17β-estradiol inhibits oxidized low-density lipoproteinyinduced increase in matrix metalloproteinase-9 expression in human macrophages

Journal of Investigative Medicine

Volumn 59, Issue 7, 2011, Pages 1104-1108

  Uzui, Hiroyasu ^a,c   Sinha, Satyesh K ^a   Rajavashisth, Tripathi B ^a,b  

^a CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b Omics Biotechnology Inc   (United States)

^c UNIVERSITY OF FUKUI   (Japan)

Author keywords

Estrogen; Lipoproteins; Macrophages; Metalloproteinases; Tissue inhibitor of metalloproteinases

Indexed keywords

ESTRADIOL; GELATINASE B; OXIDIZED LOW DENSITY LIPOPROTEIN; PROGESTERONE; TAMOXIFEN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTROGEN ACTIVITY; HORMONE ACTION; HUMAN; HUMAN CELL; MACROPHAGE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; WESTERN BLOTTING; ZYMOGRAPHY;

EID: 84856752855     PISSN: 17088267     EISSN: 17088267     Source Type: Journal    
DOI: 10.2310/JIM.0b013e3182279e4b     Document Type: Article

References (22)

1. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999;340:1801-1811. (Pubitemid 29266405)
2. Mendelsohn ME. Protective effects of estrogen on the cardiovascular system. Am J Cardiol. 2002;89(12A):12EY17E; discussion 17EY18E.
3. Shah PK. Role of inflammation and metalloproteinases in plaque disruption and thrombosis. Vasc Med. 1998;3:199-206. (Pubitemid 28553005)
4. Davies MJ, Richardson PD, Wolf N, et al. Risk of thrombosis in human atherosclerotic plaques-role of extracellular lipid, macrophage and smooth muscle cell content. Br Heart J. 1993;69:377-381. (Pubitemid 23171108)
5. Galis ZS, Sukhova GK, Kranzhofer RK, et al. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci USA. 1995;92:402-406.
6. Shah PK, Falk E, Badimon JJ, et al. Human monocyte-derived macrophages induce collagen breakdown in atherosclerotic fibrous caps: potential role of matrix degrading metalloproteinases and implication for plaque rupture. Circulation. 1995;92:1565-1569.
7. Higashikata T, Yamagishi M, Higashi T, et al. Altered expression balance of matrix metaloproteinases and their inhibitors in human carotid plaque disruption: results of quantitative tissue analysis using real time RT-PCR method. Atherosclerosis. 2006;185:165-172. (Pubitemid 43117564)
8. Huang Y, Song L, Wu S, et al. Oxidized LDL differentially regulates MMP-1 and TIMP-1 expression in vascular endothelial cells. Atherosclerosis. 2001;156:119-125. (Pubitemid 32429602)
9. Xu X-P, Merisel SR, Ong JM, et al. Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages. Circulation. 1999;99:993-998. (Pubitemid 29104486)
10. Rajavashisth TB, Xu XP, Jovinge S, et al. Membrane type-1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators. Circulation. 1999;99:3103-3109. (Pubitemid 29289074)
11. Shah PK, Galis ZS. Matrix metalloproteinase hypothesis of plaque rupture: players keep piling up but questions remain. Circulation. 2001;104:1878-1880. (Pubitemid 32983226)
12. Doherty TM, Asotra K, Pei D, et al. Therapeutic developments in matrix metalloproteinase inhibition. Expert Opinion Ther Patents. 2002;12:655-697.
13. Brown DL, Hibbs MS, Kearney M, et al. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation. 1995;91:2125-2131.
14. Galis ZS, Sukhova GK, Lark MW, et al. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94:2493-2503. (Pubitemid 24379627)
15. Li Z, Li L, Zielke HR, et al. Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions. Am J Pathol. 1996;148:121-128. (Pubitemid 26019650)
16. Vegeto E, Bonincontro C, Pollio G, et al. Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia. J Neurosci. 2001;21:1809-1818. (Pubitemid 32221364)
17. Fisher GJ, Datta SC, Talwar HS, et al. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature. 1996:379:335-339. (Pubitemid 26033074)
18. Sato H, Seiki M. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene. 1993;8:395-405. (Pubitemid 23073756)
19. Logan SK, Garabedian MJ, Campbell CE, et al. Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and its transcription factors. J Biol Chem. 1996;271: 7774-7782.
20. Deshpande R, Khalili H, Pergolizzi RG, et al. Estradiol down-regulates LPS-induced cytokine production and NF-JB activation in murine macrophages. Am J Reprod Immunol. 1997;38:46-54. (Pubitemid 27308153)
21. Crowe DL, Brown TN. Transcriptional inhibition of matrix metalloproteinase 9 (MMP-9) activity by a c-fos/estrogen receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion. Neoplasia. 1999;1(4):368-372.
22. Zanger D, Yang BK, Ardans J, et al. Divergent effects of hormone therapy on serum markers of inflammation in postmenopausal women with coronary artery disease on appropriate medical management. J Am Coll Cardiol. 2000;36:1797-1802.