A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes

Biochemical Society Transactions

Volumn 39, Issue 2, 2011, Pages 482-486

  Williams, Gwyn T ^a   Mourtada Maarabouni, Mirna ^a   Farzaneh, Farzin ^b  

^a KEELE UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Growth arrest specific transcript 5 (GAS5); Mammalian target of rapamycin (mTOR); Non coding RNA; Rapamycin; Small nucleolar RNA (snoRNA); T cell

Indexed keywords

GLUCOCORTICOID RECEPTOR; GROWTH ARREST SPECIFIC TRANSCRIPT 5; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MESSENGER RNA; SMALL NUCLEOLAR RNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

CELL CYCLE ARREST; CELL GROWTH; GENE EXPRESSION; HUMAN; INHIBITION KINETICS; INTRON; LEUKEMIA; MOLECULAR CLONING; PRIORITY JOURNAL; REVIEW; RNA TRANSLATION; T LYMPHOCYTE;

ANIMALS; CELL GROWTH PROCESSES; HUMANS; RNA, SMALL NUCLEOLAR; RNA, UNTRANSLATED; SIROLIMUS; T-LYMPHOCYTES; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 79953184710     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0390482     Document Type: Review

References (44)

1. Fruman, D.A. and Bismuth, G. (2009) Fine tuning the immune response with PI3K. Immunol. Rev. 228, 253-272
2. Rathmell, J.C. and Thompson, C.B. (2002) Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell 109, S97-S107 (Pubitemid 34457855)
3. Abraham, R.T. and Wiederrecht, G.J. (1996) Immunopharmacology of rapamycin. Annu. Rev. Immunol. 14, 483-510
4. Abdel-Karim, I.A. and Giles, F.J. (2008) Mammalian target of rapamycin as a target in hematological malignancies. Curr. Probl. Cancer 32, 161-177
5. Riedl, S.J. and Salvesen, G.S. (2007) The apoptosome, signalling platform of cell death. Nat. Rev. Mol. Cell Biol. 8, 405-413
6. Hale, A.J., Smith, C.A., Sutherland, L.C., Stoneman, V.E.A., Longthorne, V.L., Culhane, A.C. and Williams, G.T. (1996) Apoptosis, molecular regulation of cell death. Eur. J. Biochem. 236, 1-26
7. Li, W.P., Li, J., Su, C., Zou, W.Y. and Luo, S.K. (2010) New targets of PS-341, BAFF and APRIL. Med. Oncol. 27, 439-445
8. Di Pietro, C., Ragusa, M., Barbagallo, D., Duro, L.R., Guglielmino, M.R., Majorana, A., Angelica, R., Scalia, M., Statello, L., Salito, L. et al. (2009) The apoptotic machinery as a biological complex system, analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma. BMC Med. Genomics 2, 20
9. Luthi, A.U., Cullen, S.P. and Martin, S.J. (2008) Two-dimensional gel-based analysis of the demolition phase of apoptosis. Methods Enzymol. 442, 343-354
10. Williams, G.T. and Farzaneh, F. (2004) The use of gene function to identify the rate-limiting steps controlling cell fate. Cancer Immunol. Immunother. 53, 160-165
11. Stark, G.R. and Gudkov, A.V. (1999) Forward genetics in mammalian cells, functional approaches to gene discovery. Hum. Mol. Genet. 8, 1925-1938
12. Williams, G.T., Hughes, J.P., Stoneman, V., Anderson, C.L., McCarthy, N.J., Mourtada-Maarabouni, M., Pickard, M., Hedge, V.L., Trayner, I. and Farzaneh, F. (2006) Isolation of genes controlling apoptosis through their effects on cell survival. Gene Ther. Mol. Biol. 10B, 255-261 (Pubitemid 351976169)
13. Sutherland, L.C., Edwards, S.E., Cable, H.C., Poirier, G.G., Miller, B.A., Cooper, C.S. and Williams, G.T. (2000) LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis. Oncogene 19, 3774-3781 (Pubitemid 30621183)
14. Mourtada-Maarabouni, M., Sutherland, L.C. and Williams, G.T. (2002) Candidate tumour suppressor LUCA-15 can regulate multiple apoptotic pathways. Apoptosis 7, 421-432
15. Mourtada-Maarabouni, M., Sutherland, L.C., Meredith, J.M. and Williams, G.T. (2003) Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant δ-6 of the candidate tumour suppressor LUCA-15/RBM5. Genes Cells 8, 109-119
16. Mourtada-Maarabouni, M., Keen, J., Clark, J., Cooper, C.S. and Williams, G.T. (2006) Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes. Exp. Cell Res. 312, 1745-1752
17. Mourtada-Maarabouni, M., Kirkham, L., Jenkins, B., Rayner, J., Gonda, T.J., Starr, R., Trayner, I., Farzaneh, F. and Williams, G.T. (2003) Functional expression cloning reveals proapoptotic role for protein phosphatase 4. Cell Death Differ. 10, 1016-1024 (Pubitemid 37069479)
18. Mourtada-Maarabouni, M. and Williams, G.T. (2008) Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells. Biochim. Biophys. Acta 1783, 1490-1502
19. Mourtada-Maarabouni, M. and Williams, G.T. (2009) Protein phosphatase 4 regulates apoptosis in leukaemic and primary human T-cells. Leukemia Res. 33, 1539-1551
20. Anderson, C.L. and Williams, G.T. (2003) Apoptosis gene hunting using retroviral expression cloning: identification of vacuolar ATPase subunit E. TheScientificWorld 3, 51-58
21. Mourtada-Maarabouni, M., Kirkham, L., Farzaneh, F. and Williams, G.T. (2004) Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression. Oncogene 23, 9419-9426 (Pubitemid 40069674)
22. Pickard, M.R., Green, A.R., Ellis, I.O., Caldas, C., Hedge, V.L., Mourtada-Maarabouni, M. and Williams, G.T. (2009) Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. Breast Cancer Res. 11, R60
23. Pickard, M.R., Edwards, S.E., Cooper, C.S. and Williams, G.T. (2010) Apoptosis regulators Fau and Bcl-G are down-regulated in prostate cancer. Prostate 70, 1513-1523
24. Mourtacla-Maarabouni, M., Kirkham, L., Farzaneh, F. and Williams, G.T. (2005) Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis. J. Leukocyte Biol. 78, 503-514 (Pubitemid 41061322)
25. Schneider, C., King, R.M. and Philipson, L. (1988) Genes specifically expressed at growth arrest of mammalian-cells. Cell 54, 787-793
26. Tsao, B.P. (2003) The genetics of human systemic lupus erythematosus. Trends Immunol. 24, 595-602
27. Harley, J.B., Alarcón-Riquelme, M.E., Criswell, L.A., Jacob, C.O., Kimberly, R.P., Moser, K.L., Tsao, B.P., Vyse, T.J., Langefeld, C.D., Nath, S.K. et al. (2008) Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat. Genet. 40, 204-210
28. Suarez-Gestal, M., Calaza, M., Endreffy, E., Pullmann, R., Ordi-Ros, J., Sebastiani, G.D., Ruzickova, S., Jose Santos, M., Papasteriades, C., Marchini, M. et al. (2009) Replication of recently identified systemic lupus erythematosus genetic associations, a case-control study. Arthritis Res. Ther. 11, R69
29. Haywood, M., Rose, S.J., Horswell, S., Lees, M.J., Fu, G., Walport, M.J. and Morley, B.J. (2006) Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes. Genes Immun. 7, 250-263
30. Rickert, C.H., Dockhorn-Dworniczak, B., Simon, R. and Paulus, W. (1999) Chromosomal imbalances in primary lymphomas of the central nervous system. Am. J. Pathol. 155, 1445-1451
31. Dave, B.J., Nelson, M., Pickering, D.L., Chan, W.C., Greiner, T.C., Weisenburger, D.D., Armitage, J.O. and Sanger, W.G. (2002) Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization. Cancer Genet. Cytogenet. 132, 125-132 (Pubitemid 34173007)
32. Tsuji, H., Ishii-Ohba, H., Ukai, H., Katsube, T. and Ogiu, T. (2003) Radiation-induced deletions in the 5′ end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas. Carcinogenesis 24, 1257-1268 (Pubitemid 36927067)
33. Lelievre, H., Cervera, N., Finetti, P., Delhommeau, F., Vainchenker, W., Bertucci, F. and Birnbaum, D. (2006) Oncogenic kinases of myeloproliferative disorders induce both protein synthesis and G1 activators. Leukemia 20, 1885-1888 (Pubitemid 44575001)
34. Muller, A.J., Chatterjee, S., Teresky, A. and Levine, A.J. (1998) The gas5 gene is disrupted by a frameshift mutation within its longest open reading frame in several inbred mouse strains and maps to murine chromosome 1. Mamm. Genome 9, 773-774
35. Tycowski, K.T., Shu, M.D. and Steitz, J.A. (1996) A mammalian gene with introns instead of exons generating stable RNA products. Nature 379, 464-466 (Pubitemid 26039529)
36. Meyuhas, O. (2000) Synthesis of the translational apparatus is regulated at the translational level. Eur. J. Biochem. 267, 6321-6330
37. Smith, C.M. and Steitz, J.A. (1998) Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. Mol. Cell. Biol. 18, 6897-6909
38. Mourtada-Maarabouni, M., Hedge, V.L., Kirkham, L., Farzaneh, F. and Williams, G.T. (2008) Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5). J. Cell Sci. 121, 939-946
39. Mourtada-Maarabouni, M., Hasan, A.M., Farzaneh, F. and Williams, G.T. (2010) Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5). Mol. Pharmacol. 78, 19-28
40. Wullschleger, S., Loewith, R. and Hall, M.N. (2006) TOR signaling in growth and metabolism. Cell 124, 471-484
41. Thoreen, C.C., Kang, S.A., Chang, J.W., Liu, Q., Zhang, J., Gao, Y., Reichling, L.J., Sim, T., Sabatini, D.M. and Gray, N.S. (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284, 8023-8032
42. Dong, X.Y., Rodriguez, C., Guo, P., Sun, X.D., Talbot, J.T., Zhou, W., Petros, J., Li, Q., Vessella, R.L., Kibel, A.S. et al. (2008) SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer. Hum. Mol. Genet. 17, 1031-1042
43. Dong, X.Y., Guo, P., Boyd, J., Sun, X.D., Li, Q.N., Zhou, W. and Dong, J.T. (2009) Implication of snoRNA U50 in human breast cancer. J. Genet. Genom. 36, 447-454
44. Kino, T., Hurt, D.E., Ichijo, T., Nader, N. and Chrousos, G.P. (2010) Noncoding RNA Gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci. Signaling 3, ra8