HIF-1α Inhibits Wnt Signaling Pathway by Activating Sost Expression in Osteoblasts

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Chen, Dafu ^a   Li, Yang ^b   Zhou, Zhiyu ^c   Wu, Chengai ^a   Xing, Yonggang ^a   Zou, Xuenong ^c   Tian, Wei ^a   Zhang, Chi ^b  

^a Jishuitan Orthopaedic College of Tsinghua University   (China)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEFEROXAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SCLEROSTIN; WNT PROTEIN;

ARTICLE; CELL GROWTH; CELL HYPOXIA; CELL PROLIFERATION; CONTROLLED STUDY; DELETION MUTANT; EMBRYO; GENE ACTIVATION; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE LOSS; GENE SEQUENCE; HUMAN; HUMAN CELL; OSTEOBLAST; PROMOTER REGION; REPORTER GENE; SOST GENE; TRANSCRIPTION REGULATION; TRANSIENT TRANSFECTION; UPREGULATION; WNT SIGNALING PATHWAY;

ANIMALS; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE; GLYCOPROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; OSTEOBLASTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; WNT SIGNALING PATHWAY;

EID: 84878913767     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065940     Document Type: Article

References (35)

1. Zhang C, (2010) Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx. J Orthop Surg Res 5: 37.
2. Zhang C, (2012) Molecular mechanisms of osteoblast-specific transcription factor Osterix effect on bone formation. Beijing Da Xue Xue Bao 44: 659-665.
3. Zhang C, Cho K, Huang Y, Lyons JP, Zhou X, et al. (2008) Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A 105: 6936-6941.
4. Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R, (1995) Toward a molecular understanding of skeletal development. Cell 80: 371-378.
5. Harper J, Klagsbrun M, (1999) Cartilage to bone-angiogenesis leads the way. Nat Med 5: 617-618.
6. Wan C, Shao J, Gilbert SR, Riddle RC, Long F, et al. (2010) Role of HIF-1alpha in skeletal development. Ann N Y Acad Sci 1192: 322-326.
7. Wang Y, Wan C, Deng L, Liu X, Cao X, et al. (2007) The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 117: 1616-1626.
8. Rajpurohit R, Koch CJ, Tao Z, Teixeira CM, Shapiro IM, (1996) Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism. J Cell Physiol 168: 424-432.
9. Piters E, Boudin E, Van Hul W, (2008) Wnt signaling: a win for bone. Arch Biochem Biophys 473: 112-116.
10. Baron R, Rawadi G, Roman-Roman S, (2006) Wnt signaling: a key regulator of bone mass. Curr Top Dev Biol 76: 103-127.
11. Day TF, Guo X, Garrett-Beal L, Yang Y, (2005) Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8: 739-750.
12. Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C, (2005) Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8: 727-738.
13. Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, et al. (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132: 49-60.
14. Rodda SJ, McMahon AP, (2006) Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133: 3231-3244.
15. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, et al. (2001) LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107: 513-523.
16. Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157: 303-314.
17. Morvan F, Boulukos K, Clement-Lacroix P, Roman Roman S, Suc-Royer I, et al. (2006) Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 21: 934-945.
18. Li J, Sarosi I, Cattley RC, Pretorius J, Asuncion F, et al. (2006) Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39: 754-766.
19. Balemans W, Piters E, Cleiren E, Ai M, Van Wesenbeeck L, et al. (2008) The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations. Calcif Tissue Int 82: 445-453.
20. Semenov M, Tamai K, He X, (2005) SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem 280: 26770-26775.
21. ten Dijke P, Krause C, de Gorter DJ, Lowik CW, van Bezooijen RL, (2008) Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling. J Bone Joint Surg Am 90Suppl 1: 31-35.
22. Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, et al. (2003) Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J 22: 6267-6276.
23. Chen D, Li Y, Zhou Z, Xing Y, Zhong Y, et al. (2012) Synergistic Inhibition of Wnt Pathway by HIF-1alpha and Osteoblast-Specific Transcription Factor Osterix (Osx) in Osteoblasts. PLoS One 7: e52948.
24. Chen D, Tian W, Li Y, Tang W, Zhang C, (2012) Osteoblast-specific transcription factor Osterix (Osx) and HIF-1alpha cooperatively regulate gene expression of vascular endothelial growth factor (VEGF). Biochem Biophys Res Commun 424: 176-181.
25. Zhang C, Tang W, Li Y, (2012) Matrix Metalloproteinase 13 (MMP13) Is a Direct Target of Osteoblast-Specific Transcription Factor Osterix (Osx) in Osteoblasts. PLoS One 7: e50525.
26. Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, et al. (2001) Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription. J Biol Chem 276: 40614-40620.
27. Tang W, Li Y, Osimiri L, Zhang C, (2011) Osteoblast-specific Transcription Factor Osterix (Osx) Is an Upstream Regulator of Satb2 during Bone Formation. J Biol Chem 286: 32995-33002.
28. Zhang C, Dowd DR, Staal A, Gu C, Lian JB, et al. (2003) Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem 278: 35325-35336.
29. Zhang C, Tang W, Li Y, Yang F, Dowd DR, et al. (2011) Osteoblast-specific transcription factor Osterix increases vitamin D receptor gene expression in osteoblasts. PLoS One 6: e26504.
30. Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, et al. (2012) Transcriptional Regulation of Vascular Endothelial Growth Factor (VEGF) by Osteoblast-specific Transcription Factor Osterix (Osx) in Osteoblasts. J Biol Chem 287: 1671-1678.
31. Ambrosini G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J, (2002) Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem 277: 34601-34609.
32. Issack PS, Helfet DL, Lane JM, (2008) Role of Wnt signaling in bone remodeling and repair. HSS J 4: 66-70.
33. Krishnan V, Bryant HU, Macdougald OA, (2006) Regulation of bone mass by Wnt signaling. J Clin Invest 116: 1202-1209.
34. Wergedal JE, Veskovic K, Hellan M, Nyght C, Balemans W, et al. (2003) Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal. J Clin Endocrinol Metab 88: 5778-5783.
35. Maxwell PH, (2002) Oxygen homeostasis and cancer: insights from a rare disease. Clin Med 2: 356-362.