Synergistic effects of ACE inhibition and Ang II antagonism on blood pressure, cardiac weight, and renin in spontaneously hypertensive rats

Circulation

Volumn 96, Issue 9, 1997, Pages 3072-3078

  Ménard, Joël ^a,d   Campbell, Duncan J ^b   Azizi, Michel ^c   Gonzales, Marie Françoise ^a  

^a INSERM   (France)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d HÔPITAL BROUSSAIS   (France)

Author keywords

Angiotensin; Blood pressure; Enzymes; Hypertension; Renin

Indexed keywords

ANGIOTENSIN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; LOSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; HEART WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENIN RELEASE; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0342894669     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.9.3072     Document Type: Article

References (38)

1. Nussberger J, Brunner DB, Waeber B, Brunner HR. True versus immunoreactive angiotensin II in human plasma. Hypertension. 1985;7(suppl I):I-11-I-17.
2. Juillerat L, Nussberger J, Ménard J, Mooser V, Christen Y, Waeber B, Graf P, Brunner HR. Determinants of angiotensin II generation during converting enzyme inhibition. Hypertension. 1990;16: 564-572.
3. Van Den Meiracker AH, Man in't veld AJ, Admiraal PJJ, Ritsema Van Eck HJ, Boomsma F, Derkx FHM, Schalekamp MADH. Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: does it exist and does it affect the antihypertensive response? J Hypertens. 1992;10:803-812.
4. 1R) and renin mRNAs in juxtaglomerular cells of the rat kidney. Endocrinology. 1993;132:2723-2725.
5. Ménard J, Guyene TT, Chatellier G, Kleinbloesem CH, Bernadet P. Renin release regulation during acute renin inhibition in normal volunteers. Hypertension. 1991;18:257-265.
6. Wei L, Clauser E, Alhenc-Gélas F, Corvol P. The two homologous domains of human angiotensin I converting enzyme interact differently with competitive inhibitors. J Biol Chem. 1992;267:13398-13405.
7. Okunishi H, Miyazaki M, Toda N. Evidence for a putatively new angiotensin II-generating enzyme in the vascular wall. J Hypertens. 1984;2:277-284.
8. Urata H, Healy B, Stewart RW, Bumpus FM, Husain A. Angiotensin II forming pathways in normal and failing human hearts. Circ Res. 1990;66:883-890.
9. Azizi M, Chatellier G, Guyene TT, Murieta-Geoffroy D, Ménard J. Additive effects of combined angiotensin converting enzyme inhibition and angiotensin II antagonism on blood pressure and renin release in sodium-depleted normotensives. Circulation. 1995;92: 825-834.
10. Azizi M, Guyene TT, Chatellier G, Wargon M, Ménard J. Additive effects of losartan and enalapril on blood pressure and plasma active renin. Hypertension. 1997;29:634-640.
11. Giudicelli JF, Freslon JL, Glasson S, Richer C. Captopril and hypertension development in the SHR. Clin Exp Hypertens. 1980;2: 1083-1096.
12. Wong PC, Price WA, Chiu AT. Hypotensive action of DUP 753, an angiotensin II antagonist in spontaneously hypertensive rats. Hypertension. 1990;15:459-468.
13. Goldberg MR, Offen WW, Rockhold FW. Factorial design: an approach to the assessment of therapeutic drug interactions in clinical trials. J Clin Res Drug Dev. 1988;2:215-225.
14. Miller ED, Longnecker DE, Peach MJ. The regulatory function of the renin-angiotensin system during general anesthesia. Anesthesiology. 1978;48:399-403.
15. Ménard J, Catt KJ. Measurement of renin activity concentration and substrate in rat plasma by radioimmunoassay of angiotensin I. Endocrinology. 1972;90:422-430.
16. Véniant M, Whitworth CE, Ménard J, Sharp MGF, Gonzalez MF, Bruneval P, Mullins JJ. Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats. Am J Hypertens. 1995;8:1167-1176.
17. Clauser E, Bouhnik J, Gonzales MF, Corvol P, Ménard J. Influence of converting-enzyme inhibition on rat des-angiotensin I-angiotensinogen. Am J Physiol. 1984;246:E129-E133.
18. Bradford H. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
19. Ii Y, Kitami Y, Hiwada K. Effect of a rat renin inhibitor on renal renin synthesis on spontaneously hypertensive rats. Hypertens Res. 1992;15:99-104.
20. Campbell DJ, Kladis A, Duncan AM. Nephrectomy, converting enzyme inhibition, and angiotensin peptides. Hypertension. 1993;22: 513-522.
21. Greco WR, Bravo G, Parsons JC. The search for synergy: a critical review from a response surface perspective. Pharmacol Rev. 1995; 47:332-385.
22. Fossa AA, DePasquale MJ, Ringer LJ, Winslow RL. Synergistic effect on reduction in blood pressure with coadministration of a renin inhibitor or an angiotensin-converting enzyme inhibitor with an angiotensin II receptor antagonist. Drug Dev Res. 1994;33: 422-428.
23. Mento PF, Holt WF, Murphy WR, Wilkes BM. Combined renin and converting enzyme inhibition in rats. Hypertension. 1989;13: 741-748.
24. Chauveau D, Guyenne TT, Cumin F, Chatellier G, Corvol P, Ménard J. Investigation of the biochemical effects of renin inhibition in normal volunteers treated by an ACE inhibitor. Br J Clin Pharmacol. 1992;33:253-260.
25. Wong PC, Price WA, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PBMWM. In vivo pharmacology of Dup 753. Am J Hypertens. 1991;4:288s-298s.
26. Campbell DJ, Lawrence AC, Towrie A, Kladis A, Valentijn A. Differential regulation of angiotensin peptide levels in plasma and kidney of the rat. Hypertension. 1991;18:763-773.
27. Campbell DJ, Kladis A, Duncan AM. Effects of converting enzyme inhibitors on angiotensin and bradykinin peptides. Hypertension. 1994;23:439-449.
28. Wollert KC, Studer R, Von Bülow B, Drexler H. Survival after myocardial infarction in the rat: role of tissue angiotensin-converting enzyme inhibition. Circulation. 1994;90:2457-2467.
29. Ikoma M, Kawamura T, Kakinuma Y, Fogo A, Ichikawa I. Cause of variable therapeutic efficiency of angiotensin converting enzyme inhibitor on glomerular lesions. Kidney Int. 1991;40:195-202.
30. Nussberger J, Fleck E, Bahrmann H, Delius W, Schultheiss HP, Brunner HR, for the Study Group on Neurohormonal Regulation in Congestive Heart Failure. Dose-related effects of ACE inhibition in man: quinapril in patients with moderate congestive heart failure. Eur Heart J. 1994;15(suppl D):113-122.
31. Welches WR, Santos RA, Chappell MC, Brosnihan KB, Greene LJ, Ferrario CM. Evidence that prolyl endopeptidase participates in the processing of brain angiotensin. J Hypertens. 1991;9:631-638.
32. Welches WR, Brosnihan KB, Ferrario CM. A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11. Life Sci. 1993;52: 1461-1480.
33. Benter IF, Diz DI, Ferrario CM. Cardiovascular actions of angiotensin (1-7). Peptides. 1993;14:679-684.
34. Fernandez LA, Caride VJ, Strömberg C, Nävery L, Wicke JD. Angiotensin AT2 receptor stimulation increases survival in gerbils with abrupt unilateral carotid ligation. J Cardiovasc Pharmacol. 1994;24:937-940.
35. Nakajima M, Hutchinson HG, Fujinaga M, Hayashida W, Morishita R, Zhang L, Horiuchi M, Pratt RE, Dzau VS. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the ATI receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA. 1995;92:10663-10667.
36. Stoll M, Steckelings UM, Paul M, Bottari SP, Metzger R, Unger T. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest. 1995;95:651-657.
37. Kerins DM, Hao Q, Vaughan DE. Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J Clin Invest. 1995;96:2515-2520.
38. Levy BI, Benessiano J, Henrion D, Caputo L, Heymes C, Duriez M, Poitevin P, Samuel JL. Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. J Clin Invest. 1996;98:418-425.