메뉴 건너뛰기




Volumn , Issue , 2012, Pages 127-139

Naphthoquinones: Atovaquone, and other antimalarials targeting mitochondrial functions

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84928889538     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-0346-0480-2_7     Document Type: Chapter
Times cited : (3)

References (52)
  • 1
    • 0027463776 scopus 로고
    • Structural features of Plasmodium cytochrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinones
    • Vaidya AB, Lashgari MS, Pologe LG, Morrisey J (1993) Structural features of Plasmodium cytochrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinones. Mol Biochem Parasitol 58:33-42
    • (1993) Mol Biochem Parasitol , vol.58 , pp. 33-42
    • Vaidya, A.B.1    Lashgari, M.S.2    Pologe, L.G.3    Morrisey, J.4
  • 2
    • 70349536103 scopus 로고    scopus 로고
    • Mitochondrial evolution and functions in malaria parasites
    • Vaidya AB, Mather MW (2009) Mitochondrial evolution and functions in malaria parasites. Annu Rev Microbiol 63:249-267
    • (2009) Annu Rev Microbiol , vol.63 , pp. 249-267
    • Vaidya, A.B.1    Mather, M.W.2
  • 3
    • 12344312032 scopus 로고    scopus 로고
    • The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast
    • Foth BJ, Stimmler LM, Handman E, Crabb BS, Hodder AN, McFadden GI (2005) The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol 55:39-53
    • (2005) Mol Microbiol , vol.55 , pp. 39-53
    • Foth, B.J.1    Stimmler, L.M.2    Handman, E.3    Crabb, B.S.4    Hodder, A.N.5    McFadden, G.I.6
  • 5
    • 34250641971 scopus 로고    scopus 로고
    • The malaria parasite type II NADH:quinone oxidoreductase: An alternative enzyme for an alternative lifestyle
    • Fisher N, Bray PG, Ward SA, Biagini GA (2007) The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle. Trends Parasitol 23:305-310
    • (2007) Trends Parasitol , vol.23 , pp. 305-310
    • Fisher, N.1    Bray, P.G.2    Ward, S.A.3    Biagini, G.A.4
  • 6
    • 1942447877 scopus 로고    scopus 로고
    • The cytochrome bc1 complex: Function in the context of structure
    • Crofts AR (2004) The cytochrome bc1 complex: function in the context of structure. Annu Rev Physiol 66:689-733
    • (2004) Annu Rev Physiol , vol.66 , pp. 689-733
    • Crofts, A.R.1
  • 7
    • 78149467657 scopus 로고    scopus 로고
    • A structural model for across membrane coupling between the Qo and Qi active sites of cytochrome bc1
    • Cooley JW (2010) A structural model for across membrane coupling between the Qo and Qi active sites of cytochrome bc1. Biochim Biophys Acta 1797:1842-1848
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 1842-1848
    • Cooley, J.W.1
  • 9
    • 0032781364 scopus 로고    scopus 로고
    • Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites
    • Srivastava IK, Morrisey JM, Darrouzet E, Daldal F, Vaidya AB (1999) Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. Mol Microbiol 33:704-711
    • (1999) Mol Microbiol , vol.33 , pp. 704-711
    • Srivastava, I.K.1    Morrisey, J.M.2    Darrouzet, E.3    Daldal, F.4    Vaidya, A.B.5
  • 11
    • 34648828095 scopus 로고    scopus 로고
    • Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi
    • Kessl JJ, Meshnick SR, Trumpower BL (2007) Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi. Trends Parasitol 23:494-501
    • (2007) Trends Parasitol , vol.23 , pp. 494-501
    • Kessl, J.J.1    Meshnick, S.R.2    Trumpower, B.L.3
  • 12
    • 0030023406 scopus 로고    scopus 로고
    • Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand
    • Looareesuwan S, Viravan C, Webster HK, Kyle DE, Hutchinson DB, Canfield CJ (1996) Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am J Trop Med Hyg 54:62-66
    • (1996) Am J Trop Med Hyg , vol.54 , pp. 62-66
    • Looareesuwan, S.1    Viravan, C.2    Webster, H.K.3    Kyle, D.E.4    Hutchinson, D.B.5    Canfield, C.J.6
  • 13
    • 0030829371 scopus 로고    scopus 로고
    • Variations in frequencies of drug resistance in Plasmodium falciparum
    • Rathod PK, McErlean T, Lee PC (1997) Variations in frequencies of drug resistance in Plasmodium falciparum. Proc Natl Acad Sci USA 94:9389-9393
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9389-9393
    • Rathod, P.K.1    McErlean, T.2    Lee, P.C.3
  • 14
    • 0032169951 scopus 로고    scopus 로고
    • Divergent evolutionary constraints on mitochondrial and nuclear genomes of malaria parasites
    • McIntosh MT, Srivastava R, Vaidya AB (1998) Divergent evolutionary constraints on mitochondrial and nuclear genomes of malaria parasites. Mol Biochem Parasitol 95:69-80
    • (1998) Mol Biochem Parasitol , vol.95 , pp. 69-80
    • McIntosh, M.T.1    Srivastava, R.2    Vaidya, A.B.3
  • 16
    • 0023653729 scopus 로고
    • Tandemly arranged gene clusters of malarial parasites that are highly conserved and transcribed
    • Vaidya AB, Arasu P (1987) Tandemly arranged gene clusters of malarial parasites that are highly conserved and transcribed. Mol Biochem Parasitol 22:249-257
    • (1987) Mol Biochem Parasitol , vol.22 , pp. 249-257
    • Vaidya, A.B.1    Arasu, P.2
  • 18
    • 0029078941 scopus 로고
    • Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro
    • Canfield CJ, Pudney M, Gutteridge WE (1995) Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp Parasitol 80:373-381
    • (1995) Exp Parasitol , vol.80 , pp. 373-381
    • Canfield, C.J.1    Pudney, M.2    Gutteridge, W.E.3
  • 20
    • 0343832511 scopus 로고
    • Proguanil - the isolation of a metabolite with high antimalarial activity
    • Crowther AF, Levi AA (1953) Proguanil - the isolation of a metabolite with high antimalarial activity. Br J Pharmacol 8:93-97
    • (1953) Br J Pharmacol , vol.8 , pp. 93-97
    • Crowther, A.F.1    Levi, A.A.2
  • 21
    • 0033110869 scopus 로고    scopus 로고
    • Malarone (atovaquone and proguanil hydrochloride): A review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group
    • Looareesuwan S, Chulay JD, Canfield CJ, Hutchinson DB (1999) Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group. Am J Trop Med Hyg 60:533-541
    • (1999) Am J Trop Med Hyg , vol.60 , pp. 533-541
    • Looareesuwan, S.1    Chulay, J.D.2    Canfield, C.J.3    Hutchinson, D.B.4
  • 22
    • 0002450347 scopus 로고    scopus 로고
    • Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
    • Fivelman QL, Butcher GA, Adagu IS, Warhurst DC, Pasvol G (2002) Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria. Malar J 1:1
    • (2002) Malar J , vol.1 , pp. 1
    • Fivelman, Q.L.1    Butcher, G.A.2    Adagu, I.S.3    Warhurst, D.C.4    Pasvol, G.5
  • 23
    • 18944385296 scopus 로고    scopus 로고
    • Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa
    • Kuhn S, Gill MJ, Kain KC (2005) Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa. Am J Trop Med Hyg 72:407-409
    • (2005) Am J Trop Med Hyg , vol.72 , pp. 407-409
    • Kuhn, S.1    Gill, M.J.2    Kain, K.C.3
  • 25
    • 0031052025 scopus 로고    scopus 로고
    • Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite
    • Srivastava IK, Rottenberg H, Vaidya AB (1997) Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J Biol Chem 272:3961-3966
    • (1997) J Biol Chem , vol.272 , pp. 3961-3966
    • Srivastava, I.K.1    Rottenberg, H.2    Vaidya, A.B.3
  • 26
    • 0033063070 scopus 로고    scopus 로고
    • A mechanism for the synergistic antimalarial action of atovaquone and proguanil
    • Srivastava IK, Vaidya AB (1999) A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother 43:1334-1339
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1334-1339
    • Srivastava, I.K.1    Vaidya, A.B.2
  • 28
    • 78649672277 scopus 로고    scopus 로고
    • Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum
    • Painter HJ, Morrisey JM, Vaidya AB (2010) Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum. Antimicrob Agents Chemother 54:5281-5287
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 5281-5287
    • Painter, H.J.1    Morrisey, J.M.2    Vaidya, A.B.3
  • 29
    • 0026668882 scopus 로고
    • Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
    • Nagy M, Lacroute F, Thomas D (1992) Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts. Proc Natl Acad Sci USA 89:8966-8970
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8966-8970
    • Nagy, M.1    Lacroute, F.2    Thomas, D.3
  • 30
    • 33847398001 scopus 로고    scopus 로고
    • Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
    • Painter HJ, Morrisey JM, Mather MW, Vaidya AB (2007) Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446:88-91
    • (2007) Nature , vol.446 , pp. 88-91
    • Painter, H.J.1    Morrisey, J.M.2    Mather, M.W.3    Vaidya, A.B.4
  • 32
    • 45749119578 scopus 로고    scopus 로고
    • Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum
    • Phillips MA, Gujjar R, Malmquist NA, White J, El Mazouni F, Baldwin J, Rathod PK (2008) Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. J Med Chem 51:3649-3653
    • (2008) J Med Chem , vol.51 , pp. 3649-3653
    • Phillips, M.A.1    Gujjar, R.2    Malmquist, N.A.3    White, J.4    El Mazouni, F.5    Baldwin, J.6    Rathod, P.K.7
  • 33
    • 0032407858 scopus 로고    scopus 로고
    • Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase
    • Fidock DA, Nomura T, Wellems TE (1998) Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase. Mol Pharmacol 54:1140-1147
    • (1998) Mol Pharmacol , vol.54 , pp. 1140-1147
    • Fidock, D.A.1    Nomura, T.2    Wellems, T.E.3
  • 34
    • 0025307263 scopus 로고
    • In vitro metabolism of the biguanide antimalarials in human liver microsomes: Evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme
    • Helsby NA, Ward SA, Howells RE, Breckenridge AM (1990) In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme. Br J Clin Pharmacol 30:287-291
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 287-291
    • Helsby, N.A.1    Ward, S.A.2    Howells, R.E.3    Breckenridge, A.M.4
  • 36
    • 0031875471 scopus 로고    scopus 로고
    • Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations
    • Wanwimolruk S, Bhawan S, Coville PF, Chalcroft SC (1998) Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations. Eur J Clin Pharmacol 54:431-435
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 431-435
    • Wanwimolruk, S.1    Bhawan, S.2    Coville, P.F.3    Chalcroft, S.C.4
  • 37
    • 0032821754 scopus 로고    scopus 로고
    • Genetic polymorphism of (S)-mephenytoin 40-hydroxylation in populations of African descent
    • Xie HG, Kim RB, Stein CM, Wilkinson GR, Wood AJ (1999) Genetic polymorphism of (S)-mephenytoin 40-hydroxylation in populations of African descent. Br J Clin Pharmacol 48:402-408
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 402-408
    • Xie, H.G.1    Kim, R.B.2    Stein, C.M.3    Wilkinson, G.R.4    Wood, A.J.5
  • 38
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2 C19 genetic polymorphism
    • Desta Z, Zhao X, Shin JG, Flockhart DA (2002) Clinical significance of the cytochrome P450 2 C19 genetic polymorphism. Clin Pharmacokinet 41:913-958
    • (2002) Clin Pharmacokinet , vol.41 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.G.3    Flockhart, D.A.4
  • 47
    • 77949661216 scopus 로고    scopus 로고
    • Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation
    • Wang J, Huang L, Li J, Fan Q, Long Y, Li Y, Zhou B (2010) Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. PLoS One 5:e9582
    • (2010) PLoS One , vol.5 , pp. e9582
    • Wang, J.1    Huang, L.2    Li, J.3    Fan, Q.4    Long, Y.5    Li, Y.6    Zhou, B.7
  • 48
    • 77953773127 scopus 로고    scopus 로고
    • Plasmodium dihydroorotate dehydrogenase: A promising target for novel anti-malarial chemotherapy
    • Phillips MA, Rathod PK (2010) Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets 10:226-239
    • (2010) Infect Disord Drug Targets , vol.10 , pp. 226-239
    • Phillips, M.A.1    Rathod, P.K.2
  • 50
    • 33845968856 scopus 로고    scopus 로고
    • Mitochondrial drug targets in apicomplexan parasites
    • Mather MW, Henry KW, Vaidya AB (2007) Mitochondrial drug targets in apicomplexan parasites. Curr Drug Targets 8:49-60
    • (2007) Curr Drug Targets , vol.8 , pp. 49-60
    • Mather, M.W.1    Henry, K.W.2    Vaidya, A.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.