Hypoxia regulates VEGF expression and cellular proliferation by osteoblasts in vitro

Plastic and Reconstructive Surgery

Volumn 104, Issue 3, 1999, Pages 738-747

  Steinbrech, Douglas S ^a   Mehrara, Babak J ^a   Saadeh, Pierre B ^a   Chin, Gyu ^a   Dudziak, Matthew E ^a   Gerrets, Rene P ^a   Gittes, George K ^a   Longaker, Michael T ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CELL NUCLEUS ANTIGEN; CELL PROTEIN; MESSENGER RNA; OXYGEN; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BLOOD FLOW; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FRACTURE HEALING; HYPOXIA; OSTEOBLAST; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032865703     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-199909010-00019     Document Type: Article

References (56)

1. Brighton, C. T. Structure and function of the growth plate. Clin. Orthop. 136: 22, 1978.
2. Brighton, C. T., and Hunt, R. M. Early histological and ultrastructural changes in medullary fracture callus. J. Bone Joint Surg. Am. 73: 832, 1991.
3. Parfitt, A. M. Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human hone. J. Cell Biochem. 55: 273, 1994.
4. Aronson, J. Experimental and clinical experience with distraction osteogenesis. Cleft Palate Craniofac. J. 31: 473, 1994.
5. Eppley, B. L., Doucet, M., Connolly, D. T., and Feder, J. Enhancement of angiogenesis by bFGF in mandibular bone graft healing in the rabbit. J. Oral Maxillofac. Surg. 46: 391, 1988.
6. Eppley, B. L., Connolly, D. T., Winkelmann, T., Sadove, A. M., Heuvelman, D., and Feder, J. Free bone graft reconstruction of irradiated facial tissue: Experimental effects of basic fibroblast growth factor stimulation. Plast. Reconstr. Surg. 88: 1, 1991.
7. Eppley, B. L., and Sadove, A. M. Effects of material porosity on implant bonding strength in a craniofacial model. J. Craniofac. Surg. 1: 191, 1990.
8. Keck, P. J., Hauser, S. D., Krivi, G., et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309, 1989.
9. Leung, K. S., Fung, K. P., Liu, P. P. L., and Lee, K. M. Bone-specific alkaline phosphatase activities in plasma and callus during callostasis in rabbits. Life Sci. 57: 637, 1995.
10. Gospodarowicz, D., Abraham, J. A., and Schilling, J. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc. Natl. Acad. Sci. U.S.A. 86: 7311, 1989.
11. Ferrara, N., and Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161: 851, 1989.
12. Conn, G., Bayne, M. L., Soderman, D. D., et al. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc. Natl. Acad. Sci. U.S.A. 87: 2628, 1990.
13. Connolly, D. T., Heuvelman, D. M., Nelson, R., et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest. 84: 1470, 1989.
14. Ferrara, N., Carver-Moore, K., Chen, H., et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439, 1996.
15. Shweiki, D., Itin, A., Soffer, D., and Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843, 1992.
16. Namiki, A., Brogi, E., Kearney, M., et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J. Biol. Chem. 270: 31189, 1995.
17. Minchenko, A., Bauer, T., Saleda, S., and Caro, J. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab. Invest. 71: 374, 1994.
18. Saadeh, P. B., Mehrara, B. J., Steinbrech, D. S., et al. Transforming growth factor beta 1 and basic fibroblast growth factor modulate expression of vascular endothelial growth factor by osteoblasts in vitro. Surg. Forum 49: 513, 1998.
19. Heppenstall, R. B. (Ed.). Fracture Treatment and Healing. Philadelphia: Saunders, 1980. Pp. 160-172.
20. Grundes, O., and Reikeras, O. Blood flow and mechanical properties of healing bone: Femoral osteotomies studied in rats. Acta Orthop. Scand. 63: 487, 1992.
21. Rhinelander, F. W., and Baragry, R. A. Microangiography in bone healing: I. Undisplaced closed fractures. J. Bone Joint Surg. Am. 44: 1273, 1962.
22. Rhinelander, F. W., Phillips, R. S., Steel, W. M., and Beer, J. C. Microangiography and bone healing: II. Displaced closed fractures. J. Bone Joint Surg. Am. 50: 643, 1968.
23. Wray, J. B. Vascular regeneration in the healing fracture: An experimental study. Angiology 14: 134, 1963.
24. Sudo, H., Kodama, H. A., Amagai, Y., Yamamoto, S., and Kasai, S. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J. Cell. Biol. 96: 191, 1983.
25. Mehrara, B. J., Rowe, N. M., Steinbrech, D. S., et al. Rat mandibular distraction osteogenesis: II. Molecular analysis of transforming growth factor beta-1 and osteocalcin gene expression. Plast. Reconstr. Surg. 103: 536, 1999.
26. Rowe, N., Mehrara, B. J., Dudziak, M. E., et al. Rat mandibular distraction osteogenesis: I. Histologic and radiographic analysis. Plast. Reconstr. Surg. 102: 2022, 1998.
27. 2 homeostasis by hypoxia-inducible factor 1-alpha. Genes Dev. 12: 149, 1998.
28. Takahashi, Y., Watanabe, H., Fujioka, N., and Mai, M. [Correlation between labeling index by proliferating cell nuclear antigen (PCNA) staining and growth rate in nude mice: Preliminary report.] Nippon Geka Gakkai Zasshi 93: 1511, 1992.
29. Li, W., Nishimura, R., Kashishian, A., et al. A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol. 14: 509, 1994.
30. Quarles, L. D., Yohay, D. A., Lever, L. W., Caton, R., and Wenstrup, R. J. Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: An in vitro model of osteoblast development. J. Bone Miner. Res. 7: 683, 1992.
31. Cassiede, P., Dennis, J. E., Ma, F., and Caplan, A. I. Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-B1 or PDGF-BB as assayed in vivo and in vitro. J. Bone Miner. Res. 11: 1264, 1996.
32. Kueng, W., Silber, E., and Eppenberger, U. Quantification of cells cultured on 96-well plates. Anal. Biochem. 182: 16, 1989.
33. Aronson, J. Temporal and spatial increases in blood flow during distraction osteogenesis. Clin. Orthop. 301: 124, 1994.
34. Trueta, J., and Morgan, J. D. The vascular contribution to osteogenesis: I. Studies by the injection method. J. Bone Joint Surg. Br. 42: 97, 1960.
35. Trueta, J., and Little, K. The vascular contribution of osteogenesis: II. Studies with the electron microscope. J. Bone Joint Surg. Br. 42: 367, 1960.
36. Trueta, J., and Amato, V. The vascular contribution to osteogenesis: III. Changes in the growth cartilage caused by experimentally induced ischemia. J. Bone Joint Surg. Br. 42: 571, 1960.
37. Shaw, J. L., and Bassett, C. A. L. The effects of varying oxygen concentration on osteogenesis and embryonic cartilage in vitro. J. Bone Joint Surg. Am. 49: 73, 1967.
38. Bourque, W. T., Gross, M., and Hall, B. K. Expression of four growth factors during fracture repair, Int. J. Dev. Biol. 37: 573, 1993.
39. Joyce, M. E., Jingushi, S., Scully, S. P., and Bolander, M. E. Role of growth factors in fracture healing. Prog. Clin. Biol. Res. 365: 391, 1991.
40. Inui, K., Maeda, M., Sano, A., et al. Local application of basic fibroblast growth factor minipellet induces the healing of segmental bony defects in rabbits. Calcif. Tissue Int. 63: 490, 1998.
41. Sandner, P., Wolf, K., Bergmaier, U., Gess, B., and Kurtz, A. Induction of VEGF and VEGF receptor gene expression by hypoxia: Divergent regulation in vivo and in vitro. Kidney Int. 51: 448, 1997.
42. Gorden, D. L., Mandriota, S. J., Montesano, R., Orci, L., and Pepper, M. S. Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Transplantation 63: 436, 1997.
43. Kramer, B. K., Bucher, M., Sandner, P., et al. Effects of hypoxia on growth factor expression in the rat kidney in vivo. Kidney Int. 51: 444, 1997.
44. Plate, K. H., Breier, G., Weich, H. A., and Risau, W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359: 845, 1992.
45. Brown, L. F., Yeo, K. T., Berse, B., et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J. Exp. Med. 176: 1375, 1992.
46. Mack, C. A., Magovern, C. J., Budenbender, K. T., et al. Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion. J. Vasc. Surg. 27: 699, 1998.
47. Baumgartner, I., Pieczek, A., Manor, O., et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 97: 1114, 1998.
48. Takeshita, S., Weir, L., Chen, D., et al. Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia. Biochem. Biophys. Res. Commun. 227: 628, 1996.
49. Takeshita, S., Isshiki, T., Mori, H., et al. Microangiographic assessment of collateral vessel formation following direct gene transfer of vascular endothelial growth factor in rats. Cardiovasc. Res. 35: 547, 1997.
50. Melillo, G., Scoccianti, M., Kovesdi, I., Safi, J., Jr., Riccioni, T., and Capogrossi, M. C. Gene therapy for collateral vessel development. Cardiovasc. Res. 35: 480, 1997.
51. Tsurumi, Y., Kearney, M., Chen, D., et al. Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene. Circulation 96: 382, 1997.
52. Tsurumi, Y., Takeshita, S., Chen, D., et al. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion. Circulation 94: 3281, 1996.
53. Isner, J. M., Walsh, K., Symes, J., et al. Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease (news). Circulation 91: 2687, 1995.
54. Isner, J. M., Pieczek, A., Schainfeld, R., et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb (see comments). Lancet 348: 370, 1996.
55. Tuncay, O. C., Ho, D., and Barker, M. K. Oxygen tension regulates osteoblast function. Am. J. Orthod. Dentofacial Orthop. 105: 457, 1994.
56. Arany, Z., Huang, L., Eckner, R., et al. An essential role for p300/CBP in the cellular response to hypoxia. Proc. Natl. Acad. Sci. U.S.A. 93: 12969, 1996.