Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation

Journal of Biological Chemistry

Volumn 286, Issue 52, 2011, Pages 44449-44456

  Riddle, Ryan C ^a,b   Leslie, Julie M ^a   Gross, Ted S ^c   Clemens, Thomas L ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE FORMATION; HYPOXIA-INDUCIBLE FACTOR 1; MAMMALIAN TARGET; MECHANICAL LOADS; MECHANICAL SIGNALS; MECHANICAL STIMULUS; MECHANOTRANSDUCTION; MOLECULAR MECHANISM; NEGATIVE REGULATORS; OSTEOCYTES; TARGET GENES;

GENES; MAMMALS; OSTEOBLASTS;

BONE;

BETA CATENIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PROSTANOID; PROTEIN KINASE B; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE TARGETING; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TIBIA; UPREGULATION;

ANIMALS; BETA CATENIN; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, TRANSGENIC; OSTEOCYTES; OSTEOGENESIS; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES; WNT PROTEINS;

EID: 84455161875     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.276683     Document Type: Article

References (58)

1. Hillam, R. A., and Skerry, T. M. (1995) J. Bone Miner. Res. 10, 683-689
2. Pead, M. J., Skerry, T. M., and Lanyon, L. E. (1988) J. Bone Miner. Res 3, 647-656
3. Morey, E. R., and Baylink, D. J. (1978) Science 201, 1138-1141
4. Bakker, A. D., Soejima, K., Klein-Nulend, J., and Burger, E. H. (2001) J. Biomech. 34, 671-677
5. Genetos, D. C., Geist, D. J., Liu, D., Donahue, H. J., and Duncan, R. L. (2005) J. Bone Miner. Res. 20, 41-49
6. Pead, M. J., and Lanyon, L. E. (1989) Calcif. Tissue Int. 45, 34-40
7. Riddle, R. C., Taylor, A. F., Genetos, D. C., and Donahue, H. J. (2006) Am. J. Physiol. Cell Physiol. 290, C776-C784
8. You, J., Reilly, G. C., Zhen, X., Yellowley, C. E., Chen, Q., Donahue, H. J., and Jacobs, C. R. (2001) J. Biol. Chem. 276, 13365-13371
9. Sawakami, K., Robling, A. G., Ai, M., Pitner, N. D., Liu, D., Warden, S. J., Li, J., Maye, P., Rowe, D. W., Duncan, R. L., Warman, M. L., and Turner, C. H. (2006) J. Biol. Chem. 281, 23698-23711
10. Case, N., Ma, M., Sen, B., Xie, Z., Gross, T. S., and Rubin, J. (2008) J. Biol. Chem. 283, 29196-29205
11. Santos, A., Bakker, A. D., Zandieh-Doulabi, B., de Blieck-Hogervorst, J. M., and Klein-Nulend, J. (2010) Biochem. Biophys. Res. Commun. 391, 364-369
12. Yang, Z., Bidwell, J. P., Young, S. R., Gerard-O'Riley, R., Wang, H., and Pavalko, F. M. (2010) J. Cell Physiol. 223, 435-441
13. Xia, X., Batra, N., Shi, Q., Bonewald, L. F., Sprague, E., and Jiang, J. X. (2010) Mol. Cell. Biol. 30, 206-219
14. Armstrong, V. J., Muzylak, M., Sunters, A., Zaman, G., Saxon, L. K., Price, J. S., and Lanyon, L. E. (2007) J. Biol. Chem. 282, 20715-20727
15. Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., and Turner, C. H. (2008) J. Biol. Chem. 283, 5866-5875
16. Donahue, S. W., Donahue, H. J., and Jacobs, C. R. (2003) J. Biomech. 36, 35-43
17. Hung, C. T., Pollack, S. R., Reilly, T. M., and Brighton, C. T. (1995) Clin. Orthop. Relat. Res. 256-269
18. Srinivasan, S., Ausk, B. J., Poliachik, S. L., Warner, S. E., Richardson, T. S., and Gross, T. S. (2007) J. Appl. Physiol. 102, 1945-1952
19. Robling, A. G., Burr, D. B., and Turner, C. H. (2001) J. Exp. Biol. 204, 3389-3399
20. Srinivasan, S., Agans, S. C., King, K. A., Moy, N. Y., Poliachik, S. L., and Gross, T. S. (2003) Bone 33, 946-955
21. Semenza, G. L. (2000) Genes Dev. 14, 1983-1991
22. Semenza, G. L. (2001) Cell 107, 1-3
23. Treins, C., Giorgetti-Peraldi, S., Murdaca, J., Semenza, G. L., and Van Obberghen, E. (2002) J. Biol. Chem. 277, 27975-27981
24. Shi, Y. H., Wang, Y. X., Bingle, L., Gong, L. H., Heng, W. J., Li, Y., and Fang, W. G. (2005) J. Pathol. 205, 530-536
25. Phillips, R. J., Mestas, J., Gharaee-Kermani, M., Burdick, M. D., Sica, A., Belperio, J. A., Keane, M. P., and Strieter, R. M. (2005) J. Biol. Chem. 280, 22473-22481
26. Liu, X. H., Kirschenbaum, A., Lu, M., Yao, S., Dosoretz, A., Holland, J. F., and Levine, A. C. (2002) J. Biol. Chem. 277, 50081-50086
27. Akeno, N., Robins, J., Zhang, M., Czyzyk-Krzeska, M. F., and Clemens, T. L. (2002) Endocrinology 143, 420-425
28. Shomento, S. H., Wan, C., Cao, X., Faugere, M. C., Bouxsein, M. L., Clemens, T. L., and Riddle, R. C. (2010) J. Cell Biochem. 109, 196-204
29. Milkiewicz, M., Doyle, J. L., Fudalewski, T., Ispanovic, E., Aghasi, M., and Haas, T. L. (2007) J. Physiol. 583, 753-766
30. Kim, C. H., Cho, Y. S., Chun, Y. S., Park, J. W., and Kim, M. S. (2002) Circ. Res. 90, E25-33
31. Wang, Y., Wan, C., Deng, L., Liu, X., Cao, X., Gilbert, S. R., Bouxsein, M. L., Faugere, M. C., Guldberg, R. E., Gerstenfeld, L. C., Haase, V. H., Johnson, R. S., Schipani, E., and Clemens, T. L. (2007) J. Clin. Invest. 117, 1616-1626
32. Zhang, M., Xuan, S., Bouxsein, M. L., von Stechow, D., Akeno, N., Faugere, M. C., Malluche, H., Zhao, G., Rosen, C. J., Efstratiadis, A., and Clemens, T. L. (2002) J. Biol. Chem. 277, 44005-44012
33. Schipani, E., Ryan, H. E., Didrickson, S., Kobayashi, T., Knight, M., and Johnson, R. S. (2001) Genes Dev. 15, 2865-2876
34. Gruber, M., Hu, C. J., Johnson, R. S., Brown, E. J., Keith, B., and Simon, M. C. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 2301-2306
35. Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., and Piccolo, S. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3299-3304
36. Lang, C. H., Frost, R. A., Bronson, S. K., Lynch, C. J., and Vary, T. C. (2010) Am. J. Physiol. Endocrinol. Metab. 298, E1283-1294
37. Bouxsein, M. L., Boyd, S. K., Christiansen, B. A., Guldberg, R. E., Jepsen, K. J., and Müller, R. (2010) J. Bone Miner. Res. 25, 1468-1486
38. Frangos, J. A., McIntire, L. V., and Eskin, S. G. (1988) Biotechnol. Bioeng. 32, 1053-1060
39. Gross, T. S., Srinivasan, S., Liu, C. C., Clemens, T. L., and Bain, S. D. (2002) J. Bone Miner. Res. 17, 493-501
40. Parfitt, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., and Recker, R. R. (1987) J. Bone Miner. Res. 2, 595-610
41. Kato, Y., Windle, J. J., Koop, B. A., Mundy, G. R., and Bonewald, L. F. (1997) J. Bone Miner. Res. 12, 2014-2023
42. Land, S. C., and Tee, A. R. (2007) J. Biol. Chem. 282, 20534-20543
43. Hudson, C. C., Liu, M., Chiang, G. G., Otterness, D. M., Loomis, D. C., Kaper, F., Giaccia, A. J., and Abraham, R. T. (2002) Mol. Cell. Biol. 22, 7004-7014
44. Hens, J. R., Wilson, K. M., Dann, P., Chen, X., Horowitz, M. C., and Wysolmerski, J. J. (2005) J. Bone Miner. Res. 20, 1103-1113
45. Piekarski, K., and Munro, M. (1977) Nature 269, 80-82
46. McKenzie, J. A., and Silva, M. J. (2011) Bone 48, 250-258
47. Matsuzaki, H., Wohl, G. R., Novack, D. V., Lynch, J. A., and Silva, M. J. (2007) Calcif. Tissue Int. 80, 391-399
48. Powers, S. K., and Jackson, M. J. (2008) Physiol. Rev. 88, 1243-1276
49. Simon, M. C. (2006) Adv. Exp. Med. Biol. 588, 165-170
50. Brunelle, J. K., Bell, E. L., Quesada, N. M., Vercauteren, K., Tiranti, V., Zeviani, M., Scarpulla, R. C., and Chandel, N. S. (2005) Cell Metab. 1, 409-414
51. Kim, J. W., Tchernyshyov, I., Semenza, G. L., and Dang, C. V. (2006) Cell Metab. 3, 177-185
52. Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., and Denko, N. C. (2006) Cell Metab. 3, 187-197
53. Holmen, S. L., Zylstra, C. R., Mukherjee, A., Sigler, R. E., Faugere, M. C., Bouxsein, M. L., Deng, L., Clemens, T. L., and Williams, B. O. (2005) J. Biol. Chem. 280, 21162-21168
54. Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., and Hartmann, C. (2005) Dev. Cell 8, 727-738
55. Kaidi, A., Williams, A. C., and Paraskeva, C. (2007) Nat. Cell Biol. 9, 210-217
56. Lim, J. H., Chun, Y. S., and Park, J. W. (2008) Cancer Res. 68, 5177-5184
57. Mazumdar, J., O'Brien, W. T., Johnson, R. S., LaManna, J. C., Chavez, J. C., Klein, P. S., and Simon, M. C. (2010) Nat. Cell Biol. 12, 1007-1013
58. Almeida, M., Han, L., Martin-Millan, M., O'Brien, C. A., and Manolagas, S. C. (2007) J. Biol. Chem. 282, 27298-27305