Betaine alleviates hypertriglycemia and tau hyperphosphorylation in db/db mice

Toxicological Research

Volumn 29, Issue 1, 2013, Pages 7-14

  Jung, Ga Young ^a   Won, Sae Bom ^a   Kim, Juhae ^a   Jeon, Sookyoung ^a   Han, Anna ^a   Kwon, Young Hye ^a  

^a Seoul National University   (South Korea)

Author keywords

Betaine; Db db mice; ER stress; Insulin resistance; Oxidative stress; Tau phosphorylation

Indexed keywords

EID: 84880617187     PISSN: 19768257     EISSN: 22342753     Source Type: Journal    
DOI: 10.5487/TR.2013.29.1.007     Document Type: Article

References (33)

1. Kumashiro, N., Tamura, Y., Uchida, T., Ogihara, T., Fujitani, Y., Hirose, T., Mochizuki, H., Kawamori, R. and Watada, H. (2008) Impact of oxidative stress and peroxisome proliferatoractivated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes, 57, 2083-2091.
2. Ozcan, U., Cao, Q., Yilmaz, E., Lee, A.H., Iwakoshi, N.N., Ozdelen, E., Tuncman, G., Görgün, C., Glimcher, L.H. and Hotamisligil, G.S. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Sci., 306, 457-461.
3. Nakatani, Y., Kaneto, H., Kawamori, D., Yoshiuchi, K., Hatazaki, M., Matsuoka, T.A., Ozawa, K., Ogawa, S., Hori, M., Yamasaki, Y. and Matsuhisa, M. (2005) Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J. Biol. Chem., 280, 847-851.
4. Han, M.S., Chung, K.W., Cheon, H.G., Rhee, S.D., Yoon, C.H., Lee, M.K., Kim, K.W. and Lee, M.S. (2009) Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice. Diabetes, 58, 329-336.
5. Han, K.L., Choi, J.S., Lee, J.Y., Song, J., Joe, M.K., Jung, M.H. and Hwang, J.K. (2008) Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes, 57, 737-745.
6. Profenno, L.A., Porsteinsson, A.P. and Faraone, S.V. (2010) Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol. Psychiatry, 67, 505-512.
7. Beydoun, M.A., Beydoun, H.A. and Wang, Y. (2008) Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes. Rev., 9, 204-218.
8. Zhao, W.Q., Chen, H., Quon, M.J. and Alkon, D.L. (2004) Insulin and the insulin receptor in experimental models of learning and memory. Eur. J. Pharmacol., 490, 71-81.
9. Planel, E., Tatebayashi, Y., Miyasaka, T., Liu, L., Wang, L., Herman, M., Yu, W.H., Luchsinger, J.A., Wadzinski, B., Duff, K.E. and Takashima, A. (2007) Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J. Neurosci., 27, 13635-13648.
10. Ueland, P.M. (2011) Choline and betaine in health and disease. J. Inherited Metab. Dis., 34, 3-15.
11. Ji, C. and Kaplowitz, N. (2003) Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology, 124, 1488-1499.
12. Ji, C., Shinohara, M., Kuhlenkamp, J., Chan, C. and Kaplowitz, N. (2007) Mechanisms of protection by the betainehomocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology, 46, 1586-1596.
13. Erman, F., Balkan, J., Cevikba , U., Koçak-Toker, N. and Uysal, M. (2004) Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication. Amino Acids, 27, 199-205.
14. Kwon do, Y., Jung, Y.S., Kim, S.J., Park, H.K., Park, J.H. and Kim, Y.C. (2009) Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. J. Nutr., 139, 63-68.
15. Lakshman, R., Cederbaum, A.I., Hoek, J.B., Konishi, M., Koop, D. and Donohu, T.M. (2005) Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. Alcohol. Clin. Exp. Res., 29, 1726-1734.
16. Kathirvel, E., Morgan, K., Nandgiri, G., Sandoval, B.C., Caudill, M.A., Bottiglieri, T., French, S.W. and Morgan, T.R. (2010) Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. Am. J. Physiol. Gastrointest. Liver Physiol., 299, G1068-G1077.
17. Song, Z., Deaciuc, I., Zhou, Z., Song, M., Chen, T., Hill, D. and McClain, C.J. (2007) Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. Am. J. Physiol. Gastrointest. Liver Physiol., 293, G894-G902.
18. Folch, J., Lees, M. and Sloane Stanley, G.H. (1957) A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem., 226, 497-509.
19. Aebi, H. (1984) Catalase in vitro. Methods Enzymol., 105, 121-126.
20. Griffith, O.W. (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyri-dine. Anal. Biochem., 106, 207-212.
21. Ohkawa, H., Ohish, N. and Yagi, K. (1979) Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358.
22. Zhang, P., McGrath, B., Li, S., Frank, A., Zambito, F., Reinert, J., Gannon, M., Ma, K., McNaughton, K. and Cavener, D.R. (2002) The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol. Cell. Biol., 22, 3864-3874.
23. Liang, H. and Ward, W.F. (2006) PGC-1alpha: a key regulator of energy metabolism. Adv. Physiol. Educ., 30, 145-151.
24. Duval, C., Müller, M. and Kersten, S. (2007) PPARalpha and dyslipidemia. Biochim. Biophys. Acta, 1771, 961-971.
25. Satapati, S., He, T., Inagaki, T., Potthoff, M., Merritt, M.E., Esser, V., Mangelsdorf, D.J., Kliewer, S.A., Browning, J.D. and Burgess, S.C. (2008) Partial resistance to peroxisome proliferator-activated receptor-a agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism. Diabetes, 57, 2012-2021.
26. Benhamed, F., Denechaud, P.D., Lemoine, M., Robichon, C., Moldes, M., Bertrand-Michel, J., Ratziu, V., Serfaty, L., Housset, C., Capeau, J., Girard, J., Guillou, H. and Postic, C. (2012) The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J. Clin. Invest., 122, 2176-2194.
27. Lee, J.Y., Cho, H.K. and Kwon, Y.H. (2010) Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells. Metab., 59, 927-934.
28. Yoon, J.C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C.R., Granner, D.K., Newgard, C.B. and Spiegelman, B.M. (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nat., 413, 131-138.
29. Craig, S.A. (2004) Betaine in human nutrition. Am. J. Clin. Nutr., 80, 539-549.
30. Natalello, A., Liu, J., Ami, D., Doglia, S.M. and de Marco, A. (2009) The osmolyte betaine promotes protein misfolding and disruption of protein aggregates. Proteins, 75, 509-517.
31. Guo, Z., Jiang, H., Xu, X., Duan, W. and Mattson, M.P. (2008) Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. J. Biol. Chem., 283, 1754-1763.
32. Kim, B., Backus, C., Oh, S., Hayes, J.M. and Feldman, E.L. (2009) Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinol., 150, 5294-5301.
33. Clodfelder-Miller, B.J., Zmijewska, A.A., Johnson, G.V. and Jope, R.S. (2006) Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes, 55, 3320-3325.