Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Miquel, Ernesto ^a   Cassina, Adriana ^a   Martínez Palma, Laura ^a   Bolatto, Carmen ^a   Trías, Emiliano ^b   Gandelman, Mandi ^a   Radi, Rafael ^a   Barbeito, Luis ^a,c   Cassina, Patricia ^a  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^b INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

^c INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DICHLOROACETIC ACID; PYRUVATE DEHYDROGENASE COMPLEX; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; COCULTURE; CONTROLLED STUDY; COUPLING FACTOR; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; FUNCTIONAL STATUS; GENE MUTATION; GRIP STRENGTH; LUMBAR SPINAL CORD; MALE; MITOCHONDRIAL RESPIRATION; MOTONEURON; MOTOR PERFORMANCE; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROMODULATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; OXIDATION REDUCTION STATE; PROTEIN EXPRESSION; RAT; RESPIRATION CONTROL; SURVIVAL RATE; SURVIVAL TIME; ANIMAL; CELL CULTURE; CELL DEATH; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS; RATTUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ASTROCYTES; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DICHLOROACETATE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MOTOR NEURONS; OXIDATION-REDUCTION; PHOSPHORYLATION; PYRUVATE DEHYDROGENASE COMPLEX; RATS; SUPEROXIDE DISMUTASE;

EID: 84859258363     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034776     Document Type: Article

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