-
1
-
-
18544369738
-
The cardiovascular continuum and renin-angiotensin-aldosterone system blockade
-
Dzau V. The cardiovascular continuum and renin-angiotensin-aldosterone system blockade. J Hypertens Suppl 2005;23:S9-S17.
-
(2005)
J Hypertens Suppl
, vol.23
-
-
Dzau, V.1
-
2
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
Wood JM, Maibaum J, Rahuel J et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 2003;308:698-705.
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
Maibaum, J.2
Rahuel, J.3
-
3
-
-
0036372173
-
Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): Comparison with enalapril
-
Nussherger J, Wuerzner G, Jensen C, Brunner HR. Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): comparison with enalapril. Hypertension 2002; 39:E1-E8.
-
(2002)
Hypertension
, vol.39
-
-
Nussherger, J.1
Wuerzner, G.2
Jensen, C.3
Brunner, H.R.4
-
4
-
-
33845785350
-
Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan
-
Pool JL, Schmieder RE, Azizi M et al. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens 2007; 20:11-20.
-
(2007)
Am J Hypertens
, vol.20
, pp. 11-20
-
-
Pool, J.L.1
Schmieder, R.E.2
Azizi, M.3
-
5
-
-
38649102508
-
Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
-
Uresin Y, Taylor A, Kilo C et al. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst 2007;8: 190-8.
-
(2007)
J Renin Angiotensin Aldosterone Syst
, vol.8
, pp. 190-198
-
-
Uresin, Y.1
Taylor, A.2
Kilo, C.3
-
6
-
-
33845366982
-
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
-
Villamil A, Chrysant SG, Calhoun D et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 2007; 25:217-26.
-
(2007)
J Hypertens
, vol.25
, pp. 217-226
-
-
Villamil, A.1
Chrysant, S.G.2
Calhoun, D.3
-
7
-
-
56749100454
-
-
Kilo C, Taylor A, Tschope D, Ibram G, Fang H, Prescott MF. Aliskiren, a novel renin inhibitor for treatment of hypertension, enhances renin system suppression by reducing plasma renin activity alone or in combination with ramipril in patients with diabetes. Eur Heart J 2006;27(suppl):118-19 P789.
-
Kilo C, Taylor A, Tschope D, Ibram G, Fang H, Prescott MF. Aliskiren, a novel renin inhibitor for treatment of hypertension, enhances renin system suppression by reducing plasma renin activity alone or in combination with ramipril in patients with diabetes. Eur Heart J 2006;27(suppl):118-19 P789.
-
-
-
-
8
-
-
38749089277
-
Suppression of the renin system with the oral direct renin inhibitor aliskiren alone and in combination with valsartan in patients with hypertension
-
Yarows SA, Oparil S, Patel S, Zhang J, Fang H, Satlin A. Suppression of the renin system with the oral direct renin inhibitor aliskiren alone and in combination with valsartan in patients with hypertension. J Hypertens 2007, 25(suppl):S257-S258
-
(2007)
J Hypertens
, vol.25
, Issue.SUPPL.
-
-
Yarows, S.A.1
Oparil, S.2
Patel, S.3
Zhang, J.4
Fang, H.5
Satlin, A.6
-
9
-
-
0018190318
-
Acute and long-term salt depletion and beta-blockade: Plasma renin activity response and its relation to blood pressure reduction in long-term treatment
-
Nielsen I, Steiness E, Hesse B. Acute and long-term salt depletion and beta-blockade: plasma renin activity response and its relation to blood pressure reduction in long-term treatment. Acta Med Scand 1978; 203:415-18.
-
(1978)
Acta Med Scand
, vol.203
, pp. 415-418
-
-
Nielsen, I.1
Steiness, E.2
Hesse, B.3
-
10
-
-
0016794636
-
Dissociation between renin and arterial pressure responses to beta-adrenergic blockade in human essential hypertension
-
Bravo EL, Tarazi RC, Dustan HP, Lewis JW. Dissociation between renin and arterial pressure responses to beta-adrenergic blockade in human essential hypertension. Circ Res 1975;36:241-7.
-
(1975)
Circ Res
, vol.36
, pp. 241-247
-
-
Bravo, E.L.1
Tarazi, R.C.2
Dustan, H.P.3
Lewis, J.W.4
-
11
-
-
0033004196
-
Beta-adrenergic receptor blockade as a therapeutic approach for suppressing the renin-angiotensin-aldosterone system in normotensive and hypertensive subjects
-
Blumenfeld JD, Sealey JE, Mann SJ et al. Beta-adrenergic receptor blockade as a therapeutic approach for suppressing the renin-angiotensin-aldosterone system in normotensive and hypertensive subjects. Am J Hypertens 1999;12:451-9.
-
(1999)
Am J Hypertens
, vol.12
, pp. 451-459
-
-
Blumenfeld, J.D.1
Sealey, J.E.2
Mann, S.J.3
-
12
-
-
1542432170
-
Guidelines for management of hypertension: Report of the fourth working party of the British Hypertension Society, 2004-BHS IV
-
Williams B, Poulter NR, Brown MJ, et al. Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV. J Hum Hypertens 2004; 18:139-85.
-
(2004)
J Hum Hypertens
, vol.18
, pp. 139-185
-
-
Williams, B.1
Poulter, N.R.2
Brown, M.J.3
-
13
-
-
24644443331
-
Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): A multicentre randomised controlled trial
-
Dahlof B, Sever PS, Poulter NR et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005;366:895-906.
-
(2005)
Lancet
, vol.366
, pp. 895-906
-
-
Dahlof, B.1
Sever, P.S.2
Poulter, N.R.3
-
14
-
-
27544463207
-
Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis
-
Lindholm LH, Carlberg B, Samuelsson O. Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis. Lancet 2005;366:1545-53.
-
(2005)
Lancet
, vol.366
, pp. 1545-1553
-
-
Lindholm, L.H.1
Carlberg, B.2
Samuelsson, O.3
-
15
-
-
33744970717
-
Re-examining the efficacy of beta-blockers for the treatment of hypertension: A meta-analysis
-
Khan N, McAlister FA. Re-examining the efficacy of beta-blockers for the treatment of hypertension: a meta-analysis. CMAJ 2006; 174:1737-42.
-
(2006)
CMAJ
, vol.174
, pp. 1737-1742
-
-
Khan, N.1
McAlister, F.A.2
-
17
-
-
56749172469
-
-
National Institute for Health and Clinical Excellence. Hypertension: management of hypertension in adults in primary care. 2006; http://www,nice.org.uk/CG034 accessed 28th March 2007.
-
National Institute for Health and Clinical Excellence. Hypertension: management of hypertension in adults in primary care. 2006; http://www,nice.org.uk/CG034 accessed 28th March 2007.
-
-
-
-
18
-
-
33748650250
-
New hypertension guidelines from the National Institute for Health and Clinical Excellence and the British Hypertension Society
-
Sever P. New hypertension guidelines from the National Institute for Health and Clinical Excellence and the British Hypertension Society. J Renin Angiotensin Aldosterone Syst 2006;7:61-3.
-
(2006)
J Renin Angiotensin Aldosterone Syst
, vol.7
, pp. 61-63
-
-
Sever, P.1
-
19
-
-
34250350040
-
Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
-
Mancia G, De Backer G, Dominiczak A et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007;25:1105-87.
-
(2007)
J Hypertens
, vol.2007
, Issue.25
, pp. 1105-1187
-
-
Mancia, G.1
De Backer, G.2
Dominiczak, A.3
-
20
-
-
0346059331
-
Plasma renin activity levels in hypertensive persons: Their wide range and lack of suppression in diabetic and in most elderly patients
-
Alderman MH, Cohen HW, Sealey JE, Laragh JH. Plasma renin activity levels in hypertensive persons: their wide range and lack of suppression in diabetic and in most elderly patients. Am J Hypertens 2004; 17:1-7.
-
(2004)
Am J Hypertens
, vol.17
, pp. 1-7
-
-
Alderman, M.H.1
Cohen, H.W.2
Sealey, J.E.3
Laragh, J.H.4
-
21
-
-
0019954662
-
Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy
-
Veterans Administration Cooperative Study Group on Antihypertensive Agents
-
Veterans Administration Cooperative Study Group on Antihypertensive Agents. Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. JAMA 1982;248:2004-11.
-
(1982)
JAMA
, vol.248
, pp. 2004-2011
-
-
-
22
-
-
0034916227
-
Association between blood pressure level and the risk of myocardial infarction, stroke, and total mortality: The cardiovascular health study
-
Psaty BM, Furberg CD, Kuller LH et al. Association between blood pressure level and the risk of myocardial infarction, stroke, and total mortality: the cardiovascular health study. Arch Intern Med 2001;161:1183-92.
-
(2001)
Arch Intern Med
, vol.161
, pp. 1183-1192
-
-
Psaty, B.M.1
Furberg, C.D.2
Kuller, L.H.3
-
23
-
-
0033910518
-
Pulse pressure and risk for myocardial infarction and heart failure in the elderly
-
Vaccarino V, Holford TR, Krumholz HM. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. J Am Coll Cardiol 2000;36:130-8.
-
(2000)
J Am Coll Cardiol
, vol.36
, pp. 130-138
-
-
Vaccarino, V.1
Holford, T.R.2
Krumholz, H.M.3
-
24
-
-
0033609526
-
Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study
-
Franklin SS, Khan SA, Wong ND, Larson MG, Levy D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study. Circulation 1999;100: 354-60.
-
(1999)
Circulation
, vol.100
, pp. 354-360
-
-
Franklin, S.S.1
Khan, S.A.2
Wong, N.D.3
Larson, M.G.4
Levy, D.5
-
25
-
-
0034709051
-
Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients
-
Blacher J, Staessen JA, Girerd X et al. Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients. Arch Intern Med 2000;160:1085-9.
-
(2000)
Arch Intern Med
, vol.160
, pp. 1085-1089
-
-
Blacher, J.1
Staessen, J.A.2
Girerd, X.3
-
26
-
-
17144409806
-
Benefits from angiotensin-converting enzyme inhibitor 'beyond blood pressure lowering': Beyond blood pressure or beyond the brachial artery?
-
Hirata K, Vlachopoulos C, Adji A, O'Rourke MF. Benefits from angiotensin-converting enzyme inhibitor 'beyond blood pressure lowering': beyond blood pressure or beyond the brachial artery? J Hypertens 2005;23:551-6.
-
(2005)
J Hypertens
, vol.23
, pp. 551-556
-
-
Hirata, K.1
Vlachopoulos, C.2
Adji, A.3
O'Rourke, M.F.4
-
27
-
-
0029005591
-
Different effects of fosinopril and atenolol on wave reflections in hypertensive patients
-
Chen CH, Ting CT, Lin SJ et al. Different effects of fosinopril and atenolol on wave reflections in hypertensive patients. Hypertension 1995;25:1034-41.
-
(1995)
Hypertension
, vol.25
, pp. 1034-1041
-
-
Chen, C.H.1
Ting, C.T.2
Lin, S.J.3
-
28
-
-
33645518432
-
Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: Principal results of the Conduit Artery Function Evaluation (CAFE) study
-
Williams B, Lacy PS, Thom SM et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006;113:1213-25.
-
(2006)
Circulation
, vol.113
, pp. 1213-1225
-
-
Williams, B.1
Lacy, P.S.2
Thom, S.M.3
-
29
-
-
0015506533
-
Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases
-
Buhler FR, Laragh JH, Baer L, Vaughan ED Jr, Brunner HR. Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases. N Engl J Med 1972;287:1209-14.
-
(1972)
N Engl J Med
, vol.287
, pp. 1209-1214
-
-
Buhler, F.R.1
Laragh, J.H.2
Baer, L.3
Vaughan Jr, E.D.4
Brunner, H.R.5
-
30
-
-
0018601164
-
Atenolol administered once daily in primary hypertension. Effects on blood pressure in relation to pre-treatment plasma renin activity
-
Nilsson OR, Karlberg BE, Ohlsson O, Thulin T, Tolagen K. Atenolol administered once daily in primary hypertension. Effects on blood pressure in relation to pre-treatment plasma renin activity. Acta Med Scand 1979;206:303-8.
-
(1979)
Acta Med Scand
, vol.206
, pp. 303-308
-
-
Nilsson, O.R.1
Karlberg, B.E.2
Ohlsson, O.3
Thulin, T.4
Tolagen, K.5
-
31
-
-
0015289080
-
The effect of chronic adrenergic receptor blockade on plasma renin activity in man
-
Michelakis AM, McAllister RG. The effect of chronic adrenergic receptor blockade on plasma renin activity in man. J Clin Endocrinol Metab 1972;34:386-94.
-
(1972)
J Clin Endocrinol Metab
, vol.34
, pp. 386-394
-
-
Michelakis, A.M.1
McAllister, R.G.2
-
32
-
-
0015957426
-
On the mechanism of suppressed plasma-renin activity during beta-adrenergic blockade with propranolol
-
Bravo EL, Tarazi RC, Dustan HP. On the mechanism of suppressed plasma-renin activity during beta-adrenergic blockade with propranolol. J Lab Clin Med 1974;83:119-28.
-
(1974)
J Lab Clin Med
, vol.83
, pp. 119-128
-
-
Bravo, E.L.1
Tarazi, R.C.2
Dustan, H.P.3
-
33
-
-
0019403812
-
Effect of chronic diuretic treatment on the plasma renin-angiotensin-aldosterone system in essential hypertension
-
Lijnen P, Fagard R, Staessen J, Amery A. Effect of chronic diuretic treatment on the plasma renin-angiotensin-aldosterone system in essential hypertension. Br J Clin Pharmacol 1981;12:387-92.
-
(1981)
Br J Clin Pharmacol
, vol.12
, pp. 387-392
-
-
Lijnen, P.1
Fagard, R.2
Staessen, J.3
Amery, A.4
-
34
-
-
44849107992
-
Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells
-
Batenburg WW, de Bruin RJ, van Gool JM et al. Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2008; 28:1151-7.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1151-1157
-
-
Batenburg, W.W.1
de Bruin, R.J.2
van Gool, J.M.3
-
35
-
-
32944476181
-
Conformational changes in prorenin during renin inhibition in vitro and in vivo
-
Menard J, Guyene TT, Peyrard S, Azizi M. Conformational changes in prorenin during renin inhibition in vitro and in vivo. J Hypertens 2006;24:529-34.
-
(2006)
J Hypertens
, vol.24
, pp. 529-534
-
-
Menard, J.1
Guyene, T.T.2
Peyrard, S.3
Azizi, M.4
-
36
-
-
42049108426
-
Newly developed renin and prorenin assays and the clinical evaluation of renin inhibitors
-
Schalekamp MA, Derkx FH, Deinum J, Danser AJ. Newly developed renin and prorenin assays and the clinical evaluation of renin inhibitors. J Hypertens 2008;26:928-37.
-
(2008)
J Hypertens
, vol.26
, pp. 928-937
-
-
Schalekamp, M.A.1
Derkx, F.H.2
Deinum, J.3
Danser, A.J.4
-
37
-
-
29244448292
-
The diabetogenic potential of thiazide-type diuretic and beta-blocker combinations in patients with hypertension
-
Mason JM, Dickinson HO, Nicolson DJ, Campbell F, Ford GA, Williams B. The diabetogenic potential of thiazide-type diuretic and beta-blocker combinations in patients with hypertension. J Hypertens 2005; 23:1777-81.
-
(2005)
J Hypertens
, vol.23
, pp. 1777-1781
-
-
Mason, J.M.1
Dickinson, H.O.2
Nicolson, D.J.3
Campbell, F.4
Ford, G.A.5
Williams, B.6
-
38
-
-
24144490705
-
The impact of ACE inhibitors or angiotensin II type 1 receptor blockers on the development of new-onset type 2 diabetes
-
Gillespie EL, White CM, Kardas M, Lindberg M, Coleman CI. The impact of ACE inhibitors or angiotensin II type 1 receptor blockers on the development of new-onset type 2 diabetes. Diabetes Care 2005; 28:2261-6.
-
(2005)
Diabetes Care
, vol.28
, pp. 2261-2266
-
-
Gillespie, E.L.1
White, C.M.2
Kardas, M.3
Lindberg, M.4
Coleman, C.I.5
-
39
-
-
34247343986
-
Risk of diabetes in a real-world setting among patients initiating antihypertensive therapy with valsartan or amlodipine
-
Weycker D, Edelsberg J, Vincze G et al. Risk of diabetes in a real-world setting among patients initiating antihypertensive therapy with valsartan or amlodipine. J Hum Hypertens 2007; 21:374-80.
-
(2007)
J Hum Hypertens
, vol.21
, pp. 374-380
-
-
Weycker, D.1
Edelsberg, J.2
Vincze, G.3
-
40
-
-
33947182655
-
Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
-
Oh BH, Mitchell J, Herron JR, Chung J, Khan M, Keefe DL. Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension. J Am Coll Cardiol 2007;49: 1157-63.
-
(2007)
J Am Coll Cardiol
, vol.49
, pp. 1157-1163
-
-
Oh, B.H.1
Mitchell, J.2
Herron, J.R.3
Chung, J.4
Khan, M.5
Keefe, D.L.6
-
41
-
-
14844363404
-
-
Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005;111:1012-18.
-
Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005;111:1012-18.
-
-
-
-
42
-
-
56749117811
-
-
Sica D, Gradman AH, Lederballe O, Meyers M, Cai J, Keefe DL. Aliskiren, a novel renin inhibitor, is well tolerated and has sustained BP-lowering effects alone or in combination with HCTZ during long-term (52 weeks) treatment of hypertension. Eur Heart J 2006;27(suppl):121 P797.
-
Sica D, Gradman AH, Lederballe O, Meyers M, Cai J, Keefe DL. Aliskiren, a novel renin inhibitor, is well tolerated and has sustained BP-lowering effects alone or in combination with HCTZ during long-term (52 weeks) treatment of hypertension. Eur Heart J 2006;27(suppl):121 P797.
-
-
-
-
43
-
-
0037490085
-
Value of low dose combination treatment with blood pressure lowering drugs: Analysis of 354 randomised trials
-
Law MR, Wald NJ, Morris JK, Jordan RE. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ 2003;326: 1427-34.
-
(2003)
BMJ
, vol.326
, pp. 1427-1434
-
-
Law, M.R.1
Wald, N.J.2
Morris, J.K.3
Jordan, R.E.4
|