Hypoxia mimetic deferoxamine influences the expression of histone acetylation- and DNA methylation-associated genes in osteoblasts

Connective Tissue Research

Volumn 56, Issue 3, 2015, Pages 228-235

  Vrtačnik, Peter ^a   Marc, Janja ^a   Ostanek, Barbara ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Epigenetics; Oxidative stress; Posttranslational histone modification; RANK RANKL OPG system; WNT beta catenin signaling pathway

Indexed keywords

ACYLTRANSFERASE; ALDEHYDE OXIDASE; ALDEHYDE OXIDASE 1; AXIN; AXIN2; BETA CATENIN; DEFEROXAMINE; DNA METHYLTRANSFERASE 3A; HISTONE DEACETYLASE 9; K(LYSINE) ACETYLTRANSFERASE 5; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; UNCLASSIFIED DRUG; VASCULOTROPIN A; HISTONE;

ARTICLE; BONE CELL; BONE REMODELING; CELL HYPOXIA; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; HISTONE ACETYLATION; HUMAN; HUMAN CELL; OSSIFICATION; OSTEOBLAST; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY; ACETYLATION; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETIC EPIGENESIS; METABOLISM; PROTEIN PROCESSING;

ACETYLATION; CELL DIFFERENTIATION; CELL HYPOXIA; CELL LINE; DEFEROXAMINE; DNA METHYLATION; EPIGENESIS, GENETIC; HISTONES; HUMANS; OSTEOBLASTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; WNT SIGNALING PATHWAY;

EID: 84929232885     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2015.1017573     Document Type: Article

References (48)

1. Schipani E, Maes C, Carmeliet G, Semenza GL. Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res 2009; 24: 1347-53
2. Utting JC, Robins SP, Brandao-Burch A, Orriss IR, Behar J, Arnett TR. Hypoxia inhibits the growth, differentiation and boneforming capacity of rat osteoblasts. Exp Cell Res 2006; 312: 1693-702
3. Lechler P, Klein SM, Prantl L, Englert C, Renkawitz T, Grifka J. Hypoxic downregulation of cellular proliferation and loss of phenotype stability in human osteoblasts is mediated by HIF-1alpha. Clin Hemorheol Microcirc 2011; 49: 279-86
4. Chen D, Li Y, Zhou Z, Xing Y, Zhong Y, Zou X, Tian W, Zhang C. Synergistic inhibition of Wnt pathway by HIF-1alpha and osteoblast- specific transcription factor osterix (Osx) in osteoblasts. PLoS One 2012; 7: e52948
5. Steinbrech DS, Mehrara BJ, Saadeh PB, Chin G, Dudziak ME, Gerrets RP, Gittes GK, Longaker MT. Hypoxia regulates VEGF expression and cellular proliferation by osteoblasts in vitro. Plast Reconstr Surg 1999; 104: 738-47
6. Xu Y, Hammerick KE, James AW, Carre AL, Leucht P, Giaccia AJ, Longaker MT. Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adiposederived stromal cells. Tissue Eng Part A 2009; 15: 3697-707
7. Maes C, Carmeliet G, Schipani E. Hypoxia-driven pathways in bone development, regeneration and disease. Nat Rev Rheumatol 2012; 8: 358-66
8. Shomento SH, Wan C, Cao X, Faugere MC, Bouxsein ML, Clemens TL, Riddle RC. Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development. J Cell Biochem 2010; 109: 196-204
9. Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 2007; 117: 1616-26
10. Wan C, Gilbert SR, Wang Y, Cao X, Shen X, Ramaswamy G, Jacobsen KA, Alaql ZS, Eberhardt AW, Gerstenfeld LC, Einhorn TA, Deng L, Clemens TL. Activation of the hypoxiainducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci USA 2008; 105: 686-91
11. Zhao Q, Shen X, Zhang W, Zhu G, Qi J, Deng L. Mice with increased angiogenesis and osteogenesis due to conditional activation of HIF pathway in osteoblasts are protected from ovariectomy induced bone loss. Bone 2012; 50: 763-70
12. Fan L, Li J, Yu Z, Dang X, Wang K. The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration. Biomed Res Int 2014; 2014: 239356
13. Watson JA, Watson CJ, McCann A, Baugh J. Epigenetics, the epicenter of the hypoxic response. Epigenetics 2010; 5: 293-6
14. Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010; 28: 1057-68
15. Vrtačnik P, Marc J, Ostanek B. Epigenetic mechanisms in bone. Clin Chem Lab Med 2014; 52: 589-608
16. Kearns AE, Khosla S, Kostenuik PJ. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev 2008; 29: 155-92
17. Monroe DG, McGee-Lawrence ME, Oursler MJ, Westendorf JJ. Update on Wnt signaling in bone cell biology and bone disease. Gene 2012; 492: 1-18
18. Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 2010; 31: 266-300
19. Trošt Z, Trebse R, Prezelj J, Komadina R, Logar DB, Marc J. A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts. Bone 2010; 46: 72-80
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-8
21. Andersen CL, Jensen JL, Orntoft TF. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 2004; 64: 5245-50
22. Guo M, Song LP, Jiang Y, Liu W, Yu Y, Chen GQ. Hypoxiamimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms. Apoptosis 2006; 11: 67-77
23. Yao SY, Soutto M, Sriram S. Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-alpha-mediated cell death. J Neurosci Res 2008; 86: 2403-13
24. Yang DC, Yang MH, Tsai CC, Huang TF, Chen YH, Hung SC. Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST. PLoS One 2011; 6: e23965
25. Liu C, Tsai AL, Chen YC, Fan SC, Huang CH, Wu CC, Chang CH. Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury. J Cell Biochem 2012; 113: 148-55
26. Chen D, Li Y, Zhou Z, Wu C, Xing Y, Zou X, Tian W, Zhang C. HIF-1alpha inhibits Wnt signaling pathway by activating Sost expression in osteoblasts. PLoS One 2013; 8: e65940
27. Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 2008; 473: 139-46
28. Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, Li Z, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem 2012; 287: 42084-92
29. Riddle RC, Leslie JM, Gross TS, Clemens TL. Hypoxia-inducible factor-1alpha protein negatively regulates load-induced bone formation. J Biol Chem 2011; 286: 44449-56
30. Liu X, Tu Y, Zhang L, Qi J, Ma T, Deng L. Prolyl hydroxylase inhibitors protect from the bone loss in ovariectomy rats by increasing bone vascularity. Cell Biochem Biophys 2014; 69: 141-9
31. Krivoruchko A, Storey KB. Epigenetics in anoxia tolerance: a role for histone deacetylases. Mol Cell Biochem 2010; 342: 151-61
32. Yamagata Y, Asada H, Tamura I, Lee L, Maekawa R, Taniguchi K, Taketani T, Matsuoka A, Tamura H, Sugino N. DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen. Hum Reprod 2009; 24: 1126-32
33. Hou W, Dong Y, Zhang J, Yin Z, Wen H, Xiong L, Li W. Hypoxiainduced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. J Androl 2012; 33: 1379-86
34. Granger A, Abdullah I, Huebner F, Stout A, Wang T, Huebner T, Epstein JA, Gruber PJ. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J 2008; 22: 3549-60
35. Sun Y, Jiang X, Price BD. Tip60: connecting chromatin to DNA damage signaling. Cell Cycle 2010; 9: 930-6
36. Cann KL, Dellaire G. Heterochromatin and the DNA damage response: the need to relax. Biochem Cell Biol 2011; 89: 45-60
37. Brady ME, Ozanne DM, Gaughan L, Waite I, Cook S, Neal DE, Robson CN. Tip60 is a nuclear hormone receptor coactivator. J Biol Chem 1999; 274: 17599-604
38. Kaneda M, Okano M, Hata K, Sado T, Tsujimoto N, Li E, Sasaki H. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 2004; 429: 900-3
39. Hervouet E, Vallette FM, Cartron PF. Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 2009; 4: 487-99
40. Yang Q, Lu Z, Ramchandran R, Longo LD, Raj JU. Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. Am J Physiol Lung Cell Mol Physiol 2012; 303: L1001-10
41. Wu X, Sun J, Li L. Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain. Neurosci Bull 2013; 29: 685-92
42. Shahrzad S, Bertrand K, Minhas K, Coomber BL. Induction of DNA hypomethylation by tumor hypoxia. Epigenetics 2007; 2: 119-25
43. Skowronski K, Dubey S, Rodenhiser D, Coomber B. Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells. Epigenetics 2010; 5: 547-56
44. Wu Y, Han X, Guo Y, Wu H, Ren J, Li J, Ai D, Wang L, Bai D. Response of immortalized murine cementoblast cells to hypoxia in vitro. Arch Oral Biol 2013; 58: 1718-25
45. Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T. Gap-junction-mediated communication in human periodontal ligament cells. J Dent Res 2013; 92: 635-40
46. Patterson AJ, Xiao D, Xiong F, Dixon B, Zhang L. Hypoxia-derived oxidative stress mediates epigenetic repression of PKCepsilon gene in foetal rat hearts. Cardiovasc Res 2012; 93: 302-10
47. el Filali M, Missotten GS, Maat W, Ly LV, Luyten GP, van der Velden PA, Jager MJ. Regulation of VEGF-A in uveal melanoma. Invest Ophthalmol Vis Sci 2010; 51: 2329-37
48. Obrador-Hevia A, Chin SF, Gonzalez S, Rees J, Vilardell F, Greenson JK, Cordero D, Moreno V, Caldas C, Capella G. Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas. J Pathol 2010; 221: 57-67