Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery

Journal of Controlled Release

Volumn 209, Issue , 2015, Pages 77-87

  Li, Junjie ^a   Chen, Qixian ^b   Zha, Zengshi ^a   Li, Hui ^a   Toh, Kazuko ^c   Dirisala, Anjaneyulu ^b   Matsumoto, Yu ^c   Osada, Kensuke ^b,d   Kataoka, Kazunori ^b,c   Ge, Zhishen ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Cancer gene therapy; Nonviral gene delivery system; Polyplex micelle; Prolonged blood circulation; Temperature responsive

Indexed keywords

ACRYLIC MONOMERS; AMIDES; BLOCK COPOLYMERS; BLOOD; DISEASES; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; MAMMALS; MOLECULAR BIOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TUMORS;

BLOOD CIRCULATION; CANCER GENE THERAPY; NON-VIRAL GENE DELIVERY; POLYPLEX MICELLES; TEMPERATURE-RESPONSIVE;

MICELLES;

ANGIOGENIC PROTEIN; COPOLYMER; DEOXYRIBONUCLEASE I; DEXTRAN SULFATE; HEPARAN SULFATE; MACROGOL; NUCLEASE; PLASMID DNA; POLY(N ISOPROPYLACRYLAMIDE); POLYANION; DNA; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; LUCIFERASE; MICELLE; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CELLULAR DISTRIBUTION; CIRCULATION; COMPLEX FORMATION; CONFOCAL LASER MICROSCOPY; CYTOTOXICITY; DRUG EFFICACY; DRUG SYNTHESIS; FLOW CYTOMETRY; GEL PERMEATION CHROMATOGRAPHY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO GENE TRANSFER; IN VIVO GENE TRANSFER; INTERNALIZATION; MALE; MICELLE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; STATIC ELECTRICITY; TERNARY POLYPLEX MICELLE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; GENE TRANSFER; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; NEOPLASMS; PATHOLOGY; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; CELL LINE, TUMOR; DNA; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HUMANS; LUCIFERASES; MALE; MICE, INBRED ICR; MICELLES; NEOPLASMS; POLYMERS; TUMOR BURDEN;

EID: 84929086366     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.04.024     Document Type: Article

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