Immune disorders in Hashimoto's thyroiditis: What do we know so far?

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Pyzik, Aleksandra ^a   Grywalska, Ewelina ^a   Matyjaszek Matuszek, Beata ^a   Roliński, Jacek ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSOME; CASPASE 3; CASPASE 8; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; HLA ANTIGEN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LEVOTHYROXINE; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; PROTEIN BCL 2; STAT1 PROTEIN; STAT3 PROTEIN; THYROGLOBULIN; THYROID ANTIBODY; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TNFSF10 PROTEIN, HUMAN;

APOPTOSIS; AUTOIMMUNE DISEASE; AUTOIMMUNE THYROIDITIS; B LYMPHOCYTE; BYSTANDER EFFECT; CAUCASIAN; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DNA POLYMORPHISM; ENVIRONMENTAL FACTOR; GENETIC SUSCEPTIBILITY; GROUPS BY AGE; HASHIMOTO DISEASE; HUMAN; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; LYMPHOCYTE DIFFERENTIATION; MEDICAL LITERATURE; MITOCHONDRION; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; TH17 CELL; TH2 CELL; AGE; AUTOIMMUNITY; CYTOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; PATHOLOGY; SEX DIFFERENCE; THYROID GLAND;

AGE FACTORS; APOPTOSIS; AUTOIMMUNITY; B-LYMPHOCYTES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HASHIMOTO DISEASE; HUMANS; MALE; SEX FACTORS; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; THYROID GLAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84929379530     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/979167     Document Type: Review

References (63)

1. R. S. Brown, "Autoimmune thyroid disease: unlocking a complex puzzle", Current Opinion in Pediatrics, vol. 21, no. 4, pp. 523-528, 2009.
2. A. Bossowski, M. Moniuszko, M. Dąbrowska et al., "Analysis of T regulatory cells in the peripheral blood in children and adolescents with Graves' disease and Hashimoto's thyroiditis", Endokrynologia Pediatryczna, vol. 34, no. 1, pp. 37-48, 2011.
3. E. N. Pearce, A. P. Farwell, and L. E. Braverman, "Thyroiditis", The New England Journal of Medicine, vol. 348, no. 26, pp. 2646-2655, 2003.
4. K. Socha, M. Dziemianowicz, W. Omeljaniuk, J. Soroczyńska, and M. Borawska, "Dietary habits and the concentration of selenium in serum of patients with Hashimoto disease", Problemy Higieny i Epidemiologii, vol. 93, no. 4, pp. 824-827, 2012.
5. A. Bossowski and E. Otto-Buczkowska, "Schorzenia tarczycy o podłözu autoimmunologicznym", in W: Pediatria-co nowego? Pod redakcją Ewy Otto-Buczkowskiej, pp. 108-120, Cornetis, Wrocław, Poland, 2007.
6. J. R. Garber, R. H. Cobin, H. Gharib et al., "Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association", Thyroid, vol. 22, no. 12, pp. 1200-1235, 2012.
7. M. Schott and W. A. Scherbaum, "Autoimmune Thyroid disease", Deutsches Arzteblatt, vol. 103, no. 45, pp. 3023-3032, 2006.
8. H. Yoshida, N. Amino, K. Yagawa et al., "Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases", The Journal of Clinical Endocrinology & Metabolism, vol. 46, no. 6, pp. 859-862, 1978.
9. D. Peretianu, "Antithyroperoxidase antibodies (ATPO) in Hashimoto thyroiditis: variation of levels and correlation with echographic patterns", Acta Endocrinology, vol. 1, no. 1, pp. 61-78, 2005.
10. T. Kotani, K. Umeki, K. Hirai, and C. Ohtaki, "Experimental murine thyroiditis induced by porcine thyroid peroxidase and its transfer by the antigen-specific T cell line1000", Clinical and Experimental Immunology, vol. 80, no. 1, pp. 11-18, 1990.
11. N. Matsuoka, P. Unger, A. Ben-Nun, P. Graves, and T. F. Davies, "Thyroglobulin-induced murine thyroiditis assessed by intrathyroidal T cell receptor sequencing", Journal of Immunology, vol. 152, no. 5, pp. 2562-2568, 1994.
12. L. Chiovato, P. Bassi, F. Santini et al., "Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis", The Journal of Clinical Endocrinology and Metabolism, vol. 77, no. 6, pp. 1700-1705, 1993.
13. Y. Ban, D. A. Greenberg, E. Concepcion, L. Skrabanek, R. Villanueva, and Y. Tomer, "Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease", Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 25, pp. 15119-15124, 2003.
14. A. M. McGregor, H. K. Ibbertson, B. R. Smith, and R. Hall, "Carbimazole and autoantibody synthesis in Hashimoto's thyroiditis", British Medical Journal, vol. 281, no. 6246, pp. 968-969, 1980.
15. Y. Fang, G. C. Sharp, H. Yagita, and H. Braley-Mullen, "Acritical role for TRAIL in resolution of granulomatous experimental autoimmune thyroiditis", The Journal of Pathology, vol. 216, no. 4, pp. 505-513, 2008.
16. I. Ben-Skowronek, L. Szewczyk, B. Kulik-Rechberger, and E. Korobowicz, "The differences in T and B cell subsets in thyroid of children with Graves' disease and Hashimoto's thyroiditis", World Journal of Pediatrics, vol. 9, no. 3, pp. 245-250, 2013.
17. S. T. Kawashima, T. Tagami, K. Nakao et al., "Serum levels of IgG and IgG4 in Hashimoto thyroiditis", Endocrine, vol. 45, no. 2, pp. 236-243, 2014.
18. A. P. Weetman and A. M. McGregor, "Autoimmune thyroid disease: further developments in our understanding", Endocrine Reviews, vol. 15, no. 6, pp. 788-830, 1994.
19. T. Nanba, M. Watanabe, N. Inoue, and Y. Iwatani, "Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease", Thyroid, vol. 19, no. 5, pp. 495-501, 2009.
20. T. Korn, E. Bettelli, M. Oukka, and V. K. Kuchroo, "IL-17 and Th17 cells", Annual Review of Immunology, vol. 27, pp. 485-517, 2009.
21. B. Zha, X. Huang, J. Lin, J. Liu, Y. Hou, and G. Wu, "Distribution of lymphocyte subpopulations in thyroid glands of human autoimmune thyroid disease", Journal of Clinical Laboratory Analysis, vol. 28, no. 3, pp. 249-254, 2014.
22. I. Beń-Skowronek, L. Szewczyk, J. Sierocińska-Sawa, and E. Korobowicz, "Subpopulacje limfocytów w tkance tarczycowej w autoimmunologicznych i nieautoimmunologicznych chorobach tarczycy u dzieci", Endokrynologia Pediatryczna, vol. 6, no. 3(20), pp. 9-20, 2007.
23. L. L. Cunha, E. C. Morari, S. Nonogaki, F. A. Soares, J. Vassallo, and L. S. Ward, "Foxp3 expression is associated with aggressiveness in differentiated thyroid carcinomas", Clinics, vol. 67, no. 5, pp. 483-488, 2012.
24. P. Miossec and J. K. Kolls, "Targeting IL-17 and TH17 cells in chronic inflammation", Nature Reviews Drug Discovery, vol. 11, no. 10, pp. 763-776, 2012.
25. C. M. Wilke, K. Bishop, D. Fox, and W. Zou, "Deciphering the role of Th17 cells in human disease", Trends in Immunology, vol. 32, no. 12, pp. 603-611, 2011.
26. J. F. Zambrano-Zaragoza, E. J. Romo-Martínez, M. de Jesús Durán-Avelar, N. García-Magallanes, and N. Vibanco-Pérez, "Th17 cells in autoimmune and infectious diseases", International Journal of Inflammation, vol. 2014, Article ID 651503, 12 pages, 2014.
27. Y. Liu, X. Tang, J. Tian et al., "Th17/Treg cells imbalance and GITRL profile in patients with hashimoto's thyroiditis", International Journal of Molecular Sciences, vol. 15, no. 12, pp. 21674-21686, 2014.
28. Q. Qin, P. Liu, L. Liu et al., "Theincreased but non-predominant expression of Th17- and Th1-specific cytokines in hashimoto's thyroiditis but not in graves' disease", Brazilian Journal of Medical and Biological Research, vol. 45, no. 12, pp. 1202-1208, 2012.
29. A. Kimura and T. Kishimoto, "IL-6: regulator of Treg/Th17 balance", European Journal of Immunology, vol. 40, no. 7, pp. 1830-1835, 2010.
30. A. Bossowski, M. Moniuszko, E. Idźkowska et al., "Evaluation of CD4+CD161+CD196+ and CD4+IL-17+ Th17 cells in the peripheral blood of young patients with Hashimoto's thyroiditis and Graves' disease", Pediatric Endocrinology, Diabetes, and Metabolism, vol. 18, no. 3, pp. 89-95, 2012.
31. D. Li, W. Cai, R. Gu et al., "Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients", Clinical Immunology, vol. 149, no. 3, pp. 411-420, 2013.
32. Y. Shi, H. Wang, Z. Su et al., "Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto's thyroiditis", Scandinavian Journal of Immunology, vol. 72, no. 3, pp. 250-255, 2010.
33. S. Wang, S. E. Baidoo, Y. Liu et al., "T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis", Clinical and Experimental Immunology, vol. 171, no. 1, pp. 63-68, 2013.
34. P. Lewkowicz, N. Lewkowicz, and H. Tchórzewski, "CD4+CD25+ T regulatory cells: their physiology and role in modulating immune response", Postępy Higieny i Medycyny Dos̈wiadczalnej, vol. 59, pp. 362-370, 2005.
35. N. Misra, J. Bayry, S. Lacroix-Desmazes, M. D. Kazatchkine, and S. V. Kaveri, "Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells", Journal of Immunology, vol. 172, no. 8, pp. 4676-4680, 2004.
36. P. Trzonkowski, E. Szmit, J. Mys̈liwska, A. Dobyszuk, and A. Mys̈liwski, "CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-tocell interaction", Clinical Immunology, vol. 112, no. 3, pp. 258-267, 2004.
37. C. Baecher-Allan, V. Viglietta, and D. A. Hafler, "Human CD4+CD25+ regulatory T cells", Seminars in Immunology, vol. 16, no. 2, pp. 89-97, 2004.
38. H. J. Kim, B. Verbinnen, X. Tang, L. Lu, and H. Cantor, "Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance", Nature, vol. 467, no. 7313, pp. 328-332, 2010.
39. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda, "Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases", The Journal of Immunology, vol. 155, no. 3, pp. 1151-1164, 1995.
40. S. Hori, T. Nomura, and S. Sakaguchi, "Control of regulatory T cell development by the transcription factor Foxp3", Science, vol. 299, no. 5609, pp. 1057-1061, 2003.
41. A. Bossowski, M. Moniuszko, M. Dabrowska et al., "Lower proportions of CD4+CD25high and CD4+FoxP3, but not CD4+CD25+CD127low FoxP3+T cell levels in children with autoimmune thyroid diseases", Autoimmunity, vol. 46, no. 3, pp. 222-230, 2013.
42. M. Marazuela, M. A. García-López, N. Figueroa-Vega et al., "Regulatory T cells in human autoimmune thyroid disease", The Journal of Clinical Endocrinology & Metabolism, vol. 91, no. 9, pp. 3639-3646, 2006.
43. S. G. Zheng, J. H. Wang, J. D. Gray, H. Soucier, and D. A. Horwitz, "Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10", Journal of Immunology, vol. 172, no. 9, pp. 5213-5221, 2004.
44. D. A. Chistiakov and R. I. Turakulov, "CTLA-4 and its role in autoimmune thyroid disease", Journal of Molecular Endocrinology, vol. 31, no. 1, pp. 21-36, 2003.
45. A. Nakano, M. Watanabe, T. Iida et al., "Apoptosis-induced decrease of intrathyroidal CD4+CD25+ regulatory T cells in autoimmune thyroid diseases", Thyroid, vol. 17, no. 1, pp. 25-31, 2007.
46. A. B. Glick, A. Wodzinski, P. Fu, A. D. Levine, and D. N. Wald, "Impairment of regulatory T-Cell function in autoimmune thyroid disease", Thyroid, vol. 23, no. 7, pp. 871-878, 2013.
47. G. Penna, A. Roncari, S. Amuchastegui et al., "Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1, 25-dihydroxyvitamin D3", Blood, vol. 106, no. 10, pp. 3490-3497, 2005.
48. A. Bossowski, B. Czarnocka, A. Stasiak-Barmuta, K. Bardadin, M. Urban, and J. Dadan, "Analysis of Fas, FasL and Caspase-8 expression in thyroid gland in young patients with immune and non-immune thyroid diseases", Endokrynologia Polska, vol. 58, no. 4, pp. 303-313, 2007.
49. K. Łącka and A. Maciejewski, "The role of apoptosis in the etiopathogenesis of autoimmune thyroiditis", Polski Merkuriusz Lekarski, vol. 32, no. 188, pp. 87-92, 2012.
50. C. Giordano, G. Stassi, R.deMaria et al., "Potential involvement of fas and its ligand in the pathogenesis of Hashimoto's thyroiditis", Science, vol. 275, no. 5302, pp. 960-963, 1997.
51. G. Stassi, M. Todaro, F. Bucchieri et al., "Fas/Fas ligand-driven T cell apoptosis as a consequence of ineffective thyroid immunoprivilege in Hashimoto's thyroiditis", Journal of Immunology, vol. 162, no. 1, pp. 263-267, 1999.
52. H. W. Su, M. Van Antwerp, R. Kuick et al., "Microarray analysis of cytokine activation of apoptosis pathways in the thyroid", Endocrinology, vol. 148, no. 10, pp. 4844-4852, 2007.
53. J. R. Baker Jr., "The nature of apoptosis in the thyroid and the role it may play in autoimmune thyroid disease", Thyroid, vol. 11, no. 3, pp. 245-247, 2001.
54. G. H. Fisher, F. J. Rosenberg, S. E. Straus et al., "Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome", Cell, vol. 81, no. 6, pp. 935-946, 1995.
55. G. Stassi, A. Zeuner, D. di Liberto, M. Todaro, L. Ricci-Vitiani, and R. de Maria, "Fas-FasL in Hashimoto's thyroiditis", Journal of Clinical Immunology, vol. 21, no. 1, pp. 19-23, 2001.
56. J. Feldkamp, E. Pascher, A. Perniok, and W. A. Scherbaum, "Fasmediated apoptosis is inhibited by TSH and iodine inmoderate concentrations in primary human thyrocytes in vitro", Hormone and Metabolic Research, vol. 31, no. 6, pp. 355-358, 1999.
57. J. Feldkamp, E. Pascher, M. Schott, P. Goretzki, J. Seissler, and W. A. Scherbaum, "Soluble Fas is increased in hyperthyroidism independent of the underlying thyroid disease", The Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 9, pp. 4250-4253, 2001.
58. G. Bona, S. Defranco, A. Chiocchetti et al., "Defective function of Fas in T cells from paediatric patients with autoimmune thyroid diseases", Clinical & Experimental Immunology, vol. 133, no. 3, pp. 430-437, 2003.
59. N. Arata, T. Ando, P. Unger, and T. F. Davies, "By-stander activation in autoimmune thyroiditis: studies on experimental autoimmune thyroiditis in the GFP+ fluorescent mouse", Clinical Immunology, vol. 121, no. 1, pp. 108-117, 2006.
60. G. F. Bottazzo, I. Todd, and R. Pujol-Borrell, "Hypotheses on genetic contributions to the aetiology of diabetes mellitus", Immunology Today, vol. 5, no. 8, pp. 230-231, 1984.
61. E. L. Khoury, L. Pereira, and F. S. Greenspan, "Induction of HLA-DR expression on thyroid follicular cells by cytomegalovirus infection in vitro. Evidence for a dual mechanism of induction", The American Journal of Pathology, vol. 138, no. 5, pp. 1209-1223, 1991.
62. D. S. Neufeld, M. Platzer, and T. F. Davies, "Reovirus induction of MHC class II antigen in rat thyroid cells", Endocrinology, vol. 124, no. 1, pp. 543-545, 1989.
63. T. F. Davies, "The role of human thyroid cell Ia (DR) antigen in thyroid autoimmunity", in Autoimmunity and the Thyroid, P. G. Walfish, J. R. Wall, and R. Volpe, Eds., p. 51, Academic Press, New York, NY, USA, 1985.