메뉴 건너뛰기




Volumn 63, Issue 17, 2015, Pages 4305-4311

Dietary supplementation of genistein alleviates liver inflammation and fibrosis mediated by a methionine-choline-deficient diet in db / db mice

Author keywords

db db mouse; fibrosis; genistein; methionine choline deficient diet; nonalcoholic steatohepatitis

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; DIETARY SUPPLEMENTS; GENE EXPRESSION; MAMMALS; NUTRITION; OXIDATIVE STRESS; PATHOLOGY;

EID: 84928911576     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b00398     Document Type: Article
Times cited : (43)

References (46)
  • 1
    • 54049150442 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
    • Anderson, N.; Borlak, J. Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis Pharmacol Rev. 2008, 60, 311-57 10.1124/pr.108.00001
    • (2008) Pharmacol Rev. , vol.60 , pp. 311-57
    • Anderson, N.1    Borlak, J.2
  • 2
    • 56649123256 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease: A global perspective
    • Lazo, M.; Clark, J. M. The epidemiology of nonalcoholic fatty liver disease: a global perspective Semin. Liver Dis. 2008, 28, 339-50 10.1055/s-0028-1091978
    • (2008) Semin. Liver Dis. , vol.28 , pp. 339-350
    • Lazo, M.1    Clark, J.M.2
  • 3
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two hits?
    • Day, C. P.; James, O. F. Steatohepatitis: a tale of two hits? Gastroenterology 1998, 114, 842-5 10.1016/S0016-5085(98)70599-2
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 4
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: Getting both pathology and metabolic context right
    • Larter, C. Z.; Yeh, M. M. Animal models of NASH: getting both pathology and metabolic context right J. Gastroenterol. Hepatol. 2008, 23, 1635-48 10.1111/j.1440-1746.2008.05543.x
    • (2008) J. Gastroenterol. Hepatol. , vol.23 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 6
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq, I. A.; Farrell, G. C.; Field, J.; Bell, D. R.; Gonzalez, F. J.; Robertson, G. R. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis J. Clin. Invest. 2000, 105, 1067-75 10.1172/JCI8814
    • (2000) J. Clin. Invest. , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 7
    • 7044264899 scopus 로고    scopus 로고
    • Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease
    • Gao, D.; Wei, C.; Chen, L.; Huang, J.; Yang, S.; Diehl, A. M. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease Am. J. Physiol Gastrointest Liver Physiol 2004, 287, G1070-7 10.1152/ajpgi.00228.2004
    • (2004) Am. J. Physiol Gastrointest Liver Physiol , vol.287 , pp. 1070-1077
    • Gao, D.1    Wei, C.2    Chen, L.3    Huang, J.4    Yang, S.5    Diehl, A.M.6
  • 8
    • 7044241291 scopus 로고    scopus 로고
    • Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: Role of short-form leptin receptors and osteopontin
    • Sahai, A.; Malladi, P.; Pan, X.; Paul, R.; Melin-Aldana, H.; Green, R. M.; Whitington, P. F. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin Am. J. Physiol Gastrointest Liver Physiol 2004, 287, G1035-43 10.1152/ajpgi.00199.2004
    • (2004) Am. J. Physiol Gastrointest Liver Physiol , vol.287 , pp. 1035-1043
    • Sahai, A.1    Malladi, P.2    Pan, X.3    Paul, R.4    Melin-Aldana, H.5    Green, R.M.6    Whitington, P.F.7
  • 9
    • 78651352067 scopus 로고    scopus 로고
    • Prevalence, gender, ethnic variations, and prognosis of NASH
    • Hashimoto, E.; Tokushige, K. Prevalence, gender, ethnic variations, and prognosis of NASH J. Gastroenterol. 2011, 46 (Suppl 1) 63-9 10.1007/s00535-010-0311-8
    • (2011) J. Gastroenterol. , vol.46 , pp. 63-69
    • Hashimoto, E.1    Tokushige, K.2
  • 12
    • 84856752855 scopus 로고    scopus 로고
    • 17beta-estradiol inhibits oxidized low-density lipoprotein-induced increase in matrix metalloproteinase-9 expression in human macrophages
    • Uzui, H.; Sinha, S. K.; Rajavashisth, T. B. 17beta-estradiol inhibits oxidized low-density lipoprotein-induced increase in matrix metalloproteinase-9 expression in human macrophages J. Investig. Med. 2011, 59, 1104-1108
    • (2011) J. Investig. Med. , vol.59 , pp. 1104-1108
    • Uzui, H.1    Sinha, S.K.2    Rajavashisth, T.B.3
  • 13
    • 28144432694 scopus 로고    scopus 로고
    • Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells
    • Itagaki, T.; Shimizu, I.; Cheng, X.; Yuan, Y.; Oshio, A.; Tamaki, K.; Fukuno, H.; Honda, H.; Okamura, Y.; Ito, S. Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells Gut 2005, 54, 1782-9 10.1136/gut.2004.053728
    • (2005) Gut , vol.54 , pp. 1782-1789
    • Itagaki, T.1    Shimizu, I.2    Cheng, X.3    Yuan, Y.4    Oshio, A.5    Tamaki, K.6    Fukuno, H.7    Honda, H.8    Okamura, Y.9    Ito, S.10
  • 14
    • 23844554843 scopus 로고    scopus 로고
    • Soybean foods and their benefits: Potential mechanisms of action
    • Omoni, A. O.; Aluko, R. E. Soybean foods and their benefits: potential mechanisms of action Nutr. Rev. 2005, 63, 272-83 10.1111/j.1753-4887.2005.tb00141.x
    • (2005) Nutr. Rev. , vol.63 , pp. 272-283
    • Omoni, A.O.1    Aluko, R.E.2
  • 15
    • 79952045559 scopus 로고    scopus 로고
    • The role of soy in vegetarian diets
    • Messina, M.; Messina, V. The role of soy in vegetarian diets Nutrients 2010, 2, 855-88 10.3390/nu2080855
    • (2010) Nutrients , vol.2 , pp. 855-888
    • Messina, M.1    Messina, V.2
  • 16
    • 2942621925 scopus 로고    scopus 로고
    • Comprehensive phytochemical profile of soy protein isolate
    • Fang, N.; Yu, S.; Badger, T. M. Comprehensive phytochemical profile of soy protein isolate J. Agric. Food Chem. 2004, 52, 4012-20 10.1021/jf049842y
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 4012-4020
    • Fang, N.1    Yu, S.2    Badger, T.M.3
  • 17
    • 84880602076 scopus 로고    scopus 로고
    • Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases
    • Nagaraju, G. P.; Zafar, S. F.; El-Rayes, B. F. Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases Nutr. Rev. 2013, 71, 562-72 10.1111/nure.12044
    • (2013) Nutr. Rev. , vol.71 , pp. 562-572
    • Nagaraju, G.P.1    Zafar, S.F.2    El-Rayes, B.F.3
  • 18
    • 84897105602 scopus 로고    scopus 로고
    • Genistein alleviates the development of nonalcoholic steatohepatitis in ApoE(-/-) mice fed a high-fat diet
    • Jeon, S.; Park, Y. J.; Kwon, Y. H. Genistein alleviates the development of nonalcoholic steatohepatitis in ApoE(-/-) mice fed a high-fat diet Mol. Nutr. Food Res. 2014, 58, 830-41 10.1002/mnfr.201300112
    • (2014) Mol. Nutr. Food Res. , vol.58 , pp. 830-841
    • Jeon, S.1    Park, Y.J.2    Kwon, Y.H.3
  • 19
    • 79955850387 scopus 로고    scopus 로고
    • Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms
    • Ji, G.; Yang, Q.; Hao, J.; Guo, L.; Chen, X.; Hu, J.; Leng, L.; Jiang, Z. Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms Int. Immunopharmacol. 2011, 11, 762-8 10.1016/j.intimp.2011.01.036
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 762-768
    • Ji, G.1    Yang, Q.2    Hao, J.3    Guo, L.4    Chen, X.5    Hu, J.6    Leng, L.7    Jiang, Z.8
  • 21
    • 0035158466 scopus 로고    scopus 로고
    • Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice
    • Ju, Y. H.; Allred, C. D.; Allred, K. F.; Karko, K. L.; Doerge, D. R.; Helferich, W. G. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice J. Nutr. 2001, 131, 2957-2962
    • (2001) J. Nutr. , vol.131 , pp. 2957-2962
    • Ju, Y.H.1    Allred, C.D.2    Allred, K.F.3    Karko, K.L.4    Doerge, D.R.5    Helferich, W.G.6
  • 22
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J.; Lees, M.; Stanley, G. H. S. A simple method for the isolation and purification of total lipids from animal tissues J. Biol. Chem. 1957, 226, 497-509
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Stanley, G.H.S.3
  • 23
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa, H.; Ohishi, N.; Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 1979, 95, 351-8 10.1016/0003-2697(79)90738-3
    • (1979) Anal. Biochem. , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 24
    • 84880617187 scopus 로고    scopus 로고
    • Betaine alleviates hypertriglycemia and tau hyperphosphorylation in db/db mice
    • Jung, G. Y.; Won, S. B.; Kim, J.; Jeon, S.; Han, A.; Kwon, Y. H. Betaine alleviates hypertriglycemia and tau hyperphosphorylation in db/db mice Toxicol. Res. 2013, 29, 7-14 10.5487/TR.2013.29.1.007
    • (2013) Toxicol. Res. , vol.29 , pp. 7-14
    • Jung, G.Y.1    Won, S.B.2    Kim, J.3    Jeon, S.4    Han, A.5    Kwon, Y.H.6
  • 25
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi, K.; Yang, L.; McCall, S.; Huang, J.; Yu, X. X.; Pandey, S. K.; Bhanot, S.; Monia, B. P.; Li, Y. X.; Diehl, A. M. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis Hepatology 2007, 45, 1366-74 10.1002/hep.21655
    • (2007) Hepatology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Yu, X.X.5    Pandey, S.K.6    Bhanot, S.7    Monia, B.P.8    Li, Y.X.9    Diehl, A.M.10
  • 26
    • 0036853914 scopus 로고    scopus 로고
    • Orchestrating the unfolded protein response in health and disease
    • Kaufman, R. J. Orchestrating the unfolded protein response in health and disease J. Clin. Invest. 2002, 110, 1389-98 10.1172/JCI16886
    • (2002) J. Clin. Invest. , vol.110 , pp. 1389-1398
    • Kaufman, R.J.1
  • 28
    • 48449096011 scopus 로고    scopus 로고
    • MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes
    • Larter, C. Z.; Yeh, M. M.; Williams, J.; Bell-Anderson, K. S.; Farrell, G. C. MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes J. Hepatol. 2008, 49, 407-16 10.1016/j.jhep.2008.03.026
    • (2008) J. Hepatol. , vol.49 , pp. 407-416
    • Larter, C.Z.1    Yeh, M.M.2    Williams, J.3    Bell-Anderson, K.S.4    Farrell, G.C.5
  • 30
    • 33644955272 scopus 로고    scopus 로고
    • Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    • Anstee, Q. M.; Goldin, R. D. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research Int. J. Exp. Pathol. 2006, 87, 1-16 10.1111/j.0959-9673.2006.00465.x
    • (2006) Int. J. Exp. Pathol. , vol.87 , pp. 1-16
    • Anstee, Q.M.1    Goldin, R.D.2
  • 31
    • 0038643427 scopus 로고    scopus 로고
    • Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice
    • Ip, E.; Farrell, G. C.; Robertson, G.; Hall, P.; Kirsch, R.; Leclercq, I. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice Hepatology 2003, 38, 123-32 10.1053/jhep.2003.50307
    • (2003) Hepatology , vol.38 , pp. 123-132
    • Ip, E.1    Farrell, G.C.2    Robertson, G.3    Hall, P.4    Kirsch, R.5    Leclercq, I.6
  • 32
    • 34548154602 scopus 로고    scopus 로고
    • Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury
    • Lee, G. S.; Yan, J. S.; Ng, R. K.; Kakar, S.; Maher, J. J. Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury J. Lipid Res. 2007, 48, 1885-96 10.1194/jlr.M700181-JLR200
    • (2007) J. Lipid Res. , vol.48 , pp. 1885-1896
    • Lee, G.S.1    Yan, J.S.2    Ng, R.K.3    Kakar, S.4    Maher, J.J.5
  • 33
    • 0242438087 scopus 로고    scopus 로고
    • Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis
    • George, J.; Pera, N.; Phung, N.; Leclercq, I.; Yun Hou, J.; Farrell, G. Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis J. Hepatol. 2003, 39, 756-64 10.1016/S0168-8278(03)00376-3
    • (2003) J. Hepatol. , vol.39 , pp. 756-764
    • George, J.1    Pera, N.2    Phung, N.3    Leclercq, I.4    Yun Hou, J.5    Farrell, G.6
  • 34
    • 70349332736 scopus 로고    scopus 로고
    • Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis
    • Phung, N.; Pera, N.; Farrell, G.; Leclercq, I.; Hou, J. Y.; George, J. Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis Int. J. Mol. Med. 2009, 24, 171-80 10.3892/ijmm-00000220
    • (2009) Int. J. Mol. Med. , vol.24 , pp. 171-180
    • Phung, N.1    Pera, N.2    Farrell, G.3    Leclercq, I.4    Hou, J.Y.5    George, J.6
  • 35
    • 84856093034 scopus 로고    scopus 로고
    • Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice
    • Min, A. K.; Kim, M. K.; Kim, H. S.; Seo, H. Y.; Lee, K. U.; Kim, J. G.; Park, K. G.; Lee, I. K. Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice Life Sci. 2012, 90, 200-5 10.1016/j.lfs.2011.11.012
    • (2012) Life Sci. , vol.90 , pp. 200-205
    • Min, A.K.1    Kim, M.K.2    Kim, H.S.3    Seo, H.Y.4    Lee, K.U.5    Kim, J.G.6    Park, K.G.7    Lee, I.K.8
  • 37
    • 84896709837 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
    • Wree, A.; Eguchi, A.; McGeough, M. D.; Pena, C. A.; Johnson, C. D.; Canbay, A.; Hoffman, H. M.; Feldstein, A. E. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice Hepatology 2014, 59, 898-910 10.1002/hep.26592
    • (2014) Hepatology , vol.59 , pp. 898-910
    • Wree, A.1    Eguchi, A.2    McGeough, M.D.3    Pena, C.A.4    Johnson, C.D.5    Canbay, A.6    Hoffman, H.M.7    Feldstein, A.E.8
  • 39
    • 36248936506 scopus 로고    scopus 로고
    • Genistein modifies liver fibrosis and improves liver function by inducing uPA expression and proteolytic activity in CCl4-treated rats
    • Salas, A. L.; Montezuma, T. D.; Farina, G. G.; Reyes-Esparza, J.; Rodriguez-Fragoso, L. Genistein modifies liver fibrosis and improves liver function by inducing uPA expression and proteolytic activity in CCl4-treated rats Pharmacology 2008, 81, 41-9 10.1159/000107968
    • (2008) Pharmacology , vol.81 , pp. 41-49
    • Salas, A.L.1    Montezuma, T.D.2    Farina, G.G.3    Reyes-Esparza, J.4    Rodriguez-Fragoso, L.5
  • 40
    • 84872588003 scopus 로고    scopus 로고
    • Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats
    • Huang, Q.; Huang, R.; Zhang, S.; Lin, J.; Wei, L.; He, M.; Zhuo, L.; Lin, X. Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats Toxicol. Lett. 2013, 217, 102-10 10.1016/j.toxlet.2012.12.014
    • (2013) Toxicol. Lett. , vol.217 , pp. 102-110
    • Huang, Q.1    Huang, R.2    Zhang, S.3    Lin, J.4    Wei, L.5    He, M.6    Zhuo, L.7    Lin, X.8
  • 42
    • 81555220920 scopus 로고    scopus 로고
    • The potential interplay of adipokines with toll-like receptors in the development of hepatocellular carcinoma
    • Wang, S. N.; Wang, S. T.; Lee, K. T. The potential interplay of adipokines with toll-like receptors in the development of hepatocellular carcinoma Gastroenterol Res. Pract 2011, 2011, 215986 10.1155/2011/215986
    • (2011) Gastroenterol Res. Pract , vol.2011 , pp. 215986
    • Wang, S.N.1    Wang, S.T.2    Lee, K.T.3
  • 43
    • 84873720119 scopus 로고    scopus 로고
    • What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?
    • Finelli, C.; Tarantino, G. What is the role of adiponectin in obesity related non-alcoholic fatty liver disease? World J. Gastroenterol 2013, 19, 802-12 10.3748/wjg.v19.i6.802
    • (2013) World J. Gastroenterol , vol.19 , pp. 802-812
    • Finelli, C.1    Tarantino, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.