Fas/Fas ligand-driven T cell apoptosis as a consequence of ineffective thyroid immunoprivilege in Hashimoto's thyroiditis

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 263-267

  Stassi, Giorgio ^a   Todaro, Matilde ^a   Bucchieri, Fabio ^a   Stoppacciaro, Antonella ^b   Farina, Felicia ^a   Zummo, Giovanni ^a   Testi, Roberto ^c   De Maria, Ruggero ^d  

^a UNIVERSITY OF PALERMO   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE;

ADULT; ANTIGENS, CD95; APOPTOSIS; FAS LIGAND PROTEIN; FEMALE; HUMANS; LIGANDS; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; THYROID GLAND; THYROIDITIS, AUTOIMMUNE;

EID: 0032907268     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Nagata, S., and P. Golstein. 1995. The Fas death factor. Science 267:1449.
2. Krammer, P. H. 1996. The CD95(APO-1/Fas) receptor/ligand system: death signals and disease. Cell Death Differ. 3:159.
3. Nagata, S. 1997. Apoptosis by death factor. Cell 85:355.
4. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
5. Adachi, M., S. Suematsu, T. Kondo, J. Ogasawara, T. Tanaka, N. Yoshida, and S. Nagata. 1995. Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat. Genet. 11:294.
6. Peter, M. E., F. C. Kischkel, C. G. Scheuerpflug, J. P. Medema, K. M. Debatin, and P. H. Krammer. 1997. Resistance of cultured peripheral T cells toward activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex. Eur. J. Immunol. 27:1207.
7. Alderson, M. R., T. W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K. A. Schooley, R. G. Goodwin, C. A. Smith, F. Ramsdell, and D. H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71.
8. French, L. E., M. Hahne, I. Viard, G. Radlgruber, R. Zanone, K. Becker, C. Muller, and J. Tschopp. 1996. Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J. Cell Biol. 133:335.
9. Griffith, T. S., X. Yu, J. M. Herndon, D. Green, and T. A. Ferguson. 1996. CD95-induced apoptosis of lymphocytes in an immune-privileged site induces immunological tolerance. Immunity 5:7.
10. Weetman, A. P., and A. M. McGregor. 1995. Autoimmune thyroid disease: further developments in our understanding. Endocr. Rev. 15:788.
11. Dayan, C. M., and G. H. Daniles. 1996. Chronic autoimmune thyroiditis. N. Engl. J. Med. 335:99.
12. Giordano, C., G. Stassi, R. De Maria, M. Todaro, P. Richiusa, G. Papoff, G. Ruberti, M. Bagnasco, R. Testi, and A. Galluzzo. 1997. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 275:960.
13. French, L. E., and J. Tschopp. 1997. Thyroiditis and hepatitis: Fas on the road to disease. Nat. Med. 3:387.
14. De Maria, R., and R. Testi. 1998. Fas/FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity. Immunol. Today 19:121.
15. Kägi, D., F. Vignaux, B. Ledermann, K. Bürki, V. Depraetere, S. Nagata, H. Hengartner, and P. Golstein. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265:528.
16. Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370: 650.
17. Stassi, G., R. De Maria, G. Trucco, W. Rudert, R. Testi, A. Galluzzo, C. Giordano, and M. Trucco. 1997. Nitric oxide primes pancreatic β-cells for Fas-mediated destruction in IDDM. J. Exp. Med. 186:1193.
18. D'Souza, S. D., B. Bonetti, V. Balasingam, N. R. Cashman, P. A. Barker, A. B. Troutt, C. S. Raine, and J. P. Antel. 1996. Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J. Exp. Med. 184:2361.
19. Hammond, L. J., M. W. Lowdell, P. G. Cerrano, A. W. Goode, G. F. Bottazzo, and R. Mirakian. 1997. Analysis of apoptosis in relation to tissue destruction associated with Hashimoto's autoimmune thyroiditis. J. Pathol. 182:138.
20. De Maria, R., M. Boirivant, M. G. Cifone, P. Roncaioli, M. Hahne, J. Tschopp, F. Pallone, A. Santoni, and R. Testi. 1996. Functional expression of Fas and Fas Ligand on human gut lamina propria lymphocytes: a potential role for the acidic sphingomyelinase pathway in normal immunoregulation. J. Clin. Invest. 97:316.
21. De Maria, R., L. Lenti, F. Malisan, F. d' Agostino, A. Zeuner, M. R. Rippo, B. Tomassini, and R. Testi. 1997. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science 277:1652.
22. De Maria, R., M. R. Rippo, E. S. Schuchman, and R. Testi. 1998. Acidic sphingomyelinase (ASM) is necessary for Fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells. J. Exp. Med. 187:897.
23. Champion, B. R., A. Cooke, and D. C. Rayner. 1992. Thyroid autoimmunity. Curr. Opin. Immunol. 4:770.
24. Kotani, T., Y. Aratake, K. Hirai, Y. Fukazawa, H. Sato, and S. Ohtaki. 1995. Apoptosis in thyroid tissue from patients with Hashimoto's thyroiditis. Autoimmunity 20:231.