Five hTRPA1 agonists found in indigenous Korean mint, Agastache rugosa

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Moon, Hana ^a   Kim, Min Jung ^a   Son, Hee Jin ^a   Kweon, Hae Jin ^b   Kim, Jung Tae ^a   Kim, Yiseul ^a   Shim, Jaewon ^a   Suh, Byung Chang ^b   Rhyu, Mee Ra ^a  

^a Korea Food Research Institute   (South Korea)

^b Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACACETIN; ANISALDEHYDE; APIGETRIN; CARVEOL; CARYOPHYLLENE; ESTRAGOLE; GASTROINTESTINAL AGENT; METHYLEUGENOL; PACHYPODOL; ROSMARINIC ACID; TRANS PARA METHOXYCINNAMALDEHYDE; TRANSIENT RECEPTOR POTENTIAL ANKYRIN 1 AGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE; 4-ANISALDEHYDE; ACETANILIDE DERIVATIVE; ANISOLE DERIVATIVE; BENZALDEHYDE DERIVATIVE; CALCIUM CHANNEL; EUGENOL; NERVE PROTEIN; PLANT EXTRACT; PURINE DERIVATIVE; RUTHENIUM RED; SESQUITERPENE; TERPENE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

AGASTACHE; AGASTACHE RUGOSA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; PHYTOCHEMISTRY; PLANT LEAF; PLANT STEM; PROTEIN EXPRESSION; AGONISTS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; HEK293 CELL LINE; HUMAN;

AGASTACHE RUGOSA; LAMIACEAE; MENTHA;

ACETANILIDES; AGASTACHE; ANISOLES; BENZALDEHYDES; CALCIUM CHANNELS; CELL LINE; EUGENOL; HEK293 CELLS; HUMANS; MONOTERPENES; NERVE TISSUE PROTEINS; PLANT EXTRACTS; PLANT LEAVES; PLANT STEMS; PURINES; RUTHENIUM RED; SESQUITERPENES; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS;

EID: 84929378727     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127060     Document Type: Article

References (33)

1. Damann N, Voets T, Nilius B. TRPs in our senses. Curr Biol. 2008; 18: R880-889. doi: 10.1016/j.cub. 2008.07.063 PMID: 18812089
2. Pedersen SF, Owsianik G, Nilius B. TRP channels: an overview. Cell Calcium. 2005; 38: 233-252. PMID: 16098585
3. Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature. 2007; 445: 541-545. PMID: 17237762
4. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004; 41: 849-857. PMID: 15046718
5. Andrade EL, Meotti FC, Calixto JB. TRPA1 antagonists as potential analgesic drugs. Pharmacol Ther. 2012; 133: 189-204. doi: 10.1016/j.pharmthera.2011.10.008 PMID: 22119554
6. Andersson DA, Gentry C, Moss S, Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci. 2008; 28: 2485-2494. doi: 10.1523/JNEUROSCI. 5369-07.2008 PMID: 18322093
7. Zhang X, Koronowski KB, Li L, Freeman BA, Woodcock S, de Groat WC. Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons. Exp Neurol. 2004; 251: 12-21.
8. Tominaga M. Capsaicin receptor TRPV1. Brain Nerve. 2008; 60: 493-501. PMID: 18516971
9. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997; 389: 816-824. PMID: 9349813
10. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004; 427: 260-265. PMID: 14712238
11. Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A. 2005; 102: 12248-12252. PMID: 16103371
12. Shintaku M, Hashimoto K. Anaplastic ependymoma simulating glioblastoma in the cerebrum of an adult. Brain Tumor Pathol. 2012; 29: 31-36. doi: 10.1007/s10014-011-0057-x PMID: 21833575
13. Terada Y, Narukawa M, Watanabe T. Specific hydroxy fatty acids in royal jelly activate TRPA1. J Agric Food Chem. 2011; 59: 2627-2635. doi: 10.1021/jf1041646 PMID: 21348496
14. Son HJ, Kim MJ, Park JH, Ishii S, Misaka T, Rhyu MR. Methyl syringate, a low-molecular-weight phenolic ester, as an activator of the chemosensory ion channel TRPA1. Arch Pharm Res. 2012; 35: 2211-2218. doi: 10.1007/s12272-012-1220-6 PMID: 23263817
15. Kim MJ, Son HJ, Song SH, Jung M, Kim Y, Rhyu MR. The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying. PLoS One. 2013; 8: e71603. doi: 10.1371/journal.pone. 0071603 PMID: 23990963
16. Hong JJ, Choi JH, Oh SR, Lee HK, Park JH, Lee KY, et al. Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa. FEBS Lett. 2001; 495: 142-147. PMID: 11334881
17. Shin S, Kang CA. Antifungal activity of the essential oil of Agastache rugosa Kuntze and its synergism with ketoconazole. Lett Appl Microbiol. 2003; 36: 111-115. PMID: 12535132
18. Oh HM, Kang YJ, Kim SH, Lee YS, Park MK, Heo JM, et al. Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1beta. Arch Pharm Res. 2005; 28: 305-310. PMID: 15832818
19. Zakharova OI, Zakharov AM, Glyzin VI. Flavonoids of Agastache rugosa. Chem Nat Compd. 1979; 15: 561-564.
20. Choi KS, Lee HY. Characteristics of useful components in the leaves of baechohyang (Agastacherugosa, O. Kuntze). J Korean Soc Food Sci Nutr. 1999; 28: 326-332.
21. Ahn B, Yang CB. Volatile flavor components of bangah (Agastache rugosa O Kuntze) herb. Korean J Food SciTechnol. 1991; 23: 582-586.
22. Hata T, Tazawa S, Ohta S, Rhyu MR, Misaka T, Ichihara K. Artepillin C, a major ingredient of Brazilian propolis, induces a pungent taste by activating TRPA1 channels. PLoS One. 2012; 7: e48072. doi: 10. 1371/journal.pone.0048072 PMID: 23133611
23. Lee C, Kim H, Kho Y. Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay. J Nat Prod. 2002; 65: 414-416. PMID: 11908994
24. Hinman A, Chuang HH, Bautista DM, Julius D. TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A. 2006; 103: 19564-19568. PMID: 17164327
25. Gang DR, Wang J, Dudareva N, Nam KH, Simon JE, Lewinsohn E, et al. An investigation of the storage and biosynthesis of phenylpropenes in sweet basil. Plant Physiol. 2001; 125: 539-555. PMID: 11161012
26. Earley S, Gonzales AL, Garcia ZI. A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation. Mol Pharmacol. 2010; 77: 612-620. doi: 10.1124/mol.109. 060715 PMID: 20086034
27. Salazar H, Llorente I, Jara-Oseguera A, Garcia-Villegas R, Munari M, Gordon SE, et al. A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci. 2008; 11: 255-261. doi: 10.1038/nn2056 PMID: 18297068
28. Nozawa K, Kawabata-Shoda E, Doihara H, Kojima R, Okada H, Mochizuki S, et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A. 2009; 106: 3408-3413. doi: 10.1073/pnas.0805323106 PMID: 19211797
29. Wang KC, Chang JS, Chiang LC, Lin CC. 4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line. Phytomedicine. 2009; 16: 882-886. doi: 10.1016/j.phymed.2009.02.016 PMID: 19303275
30. Bevan S, Andersson DA. TRP channel antagonists for pain-opportunities beyond TRPV1. Curr Opin Investig Drugs. 2009; 10: 655-663. PMID: 19579171
31. Fernandes ES, Fernandes MA, Keeble JE. The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol. 2012; 166: 510-521. doi: 10.1111/j.1476-5381.2012.01851.x PMID: 22233379
32. Geppetti P, Nassini R, Materazzi S, Benemei S. The concept of neurogenic inflammation. BJU Int 101 Suppl. 2008; 3: 2-6.
33. Doihara H, Nozawa K, Kawabata-Shoda E, Kojima R, Yokoyama T, Ito H. TRPA1 agonists delay gastric emptying in rats through serotonergic pathways. Naunyn Schmiedebergs Arch Pharmacol. 2009; 380: 353-357. doi: 10.1007/s00210-009-0435-7 PMID: 19629446