aldosterone system inhibitors involving 158998 patients
    • van Vark LC, Bertrand M, Akkerhuis KM, et al. Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin- aldosterone system inhibitors involving 158998 patients. Eur Heart J. 2012. 33:2088-97.
    • (2012) Eur Heart J , vol.33 , pp. 2088-2097
    • Van Vark, L.C.1    Bertrand, M.2    Akkerhuis, K.M.3
  • 242
    • 81855199764 scopus 로고    scopus 로고
    • Therapeutic perspectives in hypertension: Novel means for renin- angiotensin-aldosterone system modulation and emerging device-based approaches
    • Unger T, Paulis L, Sica DA. Therapeutic perspectives in hypertension: novel means for renin- angiotensin-aldosterone system modulation and emerging device-based approaches. Eur Heart J. 2011. 32:2739-47.
    • (2011) Eur Heart J , vol.32 , pp. 2739-2747
    • Unger, T.1    Paulis, L.2    Sica, D.A.3
  • 243
    • 49249106417 scopus 로고    scopus 로고
    • Resistant hypertension: Diagnosis, evaluation, and treatment. A scientific statement from the american heart association professional education committee of the council for high blood pressure research
    • Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008. 51:1403-19.
    • (2008) Hypertension , vol.51 , pp. 1403-1419
    • Calhoun, D.A.1    Jones, D.2    Textor, S.3
  • 244
    • 77953839811 scopus 로고    scopus 로고
    • Optimal antagonism of the renin-angiotensin-aldosterone system: Do we need dual or triple therapy?
    • Werner C, Poss J, Bohm M. Optimal antagonism of the renin-angiotensin-aldosterone system: do we need dual or triple therapy? Drugs. 2010. 70:1215-30.
    • (2010) Drugs , vol.70 , pp. 1215-1230
    • Werner, C.1    Poss, J.2    Bohm, M.3
  • 245
    • 78149238346 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition with lci699. A proof-of-concept study in patients with primary aldosteronism
    • Amar L, Azizi M, Menard J, et al. Aldosterone synthase inhibition with LCI699. A proof-of-concept study in patients with primary aldosteronism. Hypertension. 2010. 56:831-8.
    • (2010) Hypertension , vol.56 , pp. 831-838
    • Amar, L.1    Azizi, M.2    Menard, J.3
  • 246
    • 20544453256 scopus 로고    scopus 로고
    • Aldosterone synthase inhibitor ameliorates angio- tensin-ii induced organ damage
    • Fiebeler A, Nussberger J, Shagdarsuren E, et al. Aldosterone synthase inhibitor ameliorates angio- tensin-II induced organ damage. Circulation. 2005. 111:3087-94.
    • (2005) Circulation , vol.111 , pp. 3087-3094
    • Fiebeler, A.1    Nussberger, J.2    Shagdarsuren, E.3
  • 247
    • 64949189157 scopus 로고    scopus 로고
    • Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt
    • Lea WB, Kwak ES, Luther JM, et al. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int. 2009. 75:936-44.
    • (2009) Kidney Int , vol.75 , pp. 936-944
    • Lea, W.B.1    Kwak, E.S.2    Luther, J.M.3
  • 248
    • 50849123772 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: A comparison with spironolactone
    • Mulder P, Mellin V, Favre J, et al. Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone. Eur Heart J. 2008. 29:2171-9.
    • (2008) Eur Heart J , vol.29 , pp. 2171-2179
    • Mulder, P.1    Mellin, V.2    Favre, J.3
  • 249
    • 0036372173 scopus 로고    scopus 로고
    • Angiotensin ii suppression in humans by the orally active renin inhibitor aliskiren (Spp100): Comparison with enalapril
    • Nussberger J, Wuerzner G, Jensen C, Brunner HR. Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension. 2002. 39:E1-8.
    • (2002) Hypertension , vol.39 , pp. E1-E8
    • Nussberger, J.1    Wuerzner, G.2    Jensen, C.3    Brunner, H.R.4
  • 250
    • 56749085787 scopus 로고    scopus 로고
    • Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension
    • Dietz R, Dechend R, Yu CM, et al. Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension. J Renin Angiotensin Aldosterone Syst. 2008. 9:163-75.
    • (2008) J Renin Angiotensin Aldosterone Syst , vol.9 , pp. 163-175
    • Dietz, R.1    Dechend, R.2    Yu, C.M.3
  • 251
    • 60549087324 scopus 로고    scopus 로고
    • Longterm antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: A 12-month randomized, double-blind comparator trial with hydrochlorothiazide
    • Schmieder RE, Philipp T, Guerediaga J, et al. Longterm antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide. Circulation. 2009. 119:417-25.
    • (2009) Circulation , vol.119 , pp. 417-425
    • Schmieder, R.E.1    Philipp, T.2    Guerediaga, J.3
  • 252
    • 39849089447 scopus 로고    scopus 로고
    • Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: A 6-month, randomized, double-blind trial
    • Andersen K, Weinberger MH, Egan B, et al. Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J Hypertens. 2008. 26:589-99.
    • (2008) J Hypertens , vol.26 , pp. 589-599
    • Andersen, K.1    Weinberger, M.H.2    Egan, B.3
  • 253
    • 77955921291 scopus 로고    scopus 로고
    • Aliskiren for geriatric lowering of systolic hypertension: A randomized controlled trial
    • Duprez DA, Munger MA, Botha J, Keefe DL, Charney AN. Aliskiren for geriatric lowering of systolic hypertension: a randomized controlled trial. J Hum Hypertens. 2010. 24:600-8.
    • (2010) J Hum Hypertens , vol.24 , pp. 600-608
    • Duprez, D.A.1    Munger, M.A.2    Botha, J.3    Keefe, D.L.4    Charney, A.N.5
  • 254
    • 0347479295 scopus 로고    scopus 로고
    • Blood pressure lowering in essential hypertensionwith an oral renin inhibitor
    • aliskiren
    • Stanton A, Jensen C, Nussberger J, O’Brien E. Blood pressure lowering in essential hypertensionwith an oral renin inhibitor, aliskiren. Hypertension. 2003. 42:1137-43.
    • (2003) Hypertension , vol.42 , pp. 1137-1143
    • Stanton, A.1    Jensen, C.2    Nussberger, J.3    O’ Brien, E.4
  • 255
    • 0342894669 scopus 로고    scopus 로고
    • Synergistic effects of ace inhibition and angii antagonism on blood pressure, cardiac weight, and renin in spontaneously hypertensive rats
    • Menard J, Campbell DJ, Azizi M, Gonzales MF. Synergistic effects of ACE inhibition and AngII antagonism on blood pressure, cardiac weight, and renin in spontaneously hypertensive rats. Circulation. 1997. 96:3072-8.
    • (1997) Circulation , vol.96 , pp. 3072-3078
    • Menard, J.1    Campbell, D.J.2    Azizi, M.3    Gonzales, M.F.4
  • 256
    • 34247644329 scopus 로고    scopus 로고
    • Aliskiren, the first renin inhibitor for treating hypertension: Reactive renin secretion may limit its effectiveness
    • Sealey JE, Laragh JH. Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness. Am J Hypertens. 2007. 20:587-97.
    • (2007) Am J Hypertens , vol.20 , pp. 587-597
    • Sealey, J.E.1    Laragh, J.H.2
  • 257
    • 56749090710 scopus 로고    scopus 로고
    • Prorenin engages the pro(Renin) receptor like renin and both ligand activities are unopposed by aliskiren
    • Schefe JH, Neumann C, Goebel M, et al. Prorenin engages the pro(renin) receptor like renin and both ligand activities are unopposed by aliskiren. J Hypertens. 2008. 26:1787-94.
    • (2008) J Hypertens , vol.26 , pp. 1787-1794
    • Schefe, J.H.1    Neumann, C.2    Goebel, M.3
  • 258
    • 57449084151 scopus 로고    scopus 로고
    • Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure
    • Westermann D, Riad A, Lettau O, et al. Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure. Hypertension. 2008. 52:1068-75.
    • (2008) Hypertension , vol.52 , pp. 1068-1075
    • Westermann, D.1    Riad, A.2    Lettau, O.3
  • 259
    • 79958249630 scopus 로고    scopus 로고
    • Effects of the oral renin inhibitor aliskiren in patients with symptomatic hf
    • McMurray JJV, Pitt B, Latini R, et al. Effects of the oral renin inhibitor aliskiren in patients with symptomatic HF. Circ Heart Fail. 2008. 1:17-24.
    • (2008) Circ Heart Fail , vol.1 , pp. 17-24
    • McMurray, J.1    Pitt, B.2    Latini, R.3
  • 260
    • 78650344825 scopus 로고    scopus 로고
    • On behalf of the astronaut investigators and study coordinators. Rationale and design of the multicentre, randomized, double-blind, placebo-controlled aliskiren trial on acute heart failure outcomes (astronaut)
    • Gheorghiade M, Albaghdadi M, Zannad F, et al. On behalf of the ASTRONAUT investigators and study coordinators. Rationale and design of the multicentre, randomized, double-blind, placebo-controlled aliskiren trial on acute heart failure outcomes (ASTRONAUT). Eur J Heart Fail. 2011. 13:100-6.
    • (2011) Eur J Heart Fail , vol.13 , pp. 100-106
    • Gheorghiade, M.1    Albaghdadi, M.2    Zannad, F.3
  • 261
    • 78650380191 scopus 로고    scopus 로고
    • Atmosphere investigators
    • Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the aliskiren trial to minimize outcomes in patients with heart failure (ATMOSPHERE) study
    • Krum H, Massie B, Abraham WT, et al. ATMOSPHERE investigators. Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the aliskiren trial to minimize outcomes in patients with heart failure (ATMOSPHERE) study. Eur J Heart Fail. 2011. 13:107-14.
    • (2011) Eur J Heart Fail , vol.13 , pp. 107-114
    • Krum, H.1    Massie, B.2    Abraham, W.T.3
  • 262
    • 79955463305 scopus 로고    scopus 로고
    • Aliskiren study in post-mi patients to reduce remodeling (Aspire) investigators
    • Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction
    • Solomon SD, Shin SH, Shah A, et al. Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) Investigators. Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. Eur Heart J. 2011. 32:1227-34.
    • (2011) Eur Heart J , vol.32 , pp. 1227-1234
    • Solomon, S.D.1    Shin, S.H.2    Shah, A.3
  • 263
    • 84949053807 scopus 로고    scopus 로고
    • The largest cardio-renal outcomes program ever
    • June, July 2013
    • Rasilez® ASPIRE HIGHER Clinical Program Expands to 35,000 Patients in 14 Trials, The Largest Cardio-renal Outcomes Program Ever. Medical News Today, 20 June 2008. http://www.medicalnewstoday. com/releases/112086.php. Accessed 31 July 2013.
    • (2008) Medical News Today , vol.20 , Issue.31
  • 264
    • 44849114597 scopus 로고    scopus 로고
    • Avoid study investigators. Aliskiren combined with losar- tan in type 2 diabetes and nephropathy
    • Parving HH, Persson F, Lewis JB, et al. AVOID study investigators. Aliskiren combined with losar- tan in type 2 diabetes and nephropathy. N Engl J Med. 2008. 358:2433-46.
    • (2008) N Engl J Med , vol.358 , pp. 2433-2446
    • Parving, H.H.1    Persson, F.2    Lewis, J.B.3
  • 265
    • 84869492851 scopus 로고    scopus 로고
    • Altitude investigators. Cardiorenal end points in a trial of aliskiren for type 2 diabetes
    • Parving HH, Brenner BM, McMurray JJ, et al. ALTITUDE Investigators. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med. 2012. 367:2204-22.
    • (2012) N Engl J Med , vol.367 , pp. 2204-2222
    • Parving, H.H.1    Brenner, B.M.2    McMurray, J.J.3
  • 266
    • 23644443397 scopus 로고    scopus 로고
    • Effect of angiotensin-converting enzyme or vasopeptidase inhibition on ventricular size and function in patients with heart failure: The omapatrilat versus enalapril randomized trial of utility in reducing events (overture) échocardiographie study
    • Solomon SD, Skali H, Bourgoun M, et al. Effect of angiotensin-converting enzyme or vasopeptidase inhibition on ventricular size and function in patients with heart failure: the omapatrilat versus enalapril randomized trial of utility in reducing events (OVERTURE) échocardiographie study. Am Heart J. 2005. 150:257-62.
    • (2005) Am Heart J , vol.150 , pp. 257-262
    • Solomon, S.D.1    Skali, H.2    Bourgoun, M.3
  • 267
    • 84867745957 scopus 로고    scopus 로고
    • Prospective comparison of arni with arb on management of heart failure with preserved ejection fraction. Paramount investigators
    • The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 doubleblind randomized clinical trial
    • Solomon SD, Zile M, Pieske B, et al. Prospective comparison of ARNI with ARB on Management Of heart failure with preserved ejectioN fracTion. PARAMOUNT investigators. The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 doubleblind randomized clinical trial. Lancet. 2012. 380(9851):1387-95.
    • (2012) Lancet , vol.380 , Issue.9851 , pp. 1387-1395
    • Solomon, S.D.1    Zile, M.2    Pieske, B.3
  • 268
    • 84880206504 scopus 로고    scopus 로고
    • On behalf of the PARADIGM-HF Committees and Investigators. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in patients with heart failure trial (PARADIGM-HF)
    • McMurray JJ, Packer M, Desai AS, et al. On behalf of the PARADIGM-HF Committees and Investigators. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in patients with heart failure trial (PARADIGM-HF). Eur J Heart Fail. 2013. 15:1062-73.
    • (2013) Eur J Heart Fail , vol.15 , pp. 1062-1073
    • McMurray, J.J.1    Packer, M.2    Desai, A.S.3


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