Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability

Advanced Materials

Volumn 25, Issue 10, 2013, Pages 1487-1493

  Eltoukhy, Ahmed A ^a   Chen, Delai ^b   Alabi, Christopher A ^b   Langer, Robert ^a   Anderson, Daniel G ^b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

DNA; gene therapy; lipid; nanoparticle; polymer

Indexed keywords

ALKYL SIDE CHAINS; AMINO ESTERS; DNA TRANSFECTION; FUNCTIONALIZATIONS; GENE DELIVERY; IN-VIVO; NON-VIRAL GENE DELIVERY; SUPPORT INTERACTION;

DNA; GENE THERAPY; GENE TRANSFER; LIPIDS; POLYMERS;

NANOPARTICLES;

DNA; LIPID; MACROGOL DERIVATIVE; NANOPARTICLE; POLY(BETA AMINO ESTER); POLY(BETA-AMINO ESTER); POLYMER;

ARTICLE; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECT; GENETIC TRANSFECTION; HELA CELL; HUMAN; METABOLISM;

CELL SURVIVAL; DNA; HELA CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYMERS; TRANSFECTION;

EID: 84874979873     PISSN: 09359648     EISSN: 15214095     Source Type: Journal    
DOI: 10.1002/adma.201204346     Document Type: Article

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