Regulatory role of Small nucleolar RNAs in human diseases

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Stepanov, Grigory A ^a   Filippova, Julia A ^a,b   Komissarov, Andrey B ^c,d   Kuligina, Elena V ^a   Richter, Vladimir A ^a   Semenov, Dmitry V ^a   Tang, Thean Hock ^e  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^c Research Institute of Influenza   (Russian Federation)

^d ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; MESSENGER RNA; RIBOSOME PROTEIN; RIBOSOME RNA; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SMALL NUCLEAR RNA; SMALL NUCLEOLAR RIBONUCLEOPROTEIN; SMALL NUCLEOLAR RNA; TAMOXIFEN; TENOFOVIR DISOPROXIL; UNTRANSLATED RNA; RNA;

ALTERNATIVE RNA SPLICING; CANCER DIAGNOSIS; CARCINOGENESIS; DEGENERATIVE DISEASE; DISEASES; GENE EXPRESSION REGULATION; HUMAN; MAMMAL CELL; NEOPLASM; PATHOLOGY; PROTEIN EXPRESSION; PROTEIN MODIFICATION; REVIEW; TRANSCRIPTION INITIATION; VIRUS INFECTION; ANIMAL; CHEMISTRY; CONFORMATION; DEMYELINATING DISEASE; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; RNA PROCESSING;

ANIMALS; DISEASE; GENE EXPRESSION REGULATION; HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM; HUMANS; NEOPLASMS; NUCLEIC ACID CONFORMATION; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, NEOPLASM; RNA, SMALL NUCLEOLAR; STRESS, PHYSIOLOGICAL; VIRUS DISEASES;

EID: 84929310669     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/206849     Document Type: Review

References (97)

1. J. Cavaillé, M. Nicoloso, and J.-P. Bachellerie, "Targeted ribose methylation of RNA in vivo directed by tailored antisense RNA guides, " Nature, vol. 383, no. 6602, pp. 732-735, 1996.
2. P. Ganot, M.-L. Bortolin, and T. Kiss, "Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs, " Cell, vol. 89, no. 5, pp. 799-809, 1997.
3. D. J. Klein, T. M. Schmeing, P. B. Moore, and T. A. Steitz, "The kink-turn: a new RNA secondary structure motif, " EMBO Journal, vol. 20, no. 15, pp. 4214-4221, 2001.
4. L. B. Szewczak, J. S. Gabrielsen, S. J. Degregorio, S. A. Strobel, and J. A. Steitz, "Molecular basis for RNA kink-turn recognition by the h15.5K small RNP protein, " RNA, vol. 11, no. 9, pp. 1407-1419, 2005.
5. N. Špačková, K. Réblová, and J. Šponer, "Structural dynamics of the box C/D RNA kink-turn and its complex with proteins: the role of the A-minor 0 interaction, long-residency water bridges, and structural ion-binding sites revealed by molecular simulations, " Journal of Physical ChemistryB, vol. 114, no. 32, pp. 10581-10593, 2010.
6. A. K. Henras, C. Dez, and Y. Henry, "RNA structure and function in C/D and H/ACA s(no)RNPs, " Current Opinion in Structural Biology, vol. 14, no. 3, pp. 335-343, 2004.
7. J. Lin, S. Lai, R. Jia et al., "Structural basis for site-specific ribose methylation by box C/D RNA protein complexes, " Nature, vol. 469, no. 7331, pp. 559-563, 2011.
8. L. Lui and T. Lowe, "Small nucleolar RNAs and RNA-guided post-transcriptional modification, " Essays in Biochemistry, vol. 54, no. 1, pp. 53-77, 2013.
9. X. Darzacq, B. E. Jády, C. Verheggen, A. M. Kiss, E. Bertrand, and T. Kiss, "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs, " EMBO Journal, vol. 21, no. 11, pp. 2746-2756, 2002.
10. P. Richard, X. Darzacq, E. Bertrand, B. E. Jády, C. Verheggen, and T. Kiss, "A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs, " EMBO Journal, vol. 22, no. 16, pp. 4283-4293, 2003.
11. A. Fedorov, J. Stombaugh, M. W. Harr, S. Yu, L. Nasalean, and V. Shepelev, "Computer identification of snoRNA genes using a Mammalian Orthologous Intron Database, " Nucleic Acids Research, vol. 33, no. 14, pp. 4578-4583, 2005.
12. P. S. Bazeley, V. Shepelev, Z. Talebizadeh et al., "snoTARGET shows that human orphan snoRNA targets locate close to alternative splice junctions, " Gene, vol. 408, no. 1-2, pp. 172-179, 2008.
13. A. Hüttenhofer, J. Cavaillé, and J.-P. Bachellerie, "Experimental RNomics: a global approach to identifying small nuclear RNAs and their targets in different model organisms, " Methods in Molecular Biology, vol. 265, pp. 409-428, 2004.
14. B. Rogelj, "Brain-specific small nucleolar RNAs, " Journal of Molecular Neuroscience, vol. 28, no. 2, pp. 103-110, 2006.
15. A. Hüttenhofer, M. Kiefmann, S. Meier-Ewert et al., "Rnomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse, " The EMBO Journal, vol. 20, no. 11, pp. 2943-2953, 2001.
16. J. Cavaillé, K. Buiting, M. Kiefmann et al., "Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization, " Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 26, pp. 14311-14316, 2000.
17. J. C. Castle, C. D. Armour, M. Löwer et al., "Digital genomewide ncRNA expression, including SnoRNAs, across 11 human tissues using polya-neutral amplification, " PLoS ONE, vol. 5, no. 7, Article ID e11779, 2010.
18. S. Kishore, A. Khanna, Z. Zhang et al., "The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing, " Human Molecular Genetics, vol. 19, no. 7, pp. 1153-1164, 2010.
19. S. Kishore and S. Stamm, "The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C, " Science, vol. 311, no. 5758, pp. 230-232, 2006.
20. P. Vitali, E. Basyuk, E. LeMeur et al., "ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs, "The Journal of Cell Biology, vol. 169, no. 5, pp. 745-753, 2005.
21. R. J. Taft, E. A. Glazov, T. Lassmann, Y.Hayashizaki, P. Carninci, and J. S. Mattick, "Small RNAs derived from snoRNAs, " RNA, vol. 15, no. 7, pp. 1233-1240, 2009.
22. M. Shen, E. Eyras, J. Wu et al., "Direct cloning of doublestranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression, " Nucleic Acids Research, vol. 39, no. 22, pp. 9720-9730, 2011.
23. M. Falaleeva and S. Stamm, "Processing of snoRNAs as a new source of regulatory non-coding RNAs: snoRNA fragments form a new class of functional RNAs, " BioEssays, vol. 35, no. 1, pp. 46-54, 2013.
24. M. Ono, K. Yamada, F. Avolio et al., "Analysis of human small nucleolar RNAs (snoRNA) and the development of snoRNA modulator of gene expression vectors, " Molecular Biology of the Cell, vol. 21, no. 9, pp. 1569-1584, 2010.
25. M. Ono, M. S. Scott, K. Yamada, F. Avolio, G. J. Barton, and A. I. Lamond, "Identification of human miRNA precursors that resemble boxC/D snoRNAs, "Nucleic Acids Research, vol. 39, no. 9, pp. 3879-3891, 2011.
26. M. S. Scott, M. Ono, K. Yamada, A. Endo, G. J. Barton, and A. I. Lamond, "Human box C/D snoRNA processing conservation acrossmultiple cell types, " Nucleic Acids Research, vol. 40, no. 8, pp. 3676-3688, 2012.
27. M. S. Scott, F. Avolio, M. Ono, A. I. Lamond, and G. J. Barton, "Human miRNA precursors with box H/ACA snoRNA features, " PLoS Computational Biology, vol. 5, no. 9, Article ID e1000507, 2009.
28. M. Brameier, A. Herwig, R. Reinhardt, L. Walter, and J. Gruber, "Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs, " Nucleic Acids Research, vol. 39, no. 2, pp. 675-686, 2011.
29. C. Ender, A. Krek, M. R. Friedländer et al., "A human snoRNA with microRNA-like functions, " Molecular Cell, vol. 32, no. 4, pp. 519-528, 2008.
30. A. M. Burroughs, Y. Ando, M. J. L. de Hoon et al., "Deepsequencing of human argonaute-associated small RNAs provides insight into miRNA sorting and reveals argonaute association with RNA fragments of diverse origin, " RNA Biology, vol. 8, no. 1, pp. 158-177, 2011.
31. D. Langenberger, M. V. Çakir, S. Hoffmann, and P. F. Stadler, "Dicer-processed small RNAs: rules and exceptions, " Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, vol. 320, no. 1, pp. 35-46, 2013.
32. J. Badhai, A.-S. Fröjmark, E. J. Davey, J. Schuster, and N. Dahl, "Ribosomal protein S19 and S24 insufficiency cause distinct cell cycle defects in Diamond-Blackfan anemia, " Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1792, no. 10, pp. 1036-1042, 2009.
33. N. Hariharan and M. A. Sussman, "Stressing on the nucleolus in cardiovascular disease, " Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1842, no. 6, pp. 798-801, 2014.
34. P. A. Trainor and A. E. Merrill, "Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders, " Biochimica et BiophysicaActa, vol. 1842, no. 6, pp.769-778, 2014.
35. J.-P. Bachellerie, J. Cavaillé, andA.Hüttenhofer, "Theexpanding snoRNA world, " Biochimie, vol. 84, no. 8, pp. 775-790, 2002.
36. D. Tollervey and T. Kiss, "Function and synthesis of small nucleolar RNAs, " Current Opinion in Cell Biology, vol. 9, no. 3, pp. 337-342, 1997.
37. H. E. Gee, F. M. Buffa, C. Camps et al., "The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis, " British Journal of Cancer, vol. 104, no. 7, pp. 1168-1177, 2011.
38. Y.-P. Mei, J.-P. Liao, J. Shen et al., "Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis, " Oncogene, vol. 31, no. 22, pp. 2794-2804, 2012.
39. H. Su, T. Xu, S. Ganapathy et al., "Elevated snoRNA biogenesis is essential in breast cancer, " Oncogene, vol. 33, no. 11, pp. 1348-1358, 2014.
40. Y. Zhang andH. Lu, "Signaling to p53: ribosomal proteins find their way, " Cancer Cell, vol. 16, no. 5, pp. 369-377, 2009.
41. L. Chu, M. Y. Su, L. B. Maggi Jr. et al., "Multiple myelomaassociated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress, " Journal of Clinical Investigation, vol. 122, no. 8, pp. 2793-2806, 2012.
42. A. Donsante, D. G. Miller, Y. Li et al., "AAV vector integration sites in mouse hepatocellular carcinoma, " Science, vol. 317, no. 5837, article 477, 2007.
43. Y.Zhou, X. Zhang, andA.Klibanski, "MEG3 noncodingRNA: a tumor suppressor, " Journal of Molecular Endocrinology, vol. 48, no. 3, pp. R45-R53, 2012.
44. Y. Zhou, Y. Zhong, Y. Wang et al., "Activation of p53 by MEG3 non-coding RNA, " The Journal of Biological Chemistry, vol. 282, no. 34, pp. 24731-24742, 2007.
45. F. E. Gordon, C. L. Nutt, P. Cheunsuchon et al., "Increased expression of angiogenic genes in the brains of mouse meg3-null embryos, " Endocrinology, vol. 151, no. 6, pp. 2443-2452, 2010.
46. J. Krell, A. E. Frampton, R. Mirnezami et al., "Growth arrestspecific transcript 5 associated snoRNA levels are related to p53 expression and DNA damage in colorectal cancer, " PLoS ONE, vol. 9, no. 6, Article IDe98561, 2014.
47. M. Mourtada-Maarabouni, M. R. Pickard, V. L. Hedge, F. Farzaneh, and G. T. Williams, "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer, " Oncogene, vol. 28, no. 2, pp. 195-208, 2009.
48. M. R. Pickard, M. Mourtada-Maarabouni, and G. T. Williams, "Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines, " Biochimica et Biophysica Acta, vol. 1832, no. 10, pp. 1613-1623, 2013.
49. M.E.Askarian-Amiri, J.Crawford, J. D. French et al., "SNORDhost RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer, " RNA, vol. 17, no. 5, pp. 878-891, 2011.
50. W. Valleron, E. Laprevotte, E.-F. Gautier et al., "Specific small nucleolar RNA expression profiles in acute leukemia, " Leukemia, vol. 26, no. 9, pp. 2052-2060, 2012.
51. A. Gaur, D. A. Jewell, Y. Liang et al., "Characterization of microRNA expression levels and their biological correlates in human cancer cell lines, " Cancer Research, vol. 67, no. 6, pp. 2456-2468, 2007.
52. H. J. Ferreira, H. Heyn, C. Moutinho, and M. Esteller, "CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer, " RNA Biology, vol. 9, no. 6, pp. 881-890, 2012.
53. P. Lopez-Serra and M. Esteller, "DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer, " Oncogene, vol. 31, no. 13, pp. 1609-1622, 2012.
54. E. S.Martens-Uzunova, S. E. Jalava, N. F. Dits et al., "Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer, " Oncogene, vol. 31, no. 8, pp. 978-991, 2012.
55. S. Belin, A. Beghin, E. Solano-Gonzàlez et al., "Dysregulation of ribosome biogenesis and translational capacity is associated with tumor progression of human breast cancer cells, " PLoS ONE, vol. 4, no. 9, Article ID e7147, 2009.
56. J. Liao, L. Yu, Y.Mei et al., "Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer, " Molecular Cancer, vol. 9, article 198, 2010.
57. X.-Y. Dong, C. Rodriguez, P. Guo et al., "SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer, " Human Molecular Genetics, vol. 17, no. 7, pp. 1031-1042, 2008.
58. X.-Y. Dong, P. Guo, J. Boyd et al., "Implication of snoRNA U50 in human breast cancer, " Journal of Genetics and Genomics, vol. 36, no. 8, pp. 447-454, 2009.
59. K. J. Teittinen, A. Laiho, A. Uusimäki, J.-P. Pursiheimo, A. Gyenesei, and O. Lohi, "Expression of small nucleolar RNAs in leukemic cells, " Cellular Oncology (Dordrecht), vol. 36, no. 1, pp. 55-63, 2013.
60. W. Valleron, L. Ysebaert, L. Berquet et al., "Small nucleolar RNA expression profiling identifies potential prognostic markers in peripheral T-cell lymphoma, " Blood, vol. 120, no. 19, pp. 3997-4005, 2012.
61. S. Hirajima, S. Komatsu, D. Ichikawa et al., "Clinical impact of circulating miR-18a in plasma of patients with oesophageal squamous cell carcinoma, " British Journal of Cancer, vol. 108, no. 9, pp. 1822-1829, 2013.
62. C. Wu, C. Wang, X. Guan et al., "Diagnostic and prognostic implications of a serummiRNApanel in oesophageal squamous cell carcinoma, " PLoSONE, vol. 9, no. 3, Article IDe92292, 2014.
63. T. A. Farazi, J. I. Hoell, P. Morozov, and T. Tuschl, "MicroRNAs in human cancer, " Advances in Experimental Medicine and Biology, vol. 774, pp. 1-20, 2013.
64. E. Zandberga, V. Kozirovskis, A. Abols, D. Andrejeva, G. Purkalne, and A. Line, "Cell-free microRNAs as diagnostic, prognostic, and predictive biomarkers for lung cancer, " Genes Chromosomes and Cancer, vol. 52, no. 4, pp. 356-369, 2013.
65. Y. Yang, X. Gu, M. Zhou, J. Xiang, and Z. Chen, "Serum microRNAs: a new diagnostic method for colorectal cancer, " Bioscience Reports, vol. 1, no. 4, pp. 495-498, 2013.
66. C. Yang, C. Wang, X. Chen et al., "Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas, " International Journal of Cancer, vol. 132, no. 1, pp. 116-127, 2013.
67. C. M. Doe, D. Relkovic, A. S. Garfield et al., "Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour, " Human Molecular Genetics, vol. 18, no. 12, pp. 2140-2148, 2009.
68. P. Sridhar, H. H. Gan, and T. Schlick, "A computational screen for C/D box snoRNAs in the human genomic region associated with Prader-Willi and Angelman syndromes, " Journal of Biomedical Science, vol. 15, no. 6, pp. 697-705, 2008.
69. A. L. Duker, B. C. Ballif, E. V. Bawle et al., "Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader-Willi syndrome, " European Journal of HumanGenetics, vol. 18, no. 11, pp. 1196-1201, 2010.
70. T. Sahoo, D. del Gaudio, J. R. German et al., "Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster, " Nature Genetics, vol. 40, no. 6, pp. 719-721, 2008.
71. M.-L. Bortolin-Cavaillé and J. Cavaillé, "The SNORD115 (H/MBII-52) and SNORD116 (H/MBII-85) gene clusters at the imprinted Prader-Willi locus generate canonical box C/D snoRNAs, " Nucleic Acids Research, vol. 40, no. 14, pp. 6800-6807, 2012.
72. B. I. Laufer, K. Mantha, M. L. Kleiber, E. J. Diehl, S. M. F. Addison, and S. M. Singh, "Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice, " DMM Disease Models and Mechanisms, vol. 6, no. 4, pp. 977-992, 2013.
73. J. Nakatani, K. Tamada, F. Hatanaka et al., "Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism, " Cell, vol. 137, no. 7, pp. 1235-1246, 2009.
74. S. D. Der, A. Zhou, B. R. G. Williams, and R. H. Silverman, "Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays, " Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 26, pp. 15623-15628, 1998.
75. G. Trinchieri, "Type I interferon: friend or foe?" Journal of Experimental Medicine, vol. 207, no. 10, pp. 2053-2063, 2010.
76. A. J. Sadler and B. R. G. Williams, "Interferon-inducible antiviral effectors, " Nature Reviews Immunology, vol. 8, no. 7, pp. 559-568, 2008.
77. L. M. Sedger, "MicroRNA control of interferons and interferon induced anti-viral activity, " Molecular Immunology, vol. 56, no. 4, pp. 781-793, 2013.
78. M. Hecker, M. Thamilarasan, D. Koczan et al., "MicroRNA expression changes during interferon-beta treatment in the peripheral blood of multiple sclerosis patients, " International Journal of Molecular Sciences, vol. 14, no. 8, pp. 16087-16110, 2013.
79. T. Saxena, B. Tandon, S. Sharma et al., "Combined miRNA and mRNA signature identifies key molecular players and pathways involved in chikungunya virus infection in human cells, " PLoS ONE, vol. 8, no. 11, Article ID e79886, 2013.
80. B. R. Cullen, "MicroRNAs as mediators of viral evasion of the immune system, "Nature Immunology, vol. 14, no. 3, pp. 205-210, 2013.
81. R. Hutzinger, R. Feederle, J.Mrazek et al., "Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome, " PLoS Pathogens, vol. 5, no. 8, Article ID e1000547, 2009.
82. S. Barth, T. Pfuhl, A. Mamiani et al., "Epstein-Barr virusencoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5, " Nucleic Acids Research, vol. 36, no. 2, pp. 666-675, 2008.
83. F. Renzi, E. Caffarelli, P. Laneve, I. Bozzoni, M. Brunori, and B. Vallone, "The structure of the endoribonuclease XendoU: from small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication, " Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 33, pp. 12365-12370, 2006.
84. X. Peng, L. Gralinski, M. T. Ferris et al., "Integrative deep sequencing of themouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection, " mBio, vol. 2, no. 6, Article ID e00198-11, 2011.
85. G. T.Williams, M. Mourtada-Maarabouni, and F. Farzaneh, "A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes, " Biochemical Society Transactions, vol. 39, no. 2, pp. 482-486, 2011.
86. S. J. Plotch and R. M. Krug, "Segments of influenza virus complementary RNA synthesized in vitro, " Journal of Virology, vol. 25, no. 2, pp. 579-586, 1978.
87. P. Narayan, D. F. Ayers, F. M. Rottman, P. A. Maroney, and T. W. Nilsen, "Unequal distribution of N6-methyladenosine in influenza virus mRNAs, " Molecular and Cellular Biology, vol. 7, no. 4, pp. 1572-1575, 1987.
88. S. Daffis, K. J. Szretter, J. Schriewer et al., "2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members, " Nature, vol. 468, no. 7322, pp. 452-456, 2010.
89. D. Guilligay, J. Kadlec, T. Crépin et al., "Comparative structural and functional analysis of Orthomyxovirus polymerase capsnatching domains, " PLoS ONE, vol. 9, no. 1, Article ID e84973, 2014.
90. S. Reich, D.Guilligay, A. Pflug et al., "Structural insight into capsnatching and RNA synthesis by influenza polymerase, " Nature, vol. 516, no. 7531, pp. 361-366, 2014.
91. L. Zhang, M. Yang, P. Marks et al., "Serum non-coding RNAs as biomarkers for osteoarthritis progression after ACL injury, " Osteoarthritis and Cartilage, vol. 20, no. 12, pp. 1631-1637, 2012.
92. C. I.Michel, C. L. Holley, B. S. Scruggs et al., "Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress, " Cell Metabolism, vol. 14, no. 1, pp. 33-44, 2011.
93. R. H. Unger, "Lipid overload and overflow: metabolic trauma and the metabolic syndrome, " Trends in Endocrinology and Metabolism, vol. 14, no. 9, pp. 398-403, 2003.
94. N.M. Borradaile, X. Han, J. D. Harp, S. E. Gale, D. S. Ory, and J. E. Schaffer, "Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death, " Journal of Lipid Research, vol. 47, no. 12, pp. 2726-2737, 2006.
95. R. E. McDaniel, P. Y. Maximov, and V. C. Jordan, "Estrogenmediated mechanisms to control the growth and apoptosis of breast cancer cells: a translational research success story, " Vitamins & Hormones, vol. 93, pp. 1-49, 2013.
96. K. J. Huber-Keener, X. Liu, Z. Wang et al., "Differential gene expression in tamoxifen-resistant breast cancer cells revealed by a new analytical model of RNA-seq data, " PLoS ONE, vol. 7, no. 7, Article ID e41333, 2012.
97. I. F. Grigsby, L. Pham, R. Gopalakrishnan, L. M.Mansky, and K. C. Mansky, "Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts, " Biochemical and Biophysical Research Communications, vol. 391, no. 3, pp. 1324-1329, 2010.