Eplerenone and atrial fibrillation in mild systolic heart failure: Results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure) study

Journal of the American College of Cardiology

Volumn 59, Issue 18, 2012, Pages 1598-1603

  Swedberg, Karl ^a   Zannad, Faiez ^b   McMurray, John J V ^c   Krum, Henry ^d   Van Veldhuisen, Dirk J ^e   Shi, Harry ^f   Vincent, John ^f   Pitt, Bertram ^g  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f PFIZER INC   (United States)

^g UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

aldosterone antagonism; atrial fibrillation; heart failure

Indexed keywords

EPLERENONE; PLACEBO;

AGED; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART DEATH; HEART EJECTION FRACTION; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD SYSTOLIC HEART FAILURE; MORBIDITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY ANALYSIS; UNSPECIFIED SIDE EFFECT;

AGED; ALDOSTERONE ANTAGONISTS; ATRIAL FIBRILLATION; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEMALE; HEART FAILURE, SYSTOLIC; HEART RATE; HOSPITALIZATION; HUMANS; INCIDENCE; MALE; PROGNOSIS; SPIRONOLACTONE; SURVIVAL RATE; UNITED STATES;

EID: 84860309326     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.11.063     Document Type: Article

References (26)

1. P.E. Carson, G.R. Johnson, W.B. Dunkman, R.D. Fletcher, L. Farrell, J.N. Cohn The influence of atrial fibrillation on prognosis in mild to moderate heart failure The V-HeFT studies. The V-HeFT VA Cooperative Studies Group Circulation 87 1993 VI102 VI110
2. H.R. Middlekauff, W.G. Stevenson, L.W. Stevenson Prognostic significance of atrial fibrillation in advanced heart failure Circulation 84 1991 40 48
3. P. Agostoni, M. Emdin, U. Corra Permanent atrial fibrillation affects exercise capacity in chronic heart failure patients Eur Heart J 29 2008 2367 2372
4. D.M. Clark, V.J. Plumb, A.E. Epstein, G.N. Kay Hemodynamic effects of an irregular sequence of ventricular cycle lengths during atrial fibrillation J Am Coll Cardiol 30 1997 1039 1045 (Pubitemid 27435898)
5. K. Swedberg, P. Eneroth, J. Kjekshus, L. Wilhelmsen Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality CONSENSUS Trial Study Group Circulation 82 1990 1730 1736 (Pubitemid 20367976)
6. C.T. Tsai, F.T. Chiang, C.D. Tseng Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation J Am Coll Cardiol 55 2010 758 770
7. U. Lendeckel, D. Dobrev, A. Goette Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation Br J Pharmacol 159 2010 1581 1583
8. J.S. Healey, A. Baranchuk, E. Crystal Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis J Am Coll Cardiol 45 2005 1832 1839 (Pubitemid 40789940)
9. L. Calo, A. Martino, L. Sciarra Upstream effect for atrial fibrillation: still a dilemma? Pacing Clin Electrophysiol 34 2011 111 128
10. M. Disertori, R. Latini, S. Barlera Valsartan for prevention of recurrent atrial fibrillation N Engl J Med 360 2009 1606 1617
11. S. Yusuf, J.S. Healey, J. Pogue Irbesartan in patients with atrial fibrillation N Engl J Med 364 2011 928 938
12. K.T. Weber Aldosterone and spironolactone in heart failure N Engl J Med 341 1999 753 755 (Pubitemid 29407377)
13. F. Zannad, J.J. McMurray, H. Krum Eplerenone in patients with systolic heart failure and mild symptoms N Engl J Med 364 2011 11 21
14. B. Pitt, F. Zannad, W.J. Remme The effect of spironolactone on morbidity and mortality in patients with severe heart failure Randomized Aldactone Evaluation Study Investigators N Engl J Med 341 1999 709 717 (Pubitemid 29407370)
15. B. Pitt, W. Remme, F. Zannad Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction N Engl J Med 348 2003 1309 1321 (Pubitemid 36384098)
16. R. Dabrowski, A. Borowiec, E. Smolis-Bak Effect of combined spironolactone-beta-blocker +/- enalapril treatment on occurrence of symptomatic atrial fibrillation episodes in patients with a history of paroxysmal atrial fibrillation (SPIR-AF study) Am J Cardiol 106 2010 1609 1614
17. F. Zannad, J.J. McMurray, H. Drexler Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF) Eur J Heart Fail 12 2010 617 622
18. P.A. Poole-Wilson, K. Swedberg, J.G. Cleland Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial Lancet 362 2003 7 13 (Pubitemid 36835815)
19. K. Swedberg, M. Komajda, M. Bohm Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study Lancet 376 2010 875 885
20. C.A. Wasywich, A.J. Pope, J. Somaratne, K.K. Poppe, G.A. Whalley, R.N. Doughty Atrial fibrillation and the risk of death in patients with heart failure: a literature-based meta-analysis Intern Med J 40 2010 347 356
21. H.R. Neuberger, C. Mewis, D.J. van Veldhuisen Management of atrial fibrillation in patients with heart failure Eur Heart J 28 2007 2568 2577 (Pubitemid 350071511)
22. I.A. Nasr, A. Bouzamondo, J.S. Hulot, O. Dubourg, J.Y. Le Heuzey, P. Lechat Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis Eur Heart J 28 2007 457 462 (Pubitemid 47343566)
23. C. Lafuente-Lafuente, S. Mouly, M.A. Longas-Tejero, J.F. Bergmann Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation Cochrane Database Syst Rev 2007 CD005049
24. L. Kober, C. Torp-Pedersen, J.J. McMurray Increased mortality after dronedarone therapy for severe heart failure N Engl J Med 358 2008 2678 2687 (Pubitemid 351860860)
25. P. Milliez, N. Deangelis, C. Rucker-Martin Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction Eur Heart J 26 2005 2193 2199 (Pubitemid 41408006)
26. J. Zhao, J. Li, W. Li Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing Br J Pharmacol 159 2010 1584 1594