Comparison of the oral bioavailability of silymarin-loaded lipid nanoparticles with their artificial lipolysate counterparts: Implications on the contribution of integral structure

International Journal of Pharmaceutics

Volumn 489, Issue 1-2, 2015, Pages 195-202

  Shangguan, Mingzhu ^a   Qi, Jianping ^a   Lu, Yi ^a   Wu, Wei ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Bioavailability; Drug delivery; Lipid nanoparticles; Lipolysis; Oral

Indexed keywords

DRUG CARRIER; LIPID; LIPOLYSATE; NANOSTRUCTURED LIPID CARRIER; OLEIC ACID; SILIBININ; SILYMARIN; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG; BILE ACID; NANOPARTICLE; POVIDONE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CENTRIFUGATION; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG RELEASE; DRUG STRUCTURE; EXPERIMENTAL DOG; LIPOLYSIS; MAXIMUM PLASMA CONCENTRATION; MICELLE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; COMPARATIVE STUDY; DOG; INTESTINAL SECRETIONS; ORAL DRUG ADMINISTRATION; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL AVAILABILITY; DOGS; DRUG LIBERATION; INTESTINAL SECRETIONS; LIPIDS; LIPOLYSIS; NANOPARTICLES; POVIDONE; SILYMARIN;

EID: 84929175262     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.05.005     Document Type: Article

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